Racial disparities in extended venous thromboembolism prophylaxis after hysterectomy.

Background: Venous thromboembolism (VTE) is a significant preventable cause of postoperative morbidity and mortality after major abdominopelvic surgery that calls for extended VTE prophylaxis (eVTEp). Literature suggests that significant racial disparities may exist in post-operative care.

Objective: The study sought to examine if racial disparities exist in the administration of eVTEp after hysterectomy in a statewide collaborative.

Characterizing temporal and global host innate immune responses against SARS-CoV-1 and -2 infection in pathologically relevant human lung epithelial cells.

Severe acute respiratory syndrome coronavirus-1 (SARS-CoV-1) and -2 (SARS-CoV-2) are beta-coronaviruses (β-CoVs) that have caused significant morbidity and mortality worldwide. Therefore, a better understanding of host responses to β-CoVs would provide insights into the pathogenesis of these viruses to identify potential targets for medical countermeasures. In this study, our objective is to use a systems biology approach to explore the magnitude and scope of innate immune responses triggered by SARS-CoV-1 and -2 infection over time in pathologically relevant human lung epithelial cells (Calu-3/2B4 cells).

Toll-like receptor 1/2 activation reduces immunoglobulin free light chain production by multiple myeloma cells in the context of bone marrow stromal cells and fibronectin.

Toll-like receptor (TLRs) activation in multiple myeloma (MM) cells induces heterogeneous functional responses including cell growth and proliferation, survival or apoptosis. These effects have been suggested to be partly due to increase in secretion of cytokines such as IL-6 or IFNα among others from MM cells following TLR activation. However, whether triggering of these receptors also modulates production of immunoglobulin free light chains (FLCs), which largely contribute to MM pathology, has not been investigated in MM cells before.

"Without a man's decision, nothing works": Building resilience to Rift Valley fever in pastoralist communities in Isiolo Kenya.

Rift Valley Fever (RVF) is a zoonotic disease that affects both livestock and humans. Men and women in pastoralist communities are vulnerable to RVF risk exposure because of their different roles and reliance on livestock products. This study sought to understand how ownership and decision-making in pastoralist male and female-headed households influence coping mechanisms and resilience to Rift Valley fever (RVF), using the three resilience capacities of absorptive, adaptive, and transformative.

A clinical study exploring the prediction of microvascular invasion in hepatocellular carcinoma through the use of combined enhanced CT and MRI radiomics.

Objective: To develop a predictive model for microvascular invasion (MVI) in hepatocellular carcinoma (HCC) through radiomics analysis, integrating data from both enhanced computed tomography (CT) and magnetic resonance imaging (MRI).

Methods: A retrospective analysis was conducted on 93 HCC patients who underwent partial hepatectomy. The gold standard for MVI was based on the histopathological diagnosis of the tissue.

Effectiveness of the program for developing leadership skills among managers of police organizations as a guarantee of their mental health.

Objective: Aim: The aim is to substantiate the program for developing leadership skills among managers of police organizations and to test its effectiveness.

Patients And Methods: Materials and Methods: The research, which was conducted in 2022-2024, involved 64 mid-level managers of police organizations and 462 officers from police units (departments, divisions) directly subordinated to these managers. To achieve the aim, a set of methods was used: bibliosemantic, diagnostic, analysis and generalization, statistical.

Fertility before and after treatment of the patient with Leydig cell tumor - case report.

Even though Leydig cell tumor (LCT) represents the most common neoplasia among testicular sex cord-stromal tumors (SCSTs), it is a rare condition, comprising 1-2% of all testicular tumors, with a 10% risk of malignancy most commonly located in retroperitoneal lymph nodes. LCTs may demonstrate various clinical manifestations - from asymptomatic intratesticular swelling through nonspecific symptoms such as loss of libido, impotence or infertility, up to feminizing or virilizing syndromes due to hormonal activity of the tumor. This article presents a case of Leydig cell tumor that was associated with azoospermia what have rarely been reported worldwide.

"Billiary-cast" syndrome in a patient with acute biliary pancreatitis and pulmonary embolism.

"Biliary-cast syndrome" ("BCS") is most often encountered in clinical practice as a complication after liver transplantation, there are also described cases of biliary-cast syndrome in patients who did not undergo liver transplantation, isolated cases of "BCS" developing in patients with acute pancreatitis, choledocholithiasis are described in literature. Ischemic damage to bile duct epithelium with development of cholestasis and retrograde biliary tract infection are considered as the main etiological factors. This work presents a clinical case of "Biliary-cast syndrome" in a patient with acute biliary pancreatitis and pulmonary embolism.

Legal regulation of the circulation of dietary food and dietary supplements in eu countries: the experience of Germany.

Despite the EU legislation regulating the circulation of dietary and food supplements within the internal market, the system of state control requires improvement. For instance, due to existing regulatory gaps, certain pharmaceutical entities commit violations of regulatory requirements, such as failing to register medicinal products and selling them under the guise of dietary and/or food supplements. Conversely, physicians may recommend ordinary dietary and food supplements to patients as if they were medicinal products.

Effectiveness of non-operative methods of treatment of carpal tunnel syndrome: a narrative review.

Carpal tunnel syndrome (CTS) can be treated with several methods, including surgical and non-surgical techniques. Non-surgical methods include wrist splinting, systemic pharmacotherapy, intracarpal injections of steroids hydrodissection, acupuncture, nerve and tendon mobilization, osteopathy, taping, topical application of ointments, laser, ultrasound and shock-wave therapies. These treatments are generally less effective than surgery, and provide only short-lived effect, but it may be quite sufficient for a certain category of patients, particularly those suffering from mild symptoms.

Mechanism for Implementing the State Guarantee Program for Medical Services at the Primary Level.

Objective: Aim: The goal of this work is to investigate the effectiveness of state regulatory tools influencing the HCS reform process and the institutional support for the implementation of SGPMS at the primary level.

Patients And Methods: Materials and Methods: To evaluate the effectiveness of SGPMS implementation at the primary level, methods of observation, analysis and synthesis, grouping, and generalization were applied.

Results: Results: In the implementation of SGPMS, PMC is prioritized.

The influence of heredity and environment on human cognitive ability.

Objective: Aim: The aim of the study is to consists in the theoretical analysis of the results of modern genetic studies of human cognitive abilities as a key to successful education and upbringing.

Patients And Methods: Materials and Methods: To solve the tasks and achieve the goal of the article, we used general scientific methods of the theoretical level (analysis, synthesis, comparison, systematization, generalization of scientific and theoretical data), regarding the influence of heredity and environment on human cognitive ability.

Conclusion: Conclusions: Human cognitive abilities develop under the influence of both genetic and environmental factors.

Practical Uses of Fruits in Ancient Medicine (based on the treatise of Quintus Gargilius Martialis Medicinae ex oleribus et pomis).

Objective: Aim: The aim of the article is to study the therapeutic effect and pharmacological characteristics of using fruits, berries, and nuts in ancient medicine, expanding and deepening knowledge in the history of medicine.

Patients And Methods: Materials and Methods: The study material was Medicinae ex oleribus et pomis, the work of Quintus Gargilius Martialis, a third-century Roman writer, a systematizer of rules for cultivating and medical application of over 60 types of vegetables and fruits. The methodological basis of the research is a set of general scientific and special research methods, including analysis and synthesis, induction and deduction, historical, interdisciplinary, descriptive methods, and the method of contextual analysis.

Treatment of delusional ideas: Analyzing the effectiveness of pharmacotherapy and psychotherapeutic methods.

Objective: Aim: To investigate the etiology, pathogenesis, and effectiveness of pharmacotherapy and psychotherapeutic modalities of delusions in Schizophrenia spectrum and other Psychotic Disorders.

Patients And Methods: Materials and Methods: In our study, we included English-language studies from online databases such as Web of Science, Scopus, Google Scholar, PubMed, and the Cochrane Library conducted until January 2024 using the following keywords "delusions", "Schizophrenia spectrum and other Psychotic Disorders", "pharmacotherapy", "psychotherapy", and "antipsychotics". Scientific novelty: There is already published evidence that has studied Schizophrenia spectrum disorders from definition to treatment.

Causes of stress and its impact on women's mental and physical health.

Objective: Aim: The aim is to investigate the causes of stress and its impact on women's mental and physical health indicators.

Patients And Methods: Materials and Methods: The research was conducted from 2022 to 2024 and involved 157 women from Zhytomyr oblast (Ukraine) of different ages, education, professions, and geographic residence. The research methods included analysis of literary sources, medical and sociological (survey), statistical method.

Comprehensive assessment of caries resistance in 6 -7 year-old children residing in Poltava and internally displaced children.

Objective: Aim: The aim of this study is to assess caries resistance in children from Poltava and internally displaced children from frontline regions by analyzing caries indicators and oral fluid properties. This will help evaluate the impact of war and displacement on their dental health.

Patients And Methods: Materials and Methods: This study was conducted at the City Children Dental Clinic in Poltava and included 330 children aged 6-7 years, of whom 56.

Immunohistochemical evaluation of SOX-10 in patients with urinary bladder cancer.

Objective: Aim: To evaluate the expression levels of SOX-10 in tissues of bladder tumor and to prove the correlation between SOX-10 expression and clinicopathological characteristics of bladder tumors, including patient age, sex, tumor grade, and muscle invasion.

Patients And Methods: Materials and Methods: Forty formalin fixed paraffin embedded FFPE tissue blocks gathered by transurethral resection of bladder tumor are collected from teaching hospitals at Al-Najaf governorate. Those blocks were stained by hematoxylin and eosin.

The effect of succinic acid in liposomal emulsion on the humoral component of the immune system of rats.

Objective: Aim: To investigate the effect of succinic acid on the humoral component of the immune system in rats.

Patients And Methods: Materials and Methods: The study was conducted on two groups of mature non-linear white rats (males) of similar weight (200-270 g, aged 6-8 months), with 5 animals in each group. The control group was fed a standard diet with free access to water throughout the experiment.

Anatomic-biomechanical substantiation of stabilization of the sacroiliac joint in cases of unstable pelvic injuries with a countersink-compression screw.

Objective: Aim: Study the mechanism of interaction between the 'sacroiliac joint - screw' system and determine the optimal parameters of the stabilizing structure, the strength of the system connection through computer modeling, and anatomical-biomechanical experiment.

Patients And Methods: Materials and Methods: The optimal parameters of the stabilizing structure for the sacroiliac joint were calculated using software package MathCAD. To validate the results of the numerical modeling, corresponding investigations of mechanical characteristics and determination of stiffness of the studied systems were conducted by an upgraded testing stand, TIRAtest-2151.

Treatment of chronic wounds of the lower limb with the use of VAC-therapy. Impact on immunity and bacterial films.

Objective: Aim: To improve the results of treatment of patients with chronic wounds of the lower extremities by using complex treatment, including surgical interventions, VAC- therapy, as well as studying the effect of negative pressure on bacterial films of wounds, based on microbiological examination and immune-histochemical data.

Patients And Methods: Materials and Methods: During the period from 2019 to 2023 at the department's clinic, 68 patients with chronic wounds of the lower extremities were examined and treated. These are mainly women (n=63) aged from 35 to 80 years.

Phytochemical analysis of ethanolic leaf extract of Cordia myxa and its anti-Inflammatory and cytotoxic activities.

Objective: Aim: Testing Cordia myxa extract on colon cancer cell line and caspase-3 gene and COX-2 protein expression.

Patients And Methods: Materials and Methods: This study used Cordia myxa ethanolic extract at various dosages on SW480 cells. Cell proliferation was measured using MTT, also examined effect of Cordia myxa extract on caspase-3 gene expression using quantitative real-time polymerase chain reaction.

Change of the anterior talus-fibular ligament length of asymptomatic patients during inversion stress test.

Objective: Aim: To study the ATFL length among asymptomatic population of young patients on both joints by using the method of ultrasound examination of the ankle joint and applying the inversion stress test.

Patients And Methods: Materials and Methods: the length of the ATFL was measured among 60 boys and 60 girls during the research. Sonography was performed on both joints, in each of the two studied positions, three times per position in order to obtain the average ligament length.

Heart rate and blood pressure in soccer players differing in sports qualification.

Objective: Aim: To investigate the effects of exercise training on heart rate and blood pressure in soccer players of different skill levels.

Patients And Methods: Materials and Methods: 693 soccer players with different sports qualifications were studied. Heart rate (HR) and blood pressure (BP) were measured at rest at the beginning of the preparatory phase of the training cycle.

Assessment of prescribing practice of anti-hypertensive medications in a sample of Iraqi patients with diabetes.

Objective: Aim: This research aims to comprehensively assess the prescribing practices of anti-hypertensive medications in a sample of Iraqi patients with diabetes. Specifically, exploring medication types and classes, adherence to clinical guidelines for managing hypertension in the context of diabetes, and factors influencing prescribing decisions.

Patients And Methods: Materials and Methods: This descriptive cross-sectional retrospective study investigates medication usage in an outpatient clinic in Najaf, Iraq, utilizing systematic sampling.

Evaluation of the clinical effectiveness of conservative (pre-surgical) treatment schemes for generalized periodontitis in patients with various somatic pathologies.

Objective: Aim: Optimization of conservative treatment schemes for generalized periodontitis (GP) against the background of somatic pathology, depending on the indicators of the Community Periodontal Index of Treatment Needs (CPITN).

Patients And Methods: Materials and Methods: CPITN was performed in 134 patients with GP against the background of various somatic pathologies and divided into main and comparison subgroups. Treatment scheme No.