[ Skan total flavones ameliorate rheumatoid arthritis in rats by suppressing formation of neutrophil extracellular traps].

Objective: To investigate the therapeutic mechanism of Skan total flavonoids (PHSTF) for rheumatoid arthritis (RA).

Methods: Twenty-five male SD rats were randomly divided into normal control group, RA model group, PHSTF treatment (45 and 90 mg/kg) groups, and Tripterygium glycosides (TPG) tablet (10 mg/kg) group (=5). Except for those in the normal control group, all the rats were subjected to collagen-induced arthritis (CIA) modeling using a secondary immunization method, after which PHSTF and TPG were administered via gavage once daily for 4 weeks.