2 results match your criteria: "Emory University Atlanta GA 30322 USA wwuest@emory.edu.[Affiliation]"
Metal chelation as an antibacterial strategy for and .
RSC Chem Biol
September 2024
Department of Chemistry, Emory University Atlanta GA 30322 USA
Article Synopsis
- By 2050, bacterial infections are projected to result in 1.8 million more deaths annually compared to cancer, highlighting a severe antibiotic discovery crisis.
- Gram-negative bacteria are particularly concerning due to their multi-drug resistance from their thick outer membrane.
- This review explores a new strategy to combat bacterial pathogenicity by disrupting metal homeostasis, improving antibiotic effectiveness, and discusses the limited success of metallophores in clinical trials.
After antibiotic treatment, a subpopulation of bacteria often remains and can lead to recalcitrant infections. This subpopulation, referred to as persisters, evades antibiotic treatment through numerous mechanisms such as decreased uptake of small molecules and slowed growth. Membrane perturbing small molecules have been shown to eradicate persisters as well as render these populations susceptible to antibiotic treatment.
View Article and Find Full Text PDF