1,453 results match your criteria: "Esthesioneuroblastoma"
Olfactory neuroblastoma: literature review and presentation of two clinical cases with different tumour infiltrations and different approaches.
Neurocirugia (Astur : Engl Ed)
December 2024
Médico General Universidad Autónoma de Bucaramanga, Bucaramanga, Colombia. Electronic address:
The olfactory neuroblastoma is a rare malignant neoplasm derived from the olfactory neuroepithelium. It can metastasize to cervical lymph node chains and distant organs through hematogenous or lymphatic routes. Two clinical cases are presented: the first, a 56-year-old man with no pathological history, exhibited symptoms evolving over 2 months, characterized by persistent rhinorrhea with frequent epistaxis, ipsilateral proptosis, left hemicranial pain, anosmia, and dysgeusia.
View Article and Find Full Text PDFEctopic olfactory neuroblastoma is associated with increased frequency of syndrome of inappropriate antidiuretic hormone secretion and reduced disease control: Case series with systematic review and pooled analysis.
Int Forum Allergy Rhinol
December 2024
Section of Otorhinolaryngology-Head and Neck Surgery, Department of Neuroscience, University of Padova, Padova, Italy.
Introduction: Olfactory neuroblastoma (ONB) is a rare malignant tumor originating from the olfactory neuroepithelium, typically within the sinonasal cavity. Cases of ONB originating outside of the olfactory cleft area are extremely rare and are referred to as "ectopic" (eONB), in contrast to "orthotopic" tumors (oONB). ONB has been associated with paraneoplastic syndromes (PNSs), including the syndrome of inappropriate antidiuretic hormone secretion (SIADH).
View Article and Find Full Text PDFAn Uncommon Encounter: Metastatic Olfactory Neuroblastoma in an Adult Male.
Cureus
November 2024
Department of Medical Oncology, 251 Air Force General Hospital, Athens, GRC.
Article Synopsis
Analysis of ASCL1/NEUROD1/POU2F3/YAP1 Yields Novel Insights for the Diagnosis of Olfactory Neuroblastoma and Identifies Sinonasal Tuft Cell-like Carcinoma.
Mod Pathol
November 2024
Department of Pathology and Laboratory Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, 10065, USA. Electronic address:
Article Synopsis
Morphological variability and its impact on survival in sinonasal malignancies: a 13-year analysis.
Eur Arch Otorhinolaryngol
November 2024
Asklepios Medical School, Hamburg, Germany.
Article Synopsis
- A study analyzed sinonasal malignancies in Germany using data from the German Center for Cancer Registry, covering 8,332 cases from 2003 to 2015 to address gaps in cancer registries.
- The findings showed an increase in cancer incidence, particularly among men, with a five-year overall survival rate of 63% for nasal cavity cancers, but lower rates for those in the frontal sinus.
- The study highlighted the varying survival rates among different tumor types, emphasizing the need for improved early-stage screening due to the moderate to high mortality rates associated with sinonasal cancers, particularly for sinonasal undifferentiated carcinoma and mucosal melanoma.
Olfactory Neuroblastoma With Divergent Differentiation: Contemporary Management of Unusual Pathology and Literature Review.
Ear Nose Throat J
November 2024
Division of Rhinology, Department of Otolaryngology-Head and Neck Surgery, University of Florida, Gainesville, FL, USA.
Olfactory neuroblastoma (ON; Esthesioneuroblastoma) is a malignant tumor that arises from the olfactory neuroepithelium. Very rarely, ON can histologically display a biphenotypic pattern, with only 7 cases reported in the literature to date. We describe a case of this poorly understood entity and review the patient's histology, pathology, and treatment.
View Article and Find Full Text PDFPathologic dural invasion is associated with regional recurrence in olfactory neuroblastoma: A multi-institutional study.
Int Forum Allergy Rhinol
November 2024
Department of Otolaryngology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Article Synopsis
- - The study investigates the role of pathological dural invasion (pathDI) as a predictor for neck metastases and recurrence in patients with olfactory neuroblastoma (ONB), using data from a multicenter database of ONB cases collected between 2005 and 2021.
- - Among the 258 patients reviewed, those with pathDI had a significantly lower 10-year neck recurrence-free survival (61.8%) compared to those without it (85.7%), indicating a strong negative impact of pathDI on prognosis.
- - The analysis revealed that pathDI is a significant predictor of neck recurrence and recurrence at other sites, suggesting that future research could lead to changes in treatment strategies for patients with pathDI. *
Olfactory Neuroblastoma and Olfactory Carcinoma: A Practical Review.
Surg Pathol Clin
December 2024
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Oncology, The Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:
Article Synopsis
- The sinonasal tract includes two main tumor types with neuroectodermal differentiation: Olfactory neuroblastoma (ONB) and the newly-recognized Olfactory carcinoma (OC).
- ONB is characterized as a keratin-negative tumor with a lobulated structure, while OC is keratin-positive and often has well-formed glands present.
- The review aims to clarify the clinical and diagnostic features of ONB and OC, and how they can be differentiated from other similar tumors in the sinonasal area.
An adolescent girl with syndrome of inappropriate antidiuretic hormone secretion preceding the diagnosis of olfactory neuroblastoma - a case report.
Front Endocrinol (Lausanne)
October 2024
Division of Pediatric Endocrinology, Department of Pediatrics, Hasbro Children's Hospital, Providence, RI, United States.
Article Synopsis
- - A 13-year-old girl diagnosed with SIADH (Syndrome of Inappropriate Antidiuretic Hormone) after restrictive eating had normal initial brain MRIs, later revealing olfactory neuroblastoma (ONB) 2.5 years post-diagnosis.
- - Initial treatments for SIADH included fluid restriction, which was somewhat effective, but the condition recurred post-surgery for ONB, indicating persistence of SIADH even after successful tumor removal.
- - The case emphasizes the need for healthcare providers to consider the possibility of ONB when evaluating children with unexplained SIADH, recommending earlier imaging and endoscopy if no clear cause is found.
The value of elective neck irradiation in management of esthesioneuroblastoma: a retrospective study based on propensity score matching.
Radiat Oncol
October 2024
Department of Radiation Oncology, Eye & ENT Hospital of Fudan University, 83 Fenyang Road, Xuhui, Shanghai, 200031, P.R. China.
Article Synopsis
- * Using propensity score matching, the results compared survival outcomes between 96 patients treated with ENI and 53 who were not, revealing significant improvements in overall survival (OS), progression-free survival (PFS), and locoregional relapse-free survival (LRFS) for those receiving ENI.
- * The study concludes that ENI appears to reduce regional failure rates and should be considered in treatment planning for locally advanced node-negative ENB patients, particularly those classified as
56Fe-ion Exposure Increases the Incidence of Lung and Brain Tumors at a Similar Rate in Male and Female Mice.
Radiat Res
November 2024
Department of Radiation Oncology, Duke University School of Medicine, Durham, North Carolina.
The main deterrent to long-term space travel is the risk of Radiation Exposure Induced Death (REID). The National Aeronautics and Space Administration (NASA) has adopted Permissible Exposure Levels (PELs) to limit the probability of REID to 3% for the risk of death due to radiation-induced carcinogenesis. The most significant contributor to current REID estimates for astronauts is the risk of lung cancer.
View Article and Find Full Text PDFRadiologic overview of sinonasal lesions.
Front Radiol
August 2024
Department of Imaging Sciences, University of Rochester Medical Center, Rochester, NY, United States.
Article Synopsis
- - Sinonasal tumors, which make up about 3% of head and neck cancers, often develop in the nasal cavity, ethmoid, and maxillary sinuses, with symptoms like headaches, nosebleeds, and vision changes.
- - Diagnostic imaging techniques like CT and MRI are crucial for locating tumors, assessing their invasion into surrounding tissues, and planning treatment.
- - The study will highlight various sinonasal tumors, including rare cases, focusing on their imaging features and the impact of tumor invasion on nearby structures, leading to neurological symptoms.
[Genomic profiles and immune microenvironment of olfactory neuroblastoma].
Zhonghua Bing Li Xue Za Zhi
September 2024
Beijing Key Laboratory of Molecular Diagnosis of Head and Neck Pathology, Department of Pathology, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
To investigate the genomic profiles and immune microenvironment of olfactory neuroblastoma (ONB). Nineteen ONB cases diagnosed in the Beijing Tongren Hospital from May 2018 to October 2022 were divided into low-grade and high-grade groups according to the Hyams grading system, including 7 low-grade and 12 high-grade ONB. Whole exome sequencing and multiplex immunofluorescence analyses were performed on tissue samples of these ONB.
View Article and Find Full Text PDF[Olfactory neuroblastoma in children: clinical analysis of five cases].
Zhonghua Yi Xue Za Zhi
September 2024
Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, Beijing 100176, China.
The clinical data of five patients diagnosed with olfactory neuroblastoma (ONB) who were admitted to the Department of Pediatrics, Beijing Tongren Hospital Affiliated to Capital Medical University from January 2012 to January 2024 were retrospectively analyzed. Two males and three females aged 6.2 (5.
View Article and Find Full Text PDFEctopic Olfactory Neuroblastoma Arising in the Nasopharynx.
J Craniofac Surg
October 2024
Department of Otorhinolaryngology Head and Neck Surgery, XuanWu Hospital, Capital Medical University.
Olfactory neuroblastoma (ONB) is an uncommon malignant tumor typically located in the upper nasal cavity. Olfactory neuroblastoma originating in the nasopharynx is extremely rare and tends to be misdiagnosed. The authors describe a rare case of ONB arising ectopically in the nasopharynx.
View Article and Find Full Text PDFOlfactory neuroblastoma with orbital protrusion arising in the background of maxillary carcinoma.
J Surg Case Rep
August 2024
Department of Oral and Maxillofacial Surgery, Sharad Pawar Dental College, Datta Meghe Institute of Higher Education and Research, Sawangi, Wardha, Maharashtra (442001), India.
An uncommon entity in the class of malignant neuroectodermal nasal tumors is the olfactory neuroblastoma, which originates in the roof of the nasal cavity from the olfactory epithelium. It is often mistaken by clinicians for a nasal polyp because it presents with indistinct features such as nasal obstruction and secondary sinus disease. Olfactory neuroblastoma has been observed to cause morbidity by distant metastasis, invasion through the cribriform plate, and secondary meningitis in most instances.
View Article and Find Full Text PDFSurvival Analysis and Prognostic Factors After Endonasal Resection of Advanced Olfactory Neuroblastomas: A Single Institution Experience.
J Otolaryngol Head Neck Surg
August 2024
ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China.
Article Synopsis
- This study examines the prognostic factors affecting patients with advanced olfactory neuroblastoma (ONB) who received endoscopic surgery, analyzing their medical records and outcomes.
- A total of 85 patients were reviewed, with significant findings indicating that certain surgical approaches, like bony skull base resection, may enhance overall survival, while dura resection did not show significant benefits.
- The researchers concluded that combining endoscopic surgery with postoperative radiotherapy is both effective and safe, emphasizing the importance of careful patient selection for dura resection to minimize complications while maximizing survival chances.
Role of induction chemotherapy in advanced-stage olfactory neuroblastoma.
Int Forum Allergy Rhinol
December 2024
Department of Otorhinolaryngology, Head and Neck Surgery, Seongnam, South Korea.
Objectives: To evaluate the treatment outcomes in patients with advanced-stage olfactory neuroblastoma (ONB) who received induction chemotherapy (IC).
Materials And Methods: The clinical data of 38 patients with advanced-stage ONB who received initial IC were retrospectively analyzed. The response was defined using the Response Evaluation Criteria in Solid Tumors version 1.
Esthesioneuroblastoma: 38 years of experience in an oncological center.
Rep Pract Oncol Radiother
June 2024
Department of Medical Oncology, IPO Porto, Porto, Portugal.
Background: Esthesioneuroblastoma (ENB) is an uncommon malignant sinonasal tumor. There are few data regarding ENB management, namely its treatment. We review our institute's experience in the treatment of ENB and evaluate survival outcomes.
View Article and Find Full Text PDFOlfaction Preservation and Long-Term Outcomes in Patients with Unilateral Endoscopic Resection of Olfactory Neuroblastoma: A Systematic Review and Institutional Experience.
World Neurosurg
October 2024
Department of Otolaryngology and Head & Neck Surgery, Emory University, Atlanta, Georgia, USA. Electronic address:
Article Synopsis
A prospective cohort study on stereotactic radiotherapy in the management of dural recurrence of olfactory neuroblastoma.
Head Neck
January 2025
Department of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
Background: Treatment for dural recurrence of olfactory neuroblastoma (ONB) is not standardized. We assess the outcomes of stereotactic body radiotherapy (SBRT) in this population.
Methods: ONB patients with dural recurrences treated between 2013 and 2022 on a prospective registry were included.