Modulating the p53-MDM2 pathway: the therapeutic potential of natural compounds in cancer treatment.

The p53-MDM2 pathway plays a crucial role regulating tumor suppression and is a focal point of cancer research. This literature review delves into the complex interplay between the tumor suppressor protein p53 and its main regulator MDM2, highlighting their interaction and implications in cancer development and progression. The review compiles and summarizes the existing understanding of the biology and regulation of p53 and MDM2, emphasizing their roles in various cellular processes, including cell cycle regulation, DNA repair, apoptosis, and metabolism.

Prevalence of overt and occult hepatitis B viral infection among pregnant women attending antenatal clinics in Edo state university teaching hospital Auchi, Nigeria.

Background: Hepatitis B virus (HBV) infection remains a major health challenge in Nigeria, with high prevalence rates among pregnant women. The prevalence of overt and occult hepatitis B infection (HBI and HBI) among pregnant women was investigated to understand the burden and associated risk factors in this population.

Methods: A cross-sectional study was conducted among 200 pregnant women.

Effects of on neurotransmission and expression of BDNF, tau, ACHE and BACE in diabetic rats.

Diabetes mellitus, a chronic metabolic disorder, has significant global health implications, particularly due to its neurological complications, such as diabetic neuropathy. This condition increases the risk of neurodegenerative diseases by affecting peripheral nerves and cognition. , known for its neuroprotective properties, shows promise as a therapeutic option for addressing these complications.

A comparative assesment of biostimulants in microbiome-based ecorestoration of polycyclic aromatic hydrocarbon polluted soil.

Polycyclic aromatic hydrocarbons (PAHs) pose severe environmental and public health risks due to their harmful and persistent nature. Therefore, developing sustainable and effective methods for PAH remediation is crucial. This study explores the biostimulation potential of various nutrient supplements in enhancing the metabolic activities of indigenous oleophilic bacteria to PAH degradation and removal.

The use of telehealth technology for lifestyle modification among patients with hypertension in Nigeria and Ghana.

Introduction: Sedentary lifestyle and consumption of an unhealthy diet are significantly associated with hypertension in Nigeria and Ghana. Increasing the uptake of physical activity and diet rich in fruits and vegetables has been a challenge in the region. This study aimed at assessing the effect of a mobile health intervention (mhealth) on physical activity, and fruits and vegetables intake in patients with hypertension in Nigeria and Ghana.

The interplay between programmed death ligand 1 (PD-L1) expression and human papillomavirus (HPV) genotypes in cervical carcinomas: findings of a Nigerian Tertiary Hospital.

Introduction: cervical cancer is primarily driven by high-risk human papillomavirus infections. It is a leading cause of cancer-related deaths among women globally. The emergence of immunotherapeutic approaches, particularly programmed death ligand-1 (PD-L1) inhibitors, has shown promise in various cancers.

Knowledge of Helping Babies Breathe Programme and the Determinants among Trainees in Edo State.

Background: Neonatal deaths contribute up to 32% of early childhood deaths in Nigeria. Most neonatal deaths (75%) occur during the first week of life. Helping Babies Breathe (HBB) programme is an intervention launched in 2010 by The American Academy of Paediatrics and found to be effective in reducing neonatal mortality by 47%.

Antibiotic Resistance Hotspot: Comparative Genomics Reveals Multiple Strains of Multidrug-Resistant in Edible Snails.

The demand for terrestrial snails as a food source is still on the increase globally, yet this has been overlooked in disease epidemiology and the spread of antimicrobial resistance. This study conducted genomic analyses of twenty strains isolated from live edible snails traded in two hubs. The isolates were subjected to MALDI-TOF MS, antimicrobial resistance testing, whole genome sequencing, and analyses for in-depth characterization.

Physical activity, obesity and risk of atherosclerotic cardiovascular diseases among patients with hypertension and diabetes attending a teaching hospital in Edo State, Nigeria.

Introduction: Preventing Atherosclerotic Cardiovascular Diseases (ASCVD) can best be achieved by promoting a healthy lifestyle through improvements in diet, physical activity, and avoidance of tobacco use and exposure to second-hand smoke. The study aimed to determine the association between physical activity as well as obesity and the risk of atherosclerotic cardiovascular diseases among patients with hypertension and diabetes attending Irrua Specialist Teaching Hospital (ISTH), Irrua, Nigeria.

Methodology: The research was a descriptive, cross-sectional study of 394 systematically selected consenting patients with hypertension and diabetes presenting to a teaching hospital in Irrua, Edo State, Nigeria.

Coffee and amyotrophic lateral sclerosis (ALS).

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder characterized by progressive loss of motor neurons. The effective treatments for ALS remain elusive, necessitating exploration into novel preventive strategies. ALS pathogenesis is triggered by oxidative stress which results in neuroinflammation, exicitotoxicity and neuronal cell death.

Elevated Levels of Gonadotrophic Hormones and Antioxidant Biomarker in Male Rats Following Administration of Hydromethanol Leaf Extract of in Response to 2,4-Dinitrophenylhydrazine Induction.

Background: 2,4-Dinitrophenylhydrazine induces testicular toxicity and can result in reproductive dysfunction in male rats.

Aim: This study investigated the effects of hydromethanolic leaf extract of on phenylhydrazine (PHZ)-induced reproductive dysfunction in male Wistar rats.

Settings And Design: Twenty rats (90-170 g) were grouped into five (A-E) ( = 4) with the approval of the research ethics committee.

Barriers and Facilitators to Dietary Salt Reduction Among Patients With Hypertension in Southern Nigeria: A Hospital-based Qualitative Study.

Introduction: Reduction in salt intake improves blood pressure control and reduces the risk of hypertension and other noncommunicable diseases (NCDs). However, salt intake remains high among Nigerians. This study aimed to identify barriers and facilitators to salt reduction among hypertensive patients attending a family medicine clinic in southern Nigeria.

Genetic engineering and genome editing technologies as catalyst for Africa's food security: the case of plant biotechnology in Nigeria.

Many African countries are unable to meet the food demands of their growing population and the situation is worsened by climate change and disease outbreaks. This issue of food insecurity may lead to a crisis of epic proportion if effective measures are not in place to make more food available. Thus, deploying biotechnology towards the improvement of existing crop varieties for tolerance or resistance to both biotic and abiotic stresses is crucial to increasing crop production.

The role of community health workers in the management of hypertension in Nigeria.

Background: Hypertension is the number one risk factor for cardiovascular death worldwide and its prevalence has been on the increase in LMICs including Nigeria. There is an increasing awareness and recognition of the contributions of the community health workers (CHWs) in the healthcare system. This study assessed their current role in the management of hypertension and patient satisfaction with the care received.

Prevalence and perception of pre-morbid lifestyle-related risk factors among covid-19 survivors in Lagos state and Abuja capital city of Nigeria.

Introduction: This study investigated the prevalence and perception of premorbid lifestyle-related risk factors among Covid-19 Survivors in Abuja and Lagos, Nigeria.

Methodology: A cross-sectional descriptive survey design was used to collect data from 522 consenting adult Covid-19 survivors in Abuja (274) and Lagos (248), Nigeria, using a self-developed, close-ended and validated questionnaire called the Lifestyle-related Factors in Covid-19 Questionnaire (LFC-19 Questionnaire) through a multistage sampling technique. Descriptive and inferential statistical analysis was done using the Statistical Package for Social Science (SPSS) with P value set at ≤ 0.

Effect of neem oil biodiesel on the surface and structural integrity of carbon steel alloy: Chromatographic, spectroscopic, and morphological investigations.

This study explores the impacts of neem oil biodiesel (BD), which was produced and characterized using GC-MS, FTIR, and UV-Vis spectroscopic techniques to elucidate pure and corrosion-product neem oil BD at room temperature (25 °C) and different immersion durations of 0, 28, 42, and 56 days. The OM and SEM were also employed to study the surface, structural integrity, and interphase interaction between the BD and the carbon steel (C1020) before and after immersion for different durations. The dominant fatty acid (FA) group in both pure and corrosion-product neem oil BD was C, with a total composition of 72.

Ethanol leaf extracts of in antioxidants and hepatotoxic effects of O157:H7 infected Swiss Mice.

Introduction: Diseases caused by bacteria can be managed with medicinal plants with rightful dosage that will not affect body physiology and organs.

Aim: This research aimed to evaluate the antioxidants and the effects of on liver function.

Materials And Methods: Ethanol leaf extracts were processed for antioxidants and hepatotoxic effects using animal models.

A comprehensive review of recent advances in the applications and biosynthesis of oxalic acid from bio-derived substrates.

Organic acids are important compounds with numerous applications in different industries. This work presents a comprehensive review of the biological synthesis of oxalic acid, an important organic acid with many industrial applications. Due to its important applications in pharmaceuticals, textiles, metal recovery, and chemical and metallurgical industries, the global demand for oxalic acid has increased.

Renoprotective effect of hyperin against CdCl prompted renal damage by activation of Nrf-2/Keap-1 ARE pathway in male mice.

Objectives: This study explored the mitigating properties of hyperin (HYP) on renotoxicity induced by cadmium chloride (CdCl).

Methods: Four groups of seven male albino mice each were used in this experiment. Group 1 served as the control, receiving no treatment.

Association between sleep quality and blood pressure control among hypertensive patients at a rural tertiary hospital in Southern Nigeria: a cross-sectional study.

Objectives: Restorative sleep is critical in preventing hypertension and other chronic diseases. Limited research has explored the relationship between sleep quality and hypertension in Africa. This study investigated the association between sleep quality and blood pressure control among hypertensive patients in Southern Nigeria.