Late first-trimester placental disruption and subsequent gestational hypertension/preeclampsia.

Objective: To evaluate the potential relationship between placental disruption in weeks 13 and 14 and the subsequent development of gestational hypertension or preeclampsia.

Methods: Using subjects recruited during a randomized trial funded by the National Institute of Child Health and Human Development, which compared early amniocentesis and late transabdominal chorionic villus sampling (CVS) in weeks 13 and 14, rates of gestational hypertension and preeclampsia were compared between cases with varying degrees of placental disruption.

Results: A total of 3,698 of 3,775 randomized subjects had cytogenetically normal pregnancies and were analyzed.