Predictors of anterior chamber angle status at the time of neovascular glaucoma diagnosis.

Purpose: To identify clinical features which may predict the angle status of a large cohort of NVG eyes at the time of diagnosis.

Observations: Chart review was performed for all NVG eyes from 2010 to 2022. Complete angle closure was defined as having >75 % PAS, partial angle closure as having 1-75 % PAS, and open angles as having 0 % PAS.

Vaping: A Safe Alternative to Counteract Smoking? Case Report.

The respiratory impact of e-cigarette usage, also known as vaping, emerged as a significant healthcare issue in 2019. This concern arose due to the sharp rise in cases of e-cigarette or vaping-associated lung injury (EVALI) among adolescents and young adults. Now, systemic manifestations have been described.

H3K14la drives endothelial dysfunction in sepsis-induced ARDS by promoting SLC40A1/transferrin-mediated ferroptosis.

Pulmonary endothelial cell (EC) activation is a key factor in acute respiratory distress syndrome (ARDS). In sepsis, increased glycolysis leads to lactate buildup, which induces lysine lactylation (Kla) on histones and other proteins. However, the role of protein lactylation in EC dysfunction during sepsis-induced ARDS remains unclear.

Disseminated intravascular coagulation: cause, molecular mechanism, diagnosis, and therapy.

Disseminated intravascular coagulation (DIC) is a complex and serious condition characterized by widespread activation of the coagulation cascade, resulting in both thrombosis and bleeding. This review aims to provide a comprehensive overview of DIC, emphasizing its clinical significance and the need for improved management strategies. We explore the primary causes of DIC, including sepsis, trauma, malignancies, and obstetric complications, which trigger an overactive coagulation response.

A programme of support for care assistants of children admitted with cerebral palsy.

Background: Cerebral palsy affects children's movement and posture because of damage to the brain's development. Care assistants in healthcare facilities provide care to children. Caring for the children is overwhelming, hence support is required.

Bibliometric Analysis of Islamic Crowdfunding: A Literature Review of Its Journey.

Background: The potential of Islamic crowdfunding to encourage the development of Islamic fintech globally, even in countries with non-Muslim majority populations, needs to be examined in a literature study on this issue. More extensive research is needed regarding the factors that most reliably predict the success of Islamic crowdfunding, such as compliance with Islamic crowdfunding laws, sustainability, and the potential of Islamic finance. This article describes a comprehensive and systematic Literature Review (SLR) regarding papers published in the field of Islamic crowdfunding.

A proteomic atlas of glypican-3 interacting partners: Identification of alpha-fetoprotein and other extracellular proteins as potential immunotherapy targets in liver cancer.

Antibody and cell-based therapeutics targeting cell surface receptors have emerged as a major class of immune therapeutics for treating cancer. However, the number of cell surface targets for cancer immunotherapy remains limited. Glypican-3 (GPC3) is a cell surface proteoglycan and an oncofetal antigen.

Smart approaches for encouraging the blood donation.

Blood is a life saver in many emergencies like accidents or for the patients suffering from deadly diseases such as cancer and thalassemia. Conventionally, blood collection is done in five steps, i.e.

Determinants of mortality after massive transfusion - A prospective study.

Introduction: Massive hemorrhage calls for massive transfusions (MTs) to maintain adequate hemostasis. Massive transfusion protocols (MTPs) are the appropriate treatment strategy for such patients replacing conventional use of crystalloids. These help in standardizing and optimizing the delivery of blood components in a well-balanced ratio.

Hybrid breeding for fall armyworm resistance: Combining ability and hybrid prediction.

Fall armyworm (FAW, ) emerged as a major lepidopteran pest destroying maize in sub-Saharan Africa. A diallel mating design was used to generate 210 experimental hybrids from 21 lines. Experimental hybrids and four checks were evaluated in two locations.

Patient and public involvement in the design and protocol development for a platform randomised trial to evaluate diagnostic tests to optimise antimicrobial therapy (PROTECT).

Background: Our patient and public involvement activities were part of a project aiming to develop a master protocol and National Institute for Health and Care research application for the PROTECT trial aiming to assess the effectiveness, implementation, and efficiency of antimicrobial stewardship interventions, to safely reduce unnecessary antibiotic usage by excluding severe bacterial infection in acutely unwell patients.

Methods: Three public involvement sessions were held with representation from young people and parents, people from diverse backgrounds and people with experience of presenting to the emergency department with undifferentiated illness. The teleconference meetings lasted between 60-90 minutes, were recorded, notes were subsequently taken, and findings summarised.

Enhancing Diagnostic Precision: Intracardiac Echocardiography-Guided Endomyocardial Biopsy for Complex Right Atrial Mass.

An 80-year-old woman with a history of B-cell non-Hodgkin lymphoma presented to the emergency department with exertional dyspnea and lower limb edema. A transthoracic echocardiogram revealed a large extracardiac mass invading the right atrium. A diagnostic transcatheter endomyocardial biopsy guided by intracardiac echocardiography was performed.

Revitalizing Innovation: Addressing the Effects of the Downturn in Venture Capital for Cardiovascular Devices.

Venture capital (VC) plays a critical role in driving advancements in medical device innovations through its investment in early-stage companies. However, a concerning trend has emerged over the past decade: a decline in interest from VC funds toward investing in medical devices. Particularly alarming is the more than 50% decrease in investment in early-stage medical device development over the span of 2 decades.

Acute Kidney Injury Survivor Remote Patient Monitoring: A Single Center's Experience and an Effectiveness Evaluation.

Rationale & Objective: Remote patient monitoring (RPM) could improve the quality and efficiency of acute kidney injury (AKI) survivor care. This study described our experience with AKI RPM and characterized its effectiveness.

Study Design: A cohort study matched 1:3 to historical controls.

Telehealth for Goals of Care Conversations in Advanced CKD: A Mixed-Methods Pilot Study of US Veterans and Their Clinicians.

Rationale & Objective: Engaging patients with advanced chronic kidney disease (CKD) in goals of care (GOC) conversations is essential to align life-sustaining treatments with patient preferences. This pilot study described the feasibility of engaging older Veterans with advanced CKD in GOC conversations via telehealth by (1) comparing patient characteristics, including life-sustaining treatment note completion rates and preferences by visit modality, and (2) exploring Veteran and clinician perspectives surrounding telehealth GOC conversations.

Study Design: Mixed-method convergent design including a prospective, quantitative observational cohort analysis (n = 40) and qualitative, semi-structured interviews with 4 clinicians and 11 Veterans.

Unveiling the physicochemical, photocatalytic, antibacterial and antioxidant properties of MWCNT-modified AgO/CuO/ZnO nanocomposites.

Water pollution, oxidative stress and the emergence of multidrug-resistant bacterial strains are significant global threats that require urgent attention to protect human health. Nanocomposites that combine multiple metal oxides with carbon-based materials have garnered significant attention due to their synergistic physicochemical properties and versatile applications in both environmental and biomedical fields. In this context, the present study was aimed at synthesizing a ternary metal-oxide nanocomposite consisting of silver oxide, copper oxide, and zinc oxide (ACZ-NC), along with a multi-walled carbon nanotubes modified ternary metal-oxide nanocomposite (MWCNTs@ACZ-NC).

A dual antibacterial action of soft quaternary ammonium compounds: bacteriostatic effects, membrane integrity, and reduced and toxicity.

Quaternary ammonium compounds (QACs) have served as essential antimicrobial agents for nearly a century due to their rapid membrane-disrupting action. However, the emergence of bacterial resistance and environmental concerns have driven interest in alternative designs, such as "soft QACs", which are designed for enhanced biodegradability and reduced resistance potential. In this study, we explored the antibacterial properties and mechanisms of action of our newly synthesized soft QACs containing a labile amide bond within a quinuclidine scaffold.

Exploring potential key genes and pathways associatedwith hepatocellular carcinoma prognosis through bioinformatics analysis, followed by experimental validation.

Background: Liver Hepatocellular Carcinoma (LIHC) is a prevalent and aggressive liver cancer with limited therapeutic options. Identifying key genes involved in LIHC can enhance our understanding of its molecular mechanisms and aid in the development of targeted therapies. This study aims to identify differentially expressed genes (DEGs) and key hub genes in LIHC using bioinformatics approaches and experimental validation.

Enhanced analgesic efficacy and reduced stress response with ropivacaine transversus abdominis plane block in laparoscopic myomectomy.

Background: Managing postoperative pain and stress response was critical in laparoscopic myomectomy, a procedure for uterine fibroids. Ropivacaine transversus abdominis plane block (RTAPB) may offer enhanced analgesic efficacy and reduced stress responses compared to traditional analgesia.

Methods: This retrospective analysis examined 217 patients undergoing laparoscopic myomectomy at Hankou Hospital of Wuhan from June 2020 to September 2023.

Resuscitation of a case of allergy, infarction, and ventricular fibrillation: Kounis syndrome type II and literature review.

To study a case of Kounis syndrome (KS) type II, characterized by allergy, myocardial infarction, and ventricular fibrillation. A patient diagnosed with KS type II was admitted to Yangpu Hospital, School of Medicine, Tongji University in 2021. After systemic treatment, routine investigations, including blood tests, electrocardiography (ECG), and biochemical and coagulation analyses, were performed.

Nursing interventions guided by the theory of stress and adaptation improve the self-management ability of T2DM patients.

Objective: To investigate the effects of nursing interventions based on stress and accommodation theory on the mental state and self-management competence of patients with type 2 diabetes mellitus (T2DM).

Methods: Fifty-five T2DM patients admitted to our hospital in 2022 who received standard nursing interventions were selected as the control group, and 61 T2DM patients admitted in 2023 who received stress and adaptation theory-based nursing intervention in addition to standard nursing interventions were enrolled as the observation group. Changes of blood glucose levels, mood state score, self-management competence and life quality were compared between the two groups before and after intervention.

Clinical value of metagenomic sequencing in system evaluation of potential donors and donor-derived infection in kidney transplantation.

Objective: To explore the application and the clinical value of metagenomic sequencing in system evaluation of potential kidney donors, along with donor-derived infection in kidney transplantation.

Methods: A prospective study was conducted on 40 voluntary renal donors in Ningbo Urology and Kidney Disease hospital from January 2021 to August 2023. The results of donor pathogen fed back by metagenomic sequencing were analyzed to understand the clinical significance of metagenomic sequencing in donor evaluation.

Influencing factors on neurological prognosis after traumatic brain injury and the role of brain tissue oxygen pressure (PbtO) monitoring.

Objective: To identify factors influencing neurological prognosis following traumatic brain injury (TBI) and to analyze the role of brain tissue oxygen pressure (PbtO) monitoring in prognostication.

Methods: In this case-control study, medical records of 412 individuals diagnosed with TBI were thoroughly examined and analyzed. The patients were divided into two groups based on their prognosis at three months post-injury: Good Prognosis (n = 321) and Poor Prognosis (n = 91).

Internal Hernia: An Uncommon and Often-Missed Differential Diagnosis of Abdominal Pain.

Abdominal pain is a common presenting symptom among patients visiting the hospital. A wide range of differential diagnoses are associated with this presentation, some of which are more uncommon than others, and require a higher degree of clinical suspicion and radiological excellence to diagnose. Although clinicians rely on physical assessment, examining a patient who is agitated and non-cooperative sometimes limits the physical exam findings, making these diagnoses even more challenging.

Evaluating the Effectiveness of Shockwave Lithotripsy vs Ureteroscopic Lithotripsy for Treatment of Renal Stones: A Prospective Cohort Study.

Background: Renal stones are a prevalent condition requiring effective treatment strategies. This study evaluates the comparative effectiveness of shockwave lithotripsy (SWL) and ureteroscopic lithotripsy (URSL) in treating renal stones in a Pakistani cohort, focusing on stone clearance, recurrence, and complications.

Methods: This prospective cohort study involved 250 patients aged 18-55 diagnosed with renal stones.