Levodopa Impairs Lysosomal Function in Sensory Neurons In Vitro.

Parkinson's disease (PD) is the second-most common neurodegenerative disease worldwide. Patients are diagnosed based upon movement disorders, including bradykinesia, tremor and stiffness of movement. However, non-motor signs, including constipation, rapid eye movement sleep behavior disorder, smell deficits and pain are well recognized.

miR-193b-5p and miR-374b-5p Are Aberrantly Expressed in Endometriosis and Suppress Endometrial Cell Migration In Vitro.

(1) Background: Endometriosis is a highly prevalent gynecological disease affecting 10% of women of reproductive age worldwide. miRNAs may play a role in endometriosis, though their exact function remains unclear. This study aimed to identify differentially expressed miRNAs in endometriosis and study their functions in the disease.

High Serum Irisin Concentration Is Associated with More Disturbed Behavioural Eating Pattern in Adolescent Rhythmic Gymnasts.

: There are strict demands on body weight and shape in highly trained adolescent female athletes, and they are in the highest risk group for the development of eating disorders. This study aims to compare the behavioural eating patterns between highly trained female adolescent athletes and untrained controls (UCs), and to describe the associations between behavioural eating patterns and different energy homeostasis hormones. : A total of 33 rhythmic gymnasts (RGs), 20 swimmers (SWs), and 20 UCs ( = 20) that were 14 to 18 years old participated in this investigation.

Revealing how internal sensors in a smart battery impact the local graphite lithiation mechanism.

Smart batteries, i.e., equipped with internal and external sensors, are emerging as promising solutions to enhance battery state of health and optimize operating conditions.

Empowering Veterinary Herd Health Management: Insights into Education, Implementation, and Regulation Across Europe.

In recent years, integrated veterinary herd health management (VHHM), improving animal health, welfare, food safety, public health, farm management, and economics, has become ever-more important in the European Union due to structural and regulatory advancements. A mixed-methods study analyzed the current state and gaps in VHHM education and training across Europe. Data from 41 European veterinary institutions showed that 83% ( = 34/41) offered VHHM education, either as standalone courses and/or integrated into other subjects.

Incidence of SARS-CoV-2 Infection Among European Healthcare Workers and Effectiveness of the First Booster COVID-19 Vaccine, VEBIS HCW Observational Cohort Study, May 2021-May 2023.

European countries have included healthcare workers (HCWs) among priority groups for COVID-19 vaccination. We established a multi-country hospital network to measure the SARS-CoV-2 incidence and effectiveness of COVID-19 vaccines among HCWs against laboratory-confirmed SARS-CoV-2 infection. HCWs from 19 hospitals in 10 countries participated in a dynamic prospective cohort study, providing samples for SARS-CoV-2 testing at enrolment and during weekly/fortnightly follow-up.

Structural, Mechanical, and Optical Properties of Laminate-Type Thin Film SWCNT/SiON Composites.

The development of new encapsulating coatings for flexible solar cells (SCs) can help address the complex problem of the short lifespan of these devices, as well as optimize the technological process of their production. In this study, new laminate-type protective composite coatings were prepared using a silicon oxynitride thin-film matrix obtained by curing the pre-ceramic polymer perhydropolysilazane (PHPS) through two low-temperature methods: (i) thermal annealing at 180 °C and (ii) exposure to UV radiation at wavelengths of 185 and 254 nm. Single-walled carbon nanotubes (SWCNTs) were used as fillers via dry transfer, facilitating their horizontal orientation within the matrix.

Modified Martin-Puplett interferometer for magneto-optical Kerr effect measurements at sub-THz frequencies.

We present a magneto-optical Kerr effect (MOKE) spectrometer based on a modified Martin-Puplett interferometer, utilizing continuous wave sub-THz low-power radiation in a broad frequency range. This spectrometer is capable of measuring the frequency dependence of the MOKE response function, both the Kerr rotation and ellipticity, simultaneously, with accuracy limited by a sub-milliradian threshold, without the need for a reference measurement. The instrument's versatility allows it to be coupled to a cryostat with optical windows, enabling studies of a variety of quantum materials such as unconventional superconductors, two-dimensional electron gas systems, quantum magnets, and other systems showing optical Hall response at sub-Kelvin temperatures and in high magnetic fields.

Wheat field earthworms under divergent farming systems across a European climate gradient.

Earthworms are a key faunal group in agricultural soils, but little is known on how farming systems affect their communities across wide climatic gradients and how farming system choice might mediate earthworms' exposure to climate conditions. Here, we studied arable soil earthworm communities on wheat fields across a European climatic gradient, covering nine pedo-climatic zones, from Mediterranean to Boreal (S to N) and from Lusitanian to Pannonian (W to E). In each zone, 20-25 wheat fields under conventional or organic farming were sampled.

Air quality prediction and control systems using machine learning and adaptive neuro-fuzzy inference system.

Accurately predicting air quality concentrations is a challenging task due to the complex interactions of pollutants and their reliance on nonlinear processes. This study introduces an innovative approach in environmental engineering, employing artificial intelligence techniques to forecast air quality in Semnan, Iran. Comprehensive data on seven different pollutants was initially collected and analyzed.

Male hysteria in theory and practice: Analyzing patient records of the Tartu Psychiatric Hospital (Estonia), 1881-1895.

During 1881-1895, a small number of male patients-18 in total-were diagnosed with hysteria at the University of Tartu Psychiatric Hospital. Rather than constituting an obscure psychiatric institution on the margins of European medical traditions, Tartu during these years witnessed the arrival of several influential psychiatrists: Hermann Emminghaus (1845-1904), Emil Kraepelin (1856-1926), and Vladimir Chizh (1855-1922). Yet, when comparing patient case records of male hysteria written by doctors who also published journal articles and medical textbooks on the topic, one can detect a clear inconsistency between the theory and practice of psychiatry at an important moment of its formation.

Safe and well-tolerated long-term parenteral nutrition regimen: Omega-3-fatty-acid-enriched medium chained/ long chained triglycerides emulsion.

Background And Aims: A limited number of randomized controlled trials (RCTs) have examined the use of lipid emulsions (LEs) of different compositions in home parenteral nutrition (HPN), and there are very few data on the long-term use of omega-3 (n-3) polyunsaturated fatty acids (PUFAs). The study's objective was to assess safety and tolerability of an n-3 PUFA-enriched LE in adult patients suffering from chronic intestinal failure (CIF) requiring long-term HPN.

Methods: In this prospective, randomized, controlled, double-blind, multicentre, international clinical trial, which was conducted at eleven sites, adult patients in need of HPN including lipids received either the investigational product, an n-3 PUFA-enriched medium/long-chain triglyceride (MCT/LCT) LE, or the reference product, a standard MCT/LCT LE, for an average duration of eight weeks.

Search for Soft Unclustered Energy Patterns in Proton-Proton Collisions at 13 TeV.

The first search for soft unclustered energy patterns (SUEPs) is performed using an integrated luminosity of 138  fb^{-1} of proton-proton collision data at sqrt[s]=13  TeV, collected in 2016-2018 by the CMS detector at the LHC. Such SUEPs are predicted by hidden valley models with a new, confining force with a large 't Hooft coupling. In events with boosted topologies, selected by high-threshold hadronic triggers, the multiplicity and sphericity of clustered tracks are used to reject the background from standard model quantum chromodynamics.

Automated extrusion-based dispensing: Personalized dosing and quality control of clopidogrel tablets for pediatric care.

The exploration of three-dimensional (3D) printing inspired technologies in pharmaceutical compounding reveals a promising frontier in personalized medicine manufacture. This study focuses on the development of clopidogrel bisulphate tablets, with doses ranging from 2 mg to 20 mg per tablet, suitable for pediatric use. The study explored a semi-solid extrusion-based deposition technology already being used in compounding pharmacies across several European locations.

Perceptions and Practices of Primary Care Providers in Europe and the US in the Diagnosis and Treatment of Irritable Bowel Syndrome: A Multinational Survey.

Background: The knowledge and proficiency of primary care practitioners (PCPs) in diagnosing and managing irritable bowel syndrome (IBS) remain generally low and variable internationally. This variability is partly due to a lack of familiarity with the Rome Foundation diagnostic criteria and treatment guidelines for this condition.

Methods: We conducted an electronic survey of PCPs in the United States and nine European countries to assess their understanding of IBS pathophysiology; the use of Rome IV criteria in diagnosis, knowledge of and frequency in prescribing various recommended treatments; and the likelihood of referring patients with suspected IBS to subspecialists.