29 results match your criteria: "Erythroplasia of Queyrat Bowen Disease of the Glans Penis"
Article Synopsis
- The article presents a clinical case of a young patient with HPV-associated penile intraepithelial neoplasia (PIN), specifically the erythematous form of bowenoid papulosis.
- It highlights the issues of delayed diagnosis due to improper diagnostic approaches and a lack of awareness among doctors about cancer-related diseases.
- The piece emphasizes the significance of early detection in preventing progression to more severe conditions like squamous cell penile carcinoma, detailing the different subtypes of PIN and their varying risks of leading to cancer.
Squamous Cell Carcinoma In Situ-The Importance of Early Diagnosis in Bowen Disease, Vulvar Intraepithelial Neoplasia, Penile Intraepithelial Neoplasia, and Erythroplasia of Queyrat.
Diagnostics (Basel)
August 2024
Faculty of Medicine, "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.
Article Synopsis
- - Cutaneous squamous cell carcinoma (cSCC) is a common skin cancer, with early recognition being crucial as delayed diagnosis can lead to more aggressive forms and surgical complications.
- - Bowen's disease (BD) is an early stage of cSCC that shows specific skin features, but histopathology is essential for accurate diagnosis and treatment planning.
- - Diagnosing precancerous conditions like vulvar and penile intraepithelial neoplasia (VIN and PeIN) can be complex, often requiring multiple biopsies and utilizing techniques like immunostaining and HPV testing to guide treatment options.
The prevalence of human leucocyte antigen and human papillomavirus DNA in penile intraepithelial neoplasia in England 2011-2012.
Int J STD AIDS
April 2021
Dermatology Department, University College Hospital, Chelsea and Westminster Hospital, London, UK.
Article Synopsis
- The study investigates the role of HPV infection and human leukocyte antigen (HLA) polymorphisms in the development of penile intraepithelial neoplasia (PeIN).
- Out of 72 cases analyzed, HPV DNA was found in 90.2% of PeIN samples, with HPV16 being the most common type, indicating a strong association between HPV and PeIN.
- Specific HLA genotypes, such as HLA-C*15 increasing risk and HLA-DQA1*01 offering protection, suggest that immune genetics may also contribute to PeIN's development.
The management of penile intraepithelial neoplasia (PeIN): clinical and histological features and treatment of 345 patients and a review of the literature.
J Dermatolog Treat
March 2022
Department of Dermatology, University College London Hospitals, London, UK.
Article Synopsis
- Penile intraepithelial neoplasia (PeIN) is a precancerous condition of the penis that can lead to serious health issues, but it is relatively rare, resulting in limited research on treatment effectiveness.
- A study of 345 patients showed that the majority had PeIN alone, with 8.7% also having invasive penile squamous cell carcinoma (PSCC); over half had some evidence of HPV and many underwent surgical treatment, mainly circumcision.
- The findings suggest that while circumcision is effective in managing PeIN, topical treatments have limited success, and a better understanding of PeIN can improve patient outcomes.
Penile intraepithelial neoplasia: Nomenclature, incidence and progression to malignancy in the Netherlands.
Int J Urol
March 2019
Department of Urology, University Medical Center Utrecht, Utrecht, the Netherlands.
Article Synopsis
- A study was conducted in the Netherlands to assess the occurrence of penile intraepithelial neoplasia (a type of premalignant penile lesion) using a comprehensive histopathology registry.
- The research analyzed data from 380 patients diagnosed with various premalignant lesions, with the majority classified as severe lesions (66%) and located primarily on the prepuce and glans.
- The findings indicate that penile intraepithelial neoplasia is rare, and the researchers suggest simplifying the terminology used to refer to these lesions to prevent confusion.
[Penile intra-epithelial neoplasia].
Prog Urol
September 2018
Service de dermatologie, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75010 Paris, France.
Article Synopsis
- Penile intra-epithelial neoplasia (PIN) consists of precancerous lesions that can lead to squamous carcinomas due to abnormal changes in the genital epithelium.
- A literature review of 174 articles on PIN published between 2007 and 2017 was conducted, and 25 relevant studies were selected to analyze clinical and pathological features, along with treatment options.
- It's crucial for urologists to differentiate between HPV-related and non-HPV-related PIN, as they present similarly but require distinct management approaches.
2013 European guideline for the management of balanoposthitis.
Int J STD AIDS
August 2014
Department of Dermatology, Havenziekenhuis, Rotterdam, The Netherlands.
Balanoposthitis can be caused by a disparate range of conditions affecting the penile skin. This guideline concentrates on a selected group of conditions and offers recommendations on the diagnostic tests and treatment regimens needed for the effective management of balanoposthitis.
View Article and Find Full Text PDF[Excision of carcinoma in situ of the glans penis with reconstructive plastic surgery].
Urologe A
March 2010
Urologische Klinik und Institut für Pathologie, Rheinisch-Westfälische Technische Hochschule, Universitätsklinikum, Pauwelsstrasse 30, 50072 Aachen.
Article Synopsis
- Bowen's disease and erythroplasia of Queyrat are considered early forms of penile squamous cell carcinoma with a low risk of progressing to invasive cancer, potentially taking up to 20 years.
- Treatment focuses on preserving the penis while completely excising the tumor, using local excision combined with reconstructive surgery to achieve good aesthetic results and maintain cancer control.
- Even though local recurrence rates can be high (up to 33%), regular follow-ups and prompt treatment for recurrences can effectively manage the disease and support organ preservation.
Bowen's disease involving the urethra.
J Dermatol
March 2005
Department of Dermatology, Gunma University Graduate School of Medicine, Maebashi, Gunma, Japan.
Article Synopsis
- - The text discusses a case of a 56-year-old man with Bowen's disease, specifically in the form known as erythroplasia of Queyrat, affecting areas of his genital region including the penis shaft and glans.
- - Physical examinations revealed bright red velvety plaques and an irregularly pigmented scaly lesion, with histopathological findings confirming the diagnosis of Bowen's disease.
- - Due to tumor cells found in the urethra's mucous epithelium, a partial penectomy was performed, and the text also reviews the limited treatment options available for Bowen's disease when it involves the urethral meatus.
Role of human papillomavirus in penile cancer, penile intraepithelial squamous cell neoplasias and in genital warts.
Med Microbiol Immunol
February 2004
Department of Dermatology and Venereology, Faculty of Medicine, University of Rostock, Augustenstrasse 80-84, 18055 Rostock, Germany.
Article Synopsis
- The prevalence of HPV DNA in penile carcinoma is about 40-45%, similar to the 50% rate found in vulvar carcinoma, with specific HPV associations in different types of penile cancer.
- There are two distinct pathways for penile carcinogenesis, with basaloid and warty cancers being strongly HPV-associated (80-100%), while only a portion of keratinizing and verrucous cancers show this association (33-35%).
- Precursors for basaloid and warty carcinomas include penile intraepithelial neoplasias, but for keratinizing and verrucous types, the connections are less clear, and HPV typing may help distinguish between similar conditions like giant condyloma and verrucous carcinoma
Common skin disorders of the penis.
BJU Int
September 2002
Department of Dermatology, University of Basel, Switzerland.
Article Synopsis
- Diseases affecting male genitalia include infections, inflammatory conditions, and skin diseases, highlighting the need for understanding their clinical features and treatments.
- Herpes genitalis and HPV are on the rise, especially among young, sexually active individuals, with issues like genital ulcers and warts frequently arising; treatments are often inadequate and recurrences happen.
- Conditions such as scabies, lichen planus, and psoriasis can manifest differently in the genital region, and allergic contact dermatitis may stem from personal care products; long-term management options are available for chronic issues like lichen sclerosus.
Laser therapy for carcinoma in situ of the penis.
J Urol
November 2001
Free University Medical Center and The Netherlands Cancer Institute-Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands.
Article Synopsis
- Carcinoma in situ of the penis can lead to invasive cancer, and laser therapy was assessed as a treatment method for it.
- A study treated 19 patients from 1986 to 2000 with lasers, reporting no complications and good cosmetic outcomes, but 26% experienced recurrence of the condition.
- The findings suggest laser therapy is effective and less invasive, but regular follow-up and self-examinations are essential due to the possibility of recurrence.
Erythroplasia of queyrat: coinfection with cutaneous carcinogenic human papillomavirus type 8 and genital papillomaviruses in a carcinoma in situ.
J Invest Dermatol
September 2000
Institute of Virology, University of Köln, Köln, Germany.
Article Synopsis
- - Erythroplasia of Queyrat is a precursor to squamous cell carcinoma primarily found on the genital areas of older men, with about 30% of cases progressing to cancer.
- - A study analyzed biopsies from patients with this condition and identified human papillomavirus (HPV) DNA, specifically HPV type 8 in all cases and HPV type 16 in 88%, which was not present in control samples from other lesions.
- - The findings indicated that HPV type 8 had notable genetic differences compared to standard strains, and viral loads of HPV type 16 were significantly higher than those of HPV type 8 in the affected biopsies.
Bowen's disease of the glans penis (erythroplasia of Queyrat) in plasma cell balanitis.
Cutis
June 2000
Institute for Dermatopathology, Jefferson Medical College, Philadelphia, Pennsylvania, USA.
Article Synopsis
- * The lesion was diagnosed as Zoon's balanitis based on clinical observations and biopsy results, but further biopsies eventually identified it as erythroplasia of Queyrat, which is a type of skin cancer.
- * After confirming the malignancy, the patient was treated with radiotherapy, leading to a positive clinical outcome and complete remission of the lesion.
Carcinoma in situ of the penis.
J Urol
April 1994
Department of Surgery, University of Chicago Pritzker School of Medicine, Illinois.
Article Synopsis
- - Bowen's disease, erythroplasia of Queyrat, and bowenoid papulosis are rare skin disorders in the anogenital area that can be mistaken for other conditions and are linked to HPV.
- - While Bowen's disease and erythroplasia of Queyrat can progress to squamous cell carcinoma, bowenoid papulosis is benign with no current evidence of cancer development.
- - Treatment typically involves surgical excision, and lasers can be effective for localized disease management and cosmetic outcomes; accurate biopsies are crucial for proper diagnosis and treatment, including partner counseling.
Conservative extirpative treatment of cancer of the penis.
Urol Clin North Am
May 1992
Division of Urologic Oncology, Medical University of South Carolina, Charleston.
Carcinoma in situ, erythroplasia of Queyrat, and Bowen's disease have been managed successfully with a variety of conservative techniques. The management of invasive carcinoma remains controversial. The goal of surgical treatment in these patients is complete excision of the tumor with adequate tumor-free margins.
View Article and Find Full Text PDFPremalignant lesions and nonsquamous malignancy of the penis and carcinoma of the scrotum.
Urol Clin North Am
February 1992
Department of Urology, Eastern Virginia Medical School, Norfolk.
Premalignant lesions of the penis include cutaneous horn, balanitis xerotica obliterans, and leukoplakia. The true incidence of progression of each of these to squamous-cell carcinoma is unknown. Bowenoid papulosis, erythroplasia of Queyrat, and Bowen's disease are histologically identical to in situ carcinoma.
View Article and Find Full Text PDF[Cancer of the penis and its treatment].
Nihon Hinyokika Gakkai Zasshi
January 1992
Department of Urology, Kobe University School of Medicine.
Article Synopsis
- Recent studies show no significant difference in the incidence of penile carcinoma between developed and developing countries, shifting focus to quality of life (QOL) post-treatment.
- Important topics in this report include the recognition of certain skin conditions as penile carcinoma, the connection between human papilloma virus and penile carcinoma, and the advantages of different classification systems (TNM vs. Jackson).
- There is a demand for collaborative studies across institutions due to the rarity of penile carcinoma, aiming to improve treatment methods and outcomes for patients globally.
Carcinoma in situ of penis. Is distinction between erythroplasia of Queyrat and Bowen's disease relevant?
Urology
December 1990
Department of Urologic Surgery, University of Minnesota Hospital and Clinic, Minneapolis.
Bowenoid papulosis of the penis: successful management with neodymium:YAG laser.
J Urol
June 1988
Department of Urology, Mayo Clinic, Rochester, Minnesota 55905.
Article Synopsis
- * While some cases may resolve on their own, treatments such as topical 5-fluorouracil, electrodissection, or surgical excision are commonly used, although recurrence can happen.
- * The text reports two successful cases of bowenoid papulosis treatment using a neodymium-yttrium-aluminum-garnet laser, which left no scarring.
Article Synopsis
- The review emphasizes the importance of finding treatments that effectively remove abnormal tissue while also being cosmetically acceptable.
- Cryosurgery has shown promising results as an effective treatment method in two cases.
Article Synopsis
- Erythroplasia of Queyrat (EQ) is a type of skin cancer that shows up on mucosal surfaces, similar to Bowen's disease, and can appear in areas like the penis, vulva, and mouth.
- Two cases are reported where EQ developed in the conjunctiva of patients after they underwent radiotherapy for eyelid basal cell carcinoma, initially presenting like chronic conjunctivitis.
- The lesions were successfully removed using Mohs surgery, and it is suggested that biopsies should be performed for patients with persistent conjunctivitis, especially if they have a history of eyelid radiation treatment.
Article Synopsis
- - Bowenoid papulosis is a condition that looks benign but is actually similar to pre-invasive cancer, presenting as multiple painless, wart-like lesions on the penis in young circumcised men aged 21 to 38.
- - Treatment options for bowenoid papulosis include excision, electrodissection, or topical application of 5-fluorouracil.
- - The report discusses two specific cases and compares bowenoid papulosis to related conditions like Bowen's disease, erythroplasia of Queyrat, and invasive carcinoma.
Cancers, precancers, and pseudocancers on the male genitalia. A review of clinical appearances, histopathology, and management.
J Dermatol Surg Oncol
December 1980
Article Synopsis
- Leukoplakia penis and balanitis xerotica obliterans are both considered precancerous lesions that can occur in the genital area.
- Bowen's disease, erythroplasia (Queyrat), and extramammary Paget's disease are examples of carcinomas in situ, which can resemble non-cancerous skin conditions.
- Accurate diagnosis often requires histologic examination, as some lesions, like giant condyloma acuminatum and Bowenoid papulosis, can appear malignant clinically but are benign on a microscopic level.