Imaging of Ischemia/Reperfusion-mediated Aminopeptidase N Expression in Surgical Rat Model Using Ga-NOTA-c(NGR).

Background/aim: Previous studies have already shown that Gallium(Ga)-labeled NGR-based radiopharmaceuticals specifically bind to the neoangiogenic molecule Aminopeptidase N (APN/CD13). The aim of this study was to evaluate the applicability of Ga-NOTA-c(NGR) in the in vivo detection of the temporal changes of APN/CD13 expression in the diabetic retinopathy rat model using positron emission tomography (PET).

Materials And Methods: Ischemia/reperfusion injury was initiated by surgical ligation of the left bulbus oculi of rats.

Adaptive fuzzy deformable fusion and optimized CNN with ensemble classification for automated brain tumor diagnosis.

Automatic classification of brain tumor plays a vital role to speed up the treatment procedure, plan and boost the survival rate of patients. Nowadays, Magnetic Resonance Imaging (MRI) is employed for determining brain tumor. However, manual identification of brain tumor is purely based on the sensitivity and experience of medical professionals.

Effects of Pre-Tensile Deformation on the Fatigue Fracture Behavior of Annealed 7005 Aluminum Alloy Plate.

In the present study, the fatigue life and fatigue fracture characteristics of annealed 7005 aluminum alloy plates subjected to different pre-tensile deformations were investigated. The results obtained upon increasing the pre-tensile deformation of the alloy plate to 20% revealed that the second-phase particles did not show any obvious changes, and that the thickness of the thin strip grain slightly decreased. The dislocation distribution in the alloy matrix varied significantly among the grains or within each grain as the dislocation density gradually increased with increasing pre-tensile deformation.

Prevalence of Anxiety and Depression in Patients With Multiple Sclerosis in Saudi Arabia: A Cross-Sectional Study.

Introduction Multiple sclerosis (MS) is a chronic disease of progressive demyelination in the central nervous system and carries a significant risk for depression and other psychological difficulties associated with low quality of life. There is a paucity of data on the prevalence of anxiety and depression in Saudi Arabia among patients with MS. We conducted a cross-sectional study to determine the prevalence of anxiety and depression in Saudi Arabia among patients with MS by age, disease severity, compliance to medication, and social support.

Reaction-Diffusion Dynamics of pH Oscillators in Oscillatory Forced Open Spatial Reactors.

Studying the effect of coupling and forcing of oscillators is a significant area of interest within nonlinear dynamics and has provided evidence of many interesting phenomena, such as synchronization, beating, oscillatory death, and phase resetting. Many studies have also reported along this line in reaction-diffusion systems, which are preferably explored experimentally by using open reactors. These reactors consist of one or two homogeneous (well-stirred) tanks, which provide the boundary conditions for a spatially distributed part.

Evaluation of different models for validating of photovoltaic cell temperature under semi-arid conditions.

Photovoltaic (PV) solar energy enables direct production of electricity. The photovoltaic effect produced in the solar cells converts light energy from the sun's rays into electricity. Some of the solar radiation absorbed by a PV module is not converted into electricity but takes the form of an increase in the temperature of the module, reducing its electrical efficiency.

Prospects for beyond the Standard Model physics searches at the Deep Underground Neutrino Experiment: DUNE Collaboration.

The Deep Underground Neutrino Experiment (DUNE) will be a powerful tool for a variety of physics topics. The high-intensity proton beams provide a large neutrino flux, sampled by a near detector system consisting of a combination of capable precision detectors, and by the massive far detector system located deep underground. This configuration sets up DUNE as a machine for discovery, as it enables opportunities not only to perform precision neutrino measurements that may uncover deviations from the present three-flavor mixing paradigm, but also to discover new particles and unveil new interactions and symmetries beyond those predicted in the Standard Model (SM).

Design of Optimized Coded LFM Waveform for Spectrum Shared Radar System.

To meet the increasing demands for remote sensing, a number of radar systems using Linear Frequency Modulation (LFM) waveforms have been deployed, causing the problem of depleting frequency resources. To address this problem, several researchers have proposed the Spectrum Shared Radar System (SSRS) in which multiple radars share the same frequency band to transmit and receive their own signals. To mitigate the interferences caused by the signal transmission by other radars, SSRS employs orthogonal waveforms that inherit the orthogonality of the waveforms from orthogonal codes.

Peptide Based Inhibitors of Protein Binding to the Mitogen-Activated Protein Kinase Docking Groove.

Mitogen-activated protein kinases (MAPK) are important regulatory units in cells and they take part in the regulation of many cellular functions such as cell division, differentiation or apoptosis. All MAPKs have a shallow docking groove that interacts with linear binding motifs of their substrate proteins and their regulatory proteins such as kinases, phosphatases, scaffolds. Inhibition of these protein-protein interactions may reduce or abolish the activity of the targeted kinase.

In vivo preclinical assessment of novel Ga-labelled peptides for imaging of tumor associated angiogenesis using positron emission tomography imaging.

Formation and growth of metastases require a new vascular network. Angiogenesis plays an essential role in the expansion and progression of most malignancies. A high number of molecular pathways regulate angiogenesis, including vascular endothelial growth factor (VEGF), αβ integrin, matrix metalloproteinases (MMPs), or aminopeptidase N.

Mepolizumab for chronic rhinosinusitis with nasal polyps (SYNAPSE): a randomised, double-blind, placebo-controlled, phase 3 trial.

Background: Chronic rhinosinusitis with nasal polyps affects approximately 2-4% of the general population, and long-term use of systemic corticosteroids is associated with adverse effects. The aim of this study was to assess the efficacy and safety of mepolizumab in adults with recurrent, refractory severe bilateral chronic rhinosinusitis with nasal polyps.

Methods: SYNAPSE was a randomised, double-blind, placebo-controlled, parallel-group, phase 3 trial done at 93 centres, mainly hospitals, in 11 countries.

A Low-Fat Diet Combined with Moderate-Intensity Aerobic Exercise is More Effective than a Low-Fat Diet or Aerobic Exercise Alone on Dyslipidemia and Depression Status in Obese Patients: A Randomized Controlled Trial.

Background & Objective: Exercise and dietary interventions are used to control dyslipidemia and depression in obese individuals, whilst rare investigations have examined the concurrent effects of a low-fat diet and moderate-intensity aerobic exercise training (MIAET) on dyslipidemia and depression in obese patients. Hence, we assessed the potential influences of a low-fat diet combined with MIAET on blood lipids and depression in those individuals.

Methods: Forty-two obese patients aged 30-50 years have been enrolled in this randomized controlled trial.

Is ischaemic modified albumin a marker in osteomyelitis patients?

Objective: To compare the levels of ischaemia modified albumin between osteomyelitis patients and healthy controls.

Methods: The cross-sectional prospective study was conducted at Van Yüzüncü Yıl University, Van, Turkey, from May 2018 to May 2019, and comprised inpatients diagnosed with osteomyelitis, and healthy controls. Serum IMA concentrations were determined spectrophotometrically at 470nm wavelength.

Molecular Imaging of the Efficacy of Aminopeptidase N (APN/CD13) Receptor Inhibitor Treatment on Experimental Tumors Using Ga-NODAGA-c(NGR) Peptide.

Introduction: The aminopeptidase N (APN/CD13) receptor plays an important role in the neoangiogenic process and metastatic tumor cell invasion. Clinical and preclinical studies reported that bestatin and actinonin are cytotoxic to APN/CD13-positive tumors and metastases due to their APN/CD13-specific inhibitor properties. Our previous studies have already shown that Ga-labeled NGR peptides bind specifically to APN/CD13 expressing tumor cells.

3D CNN with Visual Insights for Early Detection of Lung Cancer Using Gradient-Weighted Class Activation.

The 3D convolutional neural network is able to make use of the full nonlinear 3D context information of lung nodule detection from the DICOM (Digital Imaging and Communications in Medicine) images, and the Gradient Class Activation has shown to be useful for tailoring classification tasks and localization interpretation for fine-grained features and visual explanation for the internal working. Gradient-weighted class activation plays a crucial role for clinicians and radiologists in terms of trusting and adopting the model. Practitioners not only rely on a model that can provide high precision but also really want to gain the respect of radiologists.

Infrared Monitoring of Oxygenation Process Generated by Robotic Verticalization in Bedridden People.

Bedridden people, especially at home, suffer from diverse pathologies beyond the main one that brings them to a specific position. Long-term cares are suitable at home to avoid congestions within hospital facilities. There are different technologies available to improve such people's conditions in their daily life.

Canadian Rhinology Working Group consensus statement: biologic therapies for chronic rhinosinusitis.

Background: Recent evidence suggests that biologic therapy with targeted activity within the Type 2 inflammatory pathway can improve the clinical signs and symptoms of chronic rhinosinusitis with nasal polyposis (CRSwNP). There remains a population in CRSwNP that despite medical therapy and endoscopic sinus surgery have persistent signs and symptoms of disease. Therefore, biologics, monoclonal antibody agents, could be beneficial therapeutic treatments for these patients.

Formation of Phases and Microstructures in Al-8Si Alloys with Different Mg Content.

Mg-containing high-silicon aluminum alloy is a heat-treatable aluminum alloy that is now widely used in the aerospace and automotive industries because of its high specific strength, high wear resistance and corrosion resistance, low thermal expansion coefficient, and low cost. More attention has been paid to optimizing the microstructure to increase the performance of this type of aluminum alloy. In the present work, the solidification processes of Mg-free and Mg-containing (0.

Obesity induced by high-fat diet is associated with critical changes in biological and molecular functions of mesenchymal stromal cells present in visceral adipose tissue.

The mesenchymal stromal cells (MSCs) residing within the stromal component of visceral adipose tissue appear to be greatly affected by obesity, with impairment of their functions and presence of senescence. To gain further insight into these phenomena, we analyzed the changes in total proteome content and secretome of mouse MSCs after a high-fat diet (HFD) treatment compared to a normal diet (ND). In healthy conditions, MSCs are endowed with functions mainly devoted to vesicle trafficking.

Effects of Crack Tip Constraint on the Fracture Toughness Assessment of 9% Ni Steel for Cryogenic Application in Liquefied Natural Gas Storage Tanks.

Recently, increasing demand for the accurate assessment of the structural integrity and fitness-for-service (FFS) analysis of engineering structures has elevated constraint effects to one of the most important issues in fracture mechanics and structural integrity research. In this paper, the effect of crack tip constraints are investigated on the fracture toughness assessment of 9% Ni steel for application in liquefied natural gas storage tanks. Crack tip opening displacement (CTOD) tests were conducted using both conventional standard three-point bending (3PB) and wide plate (WP) specimens at a cryogenic temperature of -196 °C.

Algorithms for testing COVID-19 focused on use of RT-PCR and high-affinity serological testing: A consensus statement from a panel of Latin American experts.

Unlabelled: The COVID-19 pandemic has caused an unprecedented public health, social, and economic crisis. Improving understanding on available tests for detecting COVID-19 is critical for effective management of the pandemic. We proposed that a multidisciplinary expert panel can establish recommendations on ideal use of diagnostic tools, with a focus on RT-PCR and serological high-affinity antibodies (both IgM and IgG) tests for the Latin America region.

A Randomized Comparative Study between High-Intensity and Low-Level Laser Therapy in the Treatment of Chronic Nonspecific Low Back Pain.

Objectives: Chronic nonspecific low back pain (chronic nsLBP) is one of the most common musculoskeletal disorders leading to disabilities and physical inactivity. Laser therapy was used in chronic nsLBP treatment; however, no previous studies have assessed the impacts of high-intensity laser therapy (HILT) versus low-level laser therapy (LLLT) on chronic nsLBP. This study compared the effects of HILT versus LLLT on individuals suffering from chronic nsLBP.