8,957 results match your criteria: "FEDERAL UNIVERSITY OF MINAS GERAIS[Affiliation]"
Placebo-controlled efficacy of 5-HT3 antagonists for postoperative nausea and vomiting prophylaxis in supratentorial craniotomies: A systematic review and comparative meta-analysis of randomized clinical trials.
Clin Neurol Neurosurg
November 2024
Department of Neurosurgery, University of São Paulo, São Paulo, Brazil.
Article Synopsis
- * A total of five randomized controlled trials involving 347 patients were analyzed, showing that those receiving 5-HT3 antagonists had significantly lower rates of vomiting and nausea compared to the placebo group within the first 24 hours post-surgery.
- * The results support the use of 5-HT3 antagonists in clinical settings to reduce PONV after neurosurgery, with evidence indicating better outcomes compared to placebo treatments.
Article Synopsis
- * Recent efforts to stop smoking haven't been put into action yet, and it’s important to see what could happen if smoking rates stay the same or improve.
- * Researchers used models to predict health outcomes by 2050 based on different scenarios of smoking rates, showing that cutting smoking could greatly improve health and life expectancy.
Projected changes in heatwaves over Central and South America using high-resolution regional climate simulations.
Sci Rep
October 2024
Department of City and Regional Planning and Institute for Transportation Studies, University of California, Berkeley, CA, USA.
Article Synopsis
- - Heatwaves in Latin America are expected to become more frequent, longer, and more intense by mid-century, with even greater increases under the high emissions scenario (RCP8.5) compared to the low emissions scenario (RCP2.6).
- - The frequency of heatwaves may double across most of Latin America, leading to a significant increase in population exposure to extreme heat, projected to rise by three to ten times in Central and South America.
- - Following a low emissions pathway (RCP2.6) could significantly reduce heatwave exposure—by 57% in Central America and 50% in South America—emphasizing the need for emissions control and sustainable practices to mitigate climate change impacts. *
Synthesis and evaluation of esters obtained from phenols and phenoxyacetic acid with significant phytotoxic and cytogenotoxic activities.
Environ Sci Pollut Res Int
October 2024
Departament of Biology, Federal University of the Espírito Santo, Alto Universitário, s/n, Alegre, ES, 29500-000, Brazil.
Article Synopsis
- There is an increasing need for herbicides that are both effective and environmentally friendly, prompting a study on synthesizing new compounds from phenols and phenoxyacetic acid.
- The research involved creating seven esters through a specific chemical reaction and characterizing them using advanced techniques, followed by testing their effects on seed germination and root development of two plant species.
- Results indicated that some esters showed significant phytotoxic effects and caused noticeable damage at the cellular level in one of the plants, suggesting their potential use in developing new herbicides.
Matrix Support: interface between Specialty Dental Centers and primary oral health care in Brazil.
BMC Health Serv Res
October 2024
Faculty of Dentistry, Federal University of Mato Grosso do Sul (UFMS), Campo Grande, Brazil.
Article Synopsis
- The study investigates how Matrix Support (MS) affects integration between Primary Health Care (PHC) and Dental Specialty Centers (CEOs) in Brazil.
- Findings reveal that nearly half of the CEOs lack collaborative therapeutic projects with PHC oral health teams, which is linked to various factors like poor case discussions and absence of joint educational activities.
- The conclusion emphasizes that individual practices within CEOs play a more significant role in the integration issues than broader contextual factors from local municipalities.
Assessment of the COVID-19 impact on the Brazilian Unified Health System (SUS) financing: an analysis of the financing dynamics of 2020 and 2021.
BMC Health Serv Res
October 2024
Department of Business Administration, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Article Synopsis
- The study examines how COVID-19 affected Brazil's public health funding by analyzing historical spending data from the National Health Fund (FNS) between 2015 and 2021.
- *Using a seasonal ARIMAX model, it finds that while there was an increasing trend in health expenditure, this trend was already in place before the pandemic.
- *The increase in confirmed COVID-19 cases resulted in a modest rise in FNS spending after a month, but it also caused a slight decrease in spending growth two months later, indicating only a temporary impact.*
Mesotherapy with bicalutamide for female pattern hair loss.
Indian J Dermatol Venereol Leprol
September 2024
Department of Dermatology, Rio de Janeiro State University (UERJ), R. São Francisco Xavier, Maracanã, Rio de Janeiro, Brazil.
Occurrence, genetic diversity, and antimicrobial resistance of methicillin-resistant Staphylococcus spp. in hospitalized and non-hospitalized cats in Brazil.
PLoS One
October 2024
Veterinary School, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Article Synopsis
- A study was conducted to investigate the presence and characteristics of Staphylococcus spp. in both hospitalized and non-hospitalized cats, focusing on methicillin-resistant strains.
- A total of 218 swabs were taken from 109 cats, and various identification and genetic analysis techniques were used to isolate and categorize the bacteria.
- The findings indicated that S. felis was most common in non-hospitalized cats, while MRS strains such as MRSH and MRSP were primarily found in hospitalized ones, with factors like antibiotic use, hospitalization, and comorbidities linked to higher prevalence rates.
Challenges and limitations in meta-analyses of complications in neurosurgery: Systematic review with proposed approach and checklist to mitigate errors and improve the assessment of the real-world experience.
Neurosurg Rev
October 2024
Department of Neurosurgery, Lenox Hill Hospital/Northwell Health, New York, NY, USA.
Article Synopsis
- Meta-analyses in medical science face challenges, particularly in neurosurgery, due to inconsistencies in defining and reporting complications, which limits their effectiveness.
- A systematic review identified key limitations and created the NeuroComp Meta-Analysis Checklist to help standardize reporting and address common errors in such studies.
- The checklist, comprising 23 items across 5 domains, aims to improve the reliability of future meta-analyses of neurosurgical complications, although it may not resolve all existing issues.
Residual feed intake and gain alters the performance and carcass traits in Nellore cattle.
Trop Anim Health Prod
October 2024
Department of Veterinary Medicine, Federal University of Juiz de Fora, Rua José Lourenço Kelmer, Juiz de Fora, Minas Gerais, 36036-900, Brazil.
Article Synopsis
- - The residual intake and gain (RIG) method selects cattle with low feed intake compared to expectations, focusing on efficiency in feed usage.
- - In a study of Nellore cattle, efficient RIG animals showed better daily weight gain and larger muscle area, indicating superior growth traits.
- - While RIG can effectively help in selecting for growth traits without affecting fat deposition, it must be used cautiously due to potential body size influence.
Vulnerability, social value and the equitable sharing of benefits from research: beyond the placebo and access debates.
Front Med (Lausanne)
September 2024
Ethics Working Group of International Federation of Associations of Pharmaceutical Physicians and Pharmaceutical Medicine (IFAPP), Woerden, Netherlands.
Article Synopsis
- * The paper explores key aspects, including ethical reforms for including vulnerable participants to ensure diversity and the necessity of social value, especially for those in need.
- * It also discusses the requirements for promoting the inclusion of vulnerable groups, such as reevaluating placebo-controlled trial norms and post-trial access, and suggests directions for reforming research ethics to enhance social value and global health equity.
The ecological and evolutionary dynamics of inselbergs.
Biol Rev Camb Philos Soc
October 2024
Department of Genetics, Ecology and Evolution, Federal University of Minas Gerais, Belo Horizonte, 31270-901, Brazil.
Islands are fundamental model systems in ecology, biogeography, and evolutionary biology. However, terrestrial islands, unlike their aquatic counterparts, have received comparatively less attention. Among these land islands, inselbergs (i.
View Article and Find Full Text PDFMorphological features and genetic background in ectomesenchymal chondromyxoid tumor: A systematic review.
Histol Histopathol
September 2024
Department of Oral Surgery, Pathology and Clinical Dentistry, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Background: Ectomesenchymal chondromyxoid tumor (EMCMT) is a rare neoplasm that mainly affects the tongue and harbors recurrent, although not exclusive, gene fusions. Owing to its rarity, overlapping features with other tumors may lead to challenges in the microscopic diagnosis. We aimed to perform a systematic review focusing on the histomolecular findings of EMCMT of the oral and maxillofacial region and to evaluate the possible association between microscopic features with the genetic background.
View Article and Find Full Text PDFDeep learning for discriminating non-trivial conformational changes in molecular dynamics simulations of SARS-CoV-2 spike-ACE2.
Sci Rep
September 2024
Department of Computer Science, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Article Synopsis
- Molecular dynamics (MD) simulations generate complex data that are challenging to analyze with traditional methods; however, combining this with deep learning allows for better understanding of structural changes in proteins, such as those caused by mutations.
- The study specifically focuses on the SARS-CoV-2 spike protein's receptor-binding domain (RBD), using distance maps and deep convolutional neural networks to predict how point mutations affect the virus's infectivity and ability to evade immune responses.
- Results showed promising predictive success regarding mutant types that enhance receptor affinity and reduce immunogenicity, with significant correlations found between simulation data and binding free energy changes, potentially aiding in identifying more infectious and immune-evasive strains of the virus.
Response to Ong et al, "Hair-raising costs: Evaluating botulinum toxin treatment for androgenetic alopecia".
J Am Acad Dermatol
January 2025
Dermatology Department, Rio de Janeiro State University (UERJ), Rio de Janeiro, Brazil.
Expression levels of ACE and ACE2 in the placenta and white adipose tissue of lean and obese pregnant women.
Biomarkers
November 2024
Graduate Program in Health Sciences (Programa de Pós-Graduação em Ciências da Saúde - PPGCS), State University of Montes Claros (Universidade Estadual de Montes Claros - Unimontes), Montes Claros, Minas Gerais, Brazil.
Background: This study evaluated the expression of ACE and ACE2 in the placenta and white adipose tissue in lean and obese women, and correlated their levels with anthropometric, clinical, and laboratory parameters, and tissue count of inflammatory cells.
Methods: A cross-sectional analytical study was performed with 49 pregnant women and their respective newborns. Samples of placenta and adipose tissue were used for measuring mRNA expression for ACE and ACE2 through qRT-PCR.
Desarda versus Lichtenstein inguinal hernia repair: A meta-analysis of randomized controlled trials.
World J Surg
November 2024
Department of Surgery, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
Background: The Lichtenstein technique is the gold standard for adult open inguinal hernia repair with mesh. The Desarda technique emerged in 2001 as a novel, promising non-mesh technique that has demonstrated low recurrence and postoperative complications.
Methods: We searched MEDLINE, the Cochrane Central Register of Clinical Trials, and Embase for randomized controlled trials (RCT) published until April 2024.
Magnetic resonance-guided laser interstitial thermal therapy versus open surgical corpus callosotomy for pediatric refractory epilepsy: A systematic review and meta-analysis.
Seizure
November 2024
Department of Surgery, Neurology and Neurosurgery Unit, Federal University of Goiás, Goiânia, Brazil. Electronic address:
Purpose: Magnetic resonance-guided laser interstitial thermal therapy (MRgLITT) is a novel, minimally invasive alternative to traditional open surgery corpus callosotomy (CC). We aim to compare both approaches in terms of time of hospitalization and surgical procedure, complications, and efficacy outcomes.
Methods: A systematic search on PubMed, Embase, Web of Science, and Cochrane Library databases was performed for studies directly comparing MRgLITT and open surgery for refractory epilepsy in children.
Tailoring 3D-printed sensor properties with reduced-graphene oxide: improved conductive filaments.
Mikrochim Acta
September 2024
Institute of Chemistry, Federal University of Uberlândia, Uberlândia, Minas Gerais, 38400-902, Brazil.
The development of a tailored filament is reported composed of reduced graphene oxide (rGO) and carbon black (CB) in a polylactic acid (PLA) matrix and its use in the production of electrochemical sensors. The electrodes containing rGO showed superior performance when compared with those prepared in the absence of this material. Physicochemical and electrochemical characterizations of the electrodes showed the successful incorporation of both rGO and CB and an improved conductivity in the presence of rGO (lower resistance to charge transfer).
View Article and Find Full Text PDFThe Omicron Variant Is Associated with a Reduced Risk of the Post COVID-19 Condition and Its Main Phenotypes Compared to the Wild-Type Virus: Results from the EuCARE-POSTCOVID-19 Study.
Viruses
September 2024
Clinic of Infectious Diseases, San Paolo Hospital, ASST Santi Paolo e Carlo, Department of Health Science, University of Milan, 20142 Milan, Italy.
Article Synopsis
- Post COVID-19 condition (PCC) refers to ongoing symptoms that persist for at least one month after recovering from acute COVID-19, and the study analyzed risks associated with different viral variants among 7,699 hospitalized patients.
- The research found that the most common PCC symptoms were fatigue, brain fog, and respiratory issues, with the original wild-type virus being the most prevalent among participants, followed by Alpha, Delta, Gamma, and Omicron variants.
- Results indicated that infection with Omicron was linked to a lower risk of developing PCC compared to the wild-type strain, while Alpha and Delta variants were associated with a higher risk; ICU admission was a significant factor influencing severity and PCC risk.
Acute Chikungunya Virus Infection Triggers a Diverse Range of T Helper Lymphocyte Profiles.
Viruses
August 2024
Department of Microbiology and Parasitology, Biosciences Center, Federal University of Rio Grande do Norte, Natal 59078-970, Brazil.
Article Synopsis
- * Researchers analyzed the blood of 27 CHIKV-positive patients and 9 healthy controls, finding significant increases in transcription factors and cytokines linked to various T cell types, especially RORγt.
- * The study revealed complex immune interactions during CHIKV infection, noting that higher levels of some immune markers are associated with either lower or higher viral loads, enhancing understanding of disease mechanisms.
Temperature Interference on ZIKV and CHIKV Cycles in Mosquitoes and Mammalian Cells.
Pathogens
September 2024
Precision Medicine Research Center, Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro 21941-904, Brazil.
Article Synopsis
- The study investigates how temperature affects the viral cycles of Zika (ZIKV) and Chikungunya (CHIKV) in mammalian (Vero) and mosquito (C6/36) cells.
- At two temperatures, 28 °C and 37 °C, researchers compare the virus's genome quantification to its infectivity in both cell types.
- Techniques like transmission electron microscopy reveal unique interactions, such as CHIKV's "virus-surfing" behaviors and its larger forms, while ZIKV is less prevalent in mosquito cells compared to mammalian cells.
Genomic Analyses of Methicillin-Susceptible and Methicillin-Resistant Strains Involved in Canine Infections: A Comprehensive Genotypic Characterization.
Pathogens
September 2024
Department of Veterinary Clinical Pathology, Faculty of Veterinary Medicine, Federal University of Rio Grande do Sul, Porto Alegre 91540-000, Brazil.
Article Synopsis
- * Genomic analyses revealed that MRSP strains have larger genomes with more antimicrobial resistance genes and virulent markers than MSSP strains, indicating heightened pathogenicity in MRSP infections.
- * Pangenome analysis identified a large number of both core and variable genes, while phylogenomic analysis effectively differentiated MRSP from MSSP strains, suggesting distinct evolutionary pathways that are essential for developing strategies to combat resistant infections.
Oral Problems in Brazilian Individuals with Rare Genetic Diseases That Affect Skeletal Development.
Int J Environ Res Public Health
September 2024
Department of Social and Preventive Dentistry, School of Dentistry, Federal University of Minas Gerais, Belo Horizonte 31270-800, Brazil.
Article Synopsis
- The study examined the oral health issues in individuals with rare genetic conditions affecting skeletal development compared to those without such diseases.
- It involved 210 participants aged 2 to 54, with half having conditions like mucopolysaccharidosis (MPS) and osteogenesis imperfecta (OI), and the other half being healthy individuals recruited from similar locations in Brazil.
- Results indicated that those with rare diseases were significantly more likely to experience dental problems, being 12.9 times more likely to have oral issues than their counterparts without rare conditions.
Diet and Oral Squamous Cell Carcinoma: A Scoping Review.
Int J Environ Res Public Health
September 2024
Faculty of Medical Sciences of Minas Gerais, Alameda Ezequiel Dias, 275, Belo Horizonte 30130-110, MG, Brazil.
Article Synopsis
- Oral squamous cell carcinoma (OSCC) is a prevalent cancer worldwide, with rising cases among non-smokers prompting a need to investigate dietary influences alongside smoking.
- This scoping review utilized a systematic approach to assess the relationship between diet and OSCC, analyzing data from 17 studies involving over 10,000 patients primarily from countries with high human development.
- Findings suggest that higher consumption of fruits, vegetables, and tea may reduce OSCC risk, while diets high in salty meats, dairy, and fried/spicy foods could increase it, highlighting the need for standardized research to clarify these associations.