Hybrid stochastic and robust optimization of a hybrid system with fuel cell for building electrification using an improved arithmetic optimization algorithm.

This paper proposes a hybrid stochastic-robust optimization framework for sizing a photovoltaic/tidal/fuel cell (PV/TDL/FC) system to meet an annual educational building demand based on hydrogen storage via unscented transformation (UT), and information gap decision theory-based risk-averse strategy (IGDT-RA). The hybrid framework integrates the strengths of UT for scenario generation and IGDT-RA (hybrid UT-IGDT-RA) for optimizing the system robustness and maximum uncertainty radius (MRU) of building energy demand and renewable resource generation. The deterministic model focuses on minimizing the cost of energy production over the project's lifespan (CEPLS) and considers a reliability constraint defined as the demand shortage probability (DSHP).

Glucagon-Like Peptide 1 Receptor Agonists and Chronic Lower Respiratory Disease Among Type 2 Diabetes Patients: Replication and Reliability Assessment Across a Research Network.

Introduction: The aim of this study is to use observational methods to evaluate reliability of evidence generated by a study of the effect of glucagon-like peptide 1 receptor agonists (GLP-1RA) on chronic lower respiratory disease (CLRD) outcomes among Type-2 diabetes mellitus (T2DM) patients.

Research Design And Methods: We independently reproduced a study comparing effects of GLP-1RA versus dipeptidyl peptidase-4 inhibitors (DPP4-i) on CLRD outcomes among patients with T2DM and prior CLRD. We reproduced inputs and outputs using the original study data (national administrative claims) and evaluated the robustness of results in comparison to alternate design/analysis decisions.

Anticancer effect of a single-chain variable fragment against pro-matrix metalloproteinase-7 in colon cancer.

Disrupting the interaction between matrix metalloproteinase-7 (MMP-7) and syndecan-2 (SDC-2) can yield anticancer effects in colon cancer cells. Here, a single-chain variable fragment (scFv) targeting the pro-domain of MMP-7 was generated as a potential candidate anticancer agent. Among the generated scFvs, those designated 1B7 and 1C3 showed the strongest abilities to inhibit the ability of MMP-7 pro-domain to directly interact with SDC-2 in vitro and decrease the cancer activities of human HT29 colon adenocarcinoma cells.

Generative adversarial networks with fully connected layers to denoise PPG signals.

Objective: The detection of arterial pulsating signals at the skin periphery with Photoplethysmography (PPG) are easily distorted by motion artifacts. This work explores the alternatives to the aid of PPG reconstruction with movement sensors (accelerometer and/or gyroscope) which to date have demonstrated the best pulsating signal reconstruction.

Approach: A generative adversarial network with fully connected layers (FC-GAN) is proposed for the reconstruction of distorted PPG signals.

Relative fire-proneness of land cover types in the Brazilian Atlantic forest.

Fires are increasingly affecting tropical biomes, where landscape-fire interactions remain understudied. We investigate the fire-proneness-the likelihood of a land use or land cover (LULC) type burning more or less than expected based on availability-in the Brazilian Atlantic Forest (AF). This biodiversity hotspot is increasingly affected by fires due to human activities and climate change.

Identification of novel PfEMP1 variants containing domain cassettes 11, 15 and 8 that mediate the Plasmodium falciparum virulence-associated rosetting phenotype.

Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) is a diverse family of variant surface antigens, encoded by var genes, that mediates binding of infected erythrocytes to human cells and plays a key role in parasite immune evasion and malaria pathology. The increased availability of parasite genome sequence data has revolutionised the study of PfEMP1 diversity across multiple P. falciparum isolates.

Modulating Perovskite Surface Energetics Through Tuneable Ferrocene Interlayers for High-Performance Perovskite Solar Cells.

Achieving rational control over chemical and energetic properties at the perovskite/electron transport layer (ETL) interface is crucial for realizing highly efficient and stable next-generation inverted perovskite solar cells (PSCs). To address this, we developed multifunctional ferrocene (Fc)-based interlayers engineered to exhibit adjustable passivating and electrochemical characteristics. These interlayers are designed to minimize non-radiative recombination and, to modulate the work function (WF) and uniformity of the perovskite surface, thereby enhancing device performance.

Characterization of the Disorganization of the Inner Retinal Layers in Diabetics Using Increased Axial Resolution Optical Coherence Tomography.

Purpose: To compare a novel high-resolution optical coherence tomography (OCT) with improved axial resolution (High-Res OCT) with conventional spectral-domain OCT (SD-OCT) with regard to their capacity to characterize the disorganization of the retinal inner layers (DRIL) in diabetic maculopathy.

Methods: Diabetic patients underwent multimodal retinal imaging (SD-OCT, High-Res OCT, and color fundus photography). Best-corrected visual acuity and diabetes characteristics were recorded.

Chemotherapy-Related Cognitive Impairment and Changes in Neural Network Dynamics: A Systematic Review.

Background And Objectives: This systematic review aims to synthesize the current literature on the association between chemotherapy (CTX) and chemotherapy-related cognitive impairment (CRCI) with functional and structural brain alterations in patients with noncentral nervous system cancers.

Methods: A comprehensive search of the PubMed/MEDLINE, Web of Science, and Embase databases was conducted, and results were reported following preferred reporting items for systematic review and meta-analyses guidelines. Data on study design, comparison cohort characteristics, patient demographics, cancer type, CTX agents, neuroimaging methods, structural and functional connectivity (FC) changes, and cognitive/psychological assessments in adult patients were extracted and reported.

Impact of Fc-gamma receptor IIIA polymorphism on late-onset neutropenia and clinical outcomes in kidney transplant recipients following rituximab induction therapy.

Background: This study aimed to investigate the association between the Fc-gamma receptor IIIA (FCGR3A) 158 polymorphism and clinical outcomes in kidney transplantation (KTx) patients. Specifically, we focused on late-onset neutropenia (LON) in ABO-incompatible (ABOi) or HLA-incompatible (HLAi) KTx recipients who underwent rituximab (RTx) desensitization therapy.

Methods: FCGR3A 158F/V polymorphisms were identified in 85 ABOi or HLAi KTx recipients who underwent RTx desensitization at our institution between April 2008 and October 2021.

Off-Label Use of Anakinra in Inflammatory Conditions in Neonates and Infants Up to 3 Months of Age: A Case Series and a Review of the Literature.

Background: Anakinra is an interleukin-1 receptor antagonist (IL-1Ra). Since IL-1 has been shown to play a key role in the etiology of different autoinflammatory diseases, blocking its pathway has become an important therapeutic target, even in neonates.

Aims: We aimed to report our experience in using anakinra to treat specific neonatal inflammatory conditions.

Structure and dynamics of monoclonal antibody domains determined using spins, scattering, and simulations.

Antibody-based pharmaceuticals are the leading biologic drug platform (> $75B/year). Despite a wealth of information collected on them, there is still a lack of knowledge on their inter-domain structural distributions, which impedes innovation and development. To address this measurement gap, we have developed a new methodology to derive biomolecular structure ensembles from distance distribution measurements via a library of tagged proteins bound to an unlabeled and otherwise unmodified target biologic.

African ancestry neurodegeneration risk variant disrupts an intronic branchpoint in .

Recently, a novel African ancestry specific Parkinson's disease (PD) risk signal was identified at the gene encoding glucocerebrosidase (). This variant (rs3115534-G) is carried by ~50% of West African PD cases and imparts a dose-dependent increase in risk for disease. The risk variant has varied frequencies across African ancestry groups, but is almost absent in European and Asian ancestry populations.

Drug use and acute kidney injury: a Drug-Wide Association Study (DWAS) in Denmark and Sweden.

Background: Knowledge of which medications may lead to acute kidney injury (AKI) is limited, relying mostly on spontaneous reporting in pharmacovigilance systems. We here conducted an exploratory drug-wide association study (DWAS) to screen for associations between dispensed drugs and AKI risk.

Methods: Using two large Danish and Swedish data linkages, we identified AKI hospitalizations occurring between April 1997 and December 2021 in Denmark and between March 2007 and December 2021 in Sweden.

SHOULDER PAIN, ULTRASOUND CHANGES, AND FUNCTIONAL PERFORMANCE IN OBESE PATIENTS.

Objective: To evaluate the prevalence of shoulder pain, level of functional performance, and morphological involvement of the rotator cuff on ultrasound in morbidly obese patients.

Methods: The study included 54 morbidly obese patients receiving follow-up care in a bariatric surgery outpatient clinic, which were compared with a control group consisting of 49 participants. Presence of shoulder pain, shoulder functional performance, ultrasound of the rotator cuff and blood tests were the parameters evaluated.

ColMA-based bioprinted 3D scaffold allowed to study tenogenic events in human tendon stem cells.

The advent of bioprinting has enabled the creation of precise three-dimensional (3D) cell cultures suitable for biomimetic in vitro models. In this study, we developed a novel protocol for 3D printing methacrylated collagen (ColMa, or PhotoCol®) combined with tendon stem/progenitor cells (hTSPCs) derived from human tendon explants. Although pure ColMa has not previously been proposed as a printable hydrogel, this paper outlines a robust and highly reproducible pipeline for bioprinting this material.

Dynamically Cyclic Fe/Fe Active Sites as Electron and Proton-Feeding Centers Boosting CO Photoreduction Powered by Benzyl Alcohol Oxidation.

Solar-driven CO photoreduction holds promise for sustainable fuel and chemical productions, but the complex proton-coupled multi-electron transfer processes and sluggish oxidation half-reaction kinetics substantially hinder its efficiency. Here, we devised a rational catalyst design to address these challenges by fabricating ferrocene carboxylic acid-functionalized CsSbBr nanocrystals (CSB-Fc NCs), which facilitate simultaneous benzyl alcohol oxidation and CO reduction reactions under visible-light irradiation. The synchronized proton-coupled electron transfer processes between the reduction and oxidation half-reactions on CSB-Fc NCs resulted in a 5-fold increase in the CO reduction rate (45.

Monomeric tri-coordinated bis(ferrocenyl)haloalumanes.

The reactions of the sterically demanding ferrocenyl lithium dimer (Fc*Li) (Fc* = 2,5-bis(3,5-di--butyl-phenyl)-1-ferrocenyl) with aluminum trihalides (AlCl, AlBr, and AlI) to furnish the corresponding monomeric bis(ferrocenyl)haloalumanes are reported. In the case of the reaction with AlI, an unexpected intramolecular 1,1'-aluminum migration in the ferrocenyl moiety was found to occur. Their monomeric structures with a tri-coordinated aluminum atom show affinitive Al⋯Fe interactions.

"Excluding Myself From What I Need the Most": Experiences of Loneliness in People With Inflammatory Arthritis: A Qualitative Study.

Objective: Despite advancements in pharmacological treatments, living with inflammatory arthritis (IA) (including rheumatoid arthritis (RA), psoriatic arthritis (PsA), and axial spondyloarthritis (axSpA)) can make it challenging to engage in social activities, which may increase the risk of loneliness. Although loneliness is predominantly prevalent in IA, its origin and impact on mental health status on daily life with IA remain unexplored. Therefore, the objective of this study was to describe the experiences of people with IA in relation to loneliness.

The effect of degenerative scolioisis on segmental thoracolumbar sagittal alignment compared to age- and pelvic incidence-matched reference values.

Introduction: In asymptomatic subjects, variations of sagittal alignment parameters according to age and pelvic incidence (PI) has been reported. The aim of this observational study was to describe thoraco-lumbar sagittal alignment in patients with degenerative scoliosis and to compare them to asymptomatic individuals, seeking for the specific effect of deformity in similar age and PI groups.

Materials And Methods: Full spine radiographs of 235 asymptomatic subjects and 243 scoliosis patients were analyzed: cervico-thoracic inflexion point (CTIP), thoraco-lumbar inflexion point (TLIP), lumbar lordosis (LL) L1-S1, LL (TLIP-S1), LL superior arch (TLIP-lumbar apex), LL inferior arch (lumbar apex-S1), PI, thoracic kyphosis (TK) T5-T12, TK T1-T12, number of vertebrae CTIP-TLIPandTLIP-S1.

Functional resting state connectivity is differentially associated with IL-6 and TNF-α in depression and in healthy controls.

Inflammatory processes have been implicated in the pathophysiology of depression. In human studies, inflammation has been shown to act as a critical disease modifier, promoting susceptibility to depression and modulating specific endophenotypes of depression. However, there is scant documentation of how inflammatory processes are associated with neural activity in patients with depression.

Usefulness of body composition assessment by bioelectrical impedance vector analysis in subacute post-stroke patients in rehabilitation.

Bioelectrical Impedance Vector Analysis (BIVA) is a valuable tool for evaluating hydration and body composition, but its application in subacute post-stroke patients remains unexplored. This study aimed to fill this gap by analyzing BIVA in a cohort of 87 subacute post-stroke patients (42 women, mean age 69 ± 12) undergoing rehabilitation. At admission (T0), diagnosis of malnutrition with GLIM criteria and of sarcopenia with EWGSOP2 was done, and patients were analyzed with BIVA.

Effect of crude extract and polysaccharides derived from Fucus spiralis on radish plants Raphanus sativus L. agrophysiological traits under drought stress.

Drought is a significant environmental stressor that induces changes in the physiological, morphological, biochemical, and molecular traits of plants, ultimately resulting in reduced plant growth and crop productivity. Seaweed extracts are thought to be effective in mitigating the effects of drought stress on plants. In this study, we investigated the impact of crude extract (CE), and polysaccharides (PS) derived from the brown macroalgae Fucus spiralis (Heterokontophyta, Phaeophyceae) applied at 5% (v/v) and 0.

A New Anti-Interfering Platelet Counting Technology Utilizing Conventional Impedance and White Blood Cell Differential Channel.

Introduction: Accurate platelet (PLT) counting is crucial for disease diagnosis and treatment, especially under the condition of thrombocytopenia and platelet transfusion. A few PLT counting approaches have been established including impedance and fluorescent methods. The impedance PLT counting (PLT-I) approach could be interfered by small non-PLT particles in the blood, such as RBC/WBC fragments, microcytes, bacteria, and cryoglobulins.

First-in-human phase I trial of the bispecific CD47 inhibitor and CD40 agonist Fc-fusion protein, SL-172154 in patients with platinum-resistant ovarian cancer.

Background: SL-172154 is a hexameric fusion protein adjoining the extracellular domain of SIRPα to the extracellular domain of CD40L via an inert IgG-derived Fc domain. In preclinical studies, a murine equivalent SIRPα-Fc-CD40L fusion protein provided superior antitumor immunity in comparison to CD47- and CD40-targeted antibodies. A first-in-human phase I trial of SL-172154 was conducted in patients with platinum-resistant ovarian cancer.