6,651 results match your criteria: "Eom; Shine Animal Medical Center[Affiliation]"

A novel peptide pair-based rapid fluorescent diagnostic system for malaria Plasmodium falciparum detection.

Talanta

January 2025

Department of Tropical Medicine and Parasitology, Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea; Medical Research Center, Institute of Endemic Diseases, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea. Electronic address:

Article Synopsis
  • Scientists created new tools using special small proteins called peptides to find a malaria parasite better than current tests.
  • They designed two peptides that can stick to the malaria parasite and tested them in different ways, finding that one was really good at detecting it.
  • The new test methods showed they could spot the parasite much more effectively than regular tests, making it easier to track different types of malaria.
View Article and Find Full Text PDF

The effects of cauliflower treated with atmospheric cold plasma (ACP), as a natural nitrite source, on the curing of ground ham and nitrosamine formation were investigated. Ground ham was prepared using sodium nitrite and ACP-treated cauliflower powder (PTCP) to achieve initial nitrite concentrations of 60 and 100 mg/kg, respectively. ACP treatment generated nitrite in cauliflower but significantly reduced the antioxidant activity (P < 0.

View Article and Find Full Text PDF

Heart failure is a leading cause of morbidity and mortality. Elevated intracardiac pressures and myocyte stretch in heart failure trigger the release of counter-regulatory natriuretic peptides, which act through their receptor (NPR1) to affect vasodilation, diuresis and natriuresis, lowering venous pressures and relieving venous congestion. Recombinant natriuretic peptide infusions were developed to treat heart failure but have been limited by a short duration of effect.

View Article and Find Full Text PDF

This paper presents an adaptive active rectifier with digital feedback delay controllers (DFDC) which quickly tracks optimal on/off timing against input voltage and load variations. To efficiently generate the on/off transition, the proposed active rectifier adopts dynamically controlled coarse/fine delay lines rather than using conventional power-hungry static comparators, while removing the risk of unwanted multiple driving pulses to pass transistors. DFDC conducts the dual-loop digital feedback to independently adjust on/off timing with high-speed 13.

View Article and Find Full Text PDF
Article Synopsis
  • Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive fat accumulation in the liver and is often linked to unhealthy diets, particularly the overconsumption of soft drinks and Western diets.
  • The study explores the efficacy of hemp sprout-derived exosome-like nanovesicles (HSNVs) in preventing liver fibrosis and gut permeability issues associated with NAFLD by administering these nanovesicles to mice on a high-fat diet.
  • Results showed that HSNVs significantly reduced oxidative stress and fibrosis markers in liver tissues, as well as improved gut barrier function, suggesting their potential as a protective treatment against liver damage caused by poor dietary habits.
View Article and Find Full Text PDF

Airineme-Mediated Intercellular Communication.

Results Probl Cell Differ

September 2024

Department of Developmental and Cell Biology, University of California, Irvine, CA, USA.

Intercellular communication is indispensable across multicellular organisms, and any aberration in this process can give rise to significant anomalies in developmental and homeostatic processes. Thus, a comprehensive understanding of its mechanisms is imperative for addressing human health-related concerns. Recent advances have expanded our understanding of intercellular communication by elucidating additional signaling modalities alongside established mechanisms.

View Article and Find Full Text PDF
Article Synopsis
  • The COVID-19 pandemic has highlighted the need for effective therapeutic interventions alongside vaccines, especially given the rapid mutation of the SARS-CoV-2 virus.
  • This study investigates the antiviral properties and safety of 6'-Hydroxy justicidin B (6'-HJB), a compound from traditional Chinese medicine, as a potential treatment for COVID-19.
  • Results show that 6'-HJB effectively inhibits SARS-CoV-2 growth with lower toxicity than remdesivir and has a favorable safety profile in both cell lines and ferrets, indicating it may be a promising therapeutic option.
View Article and Find Full Text PDF

Excited state electronic structure of dimethyl disulfide involved in photodissociation at ∼200 nm.

Phys Chem Chem Phys

September 2024

Combustion Research Facility, Sandia National Laboratories, Livermore, California 94550, USA.

Dimethyl disulfide (DMDS), one of the smallest organic molecules with an S-S bond, serves as a model system for understanding photofragmentation in polypeptides and proteins. Prior studies of DMDS photodissociation excited at ∼266 nm and ∼248 nm have elucidated the mechanisms of S-S and C-S bond cleavage, which involve the lowest excited electronic states S and S. Far less is known about the dissociation mechanisms and electronic structure of relevant excited states of DMDS excited at ∼200 nm.

View Article and Find Full Text PDF

Orbital-optimized coupled-cluster methods are very helpful for theoretical predictions of the molecular properties of challenging chemical systems, such as excited states. In this research, an efficient implementation of the equation-of-motion orbital-optimized coupled-cluster doubles method with the density-fitting (DF) approach, denoted by DF-EOM-OCCD, is presented. The computational cost of the DF-EOM-OCCD method for excitation energies is compared with that of the conventional EOM-OCCD method.

View Article and Find Full Text PDF

Stretchable and biodegradable self-healing conductors for multifunctional electronics.

Sci Adv

September 2024

KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 02841, Republic of Korea.

As the regenerative mechanisms of biological organisms, self-healing provides useful functions for soft electronics or associated systems. However, there have been few examples of soft electronics where all components have self-healing properties while also ensuring compatibility between components to achieve multifunctional and resilient bio-integrated electronics. Here, we introduce a stretchable, biodegradable, self-healing conductor constructed by combination of two layers: (i) synthetic self-healing elastomer and (ii) self-healing conductive composite with additives.

View Article and Find Full Text PDF

Purpose: Invasive mucinous adenocarcinoma (IMA) of the lungs is a rare subtype of lung adenocarcinoma with a limited understanding of its prognosis, particularly in advanced stages. This study aimed to assess the prognosis of patients with advanced IMA by focusing on treatment modalities.

Methods: This single-center retrospective study evaluated 33 patients with IMAs diagnosed with advanced-stage disease or disease progression after curative treatment between 2011 and 2021.

View Article and Find Full Text PDF

Efficacy of biologics for eosinophilic otitis media.

Acta Otolaryngol

October 2024

Department of Otorhinolaryngology-Head and Neck Surgery, Seoul National University Hospital, Seoul, Republic of Korea.

Background: Eosinophilic otitis media (EOM) is an intractable condition primarily treated with steroids. Recently, biologics targeting IgE or IL-5 have been introduced.

Objectives: This study aimed to evaluate the efficacy of biologics for EOM.

View Article and Find Full Text PDF

Nanoscale dosimetry for a radioisotope-labeled metal nanoparticle using MCNP6.2 and Geant4.

Med Phys

December 2024

Department of Applied Bioengineering and Research Institute for Convergence Science, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, Republic of Korea.

Background: Metal nanoparticles (MNPs) labeled with radioisotopes (RIs) are utilized as radio-enhancers due to their ability to amplify the radiation dose in their immediate vicinity. A thorough understanding of nanoscale dosimetry around MNPs enables their effective application in radiotherapy. However, nanoscale dosimetry around MNPs still requires further investigation.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the differences observed in MRI scans between bacterial orbital cellulitis (OC) and diffuse non-specific orbital inflammation (DNSOI) to aid in diagnosis.
  • A total of 32 patients were reviewed, revealing distinct MRI characteristics such as the T2 signal intensity and contrast enhancement patterns, with OC showing hyperintense signals and specific EOM involvement.
  • The findings suggest that while certain MRI features can help distinguish between OC and DNSOI, the overlap in radiological signs creates challenges in making a definitive diagnosis between infectious and non-infectious orbital inflammation.
View Article and Find Full Text PDF

The cellular environment plays a significant role in low energy electron-mediated radiation damage to genetic materials. In this study, we have modeled the effect of the bulk medium on electron attachment to nucleobases in diethylene glycol (DEG) using uracil as a test case, in accordance with recent experimental work on the observation of dissociative quasi-free electron attachment to nucleoside via excited anion radical in solution (in DEG). Our EOM-CCSD-based quantum mechanical/molecular mechanical (QM/MM) simulations indicate that the electron scavenging by uracil in DEG is much slower than that observed in the aqueous medium due to its viscosity.

View Article and Find Full Text PDF

Background: The prognostic implications of tumor mutational burden (TMB) and programmed death ligand 1 (PD-L1) expression are poorly studied in hematologic malignancies.

Objectives: This study aimed to better understand the characteristics and prognostic value of TMB and PD-1/PD-L1 in hematologic malignancies.

Design: This real-world study was conducted among patients with hematologic malignancies who had next-generation sequencing (NGS) (Foundation Medicine) at the University of California San Diego Moores Cancer Center (2014-2018).

View Article and Find Full Text PDF

The toxic effects of polystyrene microplastic/nanoplastic particles on retinal pigment epithelial cells and retinal tissue.

Environ Sci Pollut Res Int

September 2024

Department of Ophthalmology, Guro Hospital, Korea University College of Medicine, 80, Guro-Dong, Guro-Gu, Seoul, 152-703, South Korea.

Article Synopsis
  • The increasing use of contact lenses and other eye-related products has led to greater exposure to microplastics, raising concerns about their impact on eye health, particularly the retina.
  • This study tested the effects of microplastics (MPs) and nanoplastics (NPs) on human retinal pigment epithelial cells and found that while MPs didn't significantly affect cell viability, NPs caused notable damage and increased oxidative stress.
  • In animal tests, NPs increased inflammatory markers and the presence of inflammatory cells in the retina, highlighting that NPs are more harmful than MPs, given their role in inducing oxidative stress and mitochondrial changes in retinal cells.
View Article and Find Full Text PDF

Understanding the process of molecular photoexcitation is crucial in various fields, including drug development, materials science, photovoltaics, and more. The electronic vertical excitation energy is a critical property, for example in determining the singlet-triplet gap of chromophores. However, a full understanding of excited-state processes requires additional explorations of the excited-state potential energy surface and electronic properties, which is greatly aided by the availability of analytic energy gradients.

View Article and Find Full Text PDF

Precision oncology across the ages: Impact on children, adolescents, and young adults.

Cancer Cell

September 2024

Genomic Sciences and Precision Medicine Center, and Medical College of Wisconsin Cancer Center, Milwaukee, WI, USA; Chief Medical Officer, Equal Opportunity and Diversity Office, WIN Consortium, Paris, France; Medical Oncology, University of Nebraska, Omaha, NE, USA.

Precision oncology endeavors to tailor therapies based on individual patient and tumor characteristics. This rapidly evolving field has transformed cancer treatment across all age groups. In this commentary, we review the application of precision oncology across different age groups, specifically in children, adolescents, and young adults, and emphasize that precision medicine is age and tissue agnostic.

View Article and Find Full Text PDF

Correction: Development of a reliable surgical quality assurance tool for gastrectomy in oncological trials.

Gastric Cancer

November 2024

Department of Surgery and Cancer, Imperial College London, 7th Floor Commonwealth Building, Hammersmith Hospital, Du Cane Road, London, W12 0HS, UK.

View Article and Find Full Text PDF

Hepatic graft-versus-host disease (GVHD) significantly impacts morbidity and mortality among allogeneic hematopoietic stem cell transplant recipients. However, the relationship between clinical and immunopathological phenotypes and their influence on clinical outcomes in hepatic GVHD is not well understood. In this study, we aimed to study the implications of portal T-cell infiltration on the clinical outcomes in hepatic GHVD and its similarities to autoimmune liver disease.

View Article and Find Full Text PDF

This study aimed to investigate the presence of structural and functional changes in extraocular muscles (EMs) among patients with inactive Graves' orbitopathy (GO) classified according to the Clinical Activity Score (CAS). Sixty-seven patients with Graves' disease (GD) and inactive GO were included. The data collected included clinical parameters, thyroid function, autoantibody levels, EOM morphology via orbital ultrasound (US), and ocular motility.

View Article and Find Full Text PDF

is a highly nutritious marine microalga that has various applications in aquaculture and biotechnology. However, the effects of extract (TLE) on osteoarthritis (OA) pathogenesis remain unexplored. In this study, we aimed to determine the effects of TLE on OA development.

View Article and Find Full Text PDF

Long-term (10-year) monitoring of transposon-mediated transgenic cattle.

Transgenic Res

October 2024

LARTBio Inc., Gwangmyeong-si, Gyeonggi-do, Republic of Korea.

The production of transgenic animals using non-viral methods has raised questions regarding their long-term health and genomic stability. In this study, we evaluated these aspects in transgenic cattle over ten years, using transposon-mediated gene transfer. Our longitudinal analysis included a comprehensive health assessment and whole-genome DNA resequencing.

View Article and Find Full Text PDF