The environmental health citizen interview tool: towards an inclusive qualitative environmental wellbeing approach in support of planetary health.

Background: Nature-based Solutions (NbS) are vital for addressing climate change and biodiversity loss, yet their benefits are often unequally distributed. This study introduces the Environmental Health Citizen Interview Tool, aiming to inclusively capture diverse perspectives on environmental wellbeing using qualitative research methods. The principles of epistemic justice and planetary health are central to its development.

SARS-CoV-2 N protein recruits G3BP to double membrane vesicles to promote translation of viral mRNAs.

Ras-GTPase-activating protein SH3-domain-binding proteins (G3BP) are critical for the formation of stress granules (SGs) through their RNA- and ribosome-binding properties. SARS-CoV-2 nucleocapsid (N) protein exhibits strong binding affinity for G3BP and inhibits infection-induced SG formation soon after infection. To study the impact of the G3BP-N interaction on viral replication and pathogenesis in detail, we generated a mutant SARS-CoV-2 (RATA) that specifically lacks the G3BP-binding motif in the N protein.

Contextualized race and ethnicity annotations for clinical text from MIMIC-III.

Observational health research often relies on accurate and complete race and ethnicity (RE) patient information, such as characterizing cohorts, assessing quality/performance metrics of hospitals and health systems, and identifying health disparities. While the electronic health record contains structured data such as accessible patient-level RE data, it is often missing, inaccurate, or lacking granular details. Natural language processing models can be trained to identify RE in clinical text which can supplement missing RE data in clinical data repositories.

Guidelines for Caring for Incapacitated Teachers and Students at Former Jesuit Colleges in Europe.

The aim of this article is to explore the regulations governing the treatment of incapacitated people in former Jesuit colleges in Europe, focusing on the academic staff and students residing in these institutions. This treatment was strongly influenced by the spirituality of Ignatius of Loyola, who perceived disease in dual terms: as an evil to be combated through all available means and as a test of faith from God. Ignatius instructed college superiors to prioritize the care of the sick and appointed specific officers within the community, such as prefects of health, nurses, and pharmacists, while also formulating detailed rules for the care and treatment of the sick.

Age- and sex-specific reference percentile curves for accelerometry-measured physical activity in healthy European children and adolescents.

Unlabelled: Physical activity measured by accelerometry (PA-accelerometry) is used as an indicator of physical capacity in chronic diseases. Currently, only fragmented age ranges of reference percentile curves are available for European children and adolescents. This study aimed to provide age- and sex-specific percentiles for physical activity measured by hip-worn accelerometry derived throughout the full age range of European children and adolescents.

Clinical severity and cardiac phenotype in phosphomannomutase 2-congenital disorders of glycosylation : Insights into genetics and management recommendations.

Cardiac involvement (CI) in phosphomannomutase 2-congenital disorders of glycosylation (PMM2-CDG) is part of the multisystemic presentation contributing to high mortality rates. The most common cardiac manifestations are pericardial effusion, cardiomyopathy, and structural heart defects. A genotype-phenotype correlation with organ involvement has not yet been described.

New particle formation from isoprene under upper-tropospheric conditions.

Aircraft observations have revealed ubiquitous new particle formation in the tropical upper troposphere over the Amazon and the Atlantic and Pacific oceans. Although the vapours involved remain unknown, recent satellite observations have revealed surprisingly high night-time isoprene mixing ratios of up to 1 part per billion by volume (ppbv) in the tropical upper troposphere. Here, in experiments performed with the CERN CLOUD (Cosmics Leaving Outdoor Droplets) chamber, we report new particle formation initiated by the reaction of hydroxyl radicals with isoprene at upper-tropospheric temperatures of -30 °C and -50 °C.

A fish-friendly axial flow pump turns out to be eel safe, roach unfriendly and bream unsafe.

Additional and refurbished pumping stations are required to mitigate the intensifying occurrence of droughts and floodings. These installations negatively impact threatened freshwater fish populations due to the increased risk of injury and mortality when fish pass through them. Fish-friendly pumping installations have been proposed as a potential solution to reduce these risks.

Phylogenetic Diversity of Plant and Insect Communities on Islands.

Interactions between plants and insects have long fascinated scientists. While some plants rely on insects for pollination and seed dispersal, insects rely on plants for food or as a habitat. Despite extensive research investigating pair-wise species interactions, few studies have characterized plant and insect communities simultaneously, making it unclear if diverse plant communities are generally associated with diverse insect communities.

Using multiplexed functional data to reduce variant classification inequities in underrepresented populations.

Background: Multiplexed Assays of Variant Effects (MAVEs) can test all possible single variants in a gene of interest. The resulting saturation-style functional data may help resolve variant classification disparities between populations, especially for Variants of Uncertain Significance (VUS).

Methods: We analyzed clinical significance classifications in 213,663 individuals of European-like genetic ancestry versus 206,975 individuals of non-European-like genetic ancestry from All of Us and the Genome Aggregation Database.

Venus cloud catcher as a proof of concept aerosol collection instrument.

We report on the proof-of-concept of a low-mass, low-power method for collecting micron-sized sulfuric acid aerosols in bulk from the atmosphere of Venus. The collection method uses four wired meshes in a sandwich structure with a deposition area of 225 cm. It operates in two modes: passive and electrostatic.

Disentangling the consequences of type 2 diabetes on targeted metabolite profiles using causal inference and interaction QTL analyses.

Circulating metabolite levels have been associated with type 2 diabetes (T2D), but the extent to which T2D affects metabolite levels and their genetic regulation remains to be elucidated. In this study, we investigate the interplay between genetics, metabolomics, and T2D risk in the UK Biobank dataset using the Nightingale panel composed of 249 metabolites, 92% of which correspond to lipids (HDL, IDL, LDL, VLDL) and lipoproteins. By integrating these data with large-scale T2D GWAS from the DIAMANTE meta-analysis through Mendelian randomization analyses, we find 79 metabolites with a causal association to T2D, all spanning lipid-related classes except for Glucose and Tyrosine.

Macroecology of Abiotic Stress Tolerance in Woody Plants of the Northern Hemisphere: Tolerance Biomes and Polytolerance Hotspots.

Understanding the main ecological constraints on plants' adaptive strategies to tolerate multiple abiotic stresses is a central topic in plant ecology. We aimed to uncover such constraints by analysing how the interactions between climate, soil features and species functional traits co-determine the distribution and diversity of stress tolerance strategies to drought, shade, cold and waterlogging in woody plants of the Northern Hemisphere. Functional traits and soil fertility predominantly determined drought and waterlogging/cold tolerance strategies, while climatic factors strongly influenced shade tolerance.

Pediatric Medial Humeral Condyle Fractures: Classification, Treatment, and Outcomes.

Background: The purpose of this study was to develop and validate a classification system that describes the injury pattern of pediatric medial humeral condyle fractures and provide treatment guidelines.

Methods: Patients less than 18 years old with medial humeral condyle fractures from 2012 to 2022 were identified. A classification system was developed based on fracture pattern and putative mechanism of injury.

Advocating for Lesbian, Gay, Bisexual, and Transgender Youth Sexual and Reproductive Health and Rights in Central Asia.

Lesbian, gay, bisexual, and transgender youth in Central Asia face challenges due to the current sociopolitical context, and there is a pressing need for legal and policy reforms to align with the International Conference on Population and Development agenda.

Synthesis of aromatic glycoconjugates as anti-fungal agents against Candida spp. and assessment of their covalent crosslinking capabilities.

Covalent drugs are becoming increasingly attractive in drug discovery, as they can enhance potency and selectivity for their molecular targets. Covalent inhibitors have been investigated for several therapeutic applications, including anti-cancer and anti-infection agents. However, there are only a few examples of covalent inhibitors targeting fungal pathogens.