9 results match your criteria: "Edwin SH Leong Centre for Healthy Children.[Affiliation]"
Association between maternal mRNA covid-19 vaccination in early pregnancy and major congenital anomalies in offspring: population based cohort study with sibling matched analysis.
BMJ Med
September 2024
Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.
Article Synopsis
- A study was conducted to investigate whether maternal vaccination with mRNA COVID-19 vaccines during the first trimester of pregnancy is linked to a higher rate of major congenital anomalies in newborns.
- The research utilized data from over 174,000 live births in Ontario, Canada, comparing infants born to vaccinated mothers with those born to unvaccinated mothers and their older siblings for better analysis.
- Results indicated that the incidence of major congenital anomalies was slightly lower in vaccinated mothers’ infants (24.3 per 1000 live births) compared to unvaccinated mothers’ infants (26.5 per 1000 live births), suggesting no significant increased risk associated with vaccination during early pregnancy.
Article Synopsis
- This study investigates the barriers to preventive health care, specifically well-child visits and immunizations, for children whose mothers have disabilities in Ontario, Canada.
- Results show that children of mothers with intellectual or developmental disabilities are significantly less likely to receive recommended health care compared to children of mothers without disabilities.
- The findings highlight the need for resources to improve access to preventive health care for these vulnerable populations, especially targeting those with intellectual or developmental disabilities.
Mental Illness in the 2 Years Prior to Pregnancy in a Population With Traumatic Brain Injury: A Cross-Sectional Study: La maladie mentale dans les deux ans précédant une grossesse dans une population souffrant de lésion cérébrale traumatique : une étude transversale.
Can J Psychiatry
August 2024
Women's College Research Institute, Women's College Hospital, Toronto, ON, Canada.
Objective: Existing studies, in mostly male samples such as veterans and athletes, show a strong association between traumatic brain injury (TBI) and mental illness. Yet, while an understanding of mental health before pregnancy is critical for informing preconception and perinatal supports, there are no data on the prevalence of active mental illness before pregnancy in females with TBI. We examined the prevalence of active mental illness ≤2 years before pregnancy (1) in a population with TBI, and (2) in subgroups defined by sociodemographic, health, and injury-related characteristics, all compared to those without TBI.
View Article and Find Full Text PDFNewborn and Early Infant Outcomes Following Maternal COVID-19 Vaccination During Pregnancy.
JAMA Pediatr
December 2023
ICES, Toronto, Ontario, Canada.
Importance: The study team previously showed that maternal mRNA COVID-19 vaccination during pregnancy confers protection against SARS-CoV-2 infection and COVID-19-related hospital admission in newborns and young infants. In this study, the study team evaluated newborn and early infant safety outcomes following maternal messenger RNA (mRNA) COVID-19 vaccination during pregnancy, for which there is limited comparative epidemiological evidence.
Objective: To determine if maternal mRNA COVID-19 vaccination during pregnancy is associated with adverse newborn and early infant outcomes.
Comparison of Emergency Department Use Between Pregnant People With and Without Disabilities in Ontario, Canada.
JAMA Netw Open
August 2023
ICES, Toronto, Ontario, Canada.
Importance: Emergency department (ED) use in pregnancy is common and occurs for a variety of reasons, including obstetrical complications, exacerbated underlying conditions, and inadequate outpatient health care access. People with disabilities have elevated rates of certain medical, psychiatric, and obstetrical conditions as well as inadequate access to prenatal care; their risk of ED use in pregnancy is not known, however.
Objective: To compare the risk of ED use in pregnancy among people with physical, sensory, and intellectual or developmental disabilities with those without disabilities.
Prenatal opioid exposure and well-child care in the first 2 years of life: population-based cohort study.
Arch Dis Child
September 2023
Dalla Lana School of Public Health, Division of Epidemiology, University of Toronto, Toronto, Ontario, Canada
Objectives: To quantify well-child visits by age 2 years and developmental screening at the 18-month enhanced well-child visit among children with prenatal opioid exposure (POE) and to identify factors associated with study outcomes.
Design: Population-based cohort study.
Setting: Ontario, Canada.
Receipt of adequate prenatal care for privately sponsored versus government-assisted refugees in Ontario, Canada: a population-based cohort study.
CMAJ
April 2023
Institute of Health Policy, Management and Evaluation (Evans, Ray, Austin, Guttmann), University of Toronto; ICES Central (Ray, Austin, Lu, Gandhi, Guttmann); Departments of Medicine, and Obstetrics and Gynaecology (Ray), St Michael's Hospital; The Hospital for Sick Children (Guttmann), Department of Paediatrics, and Edwin SH Leong Centre for Healthy Children (Guttmann), University of Toronto, Toronto, Ont.
Background: Canada has 2 main streams of resettlement: government-assisted refugees and privately sponsored refugees, whereby citizens can privately sponsor refugees and provide resettlement services, including health care navigation. Our objective was to compare receipt of adequate prenatal care among privately sponsored and government-assisted refugees.
Methods: This population-based study used linked health administrative and demographic databases.
Objective: To estimate the effectiveness of maternal mRNA covid-19 vaccination during pregnancy against delta and omicron severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection and hospital admission in infants.
Design: Test negative design study.
Setting: Community and hospital testing in Ontario, Canada.
Disability and in-hospital breastfeeding practices and supports in Ontario, Canada: a population-based study.
Lancet Public Health
January 2023
Department of Psychiatry, University of Toronto, Toronto, ON, Canada; ICES, Toronto, ON, Canada; Azrieli Adult Neurodevelopmental Centre, Centre for Addiction and Mental Health, Toronto, ON, Canada.
Background: Breastfeeding provides infants with nutrients required for optimal growth and development. We aimed to examine breastfeeding practices and supports that promote exclusive breastfeeding during the birth hospital stay among birthing parents with physical disabilities, sensory disabilities, intellectual or developmental disabilities, and multiple disabilities compared with those without a disability.
Methods: This population-based cohort study was done in Ontario, Canada.