The final plague outbreak in Scotland 1644-1649: Historical, archaeological, and genetic evidence.

This paper has several aims: to determine if Yersinia pestis was the causative agent in the last Scottish plague outbreak in the mid-17th century; map the geographic spread of the epidemic and isolate potential contributing factors to its spread and severity; and examine funerary behaviours in the context of a serious plague epidemic in early modern Scotland. Results confirm the presence of Y. pestis in individuals associated with a mid-17th century plague pit in Aberdeen.

Inpatient Falls: Epidemiology, Risk Assessment, and Prevention Measures. A Narrative Review.

Background Patient falls are a common inpatient dilemma and comprise the largest category of preventable adverse events in hospitalized patients. These events place a clinical burden on the patient, such as increased morbidity and reduced quality of life, in addition to an economic burden on the hospital system. Fall prevention strategies have the opportunity to decrease inpatient health care costs and length of stay.

Evaluating the Impact of Direct, Direct Video, and Indirect Video Laryngoscopy Training on the Proficiency of Medical Students in Performing Direct Laryngoscopy: A High-Fidelity Manikin-Based Assessment.

Endotracheal intubation (ETI), a potentially lifesaving intervention employed frequently in the emergent setting, is a manual skill that improves with repetitive practice and high-quality feedback. Classically, ETI centered around Direct Laryngoscopy (DL); however, with the advent and recent availability of Indirect Video Laryngoscopy (IVL) and Direct Video Laryngoscopy (DVL), studies have demonstrated varying results on the benefit of Video Laryngoscopy (VL) in training. We hypothesize that a training program centered on DVL, allowing students to visualize the anatomy and simultaneously receive instructor feedback via a real-time video feed, will practically improve student performance in DL.

Outpatient Prescribing Patterns for Uncomplicated Cystitis in Premenopausal Women With and Without an Allergy to Guideline-Recommended Antimicrobials: A Retrospective Analysis.

Objective: To determine if premenopausal women 18 to 50 years of age with uncomplicated cystitis who have an allergy to a guideline-recommended antimicrobial agent are less likely to receive guideline-preferred treatment compared to women without an allergy.

Methods: An electronic medical record report was used to identify females between the ages of 18-50 with a diagnostic code for acute uncomplicated cystitis at outpatient visits between December 1, 2017, through December 31, 2021. Patients with complicated urinary tract infections or pyelonephritis were excluded.

Recurrent Post-viral Rhabdomyolysis: A Case Report.

Rhabdomyolysis is a relatively rare condition caused by the damage and release of myocyte contents. It occurs most commonly secondary to strenuous exercise. Rhabdomyolysis carries the risk of life-threatening negative sequelae such as acute kidney injury or death.

A Rare Occurrence of Bilateral Ureteral Presence Within Inguinal Hernias in a Military Veteran: A Case Report.

Anatomical disruption of the ureter is a rare phenomenon that alters the positioning of the ureter within the abdominal or pelvic cavity. It is even rarer for ureteral presence to be located within inguinal hernias, especially bilaterally. We explore a case of a 76-year-old male with bilateral inguinal hernias, each containing a portion of the ureter from its respective kidney.

A review of virtual reality in radiology.

Virtual reality (VR) is not new to the field of medicine or radiology but has grown exponentially in recent years. Exploration of VR in medicine to augment educational experiences and aid in procedural training began in the 1990s. Surgeons have benefited from VR, both for training and planning purposes.

Preliminary investigation: Feasibility study of a virtual reality breast biopsy simulation.

Rationale And Objectives: Ultrasound-guided breast biopsies are the most frequently performed imaging-guided breast procedures. During training, learners may lack exposure due to limited volume and sensitive anatomy. Current simulation training often involves the use of manufactured or homemade (chicken or turkey breast) phantoms.

A Rare Case of Right Renal Vein Entrapment: A Cadaveric Study.

Renal vein entrapment, especially concerning the right renal vein, represents a scarcely explored anatomical aberration. The right renal vein's pivotal role in renovascular renal hemodynamics underlines the clinical significance of its compression, which can precipitate an elevated renal venous pressure gradient in relation to the inferior vena cava. This report delineates a unique instance of right renal vein entrapment in a 92-year-old male cadaver, identified during routine dissection.

Alterations in Endogenous Stem Cell Populations in the Acute Phase of Blast-Induced Spinal Cord Injury.

Background: Blast-induced spinal cord injury (bSCI) is prevalent among military populations and frequently leads to irreversible spinal cord tissue damage that manifests as sensorimotor and autonomic nervous system dysfunction. Clinical recovery from bSCI has been proven to be multifactorial, as it is heavily dependent on the function of numerous cell populations in the tissue environment, as well as extensive ongoing inflammatory processes. This varied recovery process is thought to be due to irreversible spinal cord damage after 72 hours post-injury.

Obesity's Unexpected Influence: Reduced Alphavirus Transmission and Altered Immune Activation in the Vector.

Chikungunya virus (CHIKV) and Mayaro virus (MAYV) are emerging/re-emerging alphaviruses transmitted by Aedes spp. mosquitoes and responsible for recent disease outbreaks in the Americas. The capacity of these viruses to cause epidemics is frequently associated with increased mosquito transmission, which in turn is governed by virus-host-vector interactions.

Skeletal muscle reprogramming enhances reinnervation after peripheral nerve injury.

Peripheral Nerve Injuries (PNI) affect more than 20 million Americans and severely impact quality of life by causing long-term disability. PNI is characterized by nerve degeneration distal to the site of nerve injury resulting in long periods of skeletal muscle denervation. During this period, muscle fibers atrophy and frequently become incapable of "accepting" innervation because of the slow speed of axon regeneration post injury.

Sister Mary Joseph's Nodule as a Cutaneous Expression of Metastatic Pancreatic Adenocarcinoma.

A Sister Mary Joseph's nodule (SMJN) is characterized by a palpable umbilical nodule and is often a clinical indicator of the metastasis of an advanced abdominal or pelvic malignancy. Observing the cutaneous manifestation of an abdomino-pelvic malignancy is a relatively rare phenomenon due to the appearance of visible changes in the later stages of the disease. With the pancreas being a less common primary tumor site for SMJN, this case report describes a 57-year-old male diagnosed with metastatic pancreatic adenocarcinoma with a SMJN.

An Examination of the Diagnostic Utility of Ubiquitin-Specific Peptidase 6 (USP6) Rearrangement in Differentiating Nodular Fasciitis From Inflammatory Myofibroblastic Tumor: A Case Report.

Nodular fasciitis (NF) is a benign yet diagnostically challenging mesenchymal myofibroblastic proliferation that often mimics the histological features of inflammatory myofibroblastic tumors (IMTs) and soft tissue sarcomas. The overlap in histopathological appearance, compounded by the variability in immunohistochemical (IHC) staining, frequently leads to diagnostic uncertainty. In this report, we present a case of a rapidly expanding lesion on the left medial mandible, ultimately diagnosed as NF.

Multifocal Infarction Along the Alimentary Canal in the Context of Ostensible Salmonellosis: A Case Report.

Ischemic and/or infarction events of the alimentary canal are uncommon but potentially disastrous injuries of the digestive system that often portend a poor prognosis. Alimentary ischemia occurs when the vascular supply to one of the component conduit organs is disrupted or blocked, resulting in decreased tissue perfusion, subsequent necrosis, perforation, and even death if proper perfusion is not restored. We report a case here of a 67-year-old female who originally presented to the emergency department (ED) with nausea, vomiting, diarrhea, and progressively worsening abdominal pain.

The dual timescales of gait adaptation: initial stability adjustments followed by subsequent energetic cost adjustments.

Gait adaptation during bipedal walking allows people to adjust their walking patterns to maintain balance, avoid obstacles and avoid injury. Adaptation involves complex processes that function to maintain stability and reduce energy expenditure. However, the processes that influence walking patterns during different points in the adaptation period remain to be investigated.

Renal transplant nephrolithiasis: Presentation, management and follow-up with control comparisons.

Objectives: To analyse the presentation, management and long-term outcomes of renal transplant patients who formed kidney stones in their allograft. The secondary aim was to identify risk factors for stone formation in this cohort.

Materials And Methods: Patient information from an institutional renal transplant database was used to identify individuals who both did and did not form kidney stones following renal transplantation.

The Impact of Artificial Intelligence on Internal Medicine Physicians: A Survey of Procedural and Non-procedural Specialties.

Background: Artificial intelligence (AI) is increasingly being integrated into various aspects of healthcare, including internal medicine. However, the impact of AI on physicians across different internal medicine specialties remains unclear. This study assesses AI's adoption, utilization, and perceived impact among procedural and non-procedural internal medicine physicians.

Humoral and T-cell-mediated responses to an insect-specific flavivirus-based Zika virus vaccine candidate.

Flaviviruses represent a significant global health threat and relatively few licensed vaccines exist to protect against them. Insect-specific flaviviruses (ISFVs) are incapable of replication in humans and have emerged as a novel and promising tool for flavivirus vaccine development. ISFV-based flavivirus vaccines have shown exceptional safety, immunogenicity, and efficacy, however, a detailed assessment of the correlates of protection and immune responses induced by these vaccines are still needed for vaccine optimization.

Racial Disparities in Anesthesia Care: A Systematic Review of Pain Management and Patient Outcomes.

Racial disparities in healthcare are a prominent issue that needs to be addressed to improve the quality of care for all patients. There are several disparities and biases related to the perceived pain tolerance people of color (POC) patients have and their need for analgesics. These biases lead to inadequate pain management and decreased health outcomes.