Occurrence, seasonal variation, and environmental risk of multiclass antibiotics in the urban surface water of the Buriganga River, Bangladesh.

Owing to the extensive use of antibiotics in hospitals, animal husbandry, and various human activities, antibiotic contamination is becoming an increasing global concern, including in Bangladesh. In Bangladesh, the Buriganga River is heavily polluted with multiple antibiotics, which can lead to antibiotic resistance in bacteria. In this study, we performed the first investigation of seasonal variations in the occurrence and spatial distribution of 29 antibiotics in the Buriganga River, Bangladesh, from wet season (August 2019) and dry season (February 2020).

Excessive supraventricular ectopic activity is a simple cutoff for predicting late recurrence of atrial fibrillation after ablation.

The relationship between post-ablation excessive supraventricular ectopic activity (ESVEA), a new marker for new-onset atrial fibrillation (AF), and late AF recurrence is uncertain. We enrolled 469 patients with AF who underwent initial radiofrequency catheter ablation and 24-h Holter monitoring the day after. Early AF recurrence (n = 57; 12%) and ESVEA (n = 242; 52%) were noted.

Comparison Between Attenuation Measurement and the Controlled Attenuation Parameter for the Assessment of Hepatic Steatosis Based on MRI Images.

Background And Aims: This study prospectively compared the diagnostic accuracies of the improved Attenuation Measurement (iATT) algorithm and the Controlled Attenuation Parameter (CAP) and assessed the interchangeability of iATT with magnetic resonance imaging-derived proton density fat fraction (MRI-derived PDFF).

Methods: Patients with chronic liver disease were prospectively enrolled and underwent iATT, CAP and MRI-derived PDFF measurements for hepatic steatosis evaluation. According to MRI-derived PDFF values, steatosis grades were categorised as steatosis (S)0 (< 5.

Species- and tissue-specific profiles and potential risks of polychlorinated biphenyls (PCBs) and their metabolites in dogs and cats.

In recent years, there has been growing concern about the long-term health effects of chemical exposure in pets, particularly dogs and cats, from sources such as pet food and house dust. Domestic cats (Felis silvestris catus) and dogs (Canis lupus familiaris) are continuously exposed to polychlorinated biphenyls (PCBs), with particular attention being paid to the toxicity of their metabolites, hydroxylated PCBs (OH-PCBs) and methylsulfonyl PCBs (MeSO-PCBs). However, the tissue distribution and species-specific differences of these PCB metabolites in domestic animals have not been fully elucidated.

Genetic variation in the RETN promoter, accompanied by latent sarcopenic obesity, led to insulin resistance in a Japanese cohort: the Toon Genome Study.

Aims/hypothesis: Resistin, inducing insulin resistance, is elevated in the sera of individuals with the G-A haplotype at c.-420 C>G (rs1862513) and c.-358 G>A (rs3219175).

Metal-Bridging Cyclic Bilatriene Analogue Affords Stable π-Radicaloid Dyes with Near-Infrared II Absorption.

Stable neutral metal radicaloid complexes have been synthesized from a modified tetrapyrrolic pigment, bilatriene, with iridium(I) and rhodium(I) cyclooctadiene (COD) synthons. The bilatriene skeleton contains α-linked conjugated pyrrole units, whereas an N-confused analogue used in this work possesses β-linked pyrrole moieties at the terminal, demonstrating a unique metal binding capability. Unprecedentedly, the metal-COD cations are accommodated at the outer nitrogen sites, which induced the formation of open-shell metal-radicaloid species.

Delphinidin induces a fast-to-slow muscle fiber type shift through the AMPK signaling pathway in C2C12 myotubes.

Delphinidin, a plant anthocyanidin, suppresses disuse muscle atrophy in mice. However, its effect on muscle fiber type shift is unclear. To examine whether delphinidin affects skeletal muscle fiber type, differentiated C2C12 cells were treated with delphinidin.

A prospective study on the enhancement of surgical safety in robotic surgery: The BirdView camera system.

Purpose: To investigate the surgical safety and benefits of using the BirdView camera system with a wide field of view in robotic surgery for rectal cancer in a prospective clinical study.

Methods: This study included 20 consecutive patients who underwent robotic surgery at our institution between the years 2022 and 2023. The primary endpoint was perioperative safety, which was defined as the occurrence of adverse events, including other organ injuries and malfunctions, caused by the BirdView camera system.

Standard technique in Japan for measuring hepatic venous pressure gradient.

Background: Direct measurement of portal venous pressure (PVP) is invasive, so the hepatic venous pressure gradient (HVPG) is commonly measured to evaluate portal hypertension (PH). HVPG is the gold standard for estimating PVP but few reports have covered standardized measurement techniques.

Methods: This study validated standardized techniques for PVP measurement.

Effects of Synthetic CpG Oligodeoxynucleotide K3 on Immune Response, Behavior, and Physiology in Male Layer Chicks ().

Unmethylated cytosine-phosphate-guanine (CpG) motifs are often found in bacteria and viruses, but are rare in mammals. In mammals, CpG oligodeoxynucleotides (CpG ODN) stimulate the innate immune system via toll-like receptor 9 (TLR9). However, TLR9 is absent in birds; instead, TLR21 serves as the receptor for CpG ODN.

Association of Periodontitis with Mild Cognitive Impairment in Older Adults.

Background: Early detection of cognitive decline, including mild cognitive impairment, is expected to provide a better prognosis. Several studies have suggested an association between periodontitis and mild cognitive impairment.

Objectives/design: To test the hypothesis that there is an association between severe periodontitis and mild cognitive impairment in community residents who participated in a dental health check-up program.

Can Morphology and Immune Infiltration Predict the Homologous Recombination Deficiency Status in Newly Diagnosed High-Grade Serous Ovarian Carcinoma?

Context.—: A correlation between the morphology of ovarian high-grade serous carcinomas (HGSOCs) and BRCA mutations has been previously reported.

Objective.

A New Species of the Genus Hybrizon (Hymenoptera: Ichneumonidae; Hybrizontinae) from Japan and Korea.

Hybrizon lunaris sp. nov. is described from Japan and Korea.

Cross-taxa assessment of species diversity and phylogenetic structure of benthic communities in a dam-impacted river undergoing habitat restoration.

Exploring diversity and community composition patterns across evolutionary and functionally diverse organisms is critical for understanding the general processes that shape biodiversity in response to environmental changes. Knowledge of multi-trophic relationships offers valuable insights to support the effective assessment and management of freshwater ecosystems. In this study, we conducted a cross-taxa assessment of benthic macroinvertebrates and microorganisms using metabarcoding-based surveys to evaluate habitat restoration in a dam-impacted river.

Association between iron intake and excessive daytime sleepiness in the community-dwelling Japanese: the Toon Health Study.

Purpose: Brain iron deficiency is known to cause dopaminergic dysfunction in people with restless legs syndrome. Considering the role that dopamine plays in the wake-promoting system, we speculated that iron deficiency may contribute to the development of excessive daytime sleepiness (EDS). Therefore, we conducted the present study to examine the association between iron intake and EDS in the general population.

Development of the Japanese Anticholinergic Risk Scale: English translation of the Japanese article.

Background: Anticholinergic burden, reflecting the cumulative impact of medications with anticholinergic properties, significantly predicts adverse drug reactions and geriatric syndromes in older adults. Although anticholinergic risk scales (ARS) have been developed and validated in various countries, none have been tailored specifically for Japan. The Japanese Anticholinergic Risk Scale (JARS) was developed to adapt the existing ARS frameworks to the Japanese context, considering unique medication profiles and cultural factors.

A rectal ulcer caused by hydrogel spacer insertion: A case report and review of the literature.

A 75-year-old man presented with hematochezia. He had been diagnosed with prostate cancer (stage 1) 1 month previously and had undergone gold marker injection and hydrogel spacer insertion 3 weeks previously to prepare for radiotherapy. Hydrogel spacer insertion is a safe procedure that can prevent the side effects of radiotherapy for prostate cancer.

Cell-type specific, inducible and acute degradation of targeted protein in mice by two degron systems.

Despite its broad application in in vitro studies, the application of targeted protein degradation (TPD) to animal models faces considerable challenges. Here, we develop inducible and cell-type specific TPD systems in mice using two degron systems: Oryza sativa TIR1 (OsTIR1)-auxin-inducible degron 2 (AID2) and human cereblon (hCRBN)-SALL4 degron (S4D). Efficient degradation of Satb1 protein by these systems recapitulates phenotypes observed in the Satb1-deficient mice.