Cemiplimab monotherapy in Japanese patients with recurrent or metastatic cervical cancer.

Background: In the phase 3 EMPOWER-Cervical 1/GOG-3016/ENGOT-cx9 study, cemiplimab significantly improved overall survival (OS) versus chemotherapy for patients with recurrent or metastatic cervical cancer who progressed after first-line platinum-based chemotherapy. We present a post hoc subgroup analysis of patients enrolled in Japan.

Methods: Patients were enrolled regardless of programmed cell death-ligand 1 status and randomized 1:1 to cemiplimab 350 mg intravenously every 3 weeks or investigator's choice  single-agent chemotherapy for up to 96 weeks.

Seasonal and spatial variations of dissolved inorganic nitrogen exchange between the Yellow Sea and the East China Sea and the influencing factors.

Nutrient exchange with the East China Sea plays an important role in primary production in the Yellow Sea. Owing to lack of simultaneous observations, the spatiotemporal nutrient exchanges across the boundary between the Yellow Sea and East China Sea (Section YE) remain unclear. In this study, a three-dimensional physical-biogeochemical coupled model was used to determine the flux of dissolved inorganic nitrogen (DIN) across Section YE.

Toward defining the Anthropocene onset using a rapid increase in anthropogenic fingerprints in global geological archives.

One of the remaining issues regarding the Anthropocene is the lack of stratigraphic evidence indicating when the cumulative human pressure from the early Holocene began to fundamentally change the Earth system. Herein, we compile anthropogenic fingerprints from various high-precision-dated proxy records for 137 global sites to determine the age of the unprecedented surge in these records over the last 7700 y. The cumulative number of fingerprints revealed an unprecedented surge in diverse anthropogenic fingerprints starting in 1952 ± 3 CE, corresponding to the onset of the Great Acceleration.

Cardiohistological Findings in Refeeding Syndrome.

Severe eating disorders may develop refeeding syndrome, which sometimes resembles severe cardiac dysfunction. A woman in her thirties was admitted to our hospital because of cardiogenic shock. Transthoracic echocardiography showed reduced left ventricular systolic function.

Critically ill patients' experiences of discomfort and comfort in the intensive care unit: A qualitative descriptive study.

Background: The physiological state of critically ill patients is severely impaired by illness or trauma and is uncomfortable. Such experiences cause long-term anxiety and post-traumatic stress disorder.

Objective: This study aimed to understand discomfort and comfort based on the experiences of critically ill adult patients in the intensive care unit and to explore ways to improve their comfort.

Non-destructive estimation of flesh oil content in avocado (Persea americana Mill.) using fluorescence images from 365-nm UV light excitation.

The flesh oil content (OC) is a crucial commercial indicator of avocado maturity and directly correlates with its nutritional quality. To meet export standards and optimize edible characteristics, avocados must be harvested at the appropriate stage of physiological maturity. The significant variability in OC during maturation, without any external morphological indicators, poses a longstanding challenge.

Generating interstitial water within the persisting tetrahedral H-bond network explains density increase upon compressing liquid water.

Despite its ubiquitous nature, the atomic structure of water in its liquid state is still controversially debated. We use a combination of X-ray Raman scattering spectroscopy in conjunction with ab initio and path integral molecular dynamics simulations to study the local atomic and electronic structure of water under high pressure conditions. Systematically increasing fingerprints of non-hydrogen-bonded H[Formula: see text]O molecules in the first hydration shell are identified in the experimental and computational oxygen K-edge excitation spectra.

RH5: rationally-designed malaria vaccine antigen improving efficacy.

Plasmodium falciparum reticulocyte-binding protein homolog 5 (RH5) is a unique asexual blood-stage malaria vaccine candidate because of its high conservation and essential biological function of binding to basigin on the erythrocyte surface. Recent studies by Barrett et al., Wang et al.

Elaborating the multifarious role of PGPB for sustainable food security under changing climate conditions.

Changing climate creates a challenge to agricultural sustainability and food security by changing patterns of parameters like increased UV radiation, rising temperature, altered precipitation patterns, and higher occurrence of extreme weather incidents. Plants are vulnerable to different abiotic stresses such as waterlogging, salinity, heat, cold, and drought in their natural environments. The prevailing agricultural management practices play a major role in the alteration of the Earth's climate by causing biodiversity loss, soil degradation through chemical and physical degradation, and pollution of water bodies.

Short-Term Effect of the Combined Application of Rice Husk Biochar and Organic and Inorganic Fertilizers on Radish Growth and Nitrogen Use Efficiency.

Research on soil biochar fertilization has mainly been conducted on cereal crops, and information on its potential for radish production remains inconsistent. Therefore, a pot experiment was conducted to examine the short-term effects of rice husk biochar on radish growth and nitrogen use efficiency (NUE). An investigation was conducted with two application rates of biochar alone, (10 t ha (B10) and 25 t ha (B25), and biochar + chicken manure application with and without NPK fertilizer.

Enhancing origin prediction: deep learning model for diagnosing premature ventricular contractions with dual-rhythm analysis focused on cardiac rotation.

Aims: Several algorithms can differentiate inferior axis premature ventricular contractions (PVCs) originating from the right side and left side on 12-lead electrocardiograms (ECGs). However, it is unclear whether distinguishing the origin should rely solely on PVC or incorporate sinus rhythm (SR). We compared the dual-rhythm model (incorporating both SR and PVC) to the PVC model (using PVC alone) and quantified the contribution of each ECG lead in predicting the PVC origin for each cardiac rotation.

A systems serology approach to identifying key antibody correlates of protection from cerebral malaria in Malawian children.

Background: Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) proteins are expressed on the surface of infected erythrocytes, mediating parasite sequestration in the vasculature. PfEMP1 is a major target of protective antibodies, but the features of the antibody response are poorly defined.

Methods: In Malawian children with cerebral or uncomplicated malaria, we characterized the antibody response to 39 recombinant PfEMP1 Duffy binding like (DBL) domains or cysteine-rich interdomain regions (CIDRs) in detail, including measures of antibody classes, subclasses, and engagement with Fcγ receptors and complement.

Responses of leaf gas exchange and metabolites to drought stress in different organs of sugarcane and its closely related species Erianthus arundinaceus.

The high intrinsic water-use efficiency of Erianthus may be due to the low abaxial stomatal density and the accumulation of leaf metabolites such as betaine and gamma-aminobutyric acid. Sugarcane is an important crop that is widely cultivated in tropical and subtropical regions of the world. Because drought is among the main impediments limiting sugarcane production in these regions, breeding of drought-tolerant sugarcane varieties is important for sustainable production.