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Efficacy of platinum-based chemotherapy and prognosis of patients with pancreatic cancer with homologous recombination deficiency: comparative analysis of published clinical studies.
ESMO Open
July 2021
Department of Clinical Pharmacology and Chemotherapy, FBGU National Medical Research Center of Oncology named after N N Blokhin, Moskva, Russian Federation.
The aim of our study was to determine the effect of homologous recombination deficiency (HRD) on prognosis and efficacy of platinum-based chemotherapy in patients with pancreatic cancer (PC). We performed PubMed and Embase database queries. We included 4 studies into the meta-analysis and 16 studies in the systematic review.
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