5,075 results match your criteria: "Endometrial Carcinoma* Obstetrics and Gynecology"

Hypercalcemia is a significant complication in cancer patients, primarily caused by parathyroid hormone-related peptide (PTHrP) and, rarely, by parathyroid hormone (PTH) production from tumors. We report a case of severe hypercalcemia in a woman with uterine cancer who exhibited elevated PTH and PTHrP levels. Surgical intervention revealed dedifferentiated endometrial carcinoma.

View Article and Find Full Text PDF

Unlabelled: Genetically engineered mouse models (GEMM) have fundamentally changed how ovarian cancer etiology, early detection, and treatment are understood. MYC, an oncogene, is amongst the most amplified genes in high-grade serous ovarian cancer (HGSOC), but it has not previously been utilized to drive HGSOC GEMMs. We coupled Myc and dominant-negative mutant p53-R270H with a fallopian tube epithelium (FTE)-specific promoter Ovgp1 to generate a new GEMM of HGSOC.

View Article and Find Full Text PDF

GnRH-a-based fertility-sparing treatment of atypical endometrial hyperplasia (AEH) and early endometrial carcinoma (EC) patients: a multicenter, open-label, randomized designed clinical trial protocol.

Trials

September 2024

Department of Obstetrics and Gynecology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, National Clinical Research Center for Obstetric and Gynecologic Diseases, No. 1 ShuaiFuYuan, Dongcheng District, Beijing, 100730, China.

Background: Around 4% of women receive an endometrial cancer diagnosis before turning 40, mainly those without prior childbirth experience and a strong desire to preserve their ability to conceive. Consequently, for young patients diagnosed with atypical endometrial hyperplasia (AEH) or early endometrial carcinoma (EC), a fertility-preserving approach employing high-dose oral progesterone has been adopted. However, previous research has shown a notable relapse rate.

View Article and Find Full Text PDF

Background: Since the seminal publication of the TCGA consortium in 2013, the molecular classification of endometrial cancer has been widely accepted as a new and powerful tool to better understand the natural history of this malignancy. Adoption of routine molecular classification around the world has been limited. We sought to demonstrate our initial experience in incorporating the four molecular subtypes for endometrioid carcinomas.

View Article and Find Full Text PDF
Article Synopsis
  • There is a significant challenge in diagnosing ovarian high-grade endometrioid carcinoma (HGEC) and high-grade serous carcinoma (HGSC) due to their similar histopathological features, leading to variability among observers.
  • A study analyzed a variety of ovarian cancer samples using advanced sequencing and clustering techniques, identifying four distinct tumor groups with different characteristics and survival outcomes.
  • The findings suggest that a specific subset of tumors, termed "HGEC-type," shows favorable prognosis and endometrial differentiation, which may often be misclassified as HGSCs, indicating a need for improved diagnostic strategies.
View Article and Find Full Text PDF

Sulindac exhibits anti-proliferative and anti-invasive effects in uterine serous carcinoma cells.

J Cancer Res Clin Oncol

August 2024

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA.

Purpose: Uterine serous carcinoma (USC) is a highly aggressive and frequently recurring subtype of endometrial cancer with limited treatment options for advanced or recurrent stages. Sulindac, a classic non-steroidal anti-inflammatory drug, has demonstrated anti-tumor activity in several pre-clinical tumor models. This study aims to evaluate the effect of sulindac on cell proliferation and invasion in USC cells.

View Article and Find Full Text PDF

Genetic association of lipids and lipid-lowering drug target genes with Endometrial carcinoma: a drug target Mendelian randomization study.

Front Endocrinol (Lausanne)

August 2024

Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Guangdong Provincial Key Laboratory of Major Obstetric Diseases, Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology, Guangdong-Hong Kong-Macao Greater Bay Area Higher Education Joint Laboratory of Maternal-Fetal Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China.

Article Synopsis
  • Aberrant lipid metabolism is linked to endometrial cancer, prompting the study of statins as potential therapies, using Mendelian randomization (MR) to explore lipid traits' impact on the cancer.
  • The study employed two-sample MR, finding no causal relationship between genetically predicted lipid traits and endometrial carcinoma, but identifying drug targets like apolipoprotein B (APOB) and cholesteryl ester transfer protein (CETP) as relevant.
  • Conclusions indicated no direct link between lipid traits (LDL-C, TG, TC, HDL-C) and endometrial cancer, yet highlighted APOB's association with lower risk and CETP's with higher risk for endometrioid carcinoma, pointing to
View Article and Find Full Text PDF

Background: Endometrial cancer is the most common gynecological malignancy; however, there is no useful blood diagnostic biomarker. This study aimed to determine the utility of tissue factor pathway inhibitor 2 (TFPI2), a biomarker of ovarian cancer, as a diagnostic marker for endometrial cancer.

Methods: We examined serum TFPI2 levels in patients with endometrial cancer (n = 328) compared to those in healthy controls (n = 65) and evaluated the performance of serum TFPI2 levels as a diagnostic marker.

View Article and Find Full Text PDF

Objective: The 2023 International Federation of Gynecology and Obstetrics classification with molecular classification shows superior discriminatory ability compared to staging systems lacking molecular data. However, the accuracy of endometrial biopsy data in molecular classification remains uncertain. This study aimed to assess the concordance of molecular classifications between preoperative biopsy and hysterectomy to predict prognosis before surgical staging.

View Article and Find Full Text PDF

Endometrial carcinoma with cervical stromal invasion: Three case reports.

World J Clin Cases

August 2024

Department of Radiology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China.

Article Synopsis
View Article and Find Full Text PDF

To analyze the lympho-vascular space invasion (LVSI) in different molecular subtypes of the cancer genome atlas (TCGA) molecular subtypes of endometrial cancer (EC) and to evaluate the prognostic value of LVSI in EC patients with different molecular subtypes. A total of 258 patients diagnosed EC undergoing surgery in Peking University People's Hospital from January 2016 to June 2022 were analyzed retrospectively. Among 258 patients, 14 cases were classified as POLE-ultramutated subtype, 43 as high-microsatellite instability (MSI-H) subtype, 155 as copy-number low (CNL) subtype, and 46 as copy-number high (CNH) subtype.

View Article and Find Full Text PDF

Endometrial cancer risk stratification using MRI radiomics: corroborating with choline metabolism.

Cancer Imaging

August 2024

Department of Medical Imaging and Intervention, Chang Gung Memorial Hospital at Linkou, 5 Fuhsing St, Guishan, Taoyuan, 33382, Taiwan.

Background And Purpose: Radiomics offers little explainability. This study aims to develop a radiomics model (Rad-Score) using diffusion-weighted imaging (DWI) to predict high-risk patients for nodal metastasis or recurrence in endometrial cancer (EC) and corroborate with choline metabolism.

Materials And Methods: From August 2015 to July 2018, 356 EC patients were enrolled.

View Article and Find Full Text PDF

Robotic-assisted versus conventional laparoscopic surgery for endometrial cancer: long-term results of a randomized controlled trial.

Am J Obstet Gynecol

August 2024

Department of Obstetrics and Gynecology, Tampere University Hospital, Tampere, Finland; Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland; FICAN Mid.

Background: Robotic-assisted laparoscopy has become a widely and increasingly used modality of minimally invasive surgery in the treatment of endometrial cancer. Due to its technical advantages, robotic-assisted laparoscopic surgery offers benefits, such as a lower rate of conversions compared to conventional laparoscopy. Yet, data on long-term oncological outcomes after robotic-assisted laparoscopy is scarce and based on retrospective cohort studies only.

View Article and Find Full Text PDF

Expression and clinical significance of KDM5A, KDM5B, and FOXO1 in endometrial cancer.

Pol J Pathol

August 2024

Department of Obstetrics and Gynecology, Jiangxi Cancer Hospital, The Second Affiliated Hospital of Nanchang Medical College, Jiangxi Clinical Research Center for Cancer, Nanchang, Jiangxi, China.

There is growing evidence that the KDM5 family of histone demethylases plays a causal role in human cancer. However, few studies have been reported on the KDM5 family in endometrial carcinoma (EC). Moreover, it was found that there was some correlation between the KDM5 family and FOXO1 in EC.

View Article and Find Full Text PDF

Background: Uterine endometrial cancer (UEC) is a common gynecological estrogen-dependent carcinoma, usually accompanied by intermenstrual bleeding. Active heme metabolism frequently plays an increasingly important role in many diseases, especially in cancers. Tumor-associated macrophages (TAMs) are the major population in the immune microenvironment of UEC.

View Article and Find Full Text PDF
Article Synopsis
  • Obesity is a significant risk factor for endometrial intraepithelial neoplasia (EIN) and uterine cancer, yet the use of weight-loss therapy in these patients is not well understood.
  • An analysis of data from over 15,000 patients shows that only a small percentage utilized weight-loss therapy within a year of diagnosis, although usage has increased from 2009 to 2020.
  • Factors such as younger age and higher comorbidity scores were linked to a greater likelihood of receiving weight-loss therapy, indicating a need for improved accessibility and awareness in treating obese patients with EIN or uterine cancer.
View Article and Find Full Text PDF

Introduction: This study used single-center data to analyze the clinicopathological features of site-specific endometrial cancer.

Methods: Patients with endometrial carcinoma who had undergone surgery at Peking Union Medical College Hospital, China, between March 2016 and January 2022 were enrolled. Clinical information and pathological characteristics were summarized, and microsatellite status was analyzed using the immunohistochemical method.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the role of HER2 in endometrial carcinoma, particularly focusing on its expression in different cancer types and the implications for treatment, as conventional anti-HER2 therapies are not typically used for this cancer.
  • Out of 530 patients, 124 (23%) had HER2-positive tumors, with over half displaying low HER2 expression, and a significant association was found between HER2 positivity and poorer outcomes in terms of progression-free survival (PFS) and overall survival (OS).
  • The findings suggest that HER2-targeted therapies could be beneficial for endometrial carcinoma patients, especially those with co-expression of HER2 and p53 aberrations, which serves as an independent prognostic marker for worse
View Article and Find Full Text PDF

Introduction: Advanced mixed epithelial endometrial carcinomas are rare high-grade cancers with a poor prognosis. A clear cell component infers relative chemotherapy insensitivity, likely further increased by p53 wild type status and MMR deficiency. PD-1 inhibition for MMR deficient endometrial cancers has been recently added to first-line adjuvant treatment in combination with platinum-based chemotherapy.

View Article and Find Full Text PDF

ERP29 regulates the proliferation of endometrial carcinoma via M6A modification.

Life Sci

October 2024

Department of Obstetrics and Gynecology, the Second Affiliated Hospital of Zhengzhou University, 2nd, Jingba Road, Zhengzhou 450053, Henan Province, China. Electronic address:

Aims: Endoplasmic reticulum protein 29 (ERP29) is crucial for endoplasmic reticulum stress (ERS). M6A plays an important role in the progression of endometrial cancer (EC). The study investigated the role of ERS-related gene (ERP29) and m6A in EC.

View Article and Find Full Text PDF
Article Synopsis
  • The study investigates the potential cellular origins and molecular subtypes of clear cell ovarian carcinoma (CCOC) using advanced genomic and epigenomic analyses of 78 samples.
  • Findings revealed that ARID1A and PIK3CA mutations occur without mutations in certain DNA repair genes and identified major CCOC subtypes associated with specific tissue types.
  • CCOC subtypes were categorized into three clusters based on mutations and morphological similarities, with implications for understanding their biological behavior and guide treatment approaches.
View Article and Find Full Text PDF

Exploring metastasis and recurrence patterns in low-risk grade 3 endometrial cancer: A multicenter retrospective cohort study.

Eur J Obstet Gynecol Reprod Biol

October 2024

Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Seoul, Republic of Korea; Department of Obstetrics and Gynecology, Seoul National University Bundang Hospital, Seongnam, Republic of Korea. Electronic address:

Objective: Females with low-risk endometrial cancer typically have low lymph node metastasis risk and promising prognosis without lymphadenectomy. However, the impact of grade 3 endometrial cancer on nodal involvement, recurrence, and prognosis within this specific subgroup remains unclear. Therefore, in this study, we aimed to investigate the prognosis, patterns of metastasis, and recurrence in a subgroup of females with grade 3 early-stage low-risk endometrioid endometrial cancer.

View Article and Find Full Text PDF

Introduction: This observation study aimed to differentiate between lobular endocervical glandular hyperplasia (LEGH) and gastric-type mucinous carcinoma (GAS) while evaluating the feasibility and efficacy of laparoscopic surgery in the preoperative diagnosis of cervical cystic lesions.

Method And Material: A retrospective study was conducted to evaluate the diagnostic process and laparoscopic surgical management of cervical cystic lesions suspected to be LEGH or GAS. Preoperatively and postoperatively, MRI, cytology, histology, tumor marker analysis, and surgical outcomes (blood loss during surgery, operative time) were assessed.

View Article and Find Full Text PDF

Background: The prevalence of endometrial polyps among asymptomatic, postmenopausal women is not well defined. There is no clear clinical consensus on how to manage endometrial polyps in this population and whether these polyps truly are a cause for clinical concern.

Objective: This study aimed to estimate the prevalence of endometrial polyps among asymptomatic (without bleeding), postmenopausal women and to evaluate risk factors associated with their presence.

View Article and Find Full Text PDF