2 results match your criteria: "Endocrinology and Diabetes Center Yokohama Rosai Hospital Yokohama Japan.[Affiliation]"
Article Synopsis
- - The study explored the causal relationship between primary aldosteronism (PA) and cardiovascular diseases such as coronary artery disease (CAD), congestive heart failure (CHF), and stroke, using a cross-ancestry meta-analysis of genetic data.
- - The researchers identified 7 genetic loci linked to PA risk through an extensive analysis of East Asian and European ancestry samples, finding increased risk estimates for CAD, CHF, and stroke among individuals with PA.
- - The findings suggest that PA significantly raises the risk of various cardiovascular issues, underlining the importance of early screening and intervention for individuals at risk.
Background Primary aldosteronism can cause cardiac dysfunction, including left ventricular hypertrophy, left ventricular diastolic dysfunction, and left atrial enlargement. A few studies have compared the cardioprotective effects between surgery and medication for primary aldosteronism, although most have not adjusted for baseline disease status. In this study, we investigated the difference in cardiovascular outcomes between surgery and medication treatment for primary aldosteronism after adjusting for baseline clinical characteristics, including aldosterone level and pretreatment echocardiographic information.
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