16 results match your criteria: "Experimental and clinical respiratory neurophysiology[Affiliation]"

Case 327: Exogenous Lipoid Pneumonia.

Radiology

July 2024

From the Intensive Care and Resuscitation Unit (M.D., J.P., A.G., A.P., M.F.), Department of Pathological Anatomy and Cytology, Section of Oncology, Pathology and Molecular Biology (A.F., M.A.), Department of Radiology (A.M.), and Department of Pneumology and Thoracic Oncology and GRC-04 Theranoscan (A.P.), Groupe Hospitalier Universitaire APHP-Sorbonne Université, Hôpital Tenon, Paris, France; Department of Experimental and Clinical Respiratory Neurophysiology (UMRS 1158), INSERM, Sorbonne Université, Paris, France (M.D.); and Intensive Care and Resuscitation Unit (R3S), Groupe Hospitalier Universitaire APHP-Sorbonne Université, site Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013 Paris, France (M.D., J.P.).

A 58-year-old male patient with an active smoking status was admitted twice to the intensive care unit (ICU) of a tertiary referral thoracic center for severe hypercapnic acute respiratory failure and persistent bilateral chest radiograph opacities that were unchanged over the course of the two ICU admissions within a 3-month period. The patient had obesity (body mass index, 36), stage 3 vascular chronic renal insufficiency, and hebephrenic schizophrenia treated with haloperidol, carbamazepine, and cyamemazine. He reported chronic dyspnea on exertion, which worsened for 6 months.

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Opioid free analgesia after return home in ambulatory colonic surgery patients: a single-center observational study.

BMC Anesthesiol

July 2024

UMRS 1158 Experimental and Clinical Respiratory Neurophysiology, Faculté de Médecine, INSERM, Sorbonne Université, 91Bd de l'Hôpital, Paris, 75013, France.

Background: Because of the adverse effects of morphine and its derivatives, non-opioid analgesia procedures are proposed after outpatient surgery. Without opioids, the ability to provide quality analgesia after the patient returns home may be questioned. We examined whether an opioid-free strategy could ensure satisfactory analgesia after ambulatory laparoscopic colectomy.

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Article Synopsis
  • The study focused on cytomegalovirus end-organ disease (CMV-EOD) in critically ill, immunocompromised patients across 18 ICUs in France, Israel, and Spain, analyzing clinical characteristics and patient outcomes from January 2010 to December 2021.
  • A total of 185 patients were examined, with pneumonia being the most common form of CMV-EOD, affecting 62.2%, followed by gastrointestinal disease; the overall hospital mortality rate was strikingly high at 61.4%.
  • Key factors linked to increased mortality included having hematologic malignancies, particularly with active graft-versus-host disease, experiencing CMV pneumonia, and low lymphocyte counts
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Excessive daytime sleepiness (EDS) is frequent among patients with obstructive sleep apnea hypopnea syndrome (OSAHS) and can persist despite the optimal correction of respiratory events (apnea, hypopnea and respiratory efforts), using continuous positive airway pressure (CPAP) or mandibular advancement device. Symptoms like apathy and fatigue may be mistaken for EDS. In addition, EDS has multi-factorial origin, which makes its evaluation complex.

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Full-body Postural Alignment Analysis Through Barycentremetry.

Spine (Phila Pa 1976)

December 2024

Arts et Métiers Institute of Technology, Sorbonne Paris Nord University, Georges Charpak Institute for Human Biomechanics, HESAM University, Paris, France.

Study Design: A multicentric retrospective study.

Objective: The study of center of mass (COM) locations (ie, barycentremetry) can help us understand postural alignment. The goal of this study was to determine relationships between COM locations and global postural alignment x-ray parameters in healthy subjects.

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Case 327.

Radiology

March 2024

From the Intensive Care Unit (M.D., J.P., A.G., A.P., M.F.), Department of Pathological Anatomy and Cytology, Section of Oncology, Pathology and Molecular Biology (A.F., M.A.), Department of Radiology (A.M.), and Department of Pneumology and Thoracic Oncology and GRC-04 Theranoscan (A.P.), Groupe Hospitalier Universitaire APHP-Sorbonne Université, Hôpital Tenon, Paris, France; Department of Experimental and Clinical Respiratory Neurophysiology (UMRS 1158), INSERM, Sorbonne Université, Paris, France (M.D.); and Intensive Care Unit (R3S), Groupe Hospitalier Universitaire APHP-Sorbonne Université, site Pitié-Salpêtrière, 47-83 Boulevard de l'Hôpital, 75013 Paris, France (M.D., J.P.).

A 58-year-old man who was an active smoker was admitted twice to the intensive care unit (ICU) of a tertiary referral thoracic center for severe hypercapnic acute respiratory failure and persistent bilateral chest radiograph opacities that were unchanged over the course of the two ICU admissions within a 3-month period (Fig 1). He had obesity (body mass index, 36 kg/m), stage 3 vascular chronic renal insufficiency, and hebephrenic schizophrenia treated with haloperidol, carbamazepine, and cyamemazine. He reported chronic dyspnea on exertion, which worsened for 6 months.

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Respiratory function and sleep in children with myotonic dystrophy type 1.

Neuromuscul Disord

March 2023

Pediatric Pulmonology Department, Armand Trousseau Hospital, APHP, Sorbonne University, 26, avenue du Docteur Arnold Netter, 75012 Paris, France; Sorbonne University, Inserm UMR_S1158, Experimental and clinical respiratory neurophysiology, 47-83 boulevard de l'Hôpital, 75651 Paris Cedex 13, France. Electronic address:

Myotonic dystrophy type 1 (DM1) is a rare neuromuscular disease in children causing sleep and respiratory disorders that are poorly described in the literature compared to adult forms. This retrospective observational study was performed at the Armand Trousseau University Hospital, Assistance Publique-Hôpitaux de Paris (APHP), Paris, France. We retrospectively collected data from lung function tests, nocturnal gas exchange recordings, and polysomnography of 24 children with DM1.

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Phrenic nerve stimulation in an ovine model with temporary removable pacing leads.

J Thorac Dis

August 2022

Experimental and Clinical Respiratory Neurophysiology, INSERM, UMRS1158, Sorbonne University, Paris, France.

Background: The objective of this study was to assess the feasibility and safety of a novel, removable, surgically implanted, temporary neurostimulation approach involving the distal portion of the phrenic nerve.

Methods: Temporary phrenic nerve pacing electrodes were implanted surgically using an ovine model (4 animals). The primary endpoint was the ability to successfully match the animal's minute-ventilation upon implantation of both phrenic nerve pacers on day 1.

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Diaphragm dysfunction is frequently observed in critically ill patients with difficult weaning from mechanical ventilation. To evaluate the effects of temporary transvenous diaphragm neurostimulation on weaning outcome and maximal inspiratory pressure. Multicenter, open-label, randomized, controlled study.

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Benefits and risks of bronchoalveolar lavage in severe asthma in children.

ERJ Open Res

October 2021

APHP, Sorbonne Université, Pediatric Pulmonology Dept and Reference Center for Rare Lung Diseases RespiRare, Armand Trousseau Hospital, Paris, France.

Background: Although bronchoscopy can be part of the exploration of severe asthma in children, the benefit of bronchoalveolar lavage (BAL) is unknown. The present study aimed to decipher whether systematic BAL during a flexible bronchoscopy procedure could better specify the characteristics of severe asthma and improve asthma management.

Material And Methods: The study took place in two departments of a university hospital in Paris.

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The Wide Spectrum of COVID-19 Clinical Presentation in Children.

J Clin Med

September 2020

Pediatric Pulmonology Department, APHP Hôpital Trousseau, Sorbonne Université, 75012 Paris, France.

Ten months after its appearance in December 2019, SARS-CoV-2 has infected more than 25 million patients worldwide. Because children were first identified as potential spreaders of the virus, schools were closed in several countries. However, it rapidly became evident that the number of hospitalized children infected by SARS-CoV-2 was dramatically lower than that of adults.

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Background: In Chronic Obstructive Pulmonary Disease (COPD), upper limb exercise is widely recommended. However, how the degree of shoulder flexion may influence the exercise response is unknown.

Aim: We compared metabolic, ventilatory and symptomatic responses during constant-load supported and unsupported exercise performed at 80° and 120° arm elevation.

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Evaluation of total body water in canine breeds by single-frequency bioelectrical impedance analysis method: specific equations are needed for accuracy.

BMC Res Notes

August 2015

Intensive Care Medicine Unit, École Nationale Vétérinaire de Nantes (ONIRIS), Atlanpole La Chantrerie, route de Gachet, CS 40706, 44307, Nantes Cedex 3, France.

Background: Equations based on single-frequency bioelectrical impedance analysis at 50 kHz for determination of total body water content (TBW) have been previously validated in healthy non-sedated beagle dogs. We investigated whether these equations are predictive of TBW in various canine breeds by comparing the results of these equations with TBW values evaluated directly by deuterium oxide (D2O) dilution.

Methods: Total body water content of 13 healthy adult pet dogs of various breeds was determined directly using D2O dilution and indirectly using previous equations based on values obtained with a portable bioelectric impedance device.

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