76 results match your criteria: "Erich and Hanna Klessmann Institute for Cardiovascular Research & Development EHKI[Affiliation]"
Composite polymorphisms in the ryanodine receptor 2 gene associated with arrhythmogenic right ventricular cardiomyopathy.
Cardiovasc Res
August 2006
Herz- und Diabeteszentrum NRW, Klinik der Ruhr-Universität Bochum, Erich und Hanna Klessmann-Institut für Kardiovaskuläre Forschung und Entwicklung, Georgstr. 11, 32545 Bad Oeynhausen, Germany.
Objective: Mutations in the cardiac ryanodine receptor (RYR2) gene have been reported to cause arrhythmogenic right ventricular cardiomyopathy (ARVC). The molecular mechanisms by which genetic modifications lead to ARVC are still not well understood.
Methods: ARVC patients were screened for mutations in the RYR2 gene by denaturing HPLC and DNA sequencing.