Development and comprehensive greenness assessment of HPLC method for quality control of β-sitosterol in pharmaceutical ointments with trio-color coded evaluation.

A simple, rapid, and reproducible high-performance liquid chromatography (HPLC) method has been developed and validated for the determination of β-sitosterol in the pharmaceutical dosage form of moist exposed burn ointment (MEBO). This method involved an effective sample procedure for extraction of β-sitosterol from MEBO using an alkali saponification agent composed of 0.8 N ethanolic NaOH and diethyl ether.

Boswellic acid synergizes with low-dose ionizing radiation to mitigate thioacetamide-induced hepatic encephalopathy in rats.

Hepatic encephalopathy (HE) is a syndrome that arises from acute or chronic liver failure. This study was devised to assess the impact of a combination of boswellic acid (BA) and low doses of gamma radiation (LDR) on thioacetamide (TAA)-induced HE in an animal model. The effect of daily BA treatment (175 mg/kg body weight, for four weeks) and/or fractionated low-dose γ-radiation (LDR; 0.

Genomic analysis and replication kinetics of the closely related EHV-1 neuropathogenic 21P40 and abortigenic 97P70 strains.

Varicellovirus equidalpha 1, formerly known as Equid alphaherpesvirus 1 (EHV-1), is highly prevalent and can lead to various problems, such as respiratory problems, abortion, neonatal foal death, and neurological disorders. The latter is known as equine herpes myeloencephalopathy (EHM). Cases of EHM have significantly increased since the beginning of the twenty-first century.

Uterine histomorphological and immunohistochemical investigation during the follicular phase of estrous cycle in Saidi sheep.

Background: Saidi sheep are one of the most important farm animals in Upper Egypt, particularly in the Assiut governorate. Since they can provide meat, milk, fiber, and skins from low-quality roughages, sheep are among the most economically valuable animals bred for food in Egypt. Regarding breeding, relatively little is known about the Saidi breed.

Epidemiological trends and age-period-cohort effects on ischemic stroke burden across the BRICS-plus from 1992 to 2021.

Background: Ischemic stroke, accounting for 85% of stroke cases, leads to severe disabilities and increased mortality. Its global incidence rose by 87.55% from 1990 to 2019, posing significant health and economic burdens.

Treatment of gingival recession with vestibular incision subperiosteal tunnel access and advanced platelet-rich fibrin.

Objectives: The current literature about the effect of advanced platelet rich fibrin(A-PRF) with vestibular incision subperiosteal tunnel access (VISTA) technique in treating gingival recession is scarce. Therefore, the aim of the current randomized clinical trial is to evaluate the effect of A-PRF with VISTA technique in the treatment of Cairo class 1 gingival recession (RT1).

Methods: Twenty-four patients who met the eligibility criteria were randomly allocated into two groups.

Voices on academic accreditation: lived experiences of nurse educators, administrators, students, and alumni in nursing education.

Background: Academic accreditation is a pivotal process in nursing education, ensuring program quality, consistency, and graduate readiness for professional practice. Despite its significance, limited research explores the lived experiences and perspectives of stakeholders, including academic nurse educators, administrators, students, and alumni-engaged in accreditation.

Purpose: This study aimed to explore the lived experiences, perceptions, and insights of nursing education stakeholders regarding the accreditation process, focusing on its impact on educational quality, program reputation, and professional preparation.

Improving natural red pigment production by Streptomyces phaeolivaceus strain GH27 for functionalization of textiles with in silico ADME prediction.

The red pigment was recovered from the S. phaeolivaceus GH27 isolate, which was molecularly identified using 16S rRNA gene sequencing and submitted to GenBank as OQ145635.1.

Association between risk of ischemic stroke and liver enzymes levels: a systematic review and meta-analysis.

Background: Ischemic stroke is a major public health concern, contributing significantly to global morbidity and mortality. Recent studies have suggested that alterations in liver enzymes may be linked to the risk of developing a stroke. However, the relationship between liver enzymes and ischemic stroke remains unclear.

Genetic determinants of silver nanoparticle resistance and the impact of gamma irradiation on nanoparticle stability.

Background: One of the main issues facing public health with microbial infections is antibiotic resistance. Nanoparticles (NPs) are among the best alternatives to overcome this issue. Silver nanoparticle (AgNPs) preparations are widely applied to treat multidrug-resistant pathogens.

Optimization and characterization studies of poultry waste valorization for peptone production using a newly Egyptian Bacillus subtilis strain.

Valorization of poultry waste is a significant challenge addressed in this study, which aimed to produce cost-effective and sustainable peptones from poultry waste. The isolation process yielded the highly potent proteolytic B.subtilis isolate P6, identified through 16S rRNA gene sequencing to share 94% similarity with the B.

Deciphering the nature and statistical optimization of antimicrobial metabolites of two endophytic bacilli.

In this study, Allium sativum, garlic, was selected to isolate endophytic bacteria and to evaluate the antimicrobial, antiviral, antioxidant, and cytotoxic activities of their produced metabolites followed by identification of the biosynthetic gene cluster of the antimicrobial metabolites using Oxford Nanopore Technology (ONT). Two bacterial isolates, C6 and C11, were found to have a broad-spectrum antagonistic effect against four standard microbial strains and were molecularly identified using 16 S ribosomal RNA sequence analysis and deposited in a local culture collection as B. velezensis CCASU-C6, and B.

Blood cancer prediction model based on deep learning technique.

Blood cancer is among the critical health concerns among people around the world and normally emanates from genetic and environmental issues. Early detection becomes essential, as the rate of death associated with it is high, to ensure that the rate of treatment success is up, and mortality reduced. This paper focuses on improving blood cancer diagnosis using advanced deep learning techniques like ResNetRS50, RegNetX016, AlexNet, Convnext, EfficientNet, Inception_V3, Xception, and VGG19.

A kurtosis-ESPRIT algorithm for RealTime stability assessment in droop controlled microgrids.

Although detailed analytical models for droop-controlled microgrids are available, they are computationally complex and do not consider real-time variations in microgrid parameters and operating conditions. This paper proposes Kurtosis-Estimation of Signal Parameters via Rotational Invariance Technique (ESPRIT) to identify the dominant modes in droop-controlled inverter-based microgrids (IBMGs) using local real-time measurements. In the proposed approach, a short-duration small disturbance is applied to the selected DG's active power droop gain, and then, the system's dominant modes are estimated from its local measurements.

Biosynthesized ZnO NPs loaded-electrospun PVA/sodium alginate/glycine nanofibers: synthesis, spinning optimization and antimicrobial activity evaluation.

In this work, microalgae-based zinc oxide nanoparticles loaded with electrospun polyvinyl alcohol (PVA)/sodium alginate (SA) nanofibers were fabricated by electro-spinner. PVA/SA fibrous mats were crosslinked by citric acid, which enhanced their thermal stability and swelling behavior. Green-synthesized ZnO NPs were laboratory synthesized and characterized by FTIR, XRD, EDX, SEM, TEM and TGA analyses.

Optic nerve sonographic parameters in idiopathic intracranial hypertension, case-control study.

The most common diagnostic error of IIH is inaccurate funduscopic examination. Moreover, IIH could be diagnosed without papilledema. Trans orbital sonography could be used as a non-invasive and cheap tool for discovering increased ICP (intracranial Pressure).

Dietary intake and risk assessment of nitrosamine in processed meat products among medical staff during their night shift.

The study aims to evaluate the levels of nitrosamine, a known carcinogenic compound, in processed meat products and to assess its dietary intake and margin of exposure among medical staff, including physicians, pharmacists, and nurses working night shifts at Alexandria University Hospitals. Additionally, the study seeks to evaluate the participants' knowledge of dietary sources and regulatory limits of carcinogens. A cross-sectional study was conducted with 420 participants.

Hierarchical graph-based integration network for propaganda detection in textual news articles on social media.

During the Covid-19 pandemic, the widespread use of social media platforms has facilitated the dissemination of information, fake news, and propaganda, serving as a vital source of self-reported symptoms related to Covid-19. Existing graph-based models, such as Graph Neural Networks (GNNs), have achieved notable success in Natural Language Processing (NLP). However, utilizing GNN-based models for propaganda detection remains challenging because of the challenges related to mining distinct word interactions and storing nonconsecutive and broad contextual data.

Investigating heavy quarkonia binding in an anisotropic-dense quark-gluon plasma with topological defects in the framework of fractional non-relativistic quark model.

The quark-gluon plasma analysis relies on the heavy quark potential, which is influenced by the anisotropic plasma parameter temperature (t), and baryonic chemical potential (μ). Employing the generalized fractional derivative Nikiforov-Uvarov (GFD-NU) method, we solved the topologically-fractional Schrödinger equation. Two scenarios were explored: the classical model (α = β = 1) and the fractional model (α, β < 1).

Illuminating the impact of CD38-induced adenosine formation in B-cell lymphoma.

The expression of CD38 by cancer cells may mediate an immune-suppressive effect by producing Extracellular Adenosine (ADO) acting through G-protein-coupled cell surface receptors on cellular components and tumor cells. This can increase PD-1 expression and interaction with PD-L1, suppressing CD8 + cytotoxic T cells. This study examines the impact of heightened CD38 expression and extracellular ADO on various hematological and clinical parameters in patients with mature B-cell lymphoma, alongside their correlation with the soluble counterparts of the PD-1/PD-L1 axis.

Therapeutic potential of brentuximab vedotin in breast cancer and lymphoma via targeted apoptosis and gene regulation.

This study was designed to assess the effect of brentuximab vedotin on several breast cancer cell lines in terms of promoting apoptosis and managing cancer progression. Additionally, the study investigated the potential of repurposing this drug for new therapeutic reasons, beyond its original indications. The study evaluates the cytotoxic effects of Brentuximab vedotin across five cell lines: normal human skin fibroblasts (HSF), three breast cancer cell lines (MCF-7, MDA-MB-231, and T-47D), and histiocytic lymphoma (U-937).

A New Fluorescence Probe for the Quantification of Acetylcysteine and Carbocisteine in Bulk and Spiked Urine: Greenness Appraisal by Exploiting Different GAC-Metric Strategies.

Herein, a novel spectrofluorometric sensor is proposed for the sensitive analysis of two nonfluorescent mucolytic drugs, namely, acetylcysteine (ACT) and carbocisteine (CST), utilizing the newly synthesized 2-[(2-hydroxyethyl)-(2,8,10-trimethylpyrido[2',3':3,4]pyrazolo[1,5-a]pyrimidin-4-yl)-amino]-ethanol as a fluorescence probe (Flu. Probe). This fluorophore exhibits fluorescence emission at 445 nm upon excitation at 275 nm.

Effect of dietary microalgae on growth performance and health in meat-type quails.

The purpose of this work was to ascertain the impact of dietary inclusion of Dunaliella salina (Ds) and Arthrospira platensis (Ap) mixture as growth promoters on growth performance, carcass traits, liver and renal function, lipid profile, immunology and economics in quail chicks. 240 Un -sexed seven-day quail chicks were separated into four treatment groups with six replicates of ten chicks per group. The treatment groups are: control: basal diet; DsAp0.

Mutagenicity, DNA Repair Gene Polymorphism, and Differentially Expressed Plasma Protein Fractions among Textile Dyeing Workers.

Objectives: This study aimed to assess mutagenicity biomarkers among Egyptian textile dyeing workers, their alteration with gene polymorphism, and the changes in plasma proteins' expression.

Methods: Using a detailed questionnaire, a comparative cross-sectional study was conducted on 212 workers (106 textile dyeing exposed group and 106 control group). CBMN-Cyt assay, ERCC2 gene polymorphism, and plasma protein fractions were analyzed in workers' blood samples.