338 results match your criteria: "Engineering Research Center of Bone and Joint Precision Medicine[Affiliation]"

The incidence, clinical features, and risk factors for postoperative retropharyngeal hematoma and related dyspnea following anterior cervical discectomy and fusion: a single-center study of 10,615 patients.

Spine J

December 2024

Orthopedic Department, Peking University Third Hospital, Beijing, China; Engineering Research Center of Bone and Joint Precision Medicine, Peking University, Beijing, China; Beijing Key Laboratory of Spinal Disease Research, Peking University, Beijing, China. Electronic address:

Background Context: Postoperative retropharyngeal hematoma (PRH) and related dyspnea are rare but life-threatening complications following anterior cervical discectomy and fusion (ACDF) that require urgent recognition and treatment. However, current knowledge of PRH after ACDF is limited. Meanwhile, whether the morphological features of upper airway are the risk factors of PRH remains unknown.

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Objective: A robotic system was recently introduced to improve prosthetic alignment during total knee arthroplasty (TKA). The purpose of this multicenter, prospective, randomized controlled trial (RCT) was to determine whether robotic-arm-assisted TKA improves clinical and radiological outcomes when compared to conventional TKA.

Methods: One hundred and thirty patients who underwent primary TKA were enrolled in this prospective, randomized controlled trial, which was conducted at three hospitals.

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Background: Tourniquet is applied in Total Knee Arthroplasty (TKA) to reduce intraoperative blood loss and improve view of surgical field. However, tourniquet use in TKA is still in dispute. Some researchers find that tourniquet may lead to extra side effects such as aggravated pain and limb swelling, while others consider that tourniquet has no significant adverse impact on clinical outcomes of TKA patients.

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Article Synopsis
  • - The study aimed to develop measurable criteria for assessing fusion after anterior cervical corpectomy and fusion (ACCF), addressing the limitations of current qualitative evaluation methods.
  • - Using imaging data from 178 patients, the study analyzed interspinous motion (ISM) through dynamic radiographs and CT scans, finding significant correlations and reliable cutoff values for detecting pseudarthrosis.
  • - The results indicated that ISM-dis had a sensitivity of 87.8% and specificity of 92.3% at a cutoff of 1.50 mm, while ISM-ang showed sensitivity of 79.1% and specificity of 92.3% at a cutoff of 1.75°, leading to fusion rates of 52.
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Purpose: The aims of this study were to investigate the correlations between Chinese version of Lumbar Stiffness Disability Index (C-LSDI) and other clinical outcomes, and to identify the factors independently affecting stiffness-related disability after long-segment fusion in patients with degenerative lumbar scoliosis (DLS).

Methods: We performed a retrospective study of 118 consecutive surgically treated DLS cases at a single institute. Pre- and post-operative radiological parameters and postoperative health related quality of life (HRQOL) were examined to determine their correlation coefficients with postoperative C-LSDI.

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Background: Clinical repair of critical-sized bone defects (CBDs) in the tibial diaphysis presents numerous challenges, including inadequate soft tissue coverage, limited blood supply, high load-bearing demands, and potential deformities. This study aimed to investigate the clinical feasibility and efficacy of employing 3D-printed prostheses for repairing CBDs exceeding 10 cm in the tibial diaphysis.

Methods: This retrospective study included 14 patients (11 males and 3 females) with an average age of 46.

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Article Synopsis
  • The study is a retrospective cohort analysis comparing long-term outcomes of laminoplasty (LP) versus a combined procedure (CP) involving laminoplasty and anterior cervical discectomy in patients with multilevel degenerative cervical myelopathy and simultaneous anterior and posterior compression.
  • A total of 230 patients were studied, with the final analysis matching 84 pairs based on preoperative conditions; results showed that CP had longer surgery times and greater blood loss but better improvement in neurological scores (JOA scores and recovery rates).
  • The findings suggest that both surgical options lead to significant neurological recovery, but the combined procedure may offer superior benefits in improving patient outcomes when performed by experienced surgeons.
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Purpose: This study evaluates the influence of spinal malalignment on health-related quality of life (HRQOL) in a long-level fusion spine.

Methods: This was a retrospective analysis of 121 consecutive patients with DLS after long-segment fusion. HRQOL and radiographic parameters were collected at final follow-up.

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Backgrounds: The ossification of the ligamentum flavum (OLF) is one of the major causes of thoracic myelopathy. Previous studies indicated there might be a potential link between metabolic disorder and pathogenesis of OLF. The aim of this study was to determine the potential role of metabolic disorder in the pathogenesis of OLF using the strict bioinformatic workflow for metabolism-related genes and experimental validation.

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Posterior Thoracic Antidisplacement and Fusion Surgery for a Special Type of Ossification of the Posterior Longitudinal Ligament in the Thoracic Spine: Indications and Preliminary Clinical Results of 2-Year Follow-Up.

World Neurosurg

September 2024

Department of Orthopaedics, Peking University Third Hospital, Beijing, China; Beijing Key Laboratory of Spinal Disease Research, Beijing, China; Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Beijing, China. Electronic address:

Objective: To describe a novel technique, posterior thoracic antidisplacement and fusion (PTAF), for a special type of ossification of the posterior longitudinal ligament in the thoracic spine (T-OPLL), and to evaluate its safety and efficacy.

Methods: From July to December 2020, 5 consecutive patients with beak-type T-OPLL located at the thoracic vertebral body level underwent PTAF surgery. Their demographic data, radiological parameters, perioperative complications, and surgery-related findings were recorded and analyzed.

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Purpose: Patients with total knee arthroplasty (TKA) often suffer from severe postoperative pain, which seriously hinders postoperative rehabilitation. Extended reality (XR), including virtual reality, augmented reality, and mixed reality, has been increasingly used to relieve pain after TKA. The purpose of this study was to evaluate the effectiveness of XR on relieving pain after TKA.

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Study Design: Retrospective cohort study.

Objective: This study aimed to compare postoperative pain and surgical outcomes of open-door laminoplasty (LP) and three types of muscle-sparing laminoplasties, namely unilateral muscle-preservation laminoplasty (UL), spinous process splitting double-door laminoplasty (DL) and intermuscular "raising roof" laminoplasty (RL) for multilevel degenerative cervical myelopathy (MDCM).

Methods: Consecutive MDCM patients underwent LP or modified laminoplasties (UL, DL, RL) in 2022 were enrolled.

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Background: The accelerated growth of older individuals worldwide has increased the number of patients presenting with fragility hip fractures. Having a hip fracture can cause excess mortality, and patients with hip fracture have a higher risk of death than those without hip fracture. Most studies have treated hip fracture as a single, homogeneous condition, but hip fracture includes two major anatomic types: intertrochanteric fracture and femoral neck fracture.

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Background: Osteoporotic vertebral compression fractures (OVCF) caused by osteoporosis is a common clinical fracture type. There are many surgical treatment options for OVCF, but there is a lack of comparison among different options. Therefore, we counted a total of 104 cases of OVCF operations with different surgical plans, followed up the patients, and compared the surgical outcome indications before, after and during the follow-up.

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Article Synopsis
  • * It includes 83 MDCM patients who underwent surgery between 2012 and 2014, using various clinical assessments (JOA and NDI) to evaluate outcomes, and employs propensity score matching to ensure comparable preoperative conditions between the groups.
  • * Results show that although both groups had similar preoperative scores and follow-up durations, the combined approach had a longer surgery time but better overall outcomes were not clearly defined in the text provided.
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Paraspinal muscle endurance and morphology (PMEM) score: a new method for prediction of postoperative mechanical complications after lumbar fusion.

Spine J

October 2024

Department of Orthopaedics, Peking University Third Hospital, Beijing, 100191, China; Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Beijing, 100191, China; Beijing Key Laboratory of Spinal Disease Research, Beijing, 100191, China. Electronic address:

Background Context: Although the relationships between paraspinal muscles and lumbar degenerative disorders have been acknowledged, paraspinal muscle evaluation has not been incorporated into clinical therapies.

Purpose: We aimed to establish a novel paraspinal muscle endurance and morphology (PMEM) score to better predict mechanical complications after lumbar fusion.

Study Design: Prospective cohort study.

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Patient-specific 3D-printed Brace for Adolescent Idiopathic Scoliosis: A Prospective Cohort Study.

World Neurosurg

September 2024

Department of Orthopaedics, Peking University Third Hospital, Beijing, China; Beijing Key Laboratory of Spinal Disease Research, Peking University Third Hospital, Beijing, China; Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Peking University Third Hospital, Beijing, China.

Article Synopsis
  • The study aimed to assess the effectiveness and safety of personalized 3D printed braces for treating adolescent idiopathic scoliosis (AIS) and to compare their impact on patients' health-related quality of life (HRQoL) against traditional braces.
  • Over a three-year period, 103 AIS patients were monitored, and their compliance with brace usage and the progression of spinal curvature were evaluated through clinical exams and standardized questionnaires.
  • Results showed that the 3D printed brace (3DPB) had a lower maximum Cobb angle of curvature compared to the traditional thoracolumbosacral orthosis (TLSO), indicating better outcomes in terms of both curve progression and weight, suggesting 3DPB may be a more effective treatment option
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Background: It was reported the paraspinal muscle played an important role in spinal stability. The preoperative paraspinal muscle was related to S1 screw loosening. But the relationship between preoperative and postoperative change of psoas major muscle (PS) and S1 pedicle screw loosening in degenerative lumbar spinal stenosis (DLSS) patients has not been reported.

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Article Synopsis
  • Muscle strength (MS) is crucial for diagnosing and evaluating rehabilitation, and existing wearable technologies have limitations in accuracy and analysis methods.
  • This study introduces a wearable device that uses myoelectric and strain sensors to accurately measure muscle signals during activities, employing a new deep learning model called Tcnformer for precise MS grading.
  • By utilizing deep clustering, the research achieves a detailed 25-level classification of MS, demonstrating its potential to improve recovery assessment in clinical settings, as shown by a patient's postoperative improvement from level 3.2 to 3.6.
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Mimicking the mechanical properties of cortical bone with an additively manufactured biodegradable Zn-3Mg alloy.

Acta Biomater

July 2024

Beijing Advanced Innovation Center for Materials Genome Engineering, School of Materials Science and Engineering, University of Science and Technology Beijing, 30 Xueyuan Road, Haidian District, Beijing, 100083, China; Institute of Materials Intelligent Technology, Liaoning Academy of Materials, Shenyang, 110004, China. Electronic address:

Additively manufactured (AM) biodegradable zinc (Zn) alloys have recently emerged as promising porous bone-substituting materials, due to their moderate degradation rates, good biocompatibility, geometrically ordered microarchitectures, and bone-mimicking mechanical properties. While AM Zn alloy porous scaffolds mimicking the mechanical properties of trabecular bone have been previously reported, mimicking the mechanical properties of cortical bone remains a formidable challenge. To overcome this challenge, we developed the AM Zn-3Mg alloy.

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Background: The next-generation sequencing (NGS) has developed rapidly in the past decade and is becoming a promising diagnostic tool for periprosthetic infection (PJI). However, its diagnostic value for PJI is still uncertain. The purpose of this systematic review and meta-analysis was to evaluate the diagnostic value of NGS compared to culture.

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A finite element model of cervical kyphosis was established to analyze the stress of cervical spine under suspensory traction and to explore the mechanism and effect of it. A patient with typical cervical kyphosis (C2-C5) underwent CT scan imaging, and 3D slicer was used to reconstruct the C2 to T2 vertebral bodies. The reconstructed data was imported into Hypermesh 2020 and Abaqus 2017 for meshing and finite element analysis.

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In recent years, the use of zinc (Zn) alloys as degradable metal materials has attracted considerable attention in the field of biomedical bone implant materials. This study investigates the fabrication of porous scaffolds using a Zn-1Mg-0.1Sr alloy through a three-dimensional (3D) printing technique, selective laser melting (SLM).

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Coatless modification of 3D-printed Ti6Al4V implants through tailored Cu ion implantation combined with UV photofunctionalization to enhance cell attachment, osteogenesis and angiogenesis.

Colloids Surf B Biointerfaces

June 2024

Department of Orthopedics, Peking University Third Hospital, Beijing 100191,  People's Republic of China; Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, Beijing 100191, People's Republic of China; Beijing Key Laboratory of Spinal Disease Research, Beijing 100191, People's Republic of China. Electronic address:

The three-dimensional-printed Ti6Al4V implant (3DTi) has been widely accepted for the reconstruction of massive bone defects in orthopedics owing to several advantages, such as its tailored shape design, avoiding bone graft and superior bone-implant interlock. However, the osteoinduction activity of 3DTi is inadequate when applied clinically even though it exhibits osteoconduction. This study developes a comprehensive coatless strategy for the surface improvement of 3DTi through copper (Cu) ion implantation and ultraviolet (UV) photofunctionalization to enhance osteoinductivity.

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Impact of pelvic anteversion on spinopelvic alignment in an asymptomatic population: a dynamic perspective of standing and sitting.

Spine J

September 2024

Orthopaedic Department, Peking University Third Hospital, No. 49 North Garden Road, Haidian District, Beijing 100191, China; Beijing Key Laboratory of Spinal Disease Research, No. 49 North Garden Road, Haidian District, Beijing 100191, China; Engineering Research Center of Bone and Joint Precision Medicine, Ministry of Education, No. 49 North Garden Road, Haidian District, Beijing 100191, China. Electronic address:

Background Context: A subgroup of patients with pelvic anteversion can present with an unusually large degree of lumbar lordosis (LL), a highly sloped sacrum, and a relatively small pelvic incidence (PI). Prior to lumbar surgery, it can be important to consider such unique sagittal alignment. However, until now, there has been a lack of a predictive model considering different pelvic alignments.

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