4 results match your criteria: "Equipe universitaire 3509 Paris VII-Paris XI-Paris XIII[Affiliation]"
Combinatorial therapy with two pro-coagulants and one osmotic agent reduces the extent of the lesion in the acute phase of spinal cord injury in the rat.
Intensive Care Med Exp
December 2017
INSERM U942, Equipe universitaire 3509 Paris VII-Paris XI-Paris XIII, Microcirculation, Bioénergétique, Inflammation et Insuffisance circulatoire aiguë, Paris Diderot-Paris VII, Paris, France.
Background: Spinal cord injury (SCI) is a complex disease that leads to a motor, sensitive, and vegetative impairment. So far, single therapies are ineffective for treating SCI in humans and a multifactorial therapeutic approach may be required. The aim of this work was to assess the effect of a triple therapy (TT) associating two pro-coagulant therapies (tranexamic acid and fibrinogen) with an anti-edema therapy (hypertonic saline solution), on the extent of the lesion 24 h post-injury.
View Article and Find Full Text PDFThe authors reply.
Crit Care Med
March 2014
Service d' Anesthésie-Réanimation, Hôpitaux Universitaires Paris-Sud, and "Microcirculation, Bioénergétique, Inflammation et Insuffisance circulatoire aiguë," Equipe Universitaire 3509 Paris VII-Paris XI-Paris XIII, Paris, France; "Microcirculation, Bioénergétique, Inflammation et Insuffisance circulatoire aiguë," Equipe Universitaire 3509 Paris VII-Paris XI-Paris XIII, Paris, France; Service d' Anesthésie-Réanimation, Hôpitaux Universitaires Paris-Sud, and Equipe Universitaire 3509 Paris VII-Paris XI-Paris XIII, Paris, France; Laboratoire de Microcirculation, Energétique, Inflammation, Insuffisance Circulatoire Aigue, Université Paris VII-XI-XIII, Paris, France.
Effect of norepinephrine on spinal cord blood flow and parenchymal hemorrhage size in acute-phase experimental spinal cord injury.
Eur Spine J
March 2014
"Microcirculation, Bioénergétique, Inflammation et Insuffisance Circulatoire Aiguë", Equipe Universitaire 3509 Paris VII-Paris XI-Paris XIII, Paris, France,
Purpose: In the acute phase of spinal cord injury (SCI), ischemia and parenchymal hemorrhage are believed to worsen the primary lesions induced by mechanical trauma. To minimize ischemia, keeping the mean arterial blood pressure above 85 mmHg for at least 1 week is recommended, and norepinephrine is frequently administered to achieve this goal. However, no experimental study has assessed the effect of norepinephrine on spinal cord blood flow (SCBF) and parenchymal hemorrhage size.
View Article and Find Full Text PDFRat model of spinal cord injury preserving dura mater integrity and allowing measurements of cerebrospinal fluid pressure and spinal cord blood flow.
Eur Spine J
August 2013
Equipe universitaire 3509 Paris VII-Paris XI-Paris XIII, Microcirculation, Bioénergétique, Inflammation et Insuffisance circulatoire aiguë, Paris Diderot-Paris VII University, Paris, France.
Purposes: Cerebrospinal fluid (CSF) pressure elevation may worsen spinal cord ischaemia after spinal cord injury (SCI). We developed a rat model to investigate relationships between CSF pressure and spinal cord blood flow (SCBF).
Methods: Male Wistar rats had SCI induced at Th10 (n = 7) or a sham operation (n = 10).