899 results match your criteria: "Euthyroid Sick Syndrome"
Background Roxadustat, a hypoxia-inducible factor prolyl hydroxylase inhibitor used in renal anemia treatment, has been associated with thyroid hormone suppression. This study investigated the patterns of thyroid profile changes following roxadustat administration and their clinical implications. Methods In this retrospective study (2019-2023) at Shenzhen Second People's Hospital, patients were categorized based on TSH reduction during follow-up (≥50% decrease vs<50% decrease).
View Article and Find Full Text PDFEuthyroid sick syndrome predicts the risk of ischemic stroke-associated pneumonia in the acute stage of ischemic stroke: a nested case-control study.
Front Endocrinol (Lausanne)
November 2024
Department of Neurology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, Quzhou, Zhejiang, China.
Article Synopsis
- Ischemic stroke-associated pneumonia (iSAP) affects around 10% of stroke patients during their hospital stay, highlighting the need for better predictive tools as current scales are ineffective.
- This study analyzed 1,767 acute ischemic stroke patients to assess the predictive value of euthyroid sick syndrome (ESS) as a biomarker for iSAP, finding that older age and comorbidities like atrial fibrillation and COPD increase the risk.
- Results indicate that ESS is a significant predictor of iSAP, with a sensitivity of 35.64% and specificity of 87.92%, suggesting its potential use in identifying at-risk stroke patients early on.
Association between thyroid function and prognosis of severe COVID-19 among patients with SARS-CoV-2 infection: a retrospective cohort study in China.
Front Endocrinol (Lausanne)
October 2024
Department of Endocrinology, Shanghai Public Health Clinical Center, Shanghai, China.
Objective: This study aims to examine the thyroid hormone profile and its association with severe coronavirus disease 2019 (COVID-19) in patients infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
Methods: This retrospective cohort study enrolled patients admitted to a tertiary hospital due to SARS-CoV-2 infection between February 18 and May 18, 2022. Clinical data were collected retrospectively from the electronic medical record system.
Thyroid dysfunction among patients assessed by thyroid function tests at a tertiary care hospital: a retrospective study.
Pan Afr Med J
October 2024
Department of Medical Biochemistry, University of Ghana Medical School (UGMS), University of Ghana, Legon, Ghana.
Article Synopsis
- Previous studies on thyroid disorders in Africa have mostly focused on iodine deficiency, neglecting the wider range of thyroid dysfunctions; this study aims to fill that gap by analyzing patients at Korle-Bu Teaching Hospital in Ghana.
- A retrospective analysis was conducted on 215 patients' medical records from January 2019 to December 2021, collecting data on demographics and thyroid hormones (FT3, FT4, TSH) to classify types of thyroid dysfunction according to American Thyroid Association guidelines.
- The findings revealed that 85.1% of patients were female, with primary hyperthyroidism being the most common dysfunction (57.7%), followed by primary hypothyroidism (22.3%); highlights the need for prompt
The impact of severe nephrotic syndrome on thyroid function, nutrition and coagulation.
Clin Kidney J
September 2024
Department of Internal Medicine IV, Nephrology and Hypertension, Medical University Innsbruck, Innsbruck, Austria.
Article Synopsis
- - Nephrotic syndrome (NS) can lead to protein loss in urine and potential endocrine issues, making thyroid dysfunction a key concern; this study looked at its frequency in NS patients versus controls.
- - The study found higher rates of thyroid issues, specifically euthyroid sick syndrome (ESS) and hypothyroidism, in NS patients compared to those without proteinuria, with some requiring thyroid hormone supplementation.
- - NS patients also showed lower lean body mass and signs of hypercoagulability, indicating a possible interconnection between thyroid, nutritional, and coagulation issues that needs more research.
Cytokine Storm-Induced Thyroid Dysfunction in COVID-19: Insights into Pathogenesis and Therapeutic Approaches.
Drug Des Devel Ther
September 2024
Sunway Microbiome Centre, School of Medical and Life Sciences, Sunway University, Subang Jaya, Selangor, 47500, Malaysia.
Article Synopsis
- - SARS-CoV-2 uses angiotensin-converting enzyme 2 receptors (ACE2R) to enter host thyroid cells, leading to cytopathic effects and symptoms like neck pain, muscle ache, and thyroid inflammation in COVID-19 patients.
- - The virus triggers a "cytokine storm," where pro-inflammatory cytokines (such as IL-1β, IL-6, and TNF-α) cause severe thyroid dysfunctions and autoimmune issues by activating key signaling pathways.
- - Effective treatments like dexamethasone and baricitinib have shown promise in reducing thyroid-related complications and improving outcomes for severe COVID-19 patients by managing the cytokine storm.
Low T3 low T3T4 euthyroid sick syndrome in septic shock patients: A prospective observational cohort study.
World J Crit Care Med
September 2024
Department of Internal Diseases, Cantonal Hospital, Zenica 72000, Bosnia and Herzegovina.
Article Synopsis
- The study investigates the differences between two groups of septic shock patients with euthyroid sick syndrome (ESS) based on their thyroid hormone levels, specifically low T3 and low T3T4.
- Results show that patients with low T3T4 have significantly worse outcomes, including higher mortality scores, increased need for medications like dobutamine and epinephrine, and a greater incidence of renal failure and multiple organ failure.
- The findings indicate that the low T3T4 condition might reflect harmful physiological changes during the chronic phase of septic shock, with worse laboratory and hemodynamic conditions compared to the low T3 group.
Association between systemic lupus erythematosus and autoimmune thyroid dysfunction in pediatric population: a single center experience.
Ital J Pediatr
September 2024
Pediatrics Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Background: Systemic Lupus Erythematosus (SLE) patients are more likely than the general population to suffer from thyroid illness. The major goal was to assess the thyroid dysfunctions due to immunological factors in Egyptian SLE children and how they are related to the course and severity of the illness.
Methods: Fifty children and adolescents with SLE are included in this cross-sectional observational study.
A Critical Investigation of Sick Euthyroid Syndrome in Chronic Heart Failure Patients: Addressing the Need for Accurate Thyroid Assessment.
Cureus
August 2024
Department of Medicine, Dr. D. Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth, Pune (Deemed to be University), Pune, IND.
Background The body undergoes numerous metabolic changes during severe illness or physiological stress to protect itself by lowering metabolism and reducing overall demands. This evolutionary adaptation dates back to early human development, long before the advent of ICU facilities and advanced treatments. One such protective mechanism is Sick Euthyroid Syndrome (SES), also known as Non-thyroidal Illness Syndrome (NTIS).
View Article and Find Full Text PDFArticle Synopsis
- - Euthyroid sick syndrome (ESS) is a condition where thyroid hormone levels are abnormal despite normal thyroid function, often seen in critically ill patients, leading to low triiodothyronine levels and sometimes other hormone imbalances.
- - Myxedema coma (MC) is a serious and rare emergency resulting from severe hypothyroidism, causing multiorgan failure and may happen after significant stress or poor management of hypothyroidism, despite being infrequently linked with ESS.
- - The case study involves a 36-year-old woman who, after developing septic shock and being treated in the ICU, experienced both ESS and signs of MC, highlighting the complexities and challenges in diagnosing and managing these overlapping conditions.
Thyroid dysfunction in the wake of Omicron: understanding its role in COVID-19 severity and mortality.
Front Endocrinol (Lausanne)
July 2024
Department of Respiratory and Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, China.
Purpose: SARS-CoV-2 can invade the thyroid gland. This study was to delineate the risk of thyroid dysfunction amidst the prevalence of the Omicron variant, and to investigate the correlation between thyroid function and Coronavirus disease 2019 (COVID-19) outcomes. The study also aimed to ascertain whether thyroid dysfunction persisted during COVID-19 recovery phase.
View Article and Find Full Text PDFTotal triiodothyronine level associated with disease severity for patients with emergent status.
Sci Rep
July 2024
Research Center of Endocrine and Metabolic Diseases, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, Jiangsu, China.
Article Synopsis
Low free T3 level may predict the severity of acute pancreatitis.
Postgrad Med
June 2024
Internal Medicine Department, Basaksehir Cam and Sakura City Hospital, Istanbul, Turkey.
Article Synopsis
- The study aimed to explore how changes in thyroid function tests can indicate the severity and prognosis of acute pancreatitis, even in patients with normal thyroid gland function.
- Conducted at a single center, the research analyzed patients diagnosed with acute pancreatitis and categorized them into two groups—those with healthy thyroid function (euthyroid) and those with Non-Thyroidal Illness Syndrome—which showed notable differences in thyroid hormone levels and established scoring systems.
- Results indicated that patients with Non-Thyroidal Illness Syndrome had lower free T3 levels and higher severity scores compared to the euthyroid group, suggesting that monitoring free T3 could enhance prognosis assessment for acute pancreatitis and potentially lower mortality rates.
[Related factors of euthyroid sick syndrome in patients with sepsis].
Beijing Da Xue Xue Bao Yi Xue Ban
June 2024
Department of Emergency And Critical Care, Shanghai General Hospital of Nanjing Medical University, Shanghai 201620, China.
Objective: To evaluate the prevalence of euthyroid sick syndrome (ESS) in sepsis patients and to explore its influencing factors.
Methods: In the study, 365 patients diagnosed with sepsis in the emergency critical care department of Shanghai First People's Hospital from January 2017 to January 2023 were retrospectively enrolled. The patients were divided into ESS and non-ESS groups based on whether the patients were complicated with ESS.
Cardiovascular mechanisms of thyroid hormones and heart failure: Current knowledge and perspectives.
World J Cardiol
May 2024
Department of Cardiology and Angiology, University Hospital Centre Split, University of Split School of Medicine, Split 21000, Croatia.
Article Synopsis
- * NTIS occurs in about 30% of HF patients and is linked to higher mortality rates, with certain thyroid hormone levels being better indicators of disease severity.
- * Treatment for thyroid issues in HF patients is necessary, but the best approach for NTIS remains debated, highlighting the need for further research on effective therapies and the underlying mechanisms.
Prevalence of thyroid dysfunctions and thyroid autoantibodies in Thai patients with systemic lupus erythematosus: An age- and sex-matched controlled study.
Int J Rheum Dis
May 2024
Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand.
Article Synopsis
- The study aimed to assess how common thyroid dysfunctions and thyroid autoantibodies are in Thai patients with systemic lupus erythematosus (SLE) compared to matched healthy controls.
- It found that SLE patients experienced significantly higher rates of thyroid dysfunctions, like hypothyroidism, compared to healthy individuals, although no difference was noted in thyroid autoantibody prevalence.
- Key factors linked to thyroid issues in SLE patients included a family history of thyroid disease and the use of prednisolone at doses greater than 10 mg/day.
Is Low-free Triiodothyronine (fT3) Associated with Increased Morbidity in Patients Admitted to Coronary Care Units?
Endocr Metab Immune Disord Drug Targets
April 2024
Department of Endocrinology, Cukurova University, Adana, Türkiye
Article Synopsis
- This study investigates the role of thyroid hormone levels, specifically triiodothyronine (fT3), in hospitalized patients in coronary intensive care units, aiming to understand their impact on cardiovascular health.
- A total of 208 patients, primarily presenting with acute coronary syndrome and heart failure, were analyzed; results indicated that lower fT3 levels correlated with reduced left ventricular ejection fraction (LVEF) and longer hospital stays.
- The findings suggest that monitoring fT3 levels could be important for assessing risks and developing treatment plans for heart failure patients.
Total thyroxine, triiodothyronine, and thyrotropin concentrations during acute nonthyroidal illness and recovery in dogs.
J Vet Intern Med
May 2024
Department of Veterinary Medical Sciences, Alma Mater Studiorum-University of Bologna, Ozzano Emilia, Italy.
Background: Acute illness can result in changes in serum total thyroxine (tT4), total triiodothyronine (tT3), and thyrotropin (TSH) concentrations in euthyroid dogs defined as nonthyroidal illness syndrome, but longitudinal evaluation of these hormones during the recovery phase is lacking.
Objectives: To longitudinally evaluate serum tT4, tT3, and TSH concentrations during the acute phase and recovery from acute illness in dogs.
Animals: Nineteen euthyroid client-owned dogs hospitalized for acute illness at a veterinary teaching hospital.
A Cross-Sectional Study of Acute Coronary Syndrome and Thyroid Profile: Dissecting the Relationship to Improve Patient Care.
Cureus
March 2024
Department of General Medicine, Rajendra Institute of Medical Sciences, Ranchi, IND.
Introduction: Thyroid-releasing hormones are pivotal in regulating cardiovascular (CVS) function and maintaining its hemodynamics and homeostasis. Even a minor alteration in thyroid function has an enormous implication on CVS morbidity and mortality. Moreover, hypothyroidism was found to be a potential menace for coronary artery disease (CAD).
View Article and Find Full Text PDFDoes an episode of diabetic ketoacidosis affect thyroid function tests in pediatric patients?
J Pediatr Endocrinol Metab
May 2024
Pediatric Intensive Care Unit, Health Sciences University, Dr. Behçet Uz Children's Diseases and Surgery Training and Research Hospital, İzmir, Türkiye.
Objectives: The aim of our study was to investigate the changes in thyroid hormone levels during and after acute metabolic disorder in patients with diabetic ketoacidosis (DKA).
Methods: Eighty five patients diagnosed with DKA were included in the study. Patients with control thyroid function test (TFT) values at admission (the first blood sample) and 1 month later were included in the study.
Non-thyroidal Illness in Children with Congestive Heart Failure.
J Clin Res Pediatr Endocrinol
May 2024
Govind Ballabh Pant Institute of Post-graduate Medical Training and Research, Clinic of Cardiology, New Delhi, India
Objective: To estimate the proportion and risk factors of non-thyroidal illness (NTI) in children with congenital heart disease (CHD) with congestive heart failure (CHF).
Methods: This study enrolled children (6 weeks to 60 months age) with CHD and CHF. The clinical profile and disease severity, derived from the Pediatric Early Warning Score (PEWS) was recorded.
Is Atopic Dermatitis a Risk Factor for Thyroid Autoimmunity? - A Cross-Sectional Study from a Tertiary Care Center in India.
Indian Dermatol Online J
December 2023
Department of Dermatology and STD, Lady Hardinge Medical College and Associated Hospitals, New Delhi, India.
Article Synopsis
- The study investigated the relationship between thyroid autoimmunity and atopic dermatitis (AD) in children, aiming to determine how common thyroid autoimmunity is among these patients and how it relates to the severity of their AD symptoms.
- Thyroid autoimmunity was found in 18.9% of the 53 children studied, with significant correlations between AD severity (measured using the SCORAD score) and levels of serum IgE and eosinophils, as well as a negative correlation with vitamin D levels.
- The findings suggest a potential link between thyroid autoimmunity and AD, indicating the need for careful monitoring and vitamin D supplementation in affected children, while also calling for further multi-center studies
The prevalence of thyroid disorders in COVID-19 patients: a systematic review and meta-analysis.
BMC Endocr Disord
January 2024
Safety Promotion and Injury Prevention Research Center, Research Institute for Health Sciences and Environment, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Objectives: To conduct a systematic review and meta-analysis to evaluate the prevalence of thyroid disorders in COVID-19 patients.
Data Sources: Scopus, PubMed, ISI Web of Science, and Google Scholar databases were used in this review. We also consider the results of grey literature.
Triiodothyronine hormone supplementation therapy in septic shock patients with euthyroid sick syndrome: two pilot, placebo-controlled, randomized trials.
Anaesth Crit Care Pain Med
April 2024
Department of Anesthesiology, Resuscitation and Intensive Care, Cantonal Hospital, Zenica, Bosnia and Herzegovina; Faculty of Medicine, Zenica, Bosnia and Herzegovina. Electronic address:
Background: To assess 28-day survival in two pilot groups of septic shock patients with euthyroid sick syndrome (ESS) supplemented with triiodothyronine (T3).
Methods: A total of 95 septic shock patients with ESS were divided according to values of the thyroid hormones into low T3 and low T3T4 groups. Among 48 patients with low T3, 24 (50%) were randomized to T3 for 4 days and 24 (50%) to placebo.
Thyroid function tests during nonthyroidal illness syndrome and recovery in acutely ill dogs.
J Vet Intern Med
January 2024
Department of Small Animal Clinical Sciences, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech University, Blacksburg, Virginia, USA.