Retropharyngeal salivary adenomatous hyperplasia mimicking tumor metastasis in a dog.

This report describes the case of a 13-year-old castrated male poodle with respiratory distress and coughing. The dog had had its right thyroid gland and ipsilateral lymph node resected because of thyroid follicular carcinoma originating in the right thyroid gland and metastasis to the ipsilateral medial retropharyngeal lymph node. The dog was initially treated for chronic bronchitis but showed no resolution of the clinical signs.

Understanding gut Microbiome changes in Korean children, adolescents, and young adults with hematologic malignancies.

We investigated whether changes in the gut microbiome composition are associated with infections and immunologic complications during the treatment of Korean children, adolescents, and young adults (AYAs) with hematologic malignancies. We analyzed stool samples from 26 patients and 10 healthy siblings using 16 S rRNA gene sequencing. At diagnosis, patients exhibited a lower abundance of Lachnospiraceae and a higher abundance of Enterococcaceae than their healthy siblings.

Regulatory dynamics of Nanog in chondrocyte dedifferentiation: role of KLF4/p53 and p38/AKT signaling.

Homeobox protein Nanog, a member of the transcription factor family, plays a crucial role in maintaining the pluripotency and self-renewal of embryonic stem cells. Due to its diverse activities, Nanog has been identified in multiple cell types, including embryonic stem cells (ESCs) and cancer stem cells (CSCs). However, its molecular mechanism in chondrocytes remains unclear.

MSTN knockout enhances the production of MYOD1-mediated steak-type cultivated meat.

Background: As the global population increases, the demand for protein sources is expected to increase, driving the demand for cell-based cultivated meat. This study aimed to enhance the productivity of cultivated meat through optimization of the cell source and organization process.

Results: We engineered fibroblasts into myogenic cells via non-viral introduction of the MYOD1 gene, avoiding viral methods for safety.

Mixed methods evaluation of a digital resource to build students' skills in ASsessing cardiovascular risk, MOtivating change, and SUStaining a healthier lifestyle in themselves and others- ASMOSUS: a study protocol.

Background: Cardiovascular disease (CVD) is a prevalent cause of morbidity and mortality globally. Nurses and nursing students are in an optimum role to assess, manage and promote lifestyle changes associated with CVD risk. Patients and service users are more likely to adopt these changes if the person delivering the information embodies this lifestyle themselves.

Cirsium japonicum leaf extract attenuated lipopolysaccharide-induced acute respiratory distress syndrome in mice via suppression of the NLRP3 and HIF1α pathways.

Background: Acute respiratory distress syndrome (ARDS) is a severe inflammatory disorder characterized by acute respiratory failure, alveolar barrier dysfunction, edema, and dysregulated alveolar macrophage-mediated pulmonary inflammation. Despite advancements in treatment strategies, the mortality rate in patients with ARDS remains high, ranging from 40-60 %. Current approaches are limited to supportive care, necessitating the exploration of effective therapeutic options such as suppressing broad inflammatory responses.

Potent anti-biofilm properties of plumbagin against fluconazole-resistant .

Background And Aim: The escalation of fungal infections is driving an increase in disease and mortality rates. In particular, the emergence of (), which shows powerful resistance to the antifungal drug fluconazole, is becoming a global concern. Furthermore, several biological hurdles need to be overcome by candidate therapeutics because has the ability to form biofilm.

Molecular insight into cross-interaction between amyloid β isoforms and its effect on aggregation pathways.

The self-aggregation of amyloid β (Aβ) proteins has played a crucial role in the pathogenesis of Alzheimer's diseases. Despite previous studies on the aggregation process of Aβ proteins, little is known about how the cross-interaction between Aβ isoforms affects the aggregation pathways and the resulting structures of Aβ aggregates. Here, we study the cross-interaction between Aβ40 and Aβ42 during their aggregation process by measuring the aggregation kinetics and the structures of Aβ aggregates under varied concentrations of Aβ isoform proteins in their mixture.

Mechanism of Copper Stress on Algae Determined Using Mass Spectrometry Molecular Network: Molecular Characteristics and Metabolite Identification.

Algae typically respond to environmental changes by regulating the production and release of metabolites that affect water quality and cause various environmental issues. In this study, we investigated the role of algal organic matter (AOM) in copper [Cu(II)] using high-resolution mass spectrometry and a molecular-network-based nontargeted screening. The abundance and activity of algae were inhibited after the addition of Cu(II).

The wound healing effects of linearly polarized irradiation in photobiomodulation.

We report the fabrication of a polarization-based photobiomodulation (PBM) system and its performance on wound healing effects. The light source for PBM was a 625 nm LED and two different linear polarizations (P-wave and S-wave) were generated using the wire grid linear polarizers. To confirm the effect of PBM on polarization, wounds were created on hairless mice, and the healing process was compared.

Tumour-agnostic kinase inhibitors.

Protein kinases are crucial targets for cancer treatment as they orchestrate important signals for oncogenesis and are often aberrantly activated owing to genomic alterations. In the past two decades, multiple kinase inhibitors have been developed, including those that are clinically effective regardless of tumour location, provided that the tumour harbours the aberrantly activated kinase. Consequently, a biomarker-based therapy model, untethered from tumour histology and organ of origin, has been established, which has led to transformative regulatory approvals of tumour-agnostic kinase inhibitors such as larotrectinib, selpercatinib, dabrafenib-trametinib and pemigatinib.

Sequencing in over 50,000 cases identifies coding and structural variation underlying atrial fibrillation risk.

Atrial fibrillation (AF) is a prevalent and morbid abnormality of the heart rhythm with a strong genetic component. Here, we meta-analyzed genome and exome sequencing data from 36 studies that included 52,416 AF cases and 277,762 controls. In burden tests of rare coding variation, we identified novel associations between AF and the genes MYBPC3, LMNA, PKP2, FAM189A2 and KDM5B.

Ultra tough and high resilience mechanochromic fibres for real world stress detection.

Cholesteric liquid crystal elastomer fibres gain considerable attention as promising candidates for mechanochromic smart textiles across various domains, ranging from fashion to healthcare. However, intrinsically high hysteresis of cholesteric liquid crystal elastomer during stress relaxation necessitates a time-lag between successive stimulus detections, thereby constraining the practical use in real-world systems. Here, we develop high-tough and low-hysteresis mechanochromic fibres capable of effectively detecting ultra-fast deformations at practical levels.

Unveiling the mechanisms of ultrasonic radiation-induced free radical stress on algal communities: Insights into growth inhibition, photosynthetic disruption, and antioxidant defense responses.

Algal blooms pose a significant threat to global environmental health, compromising water quality and public safety. Ultrasonic radiation has emerged as a promising, eco-friendly strategy for controlling these blooms, but the underlying mechanisms remain unclearly understood. This study investigated the effects of ultrasonic radiation on the growth, photosynthetic performance, and antioxidant defense systems of an algal mixture over a 5-day period.

Thelazia callipaeda (Nematoda: Spirurida) infections in 2 wildlife species, Prionailurus bengalensis and Nyctereutes procyonoides, in Korea.

Thelazia callipaeda (Spirurida, Thelaziidae), a parasitic eye worm causing thelaziasis has been reported in humans and dogs in Korea. However, its occurrence in other potential reservoir hosts, including wild animals, remains unclear. In the present study, we described the 2 cases of thelaziasis from both of feral and captive wild animal in Korea.

Levels of exposure markers among residents in environmentally vulnerable areas in Korea, the general population in Korea, and Asians in the United States.

This study compares biomarker levels among environmentally vulnerable residents in Korea, the general Korean population, and Asians in the United States. We selected 953 exposed residents and 204 controls from the Forensic Research via Omics Markers in Environmental Health Vulnerable Areas (FROM) study (2021-2023), 4,239 participants from the fourth Korean National Environmental Health Survey (2018-2020), and 996 Asians from the US National Health and Nutrition Examination Survey (2017-March 2020). The analyzed biomarkers included blood and urinary metals, urinary metabolites of polycyclic aromatic hydrocarbons (PAHs), nicotine, volatile organic compounds (VOCs), and serum perfluorocarbon metabolites.

Detection Ability of Quality of Life Changes and Responsiveness of the KOQUSS-40 and the EORTC QLQ-C30/STO22 in Patients Who Underwent Gastrectomy: A Prospective Comparative Study.

Purpose: The aim of this study is to compare the detection ability of quality of life (QoL) changes and responsiveness of the KOrean QUality of life in Stomach cancer patients Study group (KOQUSS)-40 and European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ).

Materials And Methods: A multicenter prospective observational study was conducted to evaluate QoL changes after various gastrectomies between January 2021 and April 2022. Participants were instructed to complete the KOQUSS-40 and EORTC QLQ-C30/STO22 preoperatively and at 1, 3, 6, and 12 months postoperatively.

Cas9-expressing cattle using the PiggyBac transposon all-in-one system.

Background: Livestock, particularly cattle, are crucial for biotechnology fields, such as genetic breeding, infectious diseases, bioreactors, and specific disease models. However, genetic engineering in cattle has lagged due to long gestation periods, single embryo pregnancies, and high rearing costs. Additionally, the slow validation of germline transmission and the absence of germline-competent embryonic stem cells hinder progress.

Intensity-difference squeezing from four-wave mixing in hot Rb and Rb atoms in single diode laser pumping system.

Squeezed states of light, generated through four-wave mixing (FWM), are increasingly recognized as valuable resources for various applications in quantum sensing, quantum imaging, and quantum information processing. In this study, we report achieving more than - 7.8 dB of intensity-difference squeezing (IDS) in two-mode squeezed states from hot Rb vapor and - 5.

Synbiotic combination of fructooligosaccharides and probiotics ameliorates the metabolic dysfunction-associated steatotic liver disease.

Synbiotics have become a new-age treatment tool for limiting the progression of metabolic dysfunction-associated steatotic liver disease; however, inclusive comparisons of various synbiotic treatments are still lacking. Here, we have explored and evaluated multiple synbiotic combinations incorporating three distinctive prebiotics, lactitol, lactulose and fructooligosaccharides. Of the synbiotic treatments evaluated, a combination of fructooligosaccharides and probiotics (FOS+Pro) exhibited superior protection against western diet-induced liver degeneration.

One-Month-Old Rabbits Exhibit a Longer Postoperative Remodeling in Extraocular Muscles Compared to 3-Month-Old Rabbits.

Purpose: To explore whether there is a difference in postoperative extraocular muscle (EOM) remodeling between 1-month-old and 3-month-old rabbits.

Methods: Recession (n = 16) and resection (n = 16) were performed on the right superior rectus (SR) muscles of 1-month-old and 3-month-old rabbits. SR tissues were harvested 1 and 4 weeks post-surgery (n = 4 for each group), and mid-belly sections were used to assess myosin heavy chain (MyHC) isoform expression (fast 2X, embryonic, and neonatal MyHCs), activated satellite cells (SCs), and centrally nucleated myofibers.

Physical Activity, Alzheimer Plasma Biomarkers, and Cognition.

Importance: Physical activity (PA) is a nonpharmacological intervention for dementia prevention. The association between PA and Alzheimer disease (AD) plasma biomarkers remains underexplored.

Objective: To investigate the associations among PA; plasma biomarkers, including β-amyloid 42/40 (Aβ42/40), phosphorylated-tau217 (ptau217), glial fibrillary acidic protein (GFAP), and neurofilament light chain (NfL); and cognition.

Can ΔSCF and ROKS DFT-Based Methods Predict the Inversion of the Singlet-Triplet Gap in Organic Molecules?

Inverted singlet-triplet gap systems (INVEST) have emerged as an intriguing class of materials with potential applications as emitters in Organic Light Emitting Diodes (OLEDs). Indeed, this type of material exhibits a negative singlet-triplet energy gap (Δ), i.e.

Treatment patterns and clinical outcomes for multiple myeloma in Korean patients: a database study.

Background: The treatment landscape for multiple myeloma (MM) has significantly progressed in recent decades.

Methods: We analyzed the treatment patterns and clinical outcomes in Korean patients using data from the National Health Insurance Service database. Patients diagnosed with MM between 2010 and 2018 were included.