Prognostic factors for disease activity in newly diagnosed teriflunomide-treated patients with multiple sclerosis: a nationwide Danish study.

Background: Clinicians frequently rely on relapse counts, T2 MRI lesion load (T2L) and Expanded Disability Status Scale (EDSS) scores to guide treatment decisions for individuals diagnosed with multiple sclerosis (MS). This study evaluates how these factors, along with age and sex, influence prognosis during treatment with teriflunomide (TFL).

Methods: We conducted a nationwide cohort study using data from the Danish Multiple Sclerosis Registry.

Waking Up in Pain: a prospective unselected cohort study of pain in 3702 patients immediately after surgery in the Danish Realm.

Background: Acute and persistent pain after surgery is well described. However, no large-scale studies on immediate postoperative pain in the operating room (OR) exist, hindering potential areas of research to improve clinical outcomes. Thus, we aimed to describe the occurrence and severity of immediate postoperative pain in a large, unselected cohort.

Serum levels of neurofilament light chain, neuron-specific enolase and S100 calcium-binding protein B during acute bacterial meningitis: a prospective cohort study.

Purpose: Acute bacterial meningitis (ABM) is a severe disease with an overall poor outcome. Neurofilament (NFL) has shown to be a promising biomarker of neuroaxonal injury in various neurological disorders but has not been investigated in ABM. The aims of this study were (i) to obtain a temporal profile of NFL, neuron-specific enolase (NSE) and S100B in serum during ABM, and (ii) to evaluate their use as biomarkers of severity (Glasgow coma score) and prognosis (Glasgow Outcome Score, GOS and death) in severe ABM.

Pregnancy outcome in patients with primary Sjögren's syndrome. a case-control study.

Objective: To study the outcome of pregnancy in patients with primary Sjögren's syndrome (pSS).

Methods: A questionnaire covering demographic data and the outcome of pregnancies was answered by 58 patients with pSS and 157 controls. For 36 patients and 93 controls, we analyzed detailed data about pregnancy, birth, and status of the newborn from the Medical Birth Registry of Norway (MFR) for birth order one, 2, and 3.

Reproduction and gynaecological manifestations in women with primary Sjögren's syndrome: a case-control study.

Background: The impact of primary Sjögren's syndrome (pSS) on reproduction and gynaecological manifestations has seldom been explored.

Aim Of Study: Assess gynaecological aspects, gynaecological interventions, and use of contraceptives in a population of pSS-patients versus controls.

Methods: In a case-control study, 58 pSS-patients and 157 controls answered a self-administered questionnaire, covering demographic data, reproductive events, gynaecological problems, and gynaecological interventions.

Diagnostic quality in hysterosalpingography. Comparison between iodixanol and iotrolan.

Purpose: To compare the diagnostic quality and adverse events of the water-soluble, non-ionic, iso-osmolar, dimeric contrast media iodixanol and iotrolan in hysterosalpingography (HSG).

Material And Methods: One hundred and twenty patients participated in a double-blind randomized parallel-group phase-III study. Questionnaires and patient interviews were used.

Film processing and the environment. Reducing pollution, water consumption, and costs.

Purpose: X-ray film processing is associated with pollution from photo chemicals and from the water used to rinse the film. We tested a new processing system that was aimed at reducing both environmental pollution and costs through the use of solid photo chemicals and recirculation of the rinsing water.

Material And Methods: Before and after the installation of new mixers for the solid chemicals and a system for recirculating the rinsing water, we measured: water consumption, processor function quality, image quality, archivability, and the waste-silver content in the rinsing water.

Sports injuries in school-aged children. A study of traumatologic and socioeconomic outcome.

In this Danish study we attempted to identify the socioeconomic consequences of sports injuries in children. A total of 1320 children, 650 boys and 670 girls, aged 6-17, completed questionnaires covering the period from the injury to recovery. The incidence rate was 74 per 1000 per year.

Renal CT after intravenous injection of nonionic dimeric or nonionic monomeric contrast media in healthy volunteers.

Purpose: To establish and compare time-density curves of the aorta, vena cava and renal cortex, medulla and pelvis after injection of the nonionic dimer iodixanol or the nonionic monomer iopromide contrast media.

Material And Methods: In 36 healthy volunteers CT at the renal hilus was performed at regular intervals before and until 30 min after injection of 13.5 g I iodixanol or 15.

The epidemiology of sports injuries in school-aged children.

In the 5-year-period 1988-1992, 6096 children aged 6-17 (54.5% boys and 45.5% girls) were treated at the Emergency Department at Esbjerg Central Hospital after having sustained a sports injury.

Ultrasonographically guided fine-needle aspiration biopsy of intrathoracic tumors.

Purpose: Evaluation of diagnostic accuracy and complication frequency at ultrasonographically guided fine-needle aspiration biopsy of intrathoracic tumors.

Material And Methods: A total of 134 ultrasonographically guided percutaneous fine-needle aspiration biopsies were performed on 128 patients with intrathoracic tumors abutting on the pleura. A cytologic diagnosis was obtained in 119 patients (93%).

The influence of the double burst stimulation (DBS) pattern on the DBS-train-of-four ratio relationship.

Unlabelled: The double-burst-stimulation (DBS) is a new stimulation pattern developed to facilitate tactile evaluation of residual neuromuscular blockade. DBS consists of two bursts of high frequency stimulations separated by a short time interval.

Methods: By changing these components, the influence of 14 different DBS patterns on the relationship between the DBS ratio and the train-of-four (TOF) ratio was investigated in 70 surgical and 10 intensive care patients during recovery from non-depolarising neuromuscular block.

A random trial comparing recovery after midazolam-alfentanil anesthesia with and without reversal with flumazenil, and standardized neurolept anesthesia for major gynecologic surgery.

Study Objective: To compare the recovery characteristics of total intravenous anesthesia (TIVA) using midazolam-alfentanil, with or without reversal with flumazenil to a standardized neurolept anesthesia with nitrous oxide (N2O).

Design: Randomized, double-blinded clinical study.

Setting: University medical center.

Maculopathy caused by welding arcs. A report of 3 cases.

It is well known that radiation from welding arcs can cause keratoconjunctivitis and 'glassblower's cataract'. In literature only few cases of welding arc maculopathy have been reported. Three cases are presented.

Laparoscopic lymphadenectomy. Preliminary experience.

Pelvic lymphadenectomy is a well established method for staging carcinoma of the bladder and prostate. Usually it is done by open surgery, but we now report preliminary experience with the laparoscopic approach. The technique is described in detail, and the results seem to indicate that the procedure is safe, has few complications and gives less pain than open surgery, with rapid recovery and early postoperative discharge from hospital.

Postoperative pain and nausea after laparoscopic cholecystectomy.

Postoperative discomfort following cholecystectomy has diminished considerably since laparoscopic surgery was introduced. This study assessed the degree of postoperative pain and nausea when, during the operation, the trocar sites had been infiltrated with bupivacaine and antiemetics (ondansetron) had been administered. Postoperative pain intensity was moderate as 20% of the patients were managed without any opiates postoperatively and 88% did not require any opiates after discharge from the recovery room.

Management of occupational risk to reproduction in a Danish county.

In Denmark pregnant women are entitled to receive maintenance allowances if the working conditions are suspected to be harmful to the fetus. The aim of the study was to evaluate these preventive measures taken to reduce occupational hazards to reproduction in Denmark. In 1985 1,247 pregnancies were identified in Ribe county during a 6-month period.

Double burst stimulation for monitoring profound neuromuscular blockade: a comparison with posttetanic count and train of four.

Double burst stimulation (DBS) is a new nerve stimulation pattern introduced to facilitate tactile evaluation of recovery from neuromuscular blockade. DBS consists of two bursts of high frequency stimulations separated by a short time interval. The relationships between DBS, post-tetanic count (PTC) and train-of-four (TOF) on the evoked twitch response was investigated in 16 surgical patients and 7 intensive care patients given atracurium for muscle relaxation.

Lipiduria after intralipid infusion of a lipid emulsion in a boy with an abdominal trauma.

A 4-year-old boy with an abdominal trauma had lipiduria following treatment with total intravenous nutrition for 4 days. Renal function was normal throughout the course and the lipiduria ceased after withdrawal of the intravenous nutrition. The lipids were possibly excreted through the kidneys or entered the urine through a traumatic communication between the lymphatic vessels and the urinary system.

Injuries in high-skilled and low-skilled soccer: a prospective study.

Fifty-five male soccer players organized in three teams, one high and two lower ranking, were followed prospectively during 1 year to register the rate, type and severity of injuries in highly skilled and low-skilled players. The injury rate of the low-skilled players was significantly higher than that of the better players. The reason for this is that low-skilled players play in more competitions.