1,221 results match your criteria: "Encephalitis Eastern Equine"
PLoS One
December 2024
Institute of Virology, Charité - Universitätsmedizin Berlin, Corporate Member of Free University Berlin, Humboldt-University Berlin, and Berlin Institute of Health, Berlin, Germany.
The genus Alphavirus harbors arboviruses of great concern, such as the Chikungunya virus and the equine encephalitis viruses. Transmission of pathogenic alphaviruses by mosquitoes could be influenced by insect-specific alphaviruses such as Eilat virus (EILV). However, insect-specific alphaviruses are rarely found in wild mosquitoes and only a few have been described in the literature.
View Article and Find Full Text PDFTrends Microbiol
December 2024
Department of Cell Biology, Albert Einstein College of Medicine, Bronx, NY, USA. Electronic address:
Alphaviruses are a serious threat to global health and can cause lethal encephalitic or arthritogenic disease in humans and animals. As there are no licensed antivirals, it is critical to improve our understanding of alphavirus interactions with the host cell. Here, we focus on the essential alphavirus protein capsid.
View Article and Find Full Text PDFArch Dermatol Res
December 2024
Northwestern University, Chicago, IL, USA.
bioRxiv
November 2024
Department of Immunology and Center for Vaccine Research, University of Pittsburgh, Pittsburgh, PA 15261.
Naturally circulating strains of eastern equine encephalitis virus (EEEV) bind heparan sulfate (HS) receptors and this interaction has been linked to its neurovirulence. Previous studies associated EEEV-HS interactions with three positively charged amino acid clusters on the E2 glycoprotein. One of these sites has recently been reported to be critical for binding EEEV to very-low-density lipoprotein receptor (VLDLR), an EEEV receptor protein.
View Article and Find Full Text PDFNew Microbes New Infect
December 2024
Department of Internal Medicine, Metropolitan Hospital Center, New York, NY, USA.
Cell Rep
October 2024
Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA; Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA; Andrew M. and Jane M. Bursky Center for Human Immunology and Immunotherapy Programs, Washington University School of Medicine, St. Louis, MO 63110, USA; Center for Vaccines and Immunity to Microbial Pathogens, Washington University School of Medicine, Saint Louis, MO 63110, USA. Electronic address:
Can Commun Dis Rep
September 2024
Department of Biological Risks, Institut national de santé publique du Québec (INSPQ), Montréal, QC.
Background: Climate change is likely to increase the risk of human transmission of arboviruses endemic to Canada, including West Nile virus (WNV), Eastern equine encephalitis virus (EEEV) and California serogroup virus (CSV), calling for enhanced surveillance, including entomological surveillance targeting mosquito vectors. A scoping review was carried out to document the public health contributions of entomological surveillance of arboviruses of importance in Canada.
Methods: The Ovid® and EBSCO platforms and the grey literature were searched to identify documents published between 2009 and 2023, in English or French, dealing with entomological surveillance of arboviruses of interest, conducted annually for human health purposes under the aegis of a government authority, with specified public health objectives and actions.
bioRxiv
August 2024
Diamond Light Source, Harwell Science & Innovation Campus, Didcot, United Kingdom.
Nat Commun
August 2024
Beijing Frontier Research Center for Biological Structure, Center for Infectious Disease Research, School of Basic Medical Sciences, Tsinghua University, Beijing, 100084, P.R. China.
Eastern Equine Encephalitis virus (EEEV) is an alphavirus that can cause severe diseases in infected humans. The very low-density lipoprotein receptor (VLDLR) was recently identified as a receptor of EEEV. Herein, we performed cryo-electron microscopy structural and biochemistry studies on the specific interactions between EEEV and VLDLR.
View Article and Find Full Text PDFNat Commun
August 2024
Department of Microbiology, Blavatnik Institute, Harvard Medical School, Boston, MA, USA.
Eastern equine encephalitis virus (EEEV) is the most virulent alphavirus that infects humans, and many survivors develop neurological sequelae, including paralysis and intellectual disability. Alphavirus spike proteins comprise trimers of heterodimers of glycoproteins E2 and E1 that mediate binding to cellular receptors and fusion of virus and host cell membranes during entry. We recently identified very-low density lipoprotein receptor (VLDLR) and apolipoprotein E receptor 2 (ApoER2) as cellular receptors for EEEV and a distantly related alphavirus, Semliki Forest virus (SFV).
View Article and Find Full Text PDFMethods Protoc
May 2024
Virology Division, U.S. Army Medical Research Institute of Infectious Diseases, Frederick, MD 21702, USA.
Vector Borne Zoonotic Dis
October 2024
VectorID LLC, Frederick, Maryland, USA.
PNAS Nexus
April 2024
Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, CO 80045, USA.
J Vet Diagn Invest
May 2024
Department of Pathobiology, University of Guelph, Guelph, Ontario, Canada.
Vaccine
April 2024
Bavarian Nordic GmbH, Fraunhoferstrasse 13, 82152 Martinsried, Germany. Electronic address:
NPJ Vaccines
February 2024
Division of Microbiology, Tulane National Primate Research Center, Covington, LA, USA.
Viruses
January 2024
Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, CT 06520, USA.
J Med Entomol
May 2024
Florida Medical Entomology Laboratory, University of Florida Institute of Food and Agricultural Sciences, Vero Beach, FL, USA.
J Neurol Sci
February 2024
Department of Neurology, Yale School of Medicine, New Haven, CT, USA. Electronic address:
Microorganisms
December 2023
Center for Infectious Disease Research, School of Systems Biology, George Mason University, Manassas, VA 20110, USA.
ACS Omega
January 2024
Department of Agricultural Biotechnology and Research Institute of Agriculture and Life Sciences, Seoul National University, Seoul 08826, Republic of Korea.
J Med Entomol
March 2024
Department of Entomology and Nematology, Institute of Food and Agricultural Sciences, University of Florida, Gainesville, FL, USA.