A newly developed high-performance thin layer chromatographic method for determination of remdesivir, favipiravir and dexamethasone, in spiked human plasma: comparison with the published methods.

Co-administration of COVID-19 RNA polymerase inhibitors, remdesivir and favipiravir, has synergistic benefits. Together they reduce viral load and inflammation more effectively than either drug used alone. Corticosteroids like dexamethasone are used alongside antivirals in multidrug combination regimens.

The ameliorative effect of selenium-loaded chitosan nanoparticles against silver nanoparticles-induced ovarian toxicity in female albino rats.

Background: Recently, silver nanoparticles (Ag-NPs) were shown to provoke oxidative stress through the release of reactive oxygen species and consequently induce cell damage. Selenium-loaded chitosan nanoparticles (CS-SeNPs) have anti-inflammatory and antioxidant effects, indicating that they ameliorate Ag-NPs-induced ovarian toxicity.

Objective: This study aimed to assess how well CS-SeNPs counteract the damaging effects of Ag-NPs on the ovarian tissue of adult female albino rats.

Arthroscopic-assisted reduction for Developmental Hip Dysplasia (DDH) through the sub-adductor and anterolateral portals; A 24-month follow-up prospective descriptive study.

Background: Developmental dysplasia of the hip (DDH) encompasses a spectrum of pathological conditions, including dislocation, subluxation, and deformities of the femoral head and acetabulum. The optimal surgical approach for DDH remains a subject of debate. Successful treatment aims to achieve a stable concentric reduction and prevent future subluxation or dislocation.

Fracture resistance and mode of failure of modified Polyether-ether-ketone versus lithium disilicate endocrowns.

Purpose: The current study aimed to compare modified Polyether-ether-ketone's fracture resistance and failure mode versus lithium disilicate glass-ceramic endocrowns.

Materials And Methods: A total of 16 butt-joint endocrown specimens on mandibular second molar teeth were fabricated and divided into two equivalent groups; Pressable modified Polyether-ether-ketone (PEEK) (BioHPP) and Pressable lithium disilicate glass ceramic (IPS e.max Press).

Global Challenges in the Access of Endovascular Treatment for Acute Ischemic Stroke (Global MT Access).

Background: Mechanical thrombectomy (MT) is the standard of care for eligible acute ischemic stroke (AIS) patients with large vessel occlusion (LVO) since 2015.

Aim: Our aim was to determine the key challenges for MT implementation and access worldwide.

Methods: We conducted an international online survey consisting of 37 questions, distributed through the World Stroke Organization network, and as invited by co-authors between December 2022 and March 2023.

Effect of early follicular phase of menstrual cycle on hip flexion-extension isokinetic parameters in sedentary female students.

Researchers conducted this observational study on sixty young females to detect the effect of the early follicular phase of the menstrual cycle on hip muscle performance. The Biodex Isokinetic dynamometer 4 pro was used. The authors used a dependent t-test and detected a statistically significant increase in the mean values of all hip flexion and extension isokinetic parameters at angular velocities 90°/sec and 180°/sec ( < 0.

Pyrimidine: A Privileged Scaffold for the Development of Anticancer Agents as Protein Kinase Inhibitors (Recent Update).

The pyrimidine nucleus is a fundamental component of human DNA and RNA, as well as the backbone of many therapeutic agents. Its significance in medicinal chemistry is well-established, with pyrimidine derivatives receiving considerable attention due to their potent anticancer properties across various cancer cell lines. Numerous derivatives have been synthesized, drawing structural inspiration from known anticancer agents like dihydropyrimidine compounds, which include the active cores of drugs such as 5-fluorouracil and monastrol, both of which have demonstrated strong anticancer efficacy.

Saracatinib, a Src kinase inhibitor, enhances the renoprotective effect of metformin and losartan in diabetic nephropathy.

Objective: This research assesses renoprotective effects of saracatinib (Src) in diabetic nephropathy (DN) and the potential underlying processes.

Materials And Methods: Rats were divided into: control, DN, DN + Met + Los, DN + Met + Src, and DN + Met + Los + Src. Rats' ABP, urinary albumin, urinary nephrin, and creatinine clearance were assessed.

Bosniak Classification of Cystic Renal Masses Version 2019: Proportion of Malignancy by Class and Subclass-Systematic Review and Meta-Analysis.

Bosniak classification version 2019 (v2019) was a major revision to version 2005 (v2005) that defined cystic renal mass subclasses based on wall or septa features. To determine the proportion of malignancy within cystic renal masses stratified by Bosniak classification v2019 class and feature-based subclass. MEDLINE and EMBASE databases were searched on July 24, 2023 for studies published in 2019 or later that reported cystic renal masses that underwent renal-mass CT or MRI, were assessed using Bosniak v2019, and had a reference standard (histopathology indicating benignity or malignancy or ≥5-year imaging follow-up indicating benignity).

Recent Advances in Metal-Organic Frameworks as Oxidase Mimics: A Comprehensive Review on Rational Design and Modification for Enhanced Sensing Applications.

Metal-organic frameworks (MOFs) have emerged as innovative nanozyme mimics, particularly in the area of oxidase catalysis, outperforming traditional MOF-based peroxidase and other nanomaterial-based oxidase systems. This review explores the various advantages that MOFs offer in terms of catalytic activity, low-cost, stability, and structural versatility. With a primary focus on their application in biochemical sensing, MOF-based oxidases have demonstrated remarkable utility, prompting a thorough exploration of their design and modification strategies.

Protocol for fecal microbiota transplantation: A microaerophilic approach for mice housed in a specific pathogen-free facility.

Recently, studies have emerged exploring the potential application of fecal microbiota transplantation (FMT) in pre-clinical settings. Here, we present a protocol for FMT for mice housed in a specific pathogen-free (SPF) facility. We describe steps for sample collection, microaerophilic processing of freshly collected fecal pellets, and administration through oral gavage.

Cloud computing practice activities and mental capacity on developing reproductive health and cognitive absorption.

The current study aims to determine how the interactions between practice (distributed/focused) and mental capacity (high/low) in the cloud-computing environment (CCE) affect the development of reproductive health skills and cognitive absorption. The study employed an experimental design, and it included a categorical variable for mental capacity (low/high) and an independent variable with two types of activities (distributed/focused). The research sample consisted of 240 students from the College of Science and College of Applied Medical Sciences at the University of Hail's.

Progress of Measles and Rubella Surveillance in the Context of Measles Elimination in the WHO Eastern Mediterranean Region, 2019-2022.

In 2015, the 62nd session of the Regional Committee [RC] of the Eastern Mediterranean Region [EMR] endorsed the Eastern Mediterranean Vaccine Action Plan 2016-2020 (EMVAP) that included postponement of the measles elimination target to before 2020. However, the EMR does not have a regional rubella control or elimination goal. We reviewed the progress of measles and rubella surveillance in context of measles elimination in the Eastern Mediterranean Region during 2019-2022.

High-Performance CP Magneto-Electric Dipole Antenna Fed by Printed Ridge Gap Waveguide at Millimeter-Wave.

This paper presents a high-performance circularly polarized (CP) magneto-electric (ME) dipole antenna optimized for wideband millimeter-wave (mm-wave) frequencies, specifically targeting advancements in 5G and 6G technologies. The CP antenna is excited through a transverse slot in a printed ridge gap waveguide (PRGW), which operates in a quasi-transverse electromagnetic (Q-TEM) mode. Fabricated on Rogers RT 3003 substrate, selected for its low-loss and cost-effective properties at high frequencies, the design significantly enhances both impedance and axial ratio (AR) bandwidths.

Towards an Accurate Real-Time Digital Elevation Model Using Various GNSS Techniques.

The objective of our research is to produce a digital elevation model (DEM) in a real-time domain. For this purpose, GNSS measurements are obtained from a kinematic trajectory in a clear location in New Aswan City, Egypt. Different real-time processing solutions are employed, including real-time precise point positioning (RT-PPP) and real-time kinematics (RTK); additionally, the widely used post-processed precise point positioning (PPP) processing scenario is used.

Integrating Wi-Fi, Li-Fi, and BPL Technologies for a Secure Indoor Communication System.

In today's digital age, there is an increasing demand for integrated wireless and wired technologies; however, there is a difficulty in achieving secure and reliable communications within buildings and facilities. This paper presents a proposal for maintaining the infrastructure while expanding it to implement communication technologies with high transmission and reception speeds and high levels of data confidentiality to enhance the operational efficiency of organizations. Three main technologies have emerged as promising solutions for this purpose: Wi-Fi, Li-Fi, and BPL.

Deep Learning-Based Spectrum Sensing for Cognitive Radio Applications.

In order for cognitive radios to identify and take advantage of unused frequency bands, spectrum sensing is essential. Conventional techniques for spectrum sensing rely on extracting features from received signals at specific locations. However, convolutional neural networks (CNNs) and recurrent neural networks (RNNs) have recently demonstrated promise in improving the precision and efficacy of spectrum sensing.

Quality by Design Approach for the Formulation and Evaluation of Stem Cells Derived Rosmarinic Acid-Loaded Nanofibers as an Anti-Wrinkle Patch: In Vitro and In Vivo Characterizations.

Skin wrinkles result from a myriad of multifaceted processes involving intrinsic and extrinsic aging. To combat this effect, plant stem cells offer a renewable and eco-friendly source for various industries, including cosmeceuticals. (SM), which contains the bioactive compound Rosmarinic acid (RA) and has been proposed for its anti-wrinkle effect.

Antimicrobial Peptides: A Promising Solution to the Rising Threat of Antibiotic Resistance.

The demand for developing novel antimicrobial drugs has increased due to the rapid appearance and global spread of antibiotic resistance. Antimicrobial peptides (AMPs) offer distinct advantages over traditional antibiotics, such as broad-range efficacy, a delayed evolution of resistance, and the capacity to enhance human immunity. AMPs are being developed as potential medicines, and current computational and experimental tools aim to facilitate their preclinical and clinical development.

RETRACTED: Ahmed et al. Thermal Analysis of a Metal-Organic Framework ZnxCo-ZIF-8 for Recent Applications. 2021, , 4051.

The journal retracts the article "Thermal Analysis of a Metal-Organic Framework ZnxCo1-X-ZIF-8 for Recent Applications" [...

Electrospun Carbon Nanofibers Derived from Polyvinyl Alcohol Embedded with Bimetallic Nickle-Chromium Nanoparticles for Sodium Borohydride Dehydrogenation.

Bimetallic NiCr nanoparticles decorated on carbon nanofibers (NiCr@CNFs) were synthesized through electrospinning and investigated as catalysts for hydrogen generation from the dehydrogenation of sodium borohydride (SBH). Four distinct compositions were prepared, with chromium content in the catalysts ranging from 5 to 25 weight percentage (wt%). Comprehensive characterization confirmed the successful formation of bimetallic NiCr@CNFs.

Assessment of Two Crosslinked Polymer Systems Including Hydrolyzed Polyacrylamide and Acrylic Acid-Hydrolyzed Polyacrylamide Co-Polymer for Carbon Dioxide and Formation Water Diversion Through Relative Permeability Reduction in Unconsolidated Sandstone Formation.

One of the most challenging aspects of manipulating the flow of fluids in subsurfaces is to control their flow direction and flow behavior. This can be especially challenging for compressible fluids, such as CO, and for multiphase flow, including both water and carbon dioxide (CO). This research studies the ability of two crosslinked polymers, including hydrolyzed polyacrylamide and acrylic acid/hydrolyzed polyacrylamide crosslinked polymers, to reduce the permeability of both CO and formation water using different salinities and permeability values and in the presence of crude oil under different injection rates.

Comprehensive Physio-Biochemical Evaluation Reveals Promising Genotypes and Mechanisms for Cadmium Tolerance in Tibetan Hull-Less Barley.

Cadmium (Cd) toxicity in agricultural soil is increasing globally and significantly impacts crop production and food safety. Tibetan hull-less barley ( L. var.

Revitalizing Soybean Plants in Saline, Cd-Polluted Soil Using Si-NPs, Biochar, and PGPR.

Excessive irrigation of saline-alkaline soils with Cd-contaminated wastewater has resulted in deterioration of both soil and plant quality. To an investigate this, a study was conducted to explore the effects of biochar (applied at 10 t ha), PGPRs ( (USDA 110) + at 1:1 ratio), and Si-NPs (25 mg L) on soybean plants grown in saline-alkali soil irrigated with wastewater. The results showed that the trio-combination of biochar with PGPRs, (as soil amendments) and Si-NPs (as foliar spraying), was more effective than individual or coupled applications in reducing Cd bioavailability in the soil, minimizing its absorption, translocation and bioconcentration in soybean tissues.

Genome-Wide Association Mapping of Macronutrient Mineral Accumulation in Wheat ( L.) Grain.

The focus on increasing wheat ( L.) grain yield at the expense of grain quality and nutrient accumulation can lead to shortages in macronutrient minerals, which are dangerous for human health. This is important, especially in nations where bread wheat is used in most daily dietary regimens.