933 results match your criteria: "Edward S. Harkness Eye Institute[Affiliation]"

A Pattern-Based OCT Metric for Glaucoma Detection.

Transl Vis Sci Technol

December 2024

Bernard and Shirlee Brown Glaucoma Research Laboratory, Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, New York, NY, USA.

Purpose: To develop and test a novel optical coherence tomography (OCT) metric for the detection of glaucoma based on a logistic regression model (LRM) and known patterns of glaucomatous damage.

Methods: The six variables of the LRM were based on characteristic patterns of damage seen on the OCT thickness maps of the ganglion cell layer plus inner plexiform layer (GCL+) and retinal nerve fiber layer (RNFL). Two cohorts were used to develop the LRM.

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Background: To evaluate the impact of testing frequency on the time required to detect statistically significant glaucoma progression for ganglion cell complex (GCC) with optical coherence tomography (OCT).

Materials And Methods: From multicentre glaucoma registries, 332 eyes of 201 glaucoma patients were enrolled over an average of 4.4 years.

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Chalazia: A Scoping Review to Identify the Evidence Behind Treatments.

Ophthalmic Plast Reconstr Surg

December 2024

Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, New York, New York, U.S.A.

Purpose: Current treatment approaches aimed at resolving a chalazion vary greatly among practice settings and practitioners. Our objective is to provide a review of existing literature on treatment modalities aimed at resolving a chalazion.

Methods: We conducted a review of existing peer-reviewed publications that described treatment methods aimed at resolving chalazia in patients of any age.

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Thyroid eye disease and ocular myasthenia gravis.

Curr Opin Neurol

February 2025

Edward S. Harkness Eye Institute, Columbia University, New York, New York, USA.

Purpose Of Review: An overview of two ocular diseases, which significantly impact quality of life: thyroid eye disease (TED) and ocular myasthenia gravis (OMG). Additionally, we describe the clinical challenge when they occur simultaneously. We will describe the pathophysiology of both conditions, the currently available diagnostic tools, and the therapies available.

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Orbital Inflammatory Disease as a Presenting Symptom of Generalized Lipodystrophy in a Young Female.

Ophthalmic Plast Reconstr Surg

November 2024

Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University, New York, NY, U.S.A.

We report the first case of generalized lipodystrophy with orbital inflammatory symptoms. A 6-year-old female with hypothyroidism who developed hepatosplenomegaly, lymphadenopathy, and progressive loss of subcutaneous fat. Following flu vaccination, she developed orbital inflammatory symptoms.

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Long-Term Blood Pressure Variability and Visual Field Progression in Glaucoma.

JAMA Ophthalmol

November 2024

Viterbi Family Department of Ophthalmology, Hamilton Glaucoma Center, Shiley Eye Institute, University of California, San Diego, La Jolla.

Article Synopsis
  • Long-term changes in blood pressure may impact the progression of visual field (VF) loss in glaucoma patients, suggesting a potential link between cardiovascular health and vision deterioration.
  • The study analyzed data from 985 glaucoma patients over an average follow-up period of 8 years, focusing on blood pressure measurements and VF testing from 2000 to 2022.
  • Results indicated that higher average blood pressure and increased blood pressure variability were associated with more rapid VF loss, highlighting the importance of monitoring blood pressure in glaucoma management.
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Purpose: To identify sociodemographic factors as predictors of keratoconus severity, progression, disease outcomes, and appropriate management in a tertiary care ophthalmology institute in the New York City metropolitan area.

Methods: This is a retrospective chart review. Patients with keratoconus presenting at a tertiary eye institute in an urban setting seen between 2015 and 2022 were included.

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Purpose: To evaluate the diagnostic accuracy of retinal nerve fiber layer thickness (RNFLT) by spectral-domain optical coherence tomography (OCT) in primary open-angle glaucoma (POAG) in eyes of African (AD) and European descent (ED).

Design: Comparative diagnostic accuracy analysis by race.

Participants: 379 healthy eyes (125 AD and 254 ED) and 442 glaucomatous eyes (226 AD and 216 ED) from the Diagnostic Innovations in Glaucoma Study and the African Descent and Glaucoma Evaluation Study.

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Purpose: To characterize two cases of focal outer retinal atrophy and hypotony after vitrectomy.

Methods: Retrospective chart review of two patients' records between 2019 and 2023.

Results: Patient 1 underwent vitrectomy, epiretinal membrane peel, and cataract extraction for visually significant macular pucker.

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Application of artificial intelligence in glaucoma care: An updated review.

Taiwan J Ophthalmol

September 2024

Shiley Eye Institute and Viterbi Family Department of Ophthalmology, University of California San Diego, La Jolla, California.

The application of artificial intelligence (AI) in ophthalmology has been increasingly explored in the past decade. Numerous studies have shown promising results supporting the utility of AI to improve the management of ophthalmic diseases, and glaucoma is of no exception. Glaucoma is an irreversible vision condition with insidious onset, complex pathophysiology, and chronic treatment.

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Article Synopsis
  • The study proposes a deep learning method to predict areas on optical coherence tomography (OCT) reports that ophthalmologists are likely to focus on, using eye tracking data.
  • By analyzing eye movement patterns of ophthalmology professionals, they trained a U-Net model to identify these focus areas effectively.
  • The results showed that their model achieved a precision of 0.723, indicating its potential to enhance glaucoma diagnosis and contribute to medical education by highlighting important regions in OCT reports.
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Background/aims: The aims of this study is to evaluate the anatomic, visual outcomes and associated prognostic factors in patients with advanced retinopathy of prematurity (ROP) following vitrectomy.

Methods: A retrospective cohort study of patients with ROP who underwent vitrectomy from 2005 to 2016 was conducted. All the patients had a follow-up period of at least 5 years.

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Accuracy of large language models in answering ophthalmology board-style questions: A meta-analysis.

Asia Pac J Ophthalmol (Phila)

October 2024

Retina Division, Wilmer Eye Institute, Johns Hopkins University, Baltimore, MD 21287, USA. Electronic address:

Article Synopsis
  • This study looked at how well large language models (LLMs) like ChatGPT and Bing Chat can answer questions about eye medicine.
  • They found that out of 14 studies, most tested different topics in eye medicine, with ChatGPT-4 being the best at answering questions.
  • Overall, the models got 65% of the answers right, but they did best in "pathology" and struggled more with basic principles of eye care.
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Characteristics of a Large Database of Healthy Eyes From Optometry Practices: Implications for a Real-World Reference Database.

Transl Vis Sci Technol

October 2024

Bernard and Shirlee Brown Glaucoma Research Laboratory, Department of Ophthalmology, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, New York, NY, USA.

Purpose: To compare an optical coherence tomography (OCT) real-world reference database (RW-RDB) of "healthy" eyes obtained from optometry practices to a commercial reference database (RDB).

Methods: OCT scans from 6804 individuals 18 years and older were sampled from a larger database tested at 10 optometry practices involved in refractive and screening services. Employing a reading center method, OCT scans from both eyes of 4932 (4.

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Background: To explore the role of gut microbiota in preterm infants at high risk of developing retinopathy of prematurity (ROP).

Methods: Preterm infants with gestational age (GA) < 32 weeks and/or birth weight (BW) < 1500 g born between 2020 and 2021 were prospectively enrolled. Their faecal samples were collected and analysed at different postnatal ages of life using 16S rRNA gene sequencing on the Miseq platform.

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The role of Perifoveal Arteriolar Tortuosity in Optical Coherence Tomography Angiography (OCTA) images as an early indicator of hypertensive retinopathy.

Graefes Arch Clin Exp Ophthalmol

September 2024

Department of Ophthalmology, Vagelos College of Physicians and Surgeons, Edward S. Harkness Eye Institute, Columbia University Irving Medical Center, New York, NY, USA.

Purpose: To assess the value of increased perifoveal retinal vascular tortuosity in optical coherence tomography angiography (OCTA) images as a biomarker of early hypertensive retinopathy and compare its clinical sensitivity and accuracy with traditional morphological changes used for Scheie classification.

Methods: OCTA images of 81 eyes (40 eyes from 20 hypertensive subjects and 41 eyes from 21 control subjects) were obtained retrospectively. Hypertensive retinopathy changes in randomized eyes were graded according to the Scheie classification, and perifoveal vessels were traced in a masked fashion.

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TAF1A, a gene encoding a TATA-box binding protein involved in ribosomal RNA synthesis, is a candidate gene for pediatric cardiomyopathy as biallelic TAF1A variants were reported in two families with affected individuals. Here, we report a third family with two siblings who presented with infantile restrictive cardiomyopathy and carried biallelic missense variants in TAF1A (NM_001201536.1:c.

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This review explored the role of mitochondria in retinal ganglion cells (RGCs), which are essential for visual processing. Mitochondrial dysfunction is a key factor in the pathogenesis of various vision-related disorders, including glaucoma, hereditary optic neuropathy, and age-related macular degeneration. This review highlighted the critical role of mitochondria in RGCs, which provide metabolic support, regulate cellular health, and respond to cellular stress while also producing reactive oxygen species (ROS) that can damage cellular components.

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Article Synopsis
  • Patient-specific induced pluripotent stem cell-derived (iPSC-derived) cell lines offer tailored therapies, enhancing treatment precision for conditions like Bietti crystalline dystrophy (BCD), a rare blinding disease affecting around 67,000 people globally.
  • The study utilized iPSC-derived retinal pigment epithelium (iRPE) cells from BCD patients to assess the effectiveness of adeno-associated virus (AAV)-mediated gene therapy, finding that this therapy can significantly reduce blue light-induced cell death in affected cells.
  • Additionally, the researchers discovered variability in cellular phenotypes linked to different genetic mutations, highlighting the importance of personalized treatment approaches in advancing therapies for BCD and potentially other diseases.
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We present a novel case of intraosseous venous malformation of the frontal bone with dehiscence of the inner table of the frontal calvarium and extension into the frontal sinus and orbit. This case report discusses the surgical management of this intraosseous lesion achieved with a multidisciplinary approach involving otolaryngology and neurosurgical teams. We also present a review of the literature of the pathophysiology of venous malformations, the imaging modalities that aid in diagnosis of these lesions and the management options.

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Implementation and Consensus.

J Glaucoma

August 2024

New York Eye and Ear Infirmary of Mount Sinai, New York, NY.

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Cross-Sectional Analysis of Outer Retinal Tubulation in Inherited Retinal Diseases: A Multicenter Study.

Am J Ophthalmol

January 2025

From the Department of Ophthalmology (P-K.L., W.L., P-Y.S., A-H.K., E.Y-C.K., S.R.L., L.A.J., P-H.L., P-L.W., E.H-H.W., S.H.T., R.A., N-K.W.), Edward S. Harkness Eye Institute, Columbia University, New York, New York, USA; Department of Ophthalmology (E.Y-C.K., L.L., K-J.C., Y-S.H., W-C.W., C-C.L., N-K.W.), Chang Gung Memorial Hospital, Linkou Medical Center, Taiwan; College of Medicine (E.Y-C.K., K-J.C., Y-S.H., W-C.W., C-C.L., N-K.W.), Chang Gung University, Taoyuan, Taiwan; Vagelos College of Physicians and Surgeons (S.H.T., R.A., N-K.W.), Columbia University, New York, New York, USA. Electronic address:

Article Synopsis
  • This study investigates genetic variants linked to outer retinal tubulation (ORT) by analyzing the prevalence and clinical consequences of ORT in patients with inherited retinal diseases (IRDs).
  • A cohort of 565 IRD patients underwent SD-OCT imaging, revealing that 104 exhibited ORT, primarily associated with specific genetic variants, especially in RPE-specific and some non-RPE-specific genes.
  • The findings show a strong correlation between ORT presence and IRDs caused by RPE-specific and non-RPE-specific genes, while no cases of ORT were found in patients with photoreceptor-specific gene variants.
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