Interoperability of health data using FHIR Mapping Language: transforming HL7 CDA to FHIR with reusable visual components.

Introduction: Ecosystem-centered healthcare innovations, such as digital health platforms, patient-centric records, and mobile health applications, depend on the semantic interoperability of health data. This ensures efficient, patient-focused healthcare delivery in a mobile world where citizens frequently travel for work and leisure. Beyond healthcare delivery, semantic interoperability is crucial for secondary health data use.

Immunohistochemical evaluation of LGR5, CD71, CD138 and CXCR3 markers in the small bowel mucosa of participants with celiac disease and persons with normal bowel mucosa.

Celiac disease (CD) is a chronic autoimmune disease of the small bowel mucosa that develops because of the altered immune response to gluten, which leads to intestinal epithelium damage and villous atrophy. However, studies on regeneration of the damaged small bowel mucosa and density of intestinal stem cells (ISC) in CD persons are still scarce. We aimed to evaluate the number of small bowel mucosa cells positive for LGR5, CD138/Syndecan-1, CD71 and CXCR3 in CD and in controls with normal bowel mucosa; to find relationship between these markers and degree of small intestinal atrophy and to compare these results with our previous data about the number of CD103 + , IDO + DCs, FOXP3 + Tregs, enterovirus (EV) density and serum zonulin level.

Scalable mechanochemical synthesis of biotin[6]uril.

Biotin[6]uril, a chiral, water-soluble and anion binding macrocycle, is formed via dynamic covalent chemistry. In this study, we present a scalable and high-yielding synthesis of biotin[6]uril via a mechanochemical solid-state approach. The optimized protocol involves mechanical grinding of solid D-biotin with paraformaldehyde in the presence of 0.

Hypoxic conditions affect transcriptome of endometrial stromal cells in endometriosis and promote TGFBI axis.

Background: Endometriosis is characterized by the ectopic growth of endometrial-like cells, causing chronic pelvic pain, adhesions and impaired fertility in women of reproductive age. Usually, these lesions grow in the peritoneal cavity in a hypoxic environment. Hypoxia is known to affect gene expression and protein kinase (PK) activity.

Spectral Emissivity and Thermal Conductivity Properties of Black Aluminum Films.

Black aluminum is a material characterized by high surface porosity due to columnar growth and exhibits unique optical properties that make it attractive for applications such as light trapping, infrared detection, and passive thermal radiation cooling. In this study, we correlate the structural and optical properties of black aluminum by comparing it with conventional reflective aluminum layers. These layers of varying thicknesses were deposited on fused silica substrates, and their optical properties were analyzed.

Integrative review of , and (Lepidoptera, Noctuidae, Xyleninae, Apameini).

The relationship of Mikkola, 1980; Mikkola, 1998; and Mikkola, 1998 is reconsidered based on 59 genitalia slides (37 males and 22 females) and 40 barcodes of adults collected from the type localities and areas in-between. Due to lack of stable morphologic differences, apart from the wing coloration of , and low genetic distance between the three, they are considered as three subspecies of : the nominotypical one and Included are photographs of all specimens covering 37 adults, and 28 male and 18 female genitalia, as well as a phylogenetic tree and a map showing collecting localities.

Eastern filbert blight resistant identified from 20 years of germplasm introduction and evaluation at Rutgers University, New Jersey, USA.

The stem canker disease eastern filbert blight (EFB), caused by , is a major impediment of European hazelnut () production in the United States. While most European hazelnut cultivars are highly susceptible to the pathogen, which remains confined to North America, EFB resistant and tolerant genotypes occur in the gene pool at low frequency. At Rutgers University, New Brunswick, NJ, USA, 5,226 trees were grown from open pollinated seeds collected from Russia, Crimea, Poland, Turkey, Estonia, Latvia, Lithuania, Moldova, Azerbaijan, Italy, and the Republic of Georgia between 2002 to 2010.

Coefficients in Taylor's law increase with the time scale of water clarity measurements in a global suite of lakes.

Identifying the scaling rules describing ecological patterns across time and space is a central challenge in ecology. Taylor's law of fluctuation scaling, which states that the variance of a population's size or density is proportional to a positive power of the mean size or density, has been widely observed in population dynamics and characterizes variability in multiple scientific domains. However, it is unclear if this phenomenon accurately describes ecological patterns across many orders of magnitude in time, and therefore links otherwise disparate observations.

Force drifts and matching errors in the lower extremities: implications for the control and perception of foot force.

Accurate control of force on the environment is mechanically necessary for many tasks involving the lower extremities. We investigated drifts in the horizontal (shear) active force produced by right-footed seated subjects and the effects of force matching by the other foot. Subjects generated constant shear force at 15% and 30% of maximal voluntary contraction (MVC) using one foot.

Biotechnological advances in plant growth-promoting rhizobacteria for sustainable agriculture.

The rhizosphere, the soil zone surrounding plant roots, serves as a reservoir for numerous beneficial microorganisms that enhance plant productivity and crop yield, with substantial potential for application as biofertilizers. These microbes play critical roles in ecological processes such as nutrient recycling, organic matter decomposition, and mineralization. Plant growth-promoting rhizobacteria (PGPR) represent a promising tool for sustainable agriculture, enabling green management of crop health and growth, being eco-friendly alternatives to replace chemical fertilizers and pesticides.

Immunogenicity and safety of the 15-valent pneumococcal conjugate vaccine, a systematic review and meta-analysis.

Pneumococcal infections are a serious health issue associated with increased morbidity and mortality. This systematic review evaluated the efficacy, effectiveness, immunogenicity, and safety of the pneumococcal conjugate vaccine (PCV)15 compared to other pneumococcal vaccines or no vaccination in children and adults. We identified 20 randomized controlled trials (RCTs).

Associations of physical activity and sedentary time with cognitive skills in preschoolers: a longitudinal study from preschool to first grade of school.

Backround: Low physical activity and high sedentary behaviour is a concern already during preschool period with potential impacts on children's future cognitive health in school. However, longitudinal data regarding the associations of physical activity, sedentary time and cognition at young age are limited, thus the aim of this study was to investigate whether objectively monitored moderate-to-vigorous physical activity (MVPA) and sedentary time at preschool age are related to cognitive skills in the first grade of school among boys and girls.

Methods: Participants were boys (n = 50, aged 6.

Immunolocalization of sodium-dependent glucose co-transporter 1 and sodium-dependent glucose co-transporter 2 in chicken's (Gallus gallus domesticus) kidneys.

In homeostasis, which plays an important role in the proper functioning and maintenance of the internal functioning of the body, kidneys play a key role in being responsible for the proper homeostasis of glucose. Among glucose transporters, sodium-dependent glucose co-transporters (SGLTs) have a major role in the kidney's ability to reabsorb glucose. Although the localization of these transporters has been extensively studied in mammals, there are still gaps in knowledge of the localization of SGLTs in birds of different age groups.

The Italian Crowdsourcing Project: Visual word recognition times for 130,495 Italian words.

Despite being largely spoken and studied by language and cognitive scientists, Italian lacks large resources of language processing data. The Italian Crowdsourcing Project (ICP) is a dataset of word recognition times and accuracy including responses to 130,465 words, which makes it the largest dataset of its kind item-wise. The data were collected in an online word knowledge task in which over 156,000 native speakers of Italian took part.

Genome-wide association study of anterior uveitis.

Background/aims: The purpose of this study is to define genetic factors associated with anterior uveitis through genome-wide association study (GWAS).

Methods: In this GWAS meta-analysis, we combined data from the FinnGen, Estonian Biobank and UK Biobank with a total of 12 205 anterior uveitis cases and 917 145 controls. We performed a phenome-wide association study (PheWAS) to investigate associations across phenotypes and traits.

Repeatable process for extracting health data from HL7 CDA documents.

Objective: This study aims to address the gap in the literature on converting real-world Clinical Document Architecture (CDA) data into the Observational Medical Outcomes Partnership (OMOP) Common Data Model (CDM), focusing on the initial steps preceding the mapping phase. We highlight the importance of a repeatable Extract-Transform-Load (ETL) pipeline for health data extraction from HL7 CDA documents in Estonia for research purposes.

Methods: We developed a repeatable ETL pipeline to facilitate the extraction, cleaning, and restructuring of health data from CDA documents to OMOP CDM, ensuring a high-quality and structured data format.

Unveiling root nodulation in Tribulus terrestris and Roystonea regia via metagenomics analysis.

Root nodule symbiosis is traditionally recognized in the Fabales, Fagales, Cucurbitales, and Rosales orders within the Rosid I clade of angiosperms. However, ambiguous root nodule formation has been reported in Zygophyllaceae and Roystonea regia (Arecaceae), although a detailed analysis has yet to be conducted. We aimed to perform morphological analyses of root structures in these plants and utilize metagenomic techniques to identify and characterize the bacterial populations within the nodule-like structures.

Individual Variations in Vergence and Accommodation Responses Following Virtual Reality Gameplay.

Virtual reality (VR) can challenge the visual system, leading to temporary oculomotor changes, though the degree of change varies among individuals. While the vergence and accommodation system plays a crucial role in VR perception, it remains unclear whether individuals whose visual functions fall outside clinical norms experience larger changes. Thus, our study aimed to investigate whether changes in vergence and accommodation responses following VR gameplay differ between individuals with and without non-strabismic binocular and accommodative disorders.

A Novel Organic-Inorganic-Nanocomposite-Based Reduced Graphene Oxide as an Efficient Nanosensor for NO Detection.

There are three components to every environmental protection system: monitoring, estimation, and control. One of the main toxic gases with considerable effects on human health is NO, which is released into the atmosphere by industrial activities and the transportation network. In the present research, a NO sensor is designed based on FeO piperidine-4-sulfonic acid grafted onto a reduced graphene oxide FeO@rGO-N-(piperidine-4-SOH) nanocomposite, due to the highly efficient detection of pollution in the air.

DAT: Deep Learning-Based Acceleration-Aware Trajectory Forecasting.

As the demand for autonomous driving (AD) systems has increased, the enhancement of their safety has become critically important. A fundamental capability of AD systems is object detection and trajectory forecasting of vehicles and pedestrians around the ego-vehicle, which is essential for preventing potential collisions. This study introduces the Deep learning-based Acceleration-aware Trajectory forecasting (DAT) model, a deep learning-based approach for object detection and trajectory forecasting, utilizing raw sensor measurements.

Immunolocalization of Na(+)-Dependent Glucose Co-Transporters in Chicken Kidneys in Norm and During T-2 Mycotoxicosis (Primary Study).

The kidney plays an essential role in the proper homeostasis of glucose. In the kidney, glucose transport is carried out across cell membranes by two families of glucose transporters-facilitated diffusion glucose transporters (GLUTs) and Na(+)-dependent glucose co-transporters (SGLT family). Among the transporters, sodium-dependent glucose co-transporters play a major role in the kidney's ability to reabsorb glucose.

Love as a Commitment Device : Evidence from a Cross-Cultural Study across 90 Countries.

Given the ubiquitous nature of love, numerous theories have been proposed to explain its existence. One such theory refers to love as a commitment device, suggesting that romantic love evolved to foster commitment between partners and enhance their reproductive success. In the present study, we investigated this hypothesis using a large-scale sample of 86,310 individual responses collected across 90 countries.

A new mesophilic member of the Chloroflexota phylum 'Ca. Сhloroploca septentrionalis' from the meromictic lake Bol'shie Khruslominy separated from the White Sea.

A new filamentous phototrophic bacterium Khr17 was isolated as an enrichment culture from the brackish polar lake Bol'shie Khruslomeny. The organism was a halotolerant, strictly anaerobic phototroph possessing photosystem II. Sulfide was required for phototrophic growth.