[Clinical analysis on children uveitis complicated cataract surgery].

Objective: To explore the efficacy of operation on children's complicated cataract induced by uveitis and discuss the therapeutic methods in perioperative period and the influencing factor of effect in treatment.

Method: Retrospective case series study. Thirteen cases (17 eyes) children's complicated cataract induced by uveitis who were treated by phacoemulsification with intraocular lens implantation in Peking union medical college hospital from Feb.

[Effects of central corneal thickness and corneal curvature on measurement of intraocular pressure with Goldmann applanation tonometer and non-contact tonometer].

Objective: To investigate the effects of central corneal thickness (CCT) and corneal curvature (CC) on intraocular pressure (IOP) measurements by the Goldmann applanation tonometer (GAT) and the non-contact tonometer (NCT).

Methods: One hundred and twenty patients were recruited from the clinic of Peking Union Medical College Hospital. The CCT was measured by ultrasound pachymetry and the mean radius of CC by using Canon PK-5 refractometer.

[Role of immune system in glaucomatous optic nerve degeneration].

Glaucoma is a chronic neurodegenerative disease characterized by progressive loss of retinal ganglion cells and optic nerve axons, and accompanying loss of visual field sensitivity. With the development of immunology, compelling evidence obtained suggests the involvement of immune system regulation in glaucomatous optic nerve degeneration. Despite the neuroprotective features of immune system, an autoimmune component resulting from a failure to properly control aberrant and stress-induced immune response likely lead to the progression of neurodegeneration in glaucoma.

[Long-term follow-up and management of choroidal osteoma].

Objective: To report the clinical characteristics, long-term follow-up and management of choroidal osteoma.

Methods: Eighteen eyes of 12 cases (5 male and 7 female) of choroidal osteoma were studied. Best corrected vision, intraocular pressure, perimetry, anterior segment and eye fundus were examined routinely.

[To reinforce the collection and usage of the genetic resource of glaucoma in China].

Positive family history is one of the risk factors of glaucoma. It indicates that gene defect may play an important role in the development of glaucoma. The advancement of genetic research provides more strategies to understand the genetic mechanism of glaucoma.

[Intravitreal injection of Ganciclovir in the treatment of acute retinal necrosis].

Objective: To evaluate the indication and clinical effects of intravitreal injection of Ganciclovir in the treatment of acute retinal necrosis (ARN).

Methods: Fourteen cases (14 eyes) of ARN which were consistent with the diagnostic criteria of American Uveitis Society were enrolled. Preoperative visual acuity was: light perception, hand movement and counting fingers (CF), each in 1 eye; 0.

[Anticardiolipin antibodies and ocular diseases].

Anticardiolipin antibodies are a group of autoantibodies. It has been found that these antibodies were associated with thrombosis, recurrent spontaneous abortions and thrombocytopenia. This paper reviews the latest findings about the epidemiology, the mechanism for immunopathology, main systemic features, ocular features, diagnosis, differential diagnosis, prevention and treatment of anticardiolipin antibodies syndrome.

[Polymorphism of HLA-DQB1 alleles in Chinese Han patients with Vogt-Koyanagi-Harada syndrome].

Objective: To investigate the frequency of HLA-DQB1 alleles in Chinese Han patients with Vogt-Koyanagi-Harada syndrome (VKH) and to analyze the relationships among the alleles and clinical manifestations.

Methods: Eighty-eight Chinese Han patients with VKH and 88 non-VKH normal controls were admitted. DNA was extracted from white blood cells of the subjects by phenol-chloroform method.

[Clinical trial of verteporfin photodynamic therapy in Chinese age-related macular degeneration with subfoveal predominant choroidal neovascularization patients].

Objective: To determine the safety and efficacy of verteporfin (visudyne) photodynamic therapy in age-related macular degeneration patients with subfoveal predominant choroidal neovascularization in China.

Methods: Multicenter, open-label, non-controlled clinical study. The included patients are diagnosed AMD patients with predominant classic CNV.

[Study on a rat model of filtering bleb scarring formation].

Objective: To investigate a rat animal model of filtering bleb scarring formation.

Methods: Thirty-five of Sprague-Dawley (SD) rats were used in this experiment. The filtration surgery was performed on one eye of each rat and the other eye served as control.

[Transpupillary thermotherapy for circumscribed choroidal hemangioma].

Objective: To evaluate the efficacy of transpupillary thermotherapy (TTT) on circumscribed choroidal hemangioma.

Methods: Ten eyes of 10 cases with circumscribed choroidal hemangioma (age 16-48, average 34.4) were included in the present study.

[Cytomegalovirus retinitis associated with Acquired immunodeficiency syndrome].

Objective: To investigate the fundus characteristics, systemic features and therapeutic outcomes of cytomegalovirus (CMV) retinitis associated with acquired immunodeficiency syndrome (AIDS).

Methods: Fundus features, visual acuity, fundus fluorescence angiography (FFA) and CD4(+)T-lymphocyte counts of 15 eyes (8 patients) of CMV retinitis associated with AIDS were analyzed. The time of average follow-up was 16 months.

[Treatment of thyroid-associated ophthalmopathy: comparative study between prednisone and COP therapy].

Objective: To evaluate the efficacy of two therapies, high-dose prednisone and COP in the treatment of patients with active thyroid-associated ophthalmopathy (TAO).

Methods: According to severity and compliance, the patients admitted in Peking Union Medical College Hospital from August 2000 to July 2003 were divided into two groups. Thirteen patients with active TAO were treated with high-dose prednisone.

[The effect of surgical treatment on thyroid-associated ophthalmopathy].

Objective: To evaluate the effect of muscle surgery on strabismus caused by extraocular muscle for thyroid-associated ophthalmopathy (TAO), and assess the change of vision acuity, intraocular pressure, visual field and blood flow velocity in central retinal artery that made by surgery treatment.

Methods: Recession and release of the extraocular muscles were used in 17 TAO patients (20 eyes) with strabismus caused by the change of extraocular muscles. In those patients one of them was undergone superior rectus tendon resection and other one was undergone superior rectus suspension.

[The progress in the prevention of blindness in China].

The surgical treatment of cataract blindness continues to be the priority of the prevention of blindness in China since the beginning of the new century. The biggest program "Sight first, China action" in prevention of blindness in the world has been gotten the great achievements. 2.

[The general situation of the development of ophthalmology in recent five years in China].

The ophthalmology in China keeps the tendency of fast development since the new century. The clinic service in ophthalmology has obviously been improved. The actual strength of the ophthalmic organizations was enhanced.

[Novel mutation of fibrillin 1 gene cause ectopia lentis in a Chinese family].

Objective: To identify the mutation gene of a Chinese family with ectopia lentis.

Methods: Clinical observation and pedigree analysis were undertaken in a family with ectopia lentis. Venous blood was drawn from 7 affected and 3 unaffected subjects.

[Krypton laser photocoagulation at low power setting for age-related macular degeneration complicated with subfoveal choroidal neovascularization].

Objective: To evaluate the efficacy of krypton laser photocoagulation for treatment of age-related macular degeneration (AMD) complicated with mainly subfoveal classic choroidal neovascularization (CNV).

Methods: Seventeen eyes of 17 cases, aged 50 - 74 years (averaged 60.8 years) with mainly subfoveal classic choroidal neovascularization were treated with krypton laser at lower power setting.

[The effect of endothelial leukocyte-adhesion molecule-1 on the shape and cytoskeleton of porcine trabecular meshwork cells].

Objective: To study the effects of endothelial leukocyte-adhesion molecule-1 (ELAM-1) on the shape and actin cytoskeleton of cultured porcine trabecular meshwork cells (PTCs).

Methods: The cultured PTCs were stimulated by interleukin-1 (IL-1) and conjugated by ELAM-1 antibody or further cross-linked by IgG. Immunocytochemical procedures were used to study the expression of ELAM-1 and FITC-phalloidin was used to stain the actin filaments on PTCs; phase contrast microscope was employed to observe the dynamic changes of cellular shape and the intercellular conjunction and confocal microscope was used to observe the changes of actin and cellular thickness.

[Eighteen years activity in prevention of blindness in the district of Shunyi, Beijing].

Objective: To investigate how the urban tertiary hospital and medical research unit cooperate with rural basic medical unit in creating the model zone in prevention of blindness.

Methods: Peking Union Medical College Hospital (PUMCH) and Shunyi District Bureau of Public Health exerted their advantages to persist and popularize the program for prevention of blindness. A collaborative program in prevention of blindness was conducted by PUMCH and Shunyi District Bureau of Public Health.

[Prevalence of glaucoma and normal intraocular pressure among adults aged 50 years or above in Shunyi county of Beijing].

Objective: To estimate the prevalence of glaucoma and normal intraocular pressure among older adults aged 50 years or above in Shunyi county of Beijing.

Methods: Cluster sampling was used in randomly selecting 5 555 individuals aged 50 years or above in Shunyi county in fall, 1996. The examines received the visual acuity and general eye examination, and in the mean time attention was paid to rule out glaucoma, including inquiry of family and personal history of glaucoma, measurement of anterior chamber depth and intraocular pressure, examination of the optic disc.