8,340 results match your criteria: "Essentials of Tissue Movement"

The coordinated movement of cell collectives is essential for normal epithelial tissue development, maintenance, and cancer progression. Here, we report on a minimal 3D extracellular matrix (ECM) system wherein both invasive collective migration (ICM) and rotational collective migration (RCM) arise spontaneously from individually seeded epithelial cells of mammary and hepatic origin, regardless of whether they express adherens junctions, and lead to ductal-like and acinar-like structures, respectively. Quantitative microscopy and cellular Potts modeling reveal that initial differences in cell protrusion dynamics and matrix-remodeling localization generate RCM and ICM behavior in confining 3D ECM.

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Recent years have seen the development of various classifications of muscle injuries, primarily based on the topographic location within the bone-tendon-muscle chain. This paper proposes an enhanced nomenclature for muscle injuries that incorporates histoarchitectural definitions alongside topographic classifications, emphasizing the importance of connective tissue damage characterization. A detailed understanding of the distinct anatomical and histological characteristics of tendon, aponeurosis, and fascia is essential for consistent terminology.

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Background: In soft tissue regeneration, the clinical efficacy of fibrin membranes has been a pressing concern. The key to this efficacy lies in the stability of membrane and its controlled absorption. Human serum albumin, with its influence on the formation and stability of fibrin networks, could hold the key to developing a more stable alternative.

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The transmission of cytoskeletal forces to the extracellular matrix through focal adhesion complexes is essential for a multitude of biological processes, such as cell migration, cell differentiation, tissue development, and cancer progression, among others. During migration, focal adhesions arrest the actin retrograde flow towards the cell interior, allowing the cell front to move forward. Here, we address a puzzling observation of the existence of two distinct phenomena: a biphasic vs a monotonic relationship of the retrograde flow and cell traction force with substrate rigidity.

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Diverse functional interactions between ABA and ethylene in plant development and responses to stress.

Physiol Plant

December 2024

State Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems, College of Ecology, Lanzhou University, Lanzhou, China.

Abscisic acid (ABA) and ethylene are two essential hormones that play crucial roles throughout the entire plant life cycle and in their tolerance to abiotic or biotic stress. In recent decades, increasing research has revealed that, in addition to their individual roles, these two hormones are more likely to function through their interactions, forming a complex regulatory network. More importantly, their functions change and their interactions vary from synergistic to antagonistic depending on the specific plant organ and development stage, which is less focused, compared and systematically summarized.

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Cardiac development is a complex developmental process. The early cardiac straight tube is composed of an external myocardial layer and an internal endocardial lining. Soon after rightward looping, the embryonic heart becomes externally covered by a new epithelial lining, the embryonic epicardium.

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Mesenchymal chondrosarcoma (MCS) is a rare, aggressive subtype of chondrosarcoma characterized by biphasic histology, often misdiagnosed due to its rarity and histological resemblance to other small round cell tumors. It predominantly affects adolescents and young adults. We report a 27-year-old male presenting with a progressively enlarging, painless mass in the right inframammary region, initially attributed to muscular strain.

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Understanding how forces are transmitted through the knee after TKA is essential, as it may explain why many patients experience pain or functional limitations during various activities. This study compared knee muscle forces and knee contact forces (KCF) during sit-to-stand in patients one year after unilateral total knee arthroplasty (TKA) with either a medial ball-and-socket (MBS) or posterior stabilized (PS) implant and compared them to a group of similarly healthy aged controls (CTRL). A musculoskeletal model and static optimization estimated lower limb kinematics, knee kinetics, muscle forces, and KCFs.

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The rapid proliferation of germinal center (GC) B cells requires metabolic reprogramming to meet energy demands, yet these metabolic processes are poorly understood. By integrating metabolomic and transcriptomic profiling of GC B cells, we identified that asparagine (Asn) metabolism was highly up-regulated and essential for B cell function. Asparagine synthetase (ASNS) was up-regulated after B cell activation through the integrated stress response sensor GCN2.

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Unlabelled: Glial cell line-derived neurotrophic factor (GDNF) is essential in maintaining the viability, function and differentiation of neuronal cells. In addition to its function in healthy nervous tissue, GDNF is involved in pathological processes, such as glioma growth. GDNF is represented by 2 main isoforms: pre-α-pro-GDNF (αGDNF) and pre-β-pro-GDNF (βGDNF).

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Type I collagen extracellular matrix facilitates nerve regeneration via the construction of a favourable microenvironment.

Burns Trauma

December 2024

Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Co-innovation Center of Neuroregeneration, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Medical School of Nantong University, Nantong University, 19 Qixiu Road, Nantong, Jiangsu 226001, China.

Background: The extracellular matrix (ECM) provides essential physical support and biochemical cues for diverse biological activities, including tissue remodelling and regeneration, and thus is commonly applied in the construction of artificial peripheral nerve grafts. Nevertheless, the specific functions of essential peripheral nerve ECM components have not been fully determined. Our research aimed to differentially represent the neural activities of main components of ECM on peripheral nerve regeneration.

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Tissue factor (TF) and protease-activated receptor 2 (PAR2) have been associated with the progression of cancer, while integrins are essential for the adhesion and migration of cancer cells. This study aimed to explore the cross-talk between the TF:FVIIa complex, PAR2 signaling, and the expression of integrin α1 in cervical cancer cells. Utilizing data from The Cancer Genome Atlas (TCGA), the research examined the relationship between the TF and PAR2 genes and the integrin α1 gene (ITGA1) in reproductive cancers, revealing a positive correlation between integrin α1 expression and both TF and PAR2 genes.

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Background Falls among elderly adults are one of the most common reasons that could lead to injury and modality, as vision is one of the modifiable risk factors for falls. By assessing it, we can detect those needing further follow-up with opticians or ophthalmologists, lowering the risk of falls secondary to poor vision. Methods Data were collected and reviewed retrospectively from a consecutive list of patients who presented with a fall or head injury to the Accident and Emergency Department at Northampton General Hospital.

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Background: Gangliocapsular stroke is a specific type of hemorrhagic stroke that primarily affects the basal ganglia and internal capsule due to rupture of the lenticulostriate perforating arteries. Patients afflicted with this condition often present with contralateral motor deficits, particularly affecting the upper extremity. Additionally, these individuals may experience challenges in coordination and stability, largely due to the involvement of the shoulder and scapular girdle.

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Forcing the code: tension modulates signaling to drive morphogenesis and malignancy.

Genes Dev

December 2024

Center for Bioengineering and Tissue Regeneration, Department of Surgery, University of California, San Francisco, San Francisco, California 94143, USA;

Development and disease are regulated by the interplay between genetics and the signaling pathways stimulated by morphogens, growth factors, and cytokines. Experimental data highlight the importance of mechanical force in regulating embryonic development, tissue morphogenesis, and malignancy. Force not only sculpts tissue movements to drive embryogenesis and morphogenesis but also modifies the context of biochemical signaling and gene expression to regulate cell and tissue fate.

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Assessing the impact of 24-hour activity behaviors on cardiorespiratory fitness in the older adult: a component analysis approach.

Front Public Health

December 2024

Tianjin Key Laboratory of Physical and Health Integration and Health Promotion, Tianjin, China.

Background: Cardiorespiratory fitness (CRF) serves as a critical measure of the cardiovascular system's efficiency in delivering oxygenated blood to tissues and organs. Understanding the relationship between various activity behaviors and CRF is essential for devising effective health interventions for the older adult population.

Objective: This study aimed to investigate the association between 24-h activity behaviors and CRF in older adult individuals, utilizing compositional data analysis.

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Quantitative Assessment of the Structural Effects in Foot Soft Tissues Depending on the Mechanical Contact Between Joints.

Int J Numer Method Biomed Eng

January 2025

Departamento de Ingeniería Mecánica, Escuela de Ingeniería y Arquitectura (EINA), Universidad de Zaragoza, Zaragoza, Spain.

Developing realistic numerical foot models is essential to accurately predict the structural behavior of its bones and soft tissues. The representation of the foot joints is a crucial point that must be considered to recreate these models' natural behavior. Numerically, different types of contact represent these interactions, two being the most common: one that allows movement between bones and one that restricts it.

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SENP3 mediates deSUMOylation of SIX1 to promote prostate cancer proliferation and migration.

Cell Mol Biol Lett

December 2024

Guangzhou Institute of Cancer Research, The Affiliated Cancer Hospital, Guangzhou Medical University, Guangzhou, 510095, China.

Background: Sentrin/SUMO-specific protease 3 (SENP3) is essential to regulate protein stability and function in normal and cancer cells. Nevertheless, its role and action mechanisms in prostate cancer (PCa) remain elusive. Thus, clarification of SENP3's involvement and the SUMOylation process in PCa is pivotal for discovering potential targets and understanding SUMOylation dynamics.

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The toxic effects of neutrophil extracellular traps on mesenchymal stem cells.

Mol Biol Rep

November 2024

Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Shahroud University of Medical Sciences, Shahroud, Iran.

Sepsis, a systemic inflammatory response syndrome resulting from an uncontrolled inflammatory reaction to infection, remains without a definitive cure despite therapeutic advancements. Mesenchymal stem cells (MSCs), renowned for their capacity to alleviate inflammation and modulate the immune system, have emerged as a potential treatment avenue for sepsis. In sepsis pathophysiology, hyperactivated neutrophils release extracellular neutrophil traps (NETs).

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In vitro regulation of collective cell migration: Understanding the role of physical and chemical microenvironments.

Prog Biophys Mol Biol

November 2024

Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an, 710072, China. Electronic address:

Article Synopsis
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Muscle development and diversity require a large number of spatially and temporally regulated events controlled by transcription factors (TFs). has long stood as a model to study myogenesis due to the highly conserved key TFs involved at all stages of muscle development. While many studies focused on the diversification of larval musculature, how distinct adult muscle types are generated is much less characterized.

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AKG, a central metabolite in the Krebs cycle, plays a vital role in cellular energy production and nitrogen metabolism. This review explores AKG's potential therapeutic applications in skeletal muscle health and exercise performance, focusing on its mechanisms for promoting muscle regeneration and counteracting muscle atrophy. A literature search was conducted using the PubMed, Web of Science, and Scopus databases, yielding 945 articles published up to 31 October 2024.

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Ultrasound evaluation of deep fascia thickness: Reliability and association with clinically evaluated changes.

J Bodyw Mov Ther

October 2024

Department of Physical Therapy, Recanati School for Community Health Professions, Faculty of Health Sciences at Ben-Gurion University of the Negev, Beer-Sheva, Israel. Electronic address:

Background: There is growing evidence of fascial involvement in musculoskeletal pathologies; thus, measuring the fascia's properties is clinically essential.

Objectives: 1) to evaluate intra- and inter-tester reliability of sonographic measurements of deep fascia thickness in healthy individuals; 2) to assess whether fascial thickness in areas of fascial movement restriction (fascial densification in Stecco's Fascial Manipulation method), differs from contralateral areas with normal fascia.

Methods: Part 1 (reliability study): Fascial thickness was sonographically measured in 10 sites (5 on each side), twice by a single examiner to assess intra-rater reliability and once by a second examiner to evaluate inter-rater reliability.

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