Metabolic and Energy Imbalance in Dysglycemia-Based Chronic Disease.

Metabolic flexibility is the ability to efficiently adapt metabolism based on nutrient availability and requirement that is essential to maintain homeostasis in times of either caloric excess or restriction and during the energy-demanding state. This regulation is orchestrated in multiple organ systems by the alliance of numerous metabolic pathways under the master control of the insulin-glucagon-sympathetic neuro-endocrine axis. This, in turn, regulates key metabolic enzymes and transcription factors, many of which interact closely with and culminate in the mitochondrial energy generation machinery.

Salutogenesis in Type 2 Diabetes Care: A Biopsychosocial Perspective.

Type 2 diabetes has emerged as a major threat to global public health. In spite of best efforts by health care professionals, persons with diabetes, and the community at large, remain unsatisfied with the approach to diabetes management. This brief communication utilizes Antonovsky's concept of salutogenesis, to suggest a person friendly and community friendly framework for diabetes care.

Metformin + Sodium-glucose Co-transporter-2 Inhibitor: Salutogenic Lifestyle Mimetics in a Tablet?

Salutogenesis is an accepted approach for chronic disease management. Calorie restriction and exercise are two evidence based salutogenic interventions in diabetes treatment. Calorie restriction mimetics and exercise mimetics may be used as pharmacological tools to help manage diabetes in a sulutogenic manner.

Diabetes Destiny in our Hands: Achieving Metabolic Karma.

Karma is the ancient Indian philosophy of cause and effect, which implies that an individual's intentions, and actions, both have consequences. None can escape the consequences of one's actions. Applying the principle of karma to medicine and healthcare, the significance of optimal and timely interventions at various stages of disease, may be realized.

Glycemic management during Jain fasts.

This review describes the various fasts observed by adherents of the Jain religion. It attempts to classify them according to their suitability for people with diabetes and suggests appropriate regime and dose modification for those observing these fasts. The review is an endeavor to encourage rational and evidence-based management in this field of diabetology.

Endocrinology in the Ramayana.

This article is one of a series of publications which highlight the possible endocrine conditions and interventions listed in the ancient texts. This compendium lists episodes from the Indian epic Ramayana and from the associated genealogy of Lord Rama's dynasty, the Suryavanshis. These episodes are chosen for their relevance to endocrinology and are listed in a gland-based order.

Insulin degludec aspart: One-year real world experience.

Background: This retrospective analysis describes the use of insulin degludec aspart (IDegAsp) in India.

Material And Methods: All subjects who had received IDegAsp for 52 weeks at two endocrine centers were included in this study.

Results: Forty-eight subjects (40 men), with mean age of 54.

The A1C Prandial Product: An objective tool to decision making in diabetes.

This brief article describes a numerical index designed to assess the relative contribution of fasting and postprandial glucose to hyperglycaemia. This helps plan appropriate insulin and oral glucose-lowering therapy in an objective manner. It also reviews three similar indices described earlier in literature.