742 results match your criteria: "Electrical Alternans"
J Mol Cell Cardiol Plus
December 2024
Key Laboratory of Medical Electrophysiology of the Ministry of Education, Medical Electrophysiological Key Laboratory of Sichuan Province, Institute of Cardiovascular Research, Southwest Medical University, Luzhou, Sichuan 646000, China.
Unlabelled: Abnormal regional variations in electrical and calcium homeostasis properties have been implicated in catecholaminergic polymorphic ventricular tachycardias (CPVT) attributable to abnormal RyR2-mediated store Ca release, but their underlying mechanism have not been well explored in intact hearts.
Methods: We performed in vivo and ex vivo studies including high throughput mapping of Ca transients (CaT) and transmembrane voltage (V) in murine wild-type (WT) and heterozygous -R2474S/+ hearts, before and during isoprenaline (ISO) challenge.
Results: ISO-challenged -R2474S/+ showed increased incidence of arrhythmia accompanied by abnormal Ca transients compared to WT.
Sci Rep
November 2024
Department of Anesthesiology, Ya 'an People's Hospital, Ya 'an, 625000, Sichuan, China.
Sci Rep
November 2024
Department of Medicine, University of Virginia, Charlottesville, USA.
Theranostics
October 2024
State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Beihua South Road, JingHai District, Tianjin 301617, China.
Stroke-related cardiovascular diseases have attracted considerable attention, with atrial fibrillation (AF) being among the most frequent complications. Despite increasing clinical evidence, experimental models of stroke-induced AF are still lacking, hindering mechanistic discoveries and the development of adequate therapeutics targeting this stroke-heart syndrome (SHS). This study aims to create a rat model of ischemic stroke-induced AF (ISIAF) and to explore the efficacy and mechanism of Wenxin Keli (WK), an antiarrhythmic Chinese medicine.
View Article and Find Full Text PDFMedicina (Kaunas)
August 2024
Department of Internal Medicine I, Faculty of Medicine, University of Medicine and Pharmacy "Grigore T. Popa", 700115 Iasi, Romania.
Int J Mol Sci
June 2024
Toronto General Hospital Research Institute, University Health Network, Toronto, ON M5G 2M1, Canada.
J Am Heart Assoc
June 2024
The Hull Family Cardiac Fibrillation Management Laboratory, Toronto General Hospital Toronto Canada.
J Am Heart Assoc
June 2024
Research Unit of Internal Medicine, Medical Research Center Oulu Oulu University Hospital and University of Oulu Oulu Finland.
Physiol Meas
June 2024
Department of Engineering, Università Campus Bio-Medico di Roma, Rome, Italy.
Cureus
February 2024
Internal Medicine, Jackson Memorial Hospital, Miami, USA.
Electrical alternans on electrocardiograph (ECG) is an uncommon but nearly pathognomonic sign of cardiac tamponade. Here, we present a male quadragenarian who came to the emergency department complaining of low back and right upper abdominal pain. Work-up revealed a large pericardial effusion associated with electrical alternans on ECG and clinical findings of cardiac tamponade.
View Article and Find Full Text PDFEpilepsy Behav Rep
March 2024
Department of Epileptology, University Hospital Bonn, Germany.
Europace
December 2023
Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, No. 100, Tzi-You 1st Road, Sanmin Dist., Kaohsiung City 80708, Taiwan.
JACC Case Rep
November 2023
Hospital do Divino Espírito Santo de Ponta Delgada, Avenida D. Manuel I, Ponta Delgada, São Miguel, Portugal.
Europace
December 2023
Georgia Institute of Technology, Department of Physics, 837 State St NW, Atlanta, GA 30332, USA.
Intern Med
June 2024
Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
Clin Res Cardiol
May 2024
Institute for Experimental Cardiovascular Medicine, Faculty of Medicine, University Heart Center Freiburg-Bad Krozingen, University of Freiburg, Freiburg, Germany.
Background: Arrhythmias may originate from surgically unaffected right ventricular (RV) regions in patients with tetralogy of Fallot (TOF). We aimed to investigate action potential (AP) remodelling and arrhythmia susceptibility in RV myocardium of patients with repaired and with unrepaired TOF, identify possible correlations with clinical phenotype and myocardial fibrosis, and compare findings with data from patients with atrial septal defect (ASD), a less severe congenital heart disease.
Methods: Intracellular AP were recorded ex vivo in RV outflow tract samples from 22 TOF and three ASD patients.
J Med Cases
August 2023
Kings County Hospital Center, Brooklyn, NY 11203, USA.
Tuberculous pericarditis, a rare but potentially lethal manifestation of tuberculosis, poses diagnostic and therapeutic challenges in clinical practice. Its nonspecific clinical presentation often mimics other conditions, leading to delayed or missed diagnoses. We report a 25-year-old male with no past medical history, who presented with nonspecific symptoms such as fatigue, weight loss, body aches, and dyspnea.
View Article and Find Full Text PDFBiophys Rev
August 2023
Institute for Molecular Medicine, Beach, Huntington, CA USA.
J Physiol
September 2024
Department of Electrical, Electronic and Information Engineering 'Guglielmo Marconi', University of Bologna, Cesena, Italy.
Mechano-electric regulations (MER) play an important role in the maintenance of cardiac performance. Mechano-calcium and mechano-electric feedback (MCF and MEF) pathways adjust the cardiomyocyte contractile force according to mechanical perturbations and affects electro-mechanical coupling. MER integrates all these regulations in one unit resulting in a complex phenomenon.
View Article and Find Full Text PDFAm J Physiol Heart Circ Physiol
August 2023
Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio, United States.
Eur Heart J
September 2023
Intensive Care Unit, Royal Adelaide Hospital, Port Road, Adelaide, South Australia.
Phys Rev E
May 2023
Department of Biomedical Engineering, The Ohio State University, Columbus, Ohio 43210, USA.
J Mol Cell Cardiol
August 2023
Vanderbilt Center for Arrhythmia Research and Therapeutics, Division of Clinical Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address:
Physiol Rep
May 2023
Department of Physiology & Biophysics, Rush University Medical Center, Chicago, Illinois, USA.