4 results match your criteria: "Erlanger Heart and Lung Institute Chattanooga[Affiliation]"
Metabolic Signatures of Cardiac Dysfunction, Multimorbidity, and Post-Transcatheter Aortic Valve Implantation Death.
J Am Heart Assoc
July 2023
Department of Medicine, Division of Cardiology The University of California San Francisco CA USA.
Article Synopsis
- Research indicates that metabolic dysfunction plays a role in heart changes due to aortic stenosis, but a significant study on human metabolism hasn't been done yet.
- In a study involving 519 patients, researchers examined 12 heart function metrics before valve implantation and identified three patterns of heart remodeling, linking these to specific metabolic profiles.
- A distinctive metabolite score for heart function was found to predict higher death rates post-surgery and was related to overall health issues, emphasizing the need to explore metabolic factors to improve patient outcomes after transcatheter aortic valve placement.
Under-representation of Women as Proceduralists and Patients in TAVR and TMVr Procedures: Data, Implications and Proposed Solutions.
Eur Cardiol
February 2022
Section of Cardiovascular Medicine, Erlanger Heart and Lung Institute Chattanooga, Tennessee, US.
Women are under-represented among transcatheter aortic valve replacement (TAVR) and transcatheter mitral valve repair (TMVr) operators. This review assesses the representation of women as patients and as proceduralists and trial authors in major structural interventions. Women are under-represented as proceduralists in structural interventions: only 2% of TAVR operators and 1% of TMVr operators are women.
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- Global longitudinal strain (GLS) serves as a measure of left ventricular function, and the study aimed to see if cardiac damage (troponin) and stress (NT-proBNP) biomarkers can enhance GLS effectiveness in identifying high-risk patients with severe aortic stenosis.
- In a study involving 499 patients who underwent transcatheter aortic valve implantation, it was found that patients with impaired GLS had higher levels of cardiac troponin and NT-proBNP compared to those with normal GLS.
- The analysis revealed that while lower GLS indicated increased mortality likelihood, the biomarkers of cardiac damage and stress were independently linked to mortality risk, suggesting that these biomarkers may be more reliable for assessing patient risk and timing for valve replacement.
Background Left ventricular hypertrophy (LVH) is associated with increased mortality risk and rehospitalization after transcatheter aortic valve replacement among those with severe aortic stenosis. Whether cardiac troponin (cTnT) and NT-proBNP (N-terminal pro-B-type natriuretic peptide) risk stratify patients with aortic stenosis and without LVH is unknown. Methods and Results In a multicenter prospective registry of 923 patients with severe aortic stenosis undergoing transcatheter aortic valve replacement, we included 674 with core-laboratory-measured LV mass index, cTnT, and NT-proBNP.
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