32,225 results match your criteria: "Endemic Syphilis"
Enhancing insights in sexually transmitted infection mapping: Syphilis in Forsyth County, North Carolina, a case study.
PLoS Comput Biol
October 2024
Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, North Carolina, United States of America.
Article Synopsis
- Forsyth County, NC saw a significant rise in syphilis cases from 2008 to 2011, reaching over 35 cases per 100,000 and reflecting trends observed in 2021 statewide.
- The study utilized advanced techniques like donut geomasking and a moving window grid to enhance data accuracy while protecting privacy and addressing statistical issues.
- Results demonstrated that these methods improved predictions of syphilis rates by 5% to 26% compared to traditional approaches, offering better insights into outbreak hotspots and transmission dynamics in the context of changing societal behaviors.
Assessing the Quality and Accuracy of Syphilis-Related Content on TikTok and YouTube: A Comprehensive Analysis.
Sex Transm Dis
February 2025
Dermatology and Dermatological Surgery Department, Prince Sultan Military Medical City, Riyadh, Saudi Arabia.
Background: Sexually transmitted infections, including syphilis, pose a significant public health challenge. The advent of social media platforms has revolutionized health information dissemination, with YouTube and TikTok emerging as prominent sources. However, concerns persist regarding the reliability of syphilis-related content on these platforms.
View Article and Find Full Text PDFAcquired syphilis in the context of pre-exposure prophylaxis for HIV: a systematic review of the scientific literature.
AIDS Rev
October 2024
Faculty of Medicine, University of Brasília (UnB), Brasília.
The aim of this study was systematically review the acquired syphilis before and during follow-up of pre-exposure prophylaxis (PrEP) for HIV. We analyzed articles that studied PrEP users with the outcome of acquired syphilis. The eligibility criteria were studies retrieved from the United States National Library of Medicine (Pubmed), Latin American and Caribbean Health Sciences Literature (Lilacs), Embase and Scopus databases, published between 2012 and 2023, in English, Spanish or Portuguese.
View Article and Find Full Text PDFThe Resurgence of Infections and Reinfections during the COVID-19 Pandemic in Greece.
Int J Environ Res Public Health
September 2024
Department of Microbiology, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Article Synopsis
- * A study analyzed medical records over 14 months after the pandemic began, finding that among mainly men with a median age of 43, syphilis cases nearly doubled, particularly in individuals with HIV.
- * The study concluded that the pandemic was a significant factor in rising syphilis rates, underscoring the need for improved healthcare access and prevention strategies during future health crises.
A retrospective analysis of syphilis cases with a focus on otolaryngology at a university hospital.
Auris Nasus Larynx
December 2024
Department of Otolaryngology, Head and Neck Surgery, Tokai University, School of Medicine, Isehara, Japan.
Objectives: In recent years, there has been a notable increase in syphilis cases in Japan and Western countries. Syphilis, a classic sexually transmitted disease caused by treponemas, presents diagnostic challenges due to its diverse clinical manifestations. This study explores the diagnosis of syphilis in patients treated at our hospital.
View Article and Find Full Text PDFAtypical Presentation of Tertiary Syphilis.
Radiol Cardiothorac Imaging
October 2024
From the Departments of Radiology (P.C., L.C.) and Internal Medicine (J.S., D.F.), University Hospital Gabriel Montpied, 58 rue Montalembert, F-63000 Clermont-Ferrand, France; and Department of Radiology, Institut Pascal, TGI, UMR6602 CNRS SIGMA Université Clermont Auvergne, Clermont-Ferrand, France (L.C.).
Article Synopsis
- Syphilis is a sexually transmitted infection that can progress through multiple stages, with tertiary syphilis potentially affecting the cardiovascular system 10 to 40 years after the initial infection.
- The case highlighted involves a 49-year-old man who experienced temporary vision loss, leading to hospital admission where imaging showed severe cardiovascular complications like aortitis and stroke.
- A postmortem examination confirmed the diagnosis of tertiary syphilis, revealing syphilitic aortitis as the underlying cause of the patient's severe health issues.
Transfusion-transmissible coinfections among US blood donors.
Transfusion
December 2024
Infectious Disease Consultant, North Potomac, Maryland, USA.
Background: Transfusion-transmissible infection (TTI) prevalence among US blood donors has been widely documented. Here we estimate the prevalence of donors presenting with ≥2 TTIs (multiple infections past or present referred to as coinfections) and describe their demographics and associations.
Methods: Data from the Transfusion-Transmissible Infections Monitoring System were compiled for October 2020-September 2023 (3 years).
Omics detection and treatment of syphilis.
Clin Chim Acta
January 2025
Department of Clinical Laboratory Medicine, Institution of Microbiology and Infectious Diseases, Hunan Province Clinical Research Center for Accurate Diagnosis and Treatment of High-incidence Sexually Transmitted Diseases, The First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang 421001, China. Electronic address:
Treponema pallidum is the source of the chronic systemic sexually transmitted illness syphilis. T. pallidum can evade immunity and spread.
View Article and Find Full Text PDFMaternal and neonatal outcomes of congenital syphilis at a tertiary care center in Turkey; a retrospective observational study.
J Obstet Gynaecol
December 2024
Department of Obstetrics and Gynecology, Antalya Training and Research Hospital, Antalya, Turkey.
Article Synopsis
- Maternal syphilis (MS) is a serious condition that can lead to problems for both mothers and their newborns, requiring careful treatment to avoid complications.
- A study reviewed medical records of 64 pregnant women with MS to assess their health outcomes and the number of cases over three years, revealing trends in patient demographics and treatment results.
- Findings showed that many women received inadequate treatment, resulting in a range of complications for both mothers and infants, highlighting the need for improved prenatal care to address these issues effectively.
A loop-mediated isothermal amplification test for yaws: a multi-country diagnostic accuracy evaluation.
Lancet Glob Health
November 2024
Faculty of Infectious Diseases, London School of Hygiene & Tropical Medicine, London, UK; Hospital for Tropical Diseases, London, UK; Division of Infection and Immunity, University College London, London, UK.
Background: To meet the WHO target of eradicating yaws by 2030, highly sensitive and specific diagnostic tools are needed. A multiplex Treponema pallidum-Haemophilus ducreyi loop-mediated isothermal amplification (TPHD-LAMP) test holds promise as a near-patient diagnostic tool for yaws and H ducreyi. We conducted a prospective evaluation in Cameroon, Côte d'Ivoire, Ghana, and the Republic of the Congo to determine the diagnostic accuracy of the TPHD-LAMP test, as well as to assess its acceptability, feasibility, and cost.
View Article and Find Full Text PDFNewborns with microcephaly in Brazil and potential vertical transmission of Oropouche virus: a case series.
Lancet Infect Dis
October 2024
Department of Arbovirology and Hemorrhagic Fever, Evandro Chagas Institute, Ananindeua, Pará, Brazil. Electronic address:
Background: Oropouche fever, an orthobunyavirus disease endemic in Brazilian Amazon, has caused many febrile epidemics. In 2024, an epidemic of Oropouche fever spread in Brazil, with more than 7930 cases reported between Jan 1 and Aug 31. Infections in pregnant people have suggested the possibility of negative fetal consequences, therefore we tested newborns with microcephaly for known congenital pathogens and Oropouche virus (OROV).
View Article and Find Full Text PDFFeasibility, Preference, and Impact of a Rapid Multiplexed Point-of-Care Digital Innovation (AideSmart!) to Expedite Screening of Sexually Transmitted Blood-Borne Infections in At-Risk Populations in Canada: Cross-Sectional Study.
J Med Internet Res
October 2024
Infectious Diseases and Immunity in Global Health, Research Institute of the McGill University Health Centre, Montreal, QC, Canada.
Article Synopsis
- There is a growing need for faster detection of sexually transmitted blood-borne infections (STBBIs), leading to the development of digital innovations like AideSmart!, an app that supports multiplexed testing by health care workers in community settings.
- The study aimed to evaluate AideSmart! for its feasibility and impact, allowing healthcare providers to perform rapid STBBI tests while offering counseling and ensuring quality care.
- Results showed that all participants accepted the app's testing strategy, with a majority preferring rapid tests to traditional methods and valuing the quick turnaround of results, which took only 15 minutes.
Paroxysmal sympathetic hyperactivity caused by neurosyphilis.
BMJ Neurol Open
October 2024
Department of Neurology, Tsuchiura Kyodo General Hospital, Tsuchiura-shi, Ibaraki, Japan.
Article Synopsis
- Paroxysmal sympathetic hyperactivity (PSH) is a condition linked to autonomic nervous system dysfunction, often seen in severe brain injuries, but non-traumatic causes like infections can also trigger it.
- A case study discusses a 30-year-old man diagnosed with neurosyphilis who experienced abnormal symptoms like seizures and agitation, leading to a PSH diagnosis after ruling out other conditions.
- Treatment with propranolol, gabapentin, and clonidine successfully managed his PSH symptoms, highlighting the importance of recognizing and addressing PSH early in cases of central nervous system infections.
Epidemic of multiple Treponema pallidum strains in men who have sex with men in Japan: efficient multi-locus sequence typing scheme and indicator biomarkers.
AIDS Res Ther
October 2024
Department of Infectious Diseases and Applied Immunology, IMSUT Hospital of The Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo, 108-8639, Japan.
Article Synopsis
- This study investigates the molecular epidemiology of syphilis in Japanese men who have sex with men (MSM), focusing on the relationship between bacteremia and disease effects.
- Researchers analyzed whole blood samples from syphilis-positive MSM predominantly living with HIV in Tokyo between 2019 and 2022 using multi-locus sequence typing for genetic analysis.
- Findings show the presence of two main strains of Treponema pallidum and a significant correlation between the detection of a specific genetic marker and elevated C-reactive protein levels, suggesting active infection.
Syndemic Approaches Are Needed to Address Maternal Substance Use and Syphilis in North Carolina.
N C Med J
March 2024
Department of Medicine, School of Medicine, Wake Forest University.
[Atypical presentation of syphilis. The great pretender].
Medicina (B Aires)
October 2024
Hospital General de Agudos José María Ramos Mejía, Buenos Aires, Argentina.
Oral syphilis - the great imitator: a series of six cases.
Br Dent J
October 2024
Division of Oral and Maxillofacial Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Dublin Dental University Hospital, School of Dental Science, Trinity College Dublin, Dublin 2, Ireland.
Article Synopsis
- Syphilis is known as the 'great mimicker' due to its ability to show non-specific symptoms and can affect various organs, with the oral cavity often involved in the early stages.
- The rise in syphilis cases worldwide, reflected in recent clinical observations, emphasizes the importance of recognizing its diverse presentations for timely diagnosis and treatment.
- Dentists play a crucial role in identifying oral syphilis manifestations, which can help prevent serious complications and reduce the spread of the infection.
18 F-THK5351 PET Is Superior to Conventional MRI in Identifying Inflammatory Lesions by Imaging Astrogliosis in 2 Cases of Neurosyphilis.
Clin Nucl Med
December 2024
From the Department of Neurology.
18 F-labeled THK5351 PET can visualize ongoing astrogliosis by estimating monoamine oxidase B levels and can be used as a neuroinflammation marker for identifying inflammatory lesions by imaging astrogliosis. Assessment of its performance is of interest, especially when compared with conventional MRI. Here, we present 2 cases of neurosyphilis, in which 18 F-THK5351 PET identified inflammatory lesions by imaging astrogliosis, whereas MRI had difficulty detecting the lesions.
View Article and Find Full Text PDFA model of prevention of mother-to-child transmission and health management team for improving adverse outcomes of pregnancy syphilis in Ningxia, China.
BMC Infect Dis
October 2024
Department of Periodontics, Stomatological Hospital, General Hospital of Ningxia Medical University, 804 Shengli South Street, Xingqing District, Yinchuan, 750003, Ningxia, China.
Article Synopsis
- The study evaluates the PMTCT (Prevention of Mother-to-Child Transmission) model combined with Health Management Teams (HMT) to reduce adverse outcomes in pregnant women with syphilis in the Ningxia region.
- Findings show that this model improved participants' knowledge and counseling rates, leading to a significant decrease in adverse pregnancy outcomes like miscarriages and preterm births.
- The study also highlights factors linked to negative outcomes, such as non-residency, unmarried status, and lower education levels, emphasizing the need for equitable healthcare for vulnerable populations in Ningxia.
A case of early-onset congenital syphilitic osteomyelitis of the calcaneus and literature review.
BMC Pediatr
October 2024
Department of Orthopaedic Surgery, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Article Synopsis
- Congenital syphilis (CS) can lead to rare cases of calcaneal osteomyelitis in infants, as illustrated by a case involving a 4-month-old boy with swelling in his foot but no prior trauma.
- Imaging revealed bone loss in the calcaneus, and the infant had a history of CS diagnosed during an earlier hospitalization.
- Timely surgical intervention and antibiotic therapy were successful in healing the bone and restoring mobility, highlighting the importance of considering CS in cases of unexplained foot infections in infants.
Intertriginous Rash in Secondary Syphilis.
N Engl J Med
October 2024
Chiang Mai University, Chiang Mai, Thailand
Prevalence of syphilis and associated factors among pregnant women in Brazil: systematic review and meta-analysis.
Rev Bras Ginecol Obstet
October 2024
Universidade Federal de Goiás GoiâniaGO Brazil Universidade Federal de Goiás, Goiânia, GO, Brazil.
Objective: This systematic review accompanied by a meta-analysis aimed to estimate the prevalence of syphilis in pregnant women in Brazil and describe its associated factors.
Methods: Following the establishment the search strategies and the registration of the review protocol in PROSPERO, we conducted a search for relevant articles in the Pubmed, LILACS, Science Direct, SciELO and Web of Science databases. Our inclusion criteria were cross-sectional studies published between 2005 and 2023, with no language restrictions.
Syphilis and pregnancy.
Rev Bras Ginecol Obstet
October 2024
Universidade Federal de Ciências da Saúde de Porto Alegre Porto AlegreRS Brazil Universidade Federal de Ciências da Saúde de Porto Alegre, Porto Alegre, RS, Brazil.
Article Synopsis
- Congenital syphilis remains a significant issue in obstetric care despite having a definitive cause, accessible diagnosis, and effective treatment due to rising syphilis rates in the general population.
- Reporting syphilis cases has improved data collection, yet it has not led to a decrease in infection rates due to various factors, including inadequate education and the lack of strict health policies for prenatal and postnatal care.
- Fear of adverse reactions to the standard treatment, benzathine penicillin, and the overall failure to adhere to specific treatment protocols hinder effective management of syphilis in pregnant women, as supported by the Brazilian Federation of Gynecology and Obstetrics Associations.
High increase of Nichols-like clade circulating Treponema pallidum subsp. pallidum in Barcelona from 2021 to 2023.
Sci Rep
October 2024
Department of Microbiology and Parasitology, Clinical Laboratories, Vall d'Hebron University Hospital, Passeig Vall d'Hebron 119-129, 08035, Barcelona, Spain.
Article Synopsis
- * The researchers identified 96 TPA-positive samples, finding 47.9% were SS14-like and 52.1% were Nichols-like, revealing a notable increase in Nichols-like strains compared to previous data.
- * All samples displayed mutations linked to resistance against macrolide antibiotics, while none showed tetracycline resistance, highlighting the need for ongoing surveillance to track syphilis strain variations and improve public health responses.