8,551 results match your criteria: "Ependymoma"
J Neuropathol Exp Neurol
December 2024
Department of Pathology and Laboratory Medicine, Children's Hospital Los Angeles, Los Angeles, CA, United States.
This study evaluates the diagnostic utility of OLIG2 immunohistochemistry for distinguishing between pediatric high-grade gliomas (pHGG) and embryonal tumors (ETs) of the CNS. Utilizing a retrospective pediatric cohort (1990-2021) of 56 CNS tumors, classified initially as primitive neuroectodermal tumors or CNS ET, we reclassified the cases based on WHO CNS5 criteria after comprehensive review and additional molecular testing that included next-generation sequencing and DNA methylation profiling. Our results indicate that OLIG2 immunopositivity was negative or minimal in a significant subset of pHGG cases (6 out of 11).
View Article and Find Full Text PDFCancers (Basel)
July 2024
Oncological Neuroradiology and Advanced Diagnostics Unit, Bambino Gesù Children's Hospital, IRCCS, 00165 Rome, Italy.
: Differentiating pediatric posterior fossa (PF) tumors such as medulloblastoma (MB), ependymoma (EP), and pilocytic astrocytoma (PA) remains relevant, because of important treatment and prognostic implications. Diffusion kurtosis imaging (DKI) has not yet been investigated for discrimination of pediatric PF tumors. Estimating diffusion values from whole-tumor-based (VOI) segmentations may improve diffusion measurement repeatability compared to conventional region-of-interest (ROI) approaches.
View Article and Find Full Text PDFClin Neurol Neurosurg
September 2024
Department of Neurosurgery, Mount Sinai Health System, New York, NY, United States. Electronic address:
Objective: Query the National Cancer Database (NCDB) to delineate epidemiologic frequency, care patterns, and survival outcomes of pediatric intramedullary spinal cord tumors (IMSCTs).
Methods: IMSCTs included ependymoma, astrocytoma, and hemangioblastoma. We examined data from the NCDB spanning 2004-2018, focusing on IMSCT in children aged 0-21 years.
BMJ Case Rep
July 2024
Neurosurgery Department, Coimbra Hospital and University Centre, Coimbra, Portugal.
Childs Nerv Syst
November 2024
Department of Clinical Neuroscience, Royal Infirmary of Edinburgh, Edinburgh, UK.
Purpose: This retrospective systematic literature review aimed to summarize available data regarding epidemiology, etiology, presentation, investigations, differentials, treatment, prevention, monitoring, complications, and prognosis for radiation-induced cavernous malformations (RICMs) in pediatric patients.
Methodology: Review conducted per PRISMA guidelines. Google Scholar, PubMed, Trip Medical Database, and Cochrane Library searched utilizing a keyphrase, articles filtered per inclusion/exclusion criteria, duplicates excluded.
Front Neurol
July 2024
Department of Pathophysiology, First Moscow State Medical University (Sechenov University), Moscow, Russia.
Objectives: Diagnosing brain tumors is critical due to their complex nature. This review explores the potential of hybridization for diagnosing brain neoplasms, examining their attributes and applications in neurology and oncology.
Methods: The review surveys literature and cross-references findings with the OMIM database, examining 513 records.
Introduction: Radiation-induced gliomas (RIGs) were reported in the literature in general. In most of the reported cases and the reviewed articles, patients have a history of primary intracranial tumors like craniopharyngioma, medulloblastoma, and ependymoma, and the commonly resulting secondary tumors are meningiomas and sarcomas, mainly not gliomas. .
View Article and Find Full Text PDFChilds Nerv Syst
September 2024
Department of Neurosurgery, Boldrini Children's Hospital, Gabriel Porto St - Cidade Universitária, 1270 Dr, São Paulo, Campinas, 13083-210, Brazil.
Objective: We aim to report the epidemiology, surgical outcomes, and survival rates of pediatric patients with posterior fossa tumors in a large single-center case series.
Methods: A retrospective analysis was conducted on pediatric patients who underwent surgical treatment for posterior fossa tumors between January 2011 and January 2019.
Results: A total of 135 pediatric patients, with an average age of 7.
Cytopathology
September 2024
Institute of Pathology, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland.
Ependymal and choroid plexus tumours arise in anatomically related regions. Their intraoperative differential diagnosis is large and depends on factors such as age, tumour site and clinical presentation. Squash cytology can provide valuable information in this context.
View Article and Find Full Text PDFCell
September 2024
Arnie Charbonneau Cancer Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada; Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada; Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada; Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA; Cancer and Hematology Center, Texas Children's Hospital, Houston, TX 77030, USA; Dan L Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:
Posterior fossa group A (PFA) ependymoma is a lethal brain cancer diagnosed in infants and young children. The lack of driver events in the PFA linear genome led us to search its 3D genome for characteristic features. Here, we reconstructed 3D genomes from diverse childhood tumor types and uncovered a global topology in PFA that is highly reminiscent of stem and progenitor cells in a variety of human tissues.
View Article and Find Full Text PDFPLoS One
July 2024
Department of Neurosurgery, Seoul National University Hospital, Seoul, Republic of Korea.
Surg Neurol Int
June 2024
Department of Neurosurgery, Gui de Chauliac Hospital, Montpellier, Occitanie, France.
Background: Patients affected by Von Hippel-Lindau (VHL) are prone to develop central nervous system neoplasms such as hemangioblastomas (HBs). Myxopapillary ependymoma (MPE) is not commonly associated with VHL disease.
Case Description: We present the first case of a VHL patient affected by simultaneous silent cauda equina MPE and a symptomatic conus medullaris HB.
Asian J Neurosurg
June 2024
Department of Neuropathology, Shanti Pathology Laboratory Cancer Diagnosis & Research Center, Kolhapur, Maharashtra, India.
Rosai-Dorfman disease (RDD) or sinus histiocytosis with massive lymphadenopathy can present with or without systemic disease. It is a benign histioproliferative disorder characterized by generalized lymphadenopathy, weakness, anemia, and rarely extranodal involvement. While RDD most commonly affects lymph nodes, extranodal involvement of multiple organs has been reported, including the central nervous system (CNS).
View Article and Find Full Text PDFFASEB J
July 2024
College of Life Science and Medicine, Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, Zhejiang Sci-Tech University, Hangzhou, China.
Explor Target Antitumor Ther
June 2024
Department of Pathology, Tata Memorial Hospital (Homi Bhabha National Institute), Mumbai, Maharashtra 400012, India.
Clin Neurol Neurosurg
September 2024
Department of Neurosurgery, Section of Surgery, Aga Khan University Hospital, Karachi, Pakistan. Electronic address:
Chemotherapy in brain tumors is tailored based on tumor type, grade, and molecular markers, which are crucial for predicting responses and survival outcomes. This review summarizes the role of chemotherapy in gliomas, glioneuronal and neuronal tumors, ependymomas, choroid plexus tumors, medulloblastomas, and meningiomas, discussing standard treatment protocols and recent developments in targeted therapies.Furthermore, the studies reporting the integration of MRI-based radiomics and deep learning models for predicting treatment outcomes are reviewed.
View Article and Find Full Text PDFNeurospine
June 2024
Department of Neurosurgery, First Hospital of Jilin University, Changchun, China.
Int J Mol Sci
June 2024
Rare Disease R&D Center, PRG S&T Co., Ltd., Busan 46274, Republic of Korea.
Cancers (Basel)
June 2024
Neurophysiology & Epilepsy Unit, Neurological Hospital P. Wertheimer, Hospices Civils de Lyon, 59 Boulevard Pinel, 69677 Bron, France.
Surgery for spinal cord tumors poses a significant challenge due to the inherent risk of neurological deterioration. Despite being performed at numerous centers, there is an ongoing debate regarding the efficacy of pre- and intraoperative neurophysiological investigations in detecting and preventing neurological lesions. This study begins by providing a comprehensive review of the neurophysiological techniques commonly employed in this context.
View Article and Find Full Text PDFAJNR Am J Neuroradiol
November 2024
From the Department of Radiology (O.S., N.S., A.M., M.W., T.P.R., A.B.), Children's Hospital of Philadelphia, Philadelphia, Pennsylvania
Background And Purpose: Hemangioblastoma is a rare vascular tumor that occurs within the central nervous system in children. Differentiating hemangioblastoma from other posterior fossa tumors can be challenging on imaging, and preoperative diagnosis can change the neurosurgical approach. We hypothesize that a "lightbulb sign" on the arterial spin-labeling (ASL) sequence (diffuse homogeneous intense hyperperfusion within the solid component of the tumor) will provide additional imaging finding to differentiate hemangioblastoma from other posterior fossa tumors.
View Article and Find Full Text PDFIndian J Pathol Microbiol
June 2024
Department of Neurosurgery, Bangur Institute of Neurosciences, Kolkata, West Bengal, India.
Background And Aims: Ependymomas exhibit heterogeneity across age, location, histology, molecular nature and survival suggestive of an epigenetic component in its pathogenesis. The CNS WHO classification (2021) classifies ependymomas based on DNA methylation profiles. Studies suggest that molecular sub-types remain stable throughout the course of disease.
View Article and Find Full Text PDFN Engl J Med
June 2024
From Massachusetts General Hospital and Harvard Medical School (S.R.P., V.L.M.) and the Dana-Farber Cancer Institute (G.F., L.T.) - all in Boston; the NYU Grossman School of Medicine (K.H.Y.) and the Children's Tumor Foundation (A.B.) - both in New York; the University of California, Los Angeles, Los Angeles (P.L.N.); the University of Miami Miller School of Medicine, Sylvester Comprehensive Cancer Center, Miami (C.T.D.); the Mayo Clinic, Rochester, MN (D.B.-V.); and Johns Hopkins University, Baltimore (J.O.B.).
Neuroradiology
August 2024
Department of Radiology, Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA, USA.
Purpose: Pediatric spinal cord gliomas (PSGs) are rare in children and few reports detail their imaging features. We tested the association of tumoral grade with imaging features and proposed a novel approach to categorize post-contrast enhancement patterns in PSGs.
Methods: This single-center, retrospective study included patients <21 years of age with preoperative spinal MRI and confirmed pathological diagnosis of PSG from 2000-2022.
Eur J Pharm Biopharm
August 2024
PRISM Research Institute, Technological University of the Shannon, Athlone, Co. Westmeath, Ireland. Electronic address:
Core-shell particles composed of polycaprolactone/polyvinyl alcohol (PCL/PVA) with pH sensitive properties were successfully fabricated by co-axial electrospraying in which PVA and PCL formed the shell and core layers respectively. The core-shell structure was confirmed by FTIR, DSC and SEM analysis. No chemical interaction between PVA and PCL core-shell were observed in the FTIR analysis.
View Article and Find Full Text PDFNeurol Med Chir (Tokyo)
August 2024
Department of Neurosurgery, Keio University School of Medicine.