1,154 results match your criteria: "Encephalitis Western Equine"
Medicina (B Aires)
December 2024
Clínica La Pequeña Familia, Junín, Buenos Aires, Argentina.
Western equine encephalitis is a zoonotic viral disease transmitted by the bite of an infected mosquito. Humans are terminal hosts and since they develop a very low and short lasting viremia, they are incapable of transmitting the disease. Most cases are asymptomatic, but it can present with high fever, myalgia and encephalitis or meningitis.
View Article and Find Full Text PDFWe report the genomic analysis from early equine cases of the Western equine encephalitis virus outbreak during 2023-2024 in Uruguay. Sequences are related to a viral isolate from an outbreak in 1958 in Argentina. A viral origin from South America or continuous enzootic circulation with infrequent spillover is possible.
View Article and Find Full Text PDFViruses
October 2024
Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA.
Western equine encephalitis virus (WEEV) is a mosquito-borne arbovirus (genus , family ) that has re-emerged in South America in late 2023, causing severe disease in both horses and humans after a nearly 40-year intermission period. We here describe the virological, serological, pathological, and molecular features of WEEV infection in horses during the 2023-2024 outbreak in Argentina. WEEV-infected horses developed neurological signs with mild to severe encephalitis associated with minimal to abundant WEEV-infected cells, as demonstrated by WEEV-specific in situ hybridization.
View Article and Find Full Text PDFPathogens
October 2024
Department of Applied Veterinary Sciences, United Graduate School of Veterinary Sciences, Gifu University, 1-1 Yanagido, Gifu 501-1193, Japan.
Equine herpesvirus type 1 (EHV-1) causes rhinopneumonitis, abortion, and neurological outbreaks (equine herpesvirus myeloencephalopathy, EHM) in horses. EHV-1 also causes lethal encephalitis in small laboratory animals such as mice and hamsters experimentally. EHV-1 ORF76 is a homolog of HSV-1 US9, which is a herpesvirus kinase.
View Article and Find Full Text PDFInfect Disord Drug Targets
October 2024
School of Pharmacy, LNCT University, Bhopal, Madhya Pradesh, 462042, India.
Cell Rep
October 2024
Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA; Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, Saint Louis, MO 63110, USA. Electronic address:
Cell Res
November 2024
Key Laboratory of Virology and Biosafety, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China.
Arch Argent Pediatr
September 2024
Department of Infectious Diseases; Hospital General de Niños Pedro de Elizalde, City of Buenos Aires, Argentina.
Arch Argent Pediatr
August 2024
Department of Infectious Diseases; Clínica La Pequeña Familia, Junín, Argentina.
Nature
August 2024
Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Infect Dis (Lond)
September 2024
Centro de Investigación en Sanidad Animal (CISA-INIA), CSIC, Valdeolmos, Spain.
Background: West Nile Virus (WNV) is a zoonotic arbovirus worldwide spread. Seasonal WNV outbreaks occur in the Mediterranean basin since the late 1990's with ever-increasing incidence. In Southern Spain WNV is endemic, as disease foci - caused by WNV lineage 1 (WNV-L1) strains - occur every year.
View Article and Find Full Text PDFMethods Protoc
May 2024
Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
medRxiv
April 2024
Secretaria de Saúde do Estado do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil.
Vaccine
April 2024
Bavarian Nordic GmbH, Fraunhoferstrasse 13, 82152 Martinsried, Germany. Electronic address:
NPJ Vaccines
February 2024
Division of Microbiology, Tulane National Primate Research Center, Covington, LA, USA.
Viruses
December 2023
Quigley BioPharma LLC, 114 Water Tower Plaza No. 1042, Leominster, MA 01453, USA.
Japanese encephalitis virus is a mosquito-borne member of the family. JEV is the leading cause of viral encephalitis in Asia and is characterized by encephalitis, high lethality, and neurological sequelae in survivors. The virus also causes severe disease in swine, which are an amplifying host in the transmission cycle, and in horses.
View Article and Find Full Text PDFXi Bao Yu Fen Zi Mian Yi Xue Za Zhi
January 2024
Department of Microbiology and Pathogenic Biology, Basic Medical Science Academy, Air Force Medical University, Xi'an 710032, China. *Corresponding authors, E-mail:
Objective To prepare mouse monoclonal antibodies against the ectodomain of E2 (E2ecto) glycoprotein of Western equine encephalitis virus (WEEV). Methods A prokaryotic expression plasmid pET-28a-WEEV E2ecto was constructed and transformed into BL21 (DE3) competent cells. E2ecto protein was expressed by IPTG induction and presented mainly as inclusion bodies.
View Article and Find Full Text PDFNat Commun
January 2024
Department of Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA.
Viruses
September 2023
Viral Zoonoses, Emerging and Vector-Borne Infections Group, Institute of Virology, University of Veterinary Medicine Vienna, Veterinärplatz 1, 1210 Vienna, Austria.
Cell
October 2023
Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Pathology & Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, Saint Louis, MO 63110, USA; Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, Saint Louis, MO 63110, USA. Electronic address:
MXRA8 is a receptor for chikungunya (CHIKV) and other arthritogenic alphaviruses with mammalian hosts. However, mammalian MXRA8 does not bind to alphaviruses that infect humans and have avian reservoirs. Here, we show that avian, but not mammalian, MXRA8 can act as a receptor for Sindbis, western equine encephalitis (WEEV), and related alphaviruses with avian reservoirs.
View Article and Find Full Text PDFPathogens
August 2023
Zoonotic Arbo- and Respiratory Virus Research Program, Centre for Viral Zoonoses, Department of Medical Virology, University of Pretoria, Pretoria 0084, South Africa.
Viruses in the genus, family, are associated with encephalitis, birth defects and fatalities in animals, and some are zoonotic. Molecular diagnostic investigations of animals with neurological signs previously identified Shuni virus (SHUV) as the most significant orthobunyavirus in South Africa (SA). To determine if other orthobunyaviruses occur in SA, we screened clinical specimens from animals with neurological signs, abortions, and acute deaths from across SA in 2021 using a small (S) segment Simbu serogroup specific TaqMan real-time reverse transcription polymerase chain reaction (RT-PCR).
View Article and Find Full Text PDFbioRxiv
August 2023
Department of Biology, University of Oxford, Oxford, United Kingdom.
While rodents are primary reservoirs of Venezuelan equine encephalitis virus (VEEV), their role in Madariaga virus (MADV) transmission remains uncertain, particularly given their overlapping geographic distribution. This study explores the interplay of alphavirus prevalence, rodent diversity, and land use within Darien and Western Panama provinces. A total of three locations were selected for rodent sampling in Darien province: Los Pavitos, El Real de Santa Maria and Santa Librada.
View Article and Find Full Text PDFA diverse group of RNA viruses including Rabies, Polio, La Crosse, West Nile, Zika, Nipah, Eastern and Western equine encephalitis, Venezuelan equine encephalitis, Japanese encephalitis, and tick-borne encephalitis viruses have the ability to gain access to and replicate in the central nervous system (CNS), causing severe neurological disease. Current treatment for these patients is generally limited to supportive care. To address the need for a generalizable antiviral, we utilized a strategy of mutagenesis to limit virus replication.
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