2,826 results match your criteria: "Erasmus University Medical Centre[Affiliation]"

Ontogeny of Hepatic Organic Cation Transporter-1 in Rat and Human.

Drug Metab Dispos

October 2024

Drug Delivery and Disposition (S.F., Pa.A., Pi.A.), Laboratory of Cell Metabolism (A.B.S., M.B.), Clinical Pharmacology and Pharmacotherapy (K.A.), Department of Pharmaceutical and Pharmacological Sciences, and Department of Development and Regeneration (K.A.), KU Leuven, Leuven, Belgium; and Department of Hospital Pharmacy, Erasmus University Medical Centre, Rotterdam, The Netherlands (K.A.)

The organic cation transporter (OCT)-1 mediates hepatic uptake of cationic endogenous compounds and xenobiotics. To date, limited information exists on how Oct1/OCT1 functionally develops with age in rat and human livers and how this would affect the pharmacokinetics of OCT substrates in children or juvenile animals. The functional ontogeny of rOct/hOCT was profiled in suspended rat (2-57 days old) and human hepatocytes (pediatric liver tissue donors: age 2-12 months) by determining uptake clearance of 4-[4-(dimethylamino)styryl]-N-methylpyridinium iodide (ASP+) as a known rOct/hOCT probe substrate.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the pharmacokinetics of oral clavulanic acid in neonates and infants, as existing data on this topic is limited.
  • It analyzes combined data from four datasets using a one-compartment model to determine dosing regimens and exposure levels based on age and body weight.
  • Findings indicate that an amoxicillin/clavulanic acid ratio of 4:1 is optimal, with significant differences in exposure levels based on varying threshold concentrations, laying groundwork for future research.
View Article and Find Full Text PDF

Performance of balloon-expandable transcatheter bioprostheses in inoperable patients with pure aortic regurgitation of a native valve: The BE-PANTHEON international project.

Cardiovasc Revasc Med

August 2024

Clinical and Interventional Cardiology Department, I.R.C.C.S. Policlinico San Donato, San Donato Milanese, Milan, Italy. Electronic address:

Article Synopsis
  • - The study compares the outcomes of different balloon-expandable (BE) transcatheter heart valve (THV) devices used to treat high-risk patients with severe pure native aortic valve regurgitation (NAVR), revealing suboptimal results with both device types.
  • - Out of 144 patients treated, those with the MyVal device had more frequent extra-large annuli, yet technical success rates were similar between MyVal (90%) and Sapien (81%).
  • - Overall, while BE devices might offer a treatment option for high-risk patients with NAVR, their effectiveness is limited and highlights the need for dedicated devices, as larger sizes might improve outcomes for traditionally unsuitable patients.
View Article and Find Full Text PDF

Influence of pairing in examiner leniency and stringency ('hawk-dove effect') in part II of the European Diploma of Anaesthesiology and Intensive Care: A cohort study.

Eur J Anaesthesiol

December 2024

From the Department of Anaesthesia, ITU and Pain Management, Mater Dei Hospital, Msida, Malta (SS), Department of Anaesthesiology, Erasmus University Medical Centre, Rotterdam, the Netherlands (MK), European Society of Anaesthesiology and Intensive Care, Brussels, Belgium (MK, BA, HS, RDL, JBE), Department of Anaesthesia, University Hospital of Wales, Cardiff, UK (BA), Institute for Medical Education, University of Bern, Bern, Switzerland (JBE), CINTESIS@RISE - Centre for Health Technology and Services Research, Porto, Portugal (JBE) and Institute of Anaesthesiology and Intensive Care, Salemspital, Hirslanden Medical Group, Bern, Switzerland (JBE).

Article Synopsis
  • The study examines the impact of examiner pairing on grading variances in the EDAIC Part II examination, focusing on the leniency and strictness of different examiner pairs.
  • Utilizing data from 325 examiners over three years, the research reveals that most examiner pairs had only slight differences in scoring, indicating a general consistency in leniency.
  • The findings highlight the potential 'hawk-dove effect', suggesting that different examiner combinations can significantly affect candidate performance and outcomes in the exam.
View Article and Find Full Text PDF

Juvenile-onset mixed connective tissue disease from a different perspective.

Int J Rheum Dis

August 2024

Sophia Children's Hospital, Erasmus University Medical Centre, Department of Pediatric Rheumatology, Rotterdam, Netherlands.

View Article and Find Full Text PDF
Article Synopsis
  • A retrospective cohort study in the Netherlands examined differences between male and female patients with ascending aortic aneurysm (AscAA) regarding their aneurysm growth and clinical outcomes.
  • The study included 1,858 adult patients, finding that women were typically older at diagnosis and had different patterns of aneurysm involvement compared to men, with women more commonly affected in the tubular area and men in the sinuses.
  • Results showed that women experienced faster growth in the tubular ascending segment, leading to lower 10-year survival rates and a higher incidence of type A dissections compared to men.
View Article and Find Full Text PDF

Imiquimod (IMQ; brand name Aldara®) is a registered topical agent that has been proven to induce local inflammation via the Toll-like receptor (TLR)7 pathway. The purpose of this study was to characterize TLR7-mediated inflammation following 7 days (168 h) of topical IMQ exposure in healthy volunteers, and to compare the effects of short exposure (48 h-72 h) with prolonged exposure (120 h-168 h). IMQ (100mg) was applied under occlusion to 5 different tape-stripped treatment sites on the back of 10 healthy participants for a maximum of 7 consecutive days.

View Article and Find Full Text PDF

Residential ambient air pollution exposure and the development of white matter microstructure throughout adolescence.

Environ Res

December 2024

ISGlobal, Barcelona, Spain; Universitat Pompeu Fabra, Barcelona, Spain; Department of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre, Rotterdam, the Netherlands; Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Instituto de Salud Carlos III, Madrid, Spain. Electronic address:

Background: Recent evidence suggests an association of air pollution exposure with brain development, but evidence on white matter microstructure in children is scarce. We investigated how air pollution exposure during pregnancy and childhood impacts longitudinal development of white matter microstructure throughout adolescence.

Methods: Our study population consisted of 4108 participants of Generation R, a large population-based birth cohort from Rotterdam, the Netherlands.

View Article and Find Full Text PDF

Background: Bipolar disorder I (BD-I) is a heterogeneous disorder with a high prevalence of comorbid anxiety. The aim of this study was to investigate whether anxiety and mania symptoms define distinct subgroups within BD-I and to explore potential differences in functional network characteristics between these subgroups.

Methods: Subgroups were identified using scores from clinical anxiety and mania scales.

View Article and Find Full Text PDF

Assessing the pathogenicity of genetic variants is a critical aspect of genomic medicine and precision healthcare. Over the last decades, the identification of genetic variants and their characterization has become simpler (advent of high-throughput sequencing technologies, analysis, and visualization support tools, etc.).

View Article and Find Full Text PDF

Trends in incidence, prevalence, and survival of breast cancer in the United Kingdom from 2000 to 2021.

Sci Rep

August 2024

Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, OX3 7LD, UK.

Article Synopsis
  • Breast cancer is the most common cancer diagnosed in females worldwide, but there is limited information regarding trends in males, prompting a study of breast cancer in the UK from 2000 to 2021 for both sexes.
  • The study analyzed over 5.8 million females and 5.5 million males, finding crude incidence rates of 194.4 per 100,000 for females and just 1.16 for males, with both genders experiencing a roughly 2.5-fold increase in prevalence over time.
  • Survival rates after diagnosis were relatively high for both sexes, with females showing improvement over time, especially those aged 50-70, while males exhibited no clear trends, and changes in female incidence were linked to
View Article and Find Full Text PDF

The Effects of Corticosteroids on Survival in Pediatric and Nonelderly Adult Patients Undergoing Cardiac Surgery: A Meta-analysis of Randomized Studies.

J Cardiothorac Vasc Anesth

November 2024

Department of Anesthesia and Intensive Care, IRCCS San Raffaele Scientific Institute, Milan, Italy; School of Medicine, Vita-Salute San Raffaele University, Milan, Italy. Electronic address:

Objective: Cardiac surgery can be complicated by the development of a systemic inflammatory response syndrome related to cardiopulmonary bypass. This potentially contributes to the occurrence of postoperative morbidity and mortality. Corticosteroids can be used to reduce such inflammation, but the overall balance between potential harm and benefit is unknown and may be age-dependent.

View Article and Find Full Text PDF
Article Synopsis
  • Elevated platelet counts in patients undergoing liver surgery for intrahepatic cholangiocarcinoma (ICC) can indicate more severe disease and poor outcomes.
  • A study of 825 patients revealed that those with high platelet counts (>300 *10/L) had worse cancer-specific survival (CSS) and overall survival (OS) compared to those with lower counts.
  • High platelet count remained an independent predictor of worse outcomes even after accounting for other clinical factors, suggesting it may help in preoperative risk assessment for surgery.
View Article and Find Full Text PDF

Purpose: Tier 1 of the International RIsk Stratification in EndoVascular Aneurysm Repair (IRIS-EVAR) project aimed to identify important risk factors for adverse events following endovascular aneurysm repair (EVAR).

Materials And Methods: Initially, the steering committee proposed a number of risk factors for adverse events following EVAR. A Delphi consensus was performed as expert panelists were presented with risk factors and provided the opportunity to propose additional risk factors during the process.

View Article and Find Full Text PDF

Introduction: β-Lactams are the most widely used antibiotics in children. Their optimal dosing is essential to maximize their efficacy, while minimizing the risk for toxicity and the further emergence of antimicrobial resistance. However, most β-lactams were developed and licensed long before regulatory changes mandated pharmacokinetic studies in children.

View Article and Find Full Text PDF

Biomarker Expression and Clinical Outcomes in International Study of Chemoradiation and Magnetic Resonance Imaging-Based Image-Guided Brachytherapy for Locally Advanced Cervical Cancer: BIOEMBRACE.

Int J Radiat Oncol Biol Phys

January 2025

Department of Radiation Oncology, Leiden University Medical Centre, Leiden, The Netherlands; Department of Radiation Oncology, Erasmus University Medical Centre, Rotterdam, The Netherlands. Electronic address:

Purpose: BIOEMBRACE was designed to study the impact of biomarkers in addition to clinicopathological factors on disease outcomes in patients treated with chemoradiation and magnetic resonance imaging (MRI)-guided brachytherapy (BT) for locally advanced cervical cancer in the EMBRACE study.

Methods And Materials: Between 2018 and 2021, 8 EMBRACE-I sites contributed tumor tissue for the immunohistochemistry of p16, PD-L1, and L1CAM. These biomarkers and clinicopathological factors (International Federation of Gynecology and Obstetrics 2009 stage, nodal status, histology, and necrosis on MRI) were analyzed to predict poor response at BT (high-risk clinical target volume [HR-CTV] ≥ 40 cc) at BT) and 5-year local control, pelvic control, and disease-free survival.

View Article and Find Full Text PDF

Genomic Study of High-Risk Clones of Collected from Tertiary Hospitals in the United Arab Emirates.

Antibiotics (Basel)

June 2024

Department of Microbiology and Immunology, College of Medicine and Health Sciences, United Arab Emirates University, Al Ain P.O. Box 15551, United Arab Emirates.

Article Synopsis
  • * Whole-genome sequencing (WGS) of eight isolates revealed the presence of multiple resistance genes, with one isolate showing dual carbapenemase genes and others having colistin resistance.
  • * The research underscores the importance of surveillance and antibiotic stewardship to control the spread of these resistant pathogens and emphasizes the significance of accurately identifying resistance mechanisms for effective treatment strategies.
View Article and Find Full Text PDF

Background And Objectives: Studying malpractice claims is important to improve quality of health care and patient safety and to educate the individual healthcare providers. The objective of this study was to describe characteristics of neurosurgical claims in the Netherlands.

Methods: A nationwide retrospective observational study of neurosurgery-related claims closed by Centramed and MediRisk, 2 major insurance companies in the Netherlands, was performed.

View Article and Find Full Text PDF

Introduction: Dementia is a multifactorial disease with Alzheimer's disease (AD) and vascular dementia (VaD) pathologies making the largest contributions. Yet, most genome-wide association studies (GWAS) focus on AD.

Methods: We conducted a GWAS of all-cause dementia (ACD) and examined the genetic overlap with VaD.

View Article and Find Full Text PDF

Prenatal Exposure to Nonpersistent Chemicals and Fetal-to-childhood Growth Trajectories.

Epidemiology

November 2024

From the Department of Health and Human Services, Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, NC.

Article Synopsis
  • Prenatal exposure to non-persistent chemicals like organophosphate pesticides, phthalates, and bisphenols affects growth patterns in children, yet few studies have explored these effects using long-term data.
  • In a study with 777 participants, researchers analyzed weight and BMI growth trajectories from prenatal to age 13, linking chemical exposure through maternal urine samples to these growth patterns.
  • The findings indicated that higher levels of phthalic acid and bisphenol A (BPA) were linked to a growth trajectory showing lower prenatal and higher childhood weight, while organophosphate pesticides were associated with lower odds of an average growth trajectory.
View Article and Find Full Text PDF

Effect of COVID-19 lockdown on maternity care and maternal outcome in the Netherlands: a national quasi-experimental study.

Public Health

October 2024

Department of Obstetrics & Gynaecology, Amsterdam University Medical Center, Amsterdam, the Netherlands; Amsterdam Reproduction & Development, Amsterdam, the Netherlands.

Objectives: The COVID-19 pandemic and associated lockdowns disrupted health care worldwide. High-income countries observed a decrease in preterm births during lockdowns, but maternal pregnancy-related outcomes were also likely affected. This study investigates the effect of the first COVID-19 lockdown (March-June 2020) on provision of maternity care and maternal pregnancy-related outcomes in the Netherlands.

View Article and Find Full Text PDF

We present an exceptional case of a lung transplant recipient successfully treated by multiple courses of alemtuzumab for refractory acute cellular rejection (ACR). The patient experienced multiple episodes of ACR following the transplantation procedure. Alemtuzumab was initiated as a third-line rejection treatment and was repeated 6 times.

View Article and Find Full Text PDF

Performance of Purpose-Built vs Off-Label Transcatheter Devices for Aortic Regurgitation: The PURPOSE Study.

JACC Cardiovasc Interv

July 2024

IRCCS Policlinico San Donato, San Donato Milanese, Milan, Italy. Electronic address:

Background: Severe pure aortic regurgitation (AR) carries a high mortality and morbidity risk, and it is often undertreated because of the inherent surgical risk. Transcatheter heart valves (THVs) have been used off-label in this setting with overall suboptimal results. The dedicated "purpose-built" Jena Valve Trilogy (JVT, JenaValve Technology) showed an encouraging performance, although it has never been compared to other THVs.

View Article and Find Full Text PDF