3 results match your criteria: "Epidemiology and Clinical Research in Digestive Cancers Team[Affiliation]"
A Cohort Study of CNS Tumors in Multiple Endocrine Neoplasia Type 1.
Clin Cancer Res
July 2024
Department of Digestive and Endocrine Surgery, Dijon University Hospital, Dijon, France.
Article Synopsis
- The study investigates the occurrence and characteristics of central nervous system tumors, specifically meningiomas and ependymomas, in patients with multiple endocrine neoplasia type 1 (MEN1) syndrome, finding a notably higher incidence compared to the general population.
- Among the 1,498 symptomatic MEN1 patients studied, there were 29 CNS tumors identified, with meningiomas and ependymomas being the most common, and specific genetic alterations (biallelic MEN1 inactivation) were noted in some of these tumors.
- The results suggest that meningiomas and ependymomas are significant components of MEN1 syndrome; however, the study lacks sufficient molecular data for definitive conclusions regarding astrocy
Life expectancy and likelihood of surgery in multiple endocrine neoplasia type 1: AFCE and GTE cohort study.
Br J Surg
August 2022
INSERM, U1231, Epidemiology and Clinical Research in Digestive Cancers Team, Dijon, France.
Background: The overall natural history, risk of death and surgical burden of patients with multiple endocrine neoplasia type 1 (MEN1) is not well known.
Methods: Patients with MEN1 from a nationwide cohort were included. The survival of patients with MEN1 was compared with that of the general population using simulated controls.
Metastatic Potential and Survival of Duodenal and Pancreatic Tumors in Multiple Endocrine Neoplasia Type 1: A GTE and AFCE Cohort Study (Groupe d'étude des Tumeurs Endocrines and Association Francophone de Chirurgie Endocrinienne).
Ann Surg
December 2020
INSERM, U1231, Epidemiology and Clinical Research in Digestive Cancers Team, Dijon, France.
Objective: To assess the distant metastatic potential of duodeno-pancreatic neuroendocrine tumors (DP-NETs) in patients with MEN1, according to functional status and size.
Summary Background Data: DP-NETs, with their numerous lesions and endocrine secretion-related symptoms, continue to be a medical challenge; unfortunately they can become aggressive tumors associated with distant metastasis, shortening survival. The survival of patients with large nonfunctional DP-NETs is known to be poor, but the overall contribution of DP-NETs to metastatic spread is poorly known.