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Article Synopsis
- Diabetes is widely prevalent and can lead to chronic high blood sugar levels, which negatively impact many organs, including bones, leading to a higher risk of osteoporosis among diabetic patients.
- The relationship between diabetes and osteoporosis involves complex mechanisms like the AGE-RAGE signaling pathway, which disrupts bone formation, and high glucose levels that can cause osteoblast cell death (ferroptosis).
- Current diabetes treatments like thiazolidinediones may help manage blood sugar but can trigger osteoporosis, and there's a need for better tools to assess fracture risk in diabetic patients to improve diagnosis and treatment outcomes.