335 results match your criteria: "Esophageal Atresia Tracheoesophageal Fistula"
Childhood Educational Outcomes of Infants Born With Esophageal Atresia With or Without Tracheoesophageal Atresia.
Birth Defects Res
December 2024
Arkansas Center for Birth Defects Research and Prevention, Little Rock, Arkansas, USA.
Article Synopsis
Esophagitis, treatment outcomes, and long-term follow-up in children with esophageal atresia.
J Pediatr Gastroenterol Nutr
December 2024
Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
Article Synopsis
Repair of Type C Tracheo-esophageal Fistula/Esophageal Atresia With or Without Trans Anastomotic Tube: A Pilot Randomized Controlled Trial.
J Pediatr Surg
September 2024
Department of Pediatric Surgery, PGIMER, Chandigarh, India.
Background: The use of trans anastomotic feeding tube (TAFT) during the repair of Esophageal atresia/Tracheo-esophageal fistula (EA/TEF) aims to enhance outcomes by enabling early feeding, reducing the requirement for parenteral nutrition, and reducing complications such as anastomotic leak by stenting the anastomosis. However, TAFT's benefits and drawbacks are debated due to conflicting reports. Thus, we conducted a prospective pilot randomized control trial to elucidate the impact of TAFT on postoperative outcomes and the potential benefits of avoidance of TAFT.
View Article and Find Full Text PDFCorrelation of Tracheomalacia Severity With Esophageal Gap Length as Assessed by Ultrashort Echo-time MRI.
J Pediatr Surg
November 2024
University of Cincinnati School of Medicine, Department of Pediatrics, Cincinnati, OH, USA; Cincinnati Children's Hospital Medical Center, Division of Neonatology and Pulmonary Biology, Cincinnati, OH, USA.
Article Synopsis
- - Ultrashort echo-time MRI offers a non-invasive method to measure tracheomalacia severity in infants with tracheoesophageal fistula and esophageal atresia (TEF/EA), aiming to clarify the link between tracheomalacia severity and esophageal atresia.
- - A review of 16 neonate patients highlighted that those with long gap esophageal atresia exhibited significantly greater tracheomalacia severity compared to those with short gap, along with a higher rate of respiratory-related hospital admissions.
- - Post-surgery measurements indicated that trachea eccentricity improved in the upper third but worsened in the lower third after TEF/EA repair, illustrating how surgical outcomes can vary across the tr
Esophageal Atresia with Tracheoesophageal Fistula Is Associated with Consanguinity.
J Pediatr
December 2024
Pediatric Gastrointestinal Unit, Soroka University Medical Center, Beer-Sheva, Israel; Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Objective: To examine the association between nonsyndromic esophageal atresia with tracheoesophageal fistula (EA-TEF) and consanguinity.
Study Design: A retrospective study comparing the incidence of EA-TEF between a low-consanguineous Jewish population and a high-consanguineous Bedouin population. All patients were treated at Soroka University Medical Center, the only tertiary medical center in southern Israel.
Association of Operative Approach With Postoperative Outcomes in Neonates Undergoing Surgical Repair of Esophageal Atresia and Tracheoesophageal Fistula.
J Pediatr Surg
November 2024
Division of Pediatric Surgery, Nemours Children's Health, Wilmington, DE, United States; Department of General Surgery, Thomas Jefferson University Hospital, Philadelphia, PA, United States. Electronic address:
Article Synopsis
- The study investigates the outcomes of minimally invasive surgery (MIS) compared to open surgery for repairing esophageal atresia/tracheoesophageal fistula (EA/TEF) in neonates, utilizing data from 2013 to 2020.
- A total of 1,738 neonates were analyzed, revealing that although MIS use increased over time, it was linked to longer surgical times and higher rates of overall postoperative interventions.
- Despite these findings, there was no significant difference in overall morbidity between the two surgical approaches, suggesting a need for further research to assess the long-term effects of MIS on EA/TEF repairs.
Birth weight and thoracoscopic approach for patients with esophageal atresia and tracheoesophageal fistula-a retrospective cohort study.
Surg Endosc
September 2024
Department of Pediatric Surgery and Urology, Wroclaw Medical University, Borowska 213, 50-556, Wroclaw, Poland.
Article Synopsis
- This study evaluated the safety and effectiveness of thoracoscopic surgery for infants with esophageal atresia and tracheoesophageal fistula (EA/TEF), focusing on how birth weight affects outcomes.
- A total of 145 newborns were analyzed, categorized based on their birth weights into three groups, showing varying rates of early mortality and surgical complications across the groups.
- The results indicate that, even for lower birth weight infants, thoracoscopic repair is a viable option, as long as it's performed by experienced surgeons, and birth weight shouldn't disqualify patients from this approach.
Clinical Signs as a Guide for Esophagram After Esophageal Atresia/Tracheoesophageal Fistula Repair.
J Surg Res
September 2024
Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin. Electronic address:
Introduction: Esophageal atresia/tracheoesophageal fistula (EA/TEF) is a congenital malformation that occurs in about 1 in 2500-4000 live births. After surgical repair, despite the lack of evidence supporting the routine use of postoperative esophagram, most surgeons report obtaining an esophagram prior to enteral feeding. We hypothesized that abnormal indicators in vital signs, drain characteristics, and chest radiograph (CXR) could be used to screen for anastomotic leak, thus reducing the need for a routine esophagram.
View Article and Find Full Text PDFThoracoscopic primary repair is useful for esophageal atresia with tracheoesophageal fistula in neonates with low body weight.
Pediatr Surg Int
June 2024
Department of Rare/Intractable Cancer Analysis Research, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan.
Article Synopsis
- The study assesses the effectiveness of thoracoscopic primary repair for esophageal atresia with tracheoesophageal fistula in newborns, specifically focusing on patients weighing less than 2000 g and those undergoing emergency surgery on their birth day.
- A total of 43 patients were analyzed, revealing that surgical outcomes were similar regardless of weight, but those who had surgery at birth had a higher incidence of anastomotic leakage compared to those operated on after one day.
- The findings suggest that while thoracoscopic primary repair is generally safe for low-weight newborns, caution is advised for those needing emergency surgery at 0 days due to the increased risk of complications.
Validation of a PHIS Esophageal Atresia and Tracheoesophageal Fistula Cohort in ICD-10.
Otolaryngol Head Neck Surg
September 2024
Department of Otolaryngology and Communication Enhancement, Boston Children's Hospital, Boston, Massachusetts, USA.
Article Synopsis
- The study aimed to validate a new cohort of patients with congenital esophageal and tracheoesophageal atresia (EA/TEF) using the International Classification of Diseases, 10th Revision, Clinical Modification (ICD-10-CM) within the Pediatric Health Information System (PHIS) database.
- Researchers adapted previous methods from ICD-9-CM to accurately identify patients treated at a specialized center from October 2015 to July 2022.
- Results showed high sensitivity (99%) and positive predictive value (94%), concluding that this validation method can effectively support multi-institutional studies and improve understanding of EA/TEF outcomes.
A 3D printed esophageal atresia-tracheoesophageal fistula thorascopy simulator for young surgeons.
Sci Rep
May 2024
Department of Pediatric Surgery, Seoul National University Hospital, Seoul, Korea.
Article Synopsis
- A 3D-printed simulator for thoracoscopic surgery was created to help train young pediatric surgeons on esophageal atresia with tracheoesophageal fistula (EA-TEF) procedures, using preoperative imaging of a patient as a guide.
- The simulator underwent multiple prototypes and incorporated both reusable and replaceable parts, made from various printing materials, to mimic real surgical conditions.
- In evaluations, the simulator received high ratings for its relevance and value, suggesting it could be an effective training tool for young surgeons with minor improvements needed.
Statewide Hospital Admissions for Adult Survivors of Infant Surgical Diseases Over a 10-Year Period.
J Surg Res
July 2024
Department of Surgery, University of South Florida Morsani College of Medicine, Tampa, Florida; Department of Surgery, John's Hopkins All Children's Hospital, St. Petersburg, Florida. Electronic address:
Introduction: The number of patients with congenital disease living to adulthood continues to grow. Often undergoing surgical correction in infancy, they continue to require lifelong care. Their numbers are largely unknown.
View Article and Find Full Text PDFSedation-free transnasal esophagoscopy to evaluate and monitor esophageal diseases in children with esophageal atresia-tracheoesophageal fistula.
JPGN Rep
May 2024
Section of Pediatric Gastroenterology, Hepatology and Nutrition Children's Hospital of Colorado, Digestive Health Institute, Children's Hospital Colorado Aurora Colorado USA.
Article Synopsis
- Patients with esophageal atresia and tracheoesophageal fistula (EA-TEF) face various gastrointestinal complications, necessitating potential lifetime endoscopic monitoring.
- There's growing interest in using pediatric unsedated transnasal endoscopy (TNE) as a safer, cost-effective alternative to traditional endoscopy for these patients.
- The report highlights four cases where TNE was effectively utilized for monitoring and managing conditions like gastroesophageal reflux and eosinophilic esophagitis, supporting its use in routine screenings as per guidelines.
Genomic Contributors to Esophageal Atresia and Tracheoesophageal Fistula: A 12 Year Retrospective Review.
J Pediatr
August 2024
Division of Human Genetics, The Children's Hospital of Philadelphia, Perelman School of Medicine at University of Pennsylvania, Philadelphia, PA; Division of Human Genetics, Roberts Individualized Medical Genetics Center, The Children's Hospital of Philadelphia, Philadelphia, PA.
Article Synopsis
- The study evaluates the use and effectiveness of genetic testing in diagnosing infants with esophageal atresia (EA) and tracheoesophageal fistula (TEF) over a 12-year period to improve future care and management.
- It involves a retrospective analysis of 212 infants, identifying different classifications (complex/syndromic, isolated/nonsyndromic) and noting varying success rates for different genetic tests performed.
- The findings suggest that EA/TEF has a complex genetic landscape, highlighting the need for advanced testing methods like exome sequencing to better understand its causes and improve diagnosis.
Outcomes of surgical treatment of tracheobronchomalacia in children.
Pediatr Pulmonol
July 2024
Division of Pulmonary Medicine, Boston Children's Hospital, Boston, Massachusetts, USA.
Article Synopsis
- Tracheobronchomalacia (TBM) leads to severe airway collapse and can cause serious health issues, especially in children, with this study focusing on those with severe primary TBM without underlying causes like esophageal atresia or vascular issues.
- A cohort of 73 children underwent airway pexy surgery, and the study compared their symptoms and bronchoscopic findings before and after the procedure.
- Results showed significant improvements in many symptoms, but about 29% of patients still had issues afterward, leading to further surgical interventions for symptom relief.
Article Synopsis
- Tracheoesophageal fistula (TEF) with or without esophageal atresia (EA) occurs due to irregular development of the trachea and esophagus in newborns, often leading to increased oral secretions and difficulty in feeding tubes after birth.
- The condition is usually diagnosed shortly after birth, making early recognition critical for improving outcomes and reducing mortality risks.
- A case series of two neonates with different types of TEF highlights the necessity for transport to specialized centers for surgery and emphasizes the importance of educating parents and caregivers about the condition and its long-term effects.
Long-term Airway Outcomes and Interventions in Children With Oesophageal Atresia With Tracheoesophageal Fistula: A 20-year Single Centre Observational Study.
J Pediatr Surg
June 2024
Department of Paediatric Otolaryngology Head and Neck Surgery, Royal Hospital for Children, Glasgow, United Kingdom.
Article Synopsis
- A study from the Royal Hospital for Children in Glasgow examined long-term airway issues in kids with oesophageal atresia and tracheoesophageal fistula (OA/TOF) and found that 83% experienced airway symptoms.* -
- Out of 121 patients, many underwent airway endoscopy, revealing issues like airway malacia and subglottic stenosis, with significant surgical interventions needed for 40% of them.* -
- The findings suggest that long-term airway problems are common and often treatable, highlighting the need for clinicians to appropriately refer these patients to airway specialists.*
Developing a core outcome set for the health outcomes for children and adults with congenital oesophageal atresia and/or tracheo-oesophageal fistula: OCELOT task group study protocol.
BMJ Paediatr Open
February 2024
Respiratory Unit, Alder Hey Children's NHS Foundation Trust, Liverpool, UK
Introduction: Heterogeneity in reported outcomes of infants with oesophageal atresia (OA) with or without tracheo-oesophageal fistula (TOF) prevents effective data pooling. Core outcome sets (COS) have been developed for many conditions to standardise outcome reporting, facilitate meta-analysis and improve the relevance of research for patients and families. Our aim is to develop an internationally-agreed, comprehensive COS for OA-TOF, relevant from birth through to transition and adulthood.
View Article and Find Full Text PDFInverse ratio ventilation versus conventional ratio ventilation during one lung ventilation in neonatal open repair of esophageal atresia/tracheoesophageal fistula: A randomized clinical trial.
Paediatr Anaesth
April 2024
Department of Anesthesiology, Intensive Care and Pain Management, Ain Shams University Faculty of Medicine, Cairo, Egypt.
Article Synopsis
- Neonatal surgery for esophageal atresia/tracheoesophageal fistula poses challenges in maintaining oxygen levels, and this study compares two ventilation methods: inverse ratio ventilation (IRV) and conventional ratio ventilation (CRV).
- The study involved 40 term neonates, comparing desaturation episodes and surgical outcomes based on ventilation strategy, finding that IRV showed a trend towards fewer severe desaturations and reduced overall desaturation rates.
- Results indicated that using IRV led to shorter surgical times and lower oxygen requirements compared to CRV, suggesting it may improve patient outcomes during these procedures.
CHRND variant in a paternally inherited esophageal atresia and tracheoesophgageal fistula: Report of a case.
Birth Defects Res
January 2024
Department of Pediatric Genetics, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Article Synopsis
- A rare familial occurrence of esophageal atresia and tracheoesophageal fistula (EA-TEF) prompted a genetic evaluation of a male infant and his father, both diagnosed with the condition.
- The infant, diagnosed with Type-C EA-TEF, and his father had blood samples analyzed, revealing four genetic variants, but only one variant in the CHRND gene was shared between them.
- The findings suggest that the CHRND variant may be a potential genetic cause of EA-TEF in this familial case, highlighting the importance of genetic research in understanding rare conditions.
Azygos vein preservation revisited: impact on early outcomes after repair of esophageal atresia/tracheoesophageal fistula in newborns.
Updates Surg
December 2023
Pediatric Surgery Unit, Department of Surgery, Al-Azhar University, Assuit, Egypt.
Article Synopsis
- Surgeons have improved techniques for repairing esophageal atresia/tracheoesophageal fistula (EA-TEF) over the last 80 years, with a focus on reducing complications by preserving the Azygos vein during surgery.
- A study conducted between April 2020 and April 2023 evaluated 64 newborns with EA-TEF, comparing outcomes between those who had Azygos vein preservation (Group A) and those who had it disconnected (Group B).
- The results showed that preserving the Azygos vein significantly reduced postoperative pneumonia, anastomotic leaks, and mortality rates, demonstrating its benefits as a valuable surgical modification.
Ear anomalies and hearing loss in patients with VACTERL association and the effect of maternal diabetes.
Am J Med Genet A
November 2023
Department of Pediatrics, Division of Genetics and Dysmorphology, UC San Diego/Rady Children's Hospital, San Diego, California, USA.
VACTERL association is typically defined as the presence of three components among these birth defects: vertebral anomalies, anal atresia, cardiac anomalies, esophageal atresia/tracheoesophageal fistula (EA/TEF), renal anomalies, and limb defects. There is increasing recognition that VACTERL and other recurrent constellations of embryonic development often overlap clinically and might share pathogenesis. We conducted a comprehensive chart review of a large patient population with VACTERL association from two tertiary care centers in California.
View Article and Find Full Text PDFProphylactic Acid-suppression Medication to Prevent Anastomotic Strictures After Oesophageal Atresia Surgery: A Systematic Review and Meta-analysis.
J Pediatr Surg
October 2023
Regional Neonatal Intensive Care Unit, University Hospital of Wales, Cardiff, UK; Centre for Medical Education, School of Medicine, Cardiff University, Cardiff, UK. Electronic address:
Article Synopsis
- Anastomotic stricture is a common complication after oesophageal atresia and tracheoesophageal fistula repair, with acid gastro-oesophageal reflux disease (GORD) thought to contribute to this issue, leading to recommendations for acid suppression post-surgery.
- A systematic review and meta-analysis were conducted, analyzing data from 12 observational studies; however, no randomized studies were found, and many studies showed a high risk of bias.
- The analysis indicated a potential slight increase in stricture odds for patients taking acid suppression medication, but the results were not statistically significant, suggesting no clear link between this medication and anastomotic stricture formation after surgery.
Preoperative Contrast Examinations Help Determine the Appropriate Cervical Approach for Congenital Gross Type C Esophageal Atresia: A Report of Two Cases.
Am J Case Rep
June 2023
Department of Rare/Intractable Cancer Analysis Research, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan.
Article Synopsis
- Kluth's research highlights the need for preoperative imaging studies to determine the surgical approach for esophageal atresia/tracheoesophageal fistula (EA/TEF) due to its anatomical variations.
- Two case reports of Japanese boys with type C EA/TEF are presented, both successfully treated using a cervical approach after contrast examinations identified the TEF and upper esophageal pouch location.
- The findings conclude that routine use of contrast examinations is beneficial for planning surgeries in EA/TEF cases, leading to successful procedures with minimal complications.
The International Network on Oesophageal Atresia (INoEA) consensus guidelines on the transition of patients with oesophageal atresia-tracheoesophageal fistula.
Nat Rev Gastroenterol Hepatol
November 2023
Division of Paediatric Gastroenterology & Oesophagus Development and Engineering Lab, Sainte-Justine Hospital, Montréal, Quebec, Canada.
Article Synopsis
- * Current management guidelines mainly focus on childhood, but there's a lack of structured care for patients transitioning into adulthood, prompting the need for new guidelines.
- * The Transition Working Group of the International Network on Oesophageal Atresia developed 42 evidence-based recommendations for managing EA-TEF complications during the transition from adolescence to adulthood, based on a comprehensive literature review and expert consensus.