Titanium nanostructure mitigating doxorubicin-induced testicular toxicity in rats via regulating major autophagy signaling pathways.

Doxorubicin (DOX) is a powerful antineoplastic FDA-approved anthracycline-derived antibiotic and is considered as the most suitable intervention for solid tumors and hematological cancers therapy. However, its therapeutic application is highly limited due to acute and chronic renal, hematological and testicular toxicity. Oxidative stress, lipid peroxidation and apoptosis in germ cells as well as low sperm count, motility and disturbing steroidogenesis are the principal machineries of DOX-induced testicular toxicity.

Developing an artificial diet for rearing (Hymenoptera: Figitidae) on spotted-wing drosophila.

(Matsumura) (Diptera: Drosophilidae) is a global invasive pest attacking soft-skinned fruit. The specialist larval parasitoid wasp, (Ihering), was recently approved in Europe and the United States for classical biological control releases against . Rearing methods are essential for supporting innundative releases but current methods using fresh fruit are costly and susceptible to variation in host quality.

The Possible Ameliorative Effect of , Ginger, and Their Combination on Experimentally Induced Diabetic Nephropathy in a Rat Model: Histological and Immunohistochemical Study.

Background: Diabetes represents a chronic disease characterized by hyperglycemia. Several changes in the renal functions had been detected in diabetic patients.

Aim Of The Work: This study was conducted to compare the possible ameliorative role of both ginger and either alone or in combination upon experimentally induced diabetic nephropathy.

Histological Assessment of Systemic Toxicity Induced by Zinc oxide Nanoparticles and the Prophylactic Potency of Ascorbate in Albino Rats.

Background: Nanoparticles of zinc oxide (ZnO-NPs) are frequently implemented in cosmetics, additives, and electronic devices. Moreover, their applications extend to water treatment, drug delivery, and cancer therapy. As a result, NP toxicity became an essential subject in biosafety research.

Enhancing detection of previously missed non-palpable breast carcinomas through artificial intelligence.

Purpose: To investigate the impact of artificial intelligence (AI) reading digital mammograms in increasing the chance of detecting missed breast cancer, by studying the AI- flagged early morphology indictors, overlooked by the radiologist, and correlating them with the missed cancer pathology types.

Methods And Materials: Mammograms done in 2020-2023, presenting breast carcinomas (n = 1998), were analyzed in concordance with the prior one year's result (2019-2022) assumed negative or benign. Present mammograms reviewed for the descriptors: asymmetry, distortion, mass, and microcalcifications.

Protective role of savory essential oil on vital organs in rats against deleterious effects induced by lead acetate.

The damaging effects of heavy metal exposure on vital organs like the heart, liver, kidneys, and brain can be lowered by natural compounds' anti-inflammatory and anti-oxidant capacity. In the current investigation, the protective potential of savory()essential oil (EO) against lead acetate-induced multi-organ damage in rats was evaluated. Thirty female Wister Albino rats were divided into the following groups: normal, positive control given lead acetate without concomitant treatment, reference given ethylene-diamine-tetra-acetic acid and groups treated with savory EO (0.

Studying the effect of processing parameters on the microstructure, strength, hardness, and corrosion characteristics of friction stir dissimilar welded AA5083 and AA7075 aluminum alloys reinforced with Al-SiC matrix.

The complementary properties of corrosion resistance and ballistic resistance of AA5083 and AA7075, respectively, explain the significance of welding these two alloys in the marine armor industry. This study investigates a novel Al-SiC matrix reinforcement with a different SiC weight ratio in dissimilar friction stir welding of the AA5083/AA7075 joint at different transverse and rotational speeds. The study deduced that the novel matrix can play an important role in improving strength and ductility simultaneously.

Bridging the gap: From petri dish to patient - Advancements in translational drug discovery.

Translational research serves as the bridge between basic research and practical applications in clinical settings. The journey from "bench to bedside" is fraught with challenges and complexities such as the often-observed disparity between how compounds behave in a laboratory setting versus in the complex systems of living organisms. The challenge is further compounded by the limited ability of in vitro models to mimic the specific biochemical environment of human tissues.

Phloretin-nanospanlastics for targeting the Akt/PI3K signaling pathways in dimethylhydrazine-induced colon cancer in mice.

Objectives: Colorectal cancer is the third most common cancer worldwide, accounting for approximately 10 % of all cancer cases. It is also the second leading cause of cancer-related deaths globally. Phloretin is a natural compound found in apples and other fruits.

Surgical Practice in Resource-Limited Settings: Perspectives of Medical Students and Early Career Doctors: A Narrative Review.

Introduction: Surgical practices in low-resource countries often fail to meet established standards. Both doctors and medical students have limited exposure to surgical cases, which hinders training and the development of surgical specialization. This study highlights the current state of surgical practice from a trainee's perspective, explores existing gaps in training and capacity building, and recommends practical solutions.

Integrating Patient-Generated Health Data from Mobile Devices into Electronic Health Records: Best Practice Recommendations by the IFCC Committee on Mobile Health and Bioengineering in Laboratory Medicine (C-MHBLM).

Background: An increasing number of wearable medical devices are being used for personal monitoring and professional health care purposes. These mobile health devices collect a variety of biometric and health data but do not routinely connect to a patient's electronic health record (EHR) or electronic medical record (EMR) for access by a patient's health care team.

Methods: The International Federation of Clinical Chemistry and Laboratory Medicine (IFCC) Committee on Mobile Health and Bioengineering in Laboratory Medicine (C-MHBLM) developed consensus recommendations for consideration when interfacing mobile health devices to an EHR/EMR.

Impact of periampullary diverticulum on endoscopic retrograde cholangiopancreatography: bridging the gap between fiction and reality.

Introduction: Periampullary diverticulum (PAD) is frequently discovered in patients undergoing endoscopic retrograde cholangiopancreatography (ERCP). Studies have yielded conflicting results regarding its impact on the technical success of ERCP and post-ERCP complications.

Aim: This study aims to assess the success and safety of ERCP in patients with PAD.

The role of intestinal ultrasound with colour Doppler in predicting the response to biologic therapy in inflammatory bowel disease patients.

Introduction: Inflammatory bowel disease patients are exposed to frequent procedures and hospital admissions as well as recurrent need for radiological examinations with a high risk of exposure to radiation and contrast.

Aim: Our objective was to evaluate the role of a combination of both intestinal ultrasound (IUS) and colour Doppler with different parameters for monitoring changes in inflammation over time and to reveal their potential role in the assessment of response to biologic therapy in inflammatory bowel disease (IBD) patients.

Material And Methods: Before the induction of biological therapy, IUS together with colour Doppler of the intestine was conducted.

Impact of cefixime and probiotics on functional abdominal bloating: a pilot study.

Introduction: Abdominal bloating is a prevalent condition that affects up to 30% of the population.

Aim: Investigate the impact of cefixime and probiotics on the bloating sensation among patients with functional abdominal bloating (FAB).

Material And Methods: Out of 763 patients with bloating, 122 patients were diagnosed with FAB.

Colorectal cancer and microbiota: systematic review.

Introduction: The gut microbiome maintains the mucus membrane barrier's integrity, and it is modulated by the host's immune system.

Aim: To detect the effect of microbiota modulation using probiotics, prebiotics, symbiotics, and natural changes on colorectal cancers (CRCs).

Methods: A PubMed search was conducted to retrieve the original and articles published in English language from 2010 until 2021 containing the following keywords: 1) CRCs, 2) CRCs treatment (i.

Exploring the Versatility of Azine Derivatives: A Comprehensive Review on Synthesis and Biological Applications.

Organic compounds containing azines, di-imines, or bis-Schiff-bases have two azomethine (-CH=N-) functional groups associated with a bridging component. These constituents have attracted attention from a diversity of disciplines, comprising coordination, medicinal, agriculture chemistry, and organic synthesis, because of their comprehensive chemical reactivity and nature. This study determines common synthetic approaches and various biological and pharmacological activities of several substituted bis-Schiff byproducts.

Prognostic role of midregional proadrenomedullin in predicting infection in pediatric cancer with febrile neutropenia.

Background: Febrile neutropenia (FN) remains an important complication of cytotoxic chemotherapy for which an urgent and appropriate evaluation is imperative.

Purpose: To assess the diagnostic and prognostic roles of mid-regional pro-adrenomedullin (MR-ProADM) levels in predicting infection in patients with FN.

Methods: This comparative cross-sectional study included 137 patients with chemotherapy-induced FN.

Stress Response of the Juvenile Tri-Spine Horseshoe Crab Tachypleus tridentatus to Hypoxia: Insights From Phenotypic, Metabolomic, and Microbial Analyses.

Over the past few decades, ocean hypoxia has been increasing due to human activities. Hypoxic stress, characterized by a reduced level of dissolved oxygen, is an escalating threat to marine ecosystems, with potentially devastating effects on the viability of endangered species such as the tri-spine horseshoe crab Tachypleus tridentatus. Even though this species is remarkably resilient to low oxygen levels, persistent hypoxia can negatively impact its population's survivability.

Investigator-Initiated Clinical Pharmacokinetic Studies in Resource-Limited Settings: Minimal Requirements and Practical Guidance.

Clinical pharmacology studies are critical for determining the efficacy and safety of drugs. Due to the resource-intensive nature of these studies, most have been conducted in high-income countries, leading to a significant gap in clinical pharmacology data for patients in low- and middle-income countries. This paper provides an overview of the minimal requirements for performing a clinical pharmacology investigator-initiated trial (IIT), including pharmacokinetic sampling.

A green bioanalytical spectrofluorimetric approach for estimation of Avapritinib anti-tumor drug; application to quality control and clinical studies.

Aims: Gastrointestinal stromal tumors (GISTs) account for about 80% of the mesenchymal tumors of the GI tract. About 5000-6000 patients are diagnosed in the United States (US) alone, and up to 14.5 cases per million discovered in Europe annually.

Monkeypox: a re-emergent virus with global health implications - a comprehensive review.

Monkeypox virus (MPXV) is an enclosed, double-stranded DNA virus from the Orthopoxvirus genus, which also contains variola, vaccinia, and cowpox. MPXV, which was once confined to West and Central Africa, has recently had a rebound, spreading beyond its original range since 2017. The virus is distinguished by its unique morphology, which includes an oval or brick-shaped structure and a complex lipid and protein makeup.

Microalgae-based bioremediation of refractory pollutants: an approach towards environmental sustainability.

Extensive anthropogenic activity has led to the accumulation of organic and inorganic contaminants in diverse ecosystems, which presents significant challenges for the environment and its inhabitants. Utilizing microalgae as a bioremediation tool can present a potential solution to these challenges. Microalgae have gained significant attention as a promising biotechnological solution for detoxifying environmental pollutants.

Outcome of Er, Cr:YSGG laser and antioxidant pretreatments on bonding quality to caries-induced dentin.

Background: This study aimed to assess the influence of different pretreatment protocols and antioxidants application on the shear bond strength (SBS) of universal adhesive to sound (SoD) and caries-induced dentin (CID).

Methods: One hundred and twenty posterior teeth had their occlusal enamel removed, then the specimens were divided into two main groups according to dentin substrates; SoD and CID, three subgroups according to pretreatments protocols control (no pretreatment), NaOCl-treated, and Er, Cr:YSGG-treated and two divisions according to antioxidant application (with and without sodium ascorbate (SA) application). All-Bond Universal (ABU) universal adhesives was applied in self-etch (SE) mode then resin composite discs were built.