333 results match your criteria: "Era University[Affiliation]"
Protein J
December 2024
Plant Genetic Resources and Improvement Division, CSIR-National Botanical Research Institute, Lucknow, Uttar Pradesh, India.
Trypsin inhibitor from the root-tuber of underutilized legume Winged bean (Psophocarpus tetragonolobus (L.) DC.) (WbT-TI) was purified using ion exchange chromatography followed by size-exclusion chromatography.
View Article and Find Full Text PDFMol Neurobiol
December 2024
Laboratory for Stem Cell & Restorative Neurology, Department of Biotechnology, Era's Lucknow Medical College and Hospital, Era University, Sarfarazganj, Lucknow, 226003, India.
Alzheimer's disease (AD) is currently the seventh leading cause of death worldwide. In this study, we explored the critical role of autophagy in AD pathology using a streptozotocin (STZ)-induced AD model in Wistar rats. The experimental groups included sham, STZ-induced AD, and STZ + MCC950-treated animals.
View Article and Find Full Text PDFNanomaterials (Basel)
November 2024
College of Electrical Engineering and Control Science, Nanjing Tech University, Nanjing 211816, China.
Reduced graphene oxide (rGO) exhibits mechanical, optoelectronic, and conductive properties comparable to pristine graphene, which has led to its widespread use as a method for producing graphene-like materials in bulk. This paper reviews the characteristics of graphene oxide and the evolution of traditional reduction methods, including chemical and thermal techniques. A comparative analysis reveals that these traditional methods encounter challenges, such as toxicity and high energy consumption, while plasma reduction offers advantages like enhanced controllability, the elimination of additional reducing agents, and reduced costs.
View Article and Find Full Text PDFDiagnostics (Basel)
November 2024
Department of Gediatrics, PJ Safaric University, 04001 Kosice, Slovakia.
Despite increased availability of effective drug therapy for treatment of heart failure (HF), the morbidity and mortality in chronic heart failure (CHF) are unacceptably high. Therefore, there is an urgent need to ascertain new imaging techniques to identify early sub-clinical forms of cardiac dysfunctions, to guide early relevant treatment. It seems that all the behavioral risk factors-such as tobacco, alcoholism, Western-type diet, sedentary behavior and obesity, emotional disorders, and sleep disorder are associated with early cardiac dysfunction, which may be identified by speckle-tracking echocardiography (STE).
View Article and Find Full Text PDFJ Complement Integr Med
December 2024
Department of Biochemistry, University of Lucknow, Lucknow, UP, India.
Objectives: (commonly known as kokum) has been employed in Ayurvedic and Siddha medicine since ancient times. Every part of the plant has its own set of advantages and applications. Therefore, the present evaluates the phytochemical composition and biological activity spectrum of the ethanolic fruit extract of
Methods: Ethanolic extract of fruits of (GIFEE) underwent TPC and TFC quantification, with bioactive components characterized GC-MS and HPLC.
Int J Nanomedicine
December 2024
King Abdullah Institute for Nanotechnology, King Saud University, Riyadh, 11451, Saudi Arabia.
Background: Researchers have shown substantial interest in bismuth oxide/reduced graphene oxide (BiO/RGO) nanocomposites due to their superior features that are not achievable by each material alone. The growing applications and manufacturing of BiO/RGO nanocomposites have raised concerns regarding their potential human health risks. This work was designed to explore the possible toxicity mechanisms of BiO/RGO nanocomposites in two distinct mammalian cell lines, normal rat kidney cells (NRK52E) and human liver cancer cells (HepG2).
View Article and Find Full Text PDFJ Phys Condens Matter
December 2024
Department of Allied Science, Graphic Era University, Dehradun 248002, India.
An anomalous Raman phenomenon (ARP) refers to a scenario in which the Stokes and anti-Stokes frequencies of a Raman mode are different. Here we report that ARP introduces different line shifts in Stokes and anti-Stokes frequencies in 4-Decyloxy Benzoic acid with temperature across two thermally driven structural transitions: the smectic (S) to nematic (N) phase transition at 375 K and the nematic (N) to isotropic (I) transition at 390 K. Four Raman modes near 663, 773, 1128, and 1168 cmshift towards higher frequencies (blueshift) in the Stokes frequency and towards lower frequencies (redshift) in the anti-Stokes frequency with rise in temperature near S to N phase transitions.
View Article and Find Full Text PDFCureus
October 2024
Pediatric Dentistry, Career Dental College and Hospital, Lucknow, IND.
Sci Rep
November 2024
School of Computer Science and Engineering (SCOPE), VIT-AP University, Amravati, Andhra Pradesh, India.
Breast cancer (BC) is a type of cancer which progresses and spreads from breast tissues and gradually exceeds the entire body; this kind of cancer originates in both sexes. Prompt recognition of this disorder is most significant in this phase, and it is measured by providing patients with the essential treatment so their efficient lifetime can be protected. Scientists and researchers in numerous studies have initiated techniques to identify tumours in early phases.
View Article and Find Full Text PDFCureus
October 2024
Medicine, Kufa University, Najaf, IRQ.
Magnesium (Mg), an essential mineral abundantly present within the human body, is intricately involved in a multitude of biochemical processes vital for maintaining health and overall well-being. This review aims to delve into the multifaceted impact of Mg on human health, exploring its physiological functions, dietary sources, and potential health implications of deficiency or insufficiency. Mg plays a pivotal role in various physiological processes, including energy metabolism, muscle contraction, protein synthesis, and DNA synthesis.
View Article and Find Full Text PDFHepatoma Res
October 2024
Hind Institute of Medical Sciences, Sitapur 261304, India.
Chem Biodivers
November 2024
Green Chemistry Laboratory, Organic Chemistry Division, Department of Chemistry, Aligarh Muslim University, Aligarh, 202002, India.
This study explores new anti-inflammatory agents by synthesizing pyrazoline-pyridine hybrids with N-butylsulfonated covalent organic framework (COF-SOH) as a recyclable catalyst, achieving excellent yields in just one minute. The protocol was successfully scaled up to a multi-gram scale, highlighting its robustness and efficiency, and it operates without the need for column chromatography. Among the synthesized hybrids, compound 5d, a pyrazoline-pyridine hybrid bearing an indole moiety, emerged as a potent anti-inflammatory and antioxidant agent.
View Article and Find Full Text PDFChem Biodivers
November 2024
Department of Chemistry, Govt. Raza P.G. College, (M.J.P Rohil Khand University, Bareilly), Rampur, 244901, UP, India.
Food Sci Nutr
October 2024
Department of Pharmacology and Therapeutics, Faculty of Medicine University of Kufa Kufa Iraq.
Magnesium is an essential nutrient for various physiological processes and becomes even more vital during pregnancy, contributing to muscle relaxation, bone development, electrolyte balance, and blood pressure regulation. Despite the fact that the dietary sources of magnesium are diversified, it is still challenging to obtain it in sufficient quantities during pregnancy. We have elucidated its interactions and its specific impact on maternal-fetal health in different research publications.
View Article and Find Full Text PDFCNS Neurol Disord Drug Targets
October 2024
Department of Pharmaceutical Chemistry, Era College of Pharmacy, Era University, Lucknow, 226003, Uttar Pradesh, India.
Background: Alzheimer's disease (AD) is a prevalent neurodegenerative condition characterized by progressive cognitive decline and memory impairment resulting from the degeneration and death of brain neurons. Acetylcholinesterase (AChE) inhibitors are used in primary pharmacotherapy for numerous neurodegenerative conditions, providing their capacity to modulate acetylcholine levels crucial for cognitive function. Recently, quinazoline derivatives have emerged as a compelling model for neurodegenerative disease treatment, showcasing promising pharmacological features.
View Article and Find Full Text PDFChem Biodivers
October 2024
Department of Pharmaceutical Chemistry, Era College of Pharmacy, Era University, 226003, Lucknow, Uttar Pradesh, India.
The low effectiveness of currently available antibiotics is driving efforts worldwide to generate new antimicrobial drugs. So, we synthesized some new formazan derivatives containing sulfonamide moiety, and assessed their in-silico biochemical properties as well as in-vitro antibacterial activity against some pathogenic Gram-positive (B. subtilis and S.
View Article and Find Full Text PDFComput Med Imaging Graph
October 2024
Department of Electrical and Computer Engineering, Idaho State University, Pocatello, ID, 83209, USA; Department of CS, Graphics Era University, Dehradun, India; University Center for Research & Development, Chandigarh University, Mohali, India; Symbiosis Institute of Technology, Nagpur Campus, Symbiosis International (Deemed University), Pune, India; Stroke Monitoring Division, AtheroPoint™ LLC, Roseville, CA, USA. Electronic address:
Background: Cardiovascular diseases (CVD) cause 19 million fatalities each year and cost nations billions of dollars. Surrogate biomarkers are established methods for CVD risk stratification; however, manual inspection is costly, cumbersome, and error-prone. The contemporary artificial intelligence (AI) tools for segmentation and risk prediction, including older deep learning (DL) networks employ simple merge connections which may result in semantic loss of information and hence low in accuracy.
View Article and Find Full Text PDF3 Biotech
October 2024
Department of Biotechnology, Era's Lucknow Medical College & Hospital, Era University, Sarfarazganj, Hardoi Road, Lucknow, 226003 India.
Bio Protoc
September 2024
Laboratory for Stem Cell and Restorative Neurology, Department of Biotechnology, Era's Lucknow Medical College and Hospital, Era University, Lucknow, Uttar Pradesh, India.
Current ischemic models strive to replicate ischemia-mediated injury. However, they face challenges such as inadequate reproducibility, difficulties in translating rodent findings to humans, and ethical, financial, and practical constraints that limit the accuracy of extensive research. This study introduces a novel approach to inducing persistent ischemia in 3-day-old chicken embryos using endothelin-1.
View Article and Find Full Text PDFPhytomedicine
November 2024
Department of Chemistry, University of Allahabad, Prayagraj (Allahabad) 211002, India; Department of Chemistry, G. R. P. B. Degree College, P. R. S. University, Prayagraj (Allahabad) 211010, India. Electronic address:
Indian J Pharmacol
July 2024
Department of Regulatory Toxicology, National Institute of Pharmaceutical Education and Research (NIPER), Raebareli, Uttar Pradesh, India.
Phytother Res
September 2024
Integral Information & Research Center (IIRC-5), Clinical Biochemistry & Natural Product Research Lab, Department of Biosciences, Integral University, Lucknow, Uttar Pradesh, India.
Metabolic syndrome (MetS) is an ever-evolving set of diseases that poses a serious health risk in many countries worldwide. Existing evidence illustrates that individuals with MetS have a 30%-40% higher chance of acquiring type 2 diabetes mellitus (T2DM), cardiovascular disease (CVD), or both. This study was undertaken to uncover the regulatory role of natural organosulfur compounds (OSCs), S-allyl-L-cysteine (SAC), and S-ethyl-L-cysteine (SEC), in targeting high carbohydrate high fat (HCHF)-diet-induced MetS-associated risk management.
View Article and Find Full Text PDFPharmaceuticals (Basel)
July 2024
Department of Biotechnology, School of Biosciences and Biotechnology, Baba Ghulam Shah Badshah University, Rajouri 185234, Jammu and Kashmir, India.
Oxidative stress, driven by reactive oxygen, nitrogen, and sulphur species (ROS, RNS, RSS), poses a significant threat to cellular integrity and human health. Generated during mitochondrial respiration, inflammation, UV exposure and pollution, these species damage cells and contribute to pathologies like cardiovascular issues, neurodegeneration, cancer, and metabolic syndromes. Lifestyle factors exert a substantial influence on oxidative stress levels, with mitochondria emerging as pivotal players in ROS generation and cellular equilibrium.
View Article and Find Full Text PDFBiology (Basel)
August 2024
School of the Environment and Safety Engineering, Jiangsu University, Zhenjiang 212013, China.
Urban lakes commonly suffer from nutrient over-enrichment, resulting in water quality deterioration and eutrophication. Constructed wetlands are widely employed for ecological restoration in such lakes but their efficacy in water purification noticeably fluctuates with the seasons. This study takes the constructed wetland of Jinshan Lake as an example.
View Article and Find Full Text PDFClin Nutr ESPEN
October 2024
Department of Personalized and Molecular Medicine, Era University, Lucknow 226003, Uttar Pradesh, India.