[Identification of non-steroidal anti-inflammatory drugs as a necessity basis of effectiveness and risk correlation conception].

Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for treatment of pain, fever and inflammatory diseases. However, along with a high rate of efficacy, NSAIDs have been associated with an increased risk of gastrointestinal and cardiovascular complications related to the inhibition of the enzymes cyclooxygenase 1 and 2. The review addresses contemporary mechanisms of NSAID's side-effects and analyzes clinical trials of the efficacy and tolerability of aceclofenac, which is the most frequently prescribed NSAID, as in its traditional release form (100 mg 2 times a day) as well as in the controlled-release (200 mg a day) form.

[The role of cefepime, a 4th-generation cephalosporin, in treating patients with surgical sepsis].

Cefepime (Maxipime) was used in the management of 22 patients at the age of 18 to 73 years with the surgical sepsis syndrome (SAPS > 15). In 16 patients surgical sepsis was due to pancreatitis, appendititis, abdominal wound or trauma or complications after planned surgical interventions on the organs of the abdominal cavity. In the other 6 patients surgical sepsis was due to inflammatory processes in soft tissues after minor trauma.