1,118 results match your criteria: "Edith Wolfson Medical Center[Affiliation]"

Background: Impaired sleep quality often drives patients with rotator cuff tears (RCT) to seek surgical intervention. This meta-analysis reviews the impact of arthroscopic rotator cuff repair (ARCR) on sleep quality beyond six months and identifies influencing factors, primarily narcotics, on sleep quality.

Methods: The search spanned PubMed, Google Scholar, Embase, and the Cochrane Central Register, targeting articles evaluating rotator cuff injury and sleep quality.

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Treatment of Early Pregnancy Loss With Mifepristone and Misoprostol Compared With Misoprostol Only.

Obstet Gynecol

December 2024

Department of Obstetrics and Gynecology, Edith Wolfson Medical Center, Holon, and the School of Medicine, Tel Aviv University, Tel Aviv, Israel.

Article Synopsis
  • The study aimed to compare the effectiveness of mifepristone-misoprostol versus misoprostol alone in treating early pregnancy loss.
  • A total of 999 patients were analyzed, showing a lower treatment failure rate of 17.8% in the mifepristone-misoprostol group compared to 25.1% in the misoprostol-only group.
  • The findings indicated that using mifepristone in combination reduced the odds of treatment failure by 34%, while factors such as prior vaginal delivery and gestational age also influenced treatment outcomes.
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Purpose: To examine the safety and efficacy of combined treatment with topical ivermectin 1% and intense pulsed light (IPL) for dry eye disease (DED) secondary to demodex blepharitis.

Methods: A retrospective review of medical files of patients treated at a private clinic specializing in DED between November 2022 and February 2024 was performed. Sixty-one patients aged 18 years or older with DED because of demodex blepharitis, who received the IPL and ivermectin 1% combination therapy, were included.

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Balloon-Expandable vs Self-Expanding Valves for Transcatheter Treatment of Sievers Type 1 Bicuspid Aortic Stenosis.

JACC Cardiovasc Interv

September 2024

Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padua Medical School, Padua, Italy. Electronic address:

Article Synopsis
  • Balloon-expandable valves (BEVs) and self-expanding valves (SEVs) are compared for their effects on patients with Sievers type 1 bicuspid aortic valve (BAV) stenosis undergoing transcatheter aortic valve replacement.
  • The analysis, based on a registry of 955 patients, found no significant difference in midterm major adverse events or technical success between BEVs and SEVs after adjusting for baseline differences.
  • However, BEVs had lower risks of new permanent pacemaker implantation and moderate or greater paravalvular regurgitation, but a higher risk of severe patient-prosthesis mismatch compared to SEVs.
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Background: Late-onset sporadic nemaline myopathy (SLONM) is a rare, treatable or potentially life-threatening muscle disorder that typically manifests late in life and is characterised by the presence of nemaline rods within muscle fibres, serving as the hallmark of the disease and the key to diagnosis.

Methods: We report a case of an elderly patient with subacute onset of severe weakness affecting the upper and lower limbs, neck extensors and abdominal muscles. A comprehensive laboratory workup was performed.

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Article Synopsis
  • The study compares the effectiveness and safety of combined CTLA-4 and PD-1 blockade therapy to anti-PD-1 monotherapy in treating metastatic melanoma patients.
  • Results indicate no overall survival difference between the two treatments for the entire cohort, but combined therapy showed better results for patients with multi-organ metastasis, while monotherapy was more beneficial for those with oligo-organ metastasis.
  • Patients receiving combination therapy also faced significantly higher hospitalization rates from adverse immune-related events when they had oligo-organ metastasis, highlighting the need for careful treatment selection.
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Background/objectives: To evaluate the refractive outcomes, optical performance, and the quality of vision in patients implanted with a new diffractive intraocular lens (IOL), the Intensity Hanita.

Subjects/methods: This observational, prospective, longitudinal study included 64 eyes underwent bilateral cataract surgery with the Intensity IOL (Hanita Israel) implantation. Main outcome measures after 6 months were the following visual acuities (VAs) of uncorrected and corrected distance (UDVA and CDVA), uncorrected and distance corrected intermediate VAs (UIVA and DCIVA), uncorrected and distance corrected near (UNVA and DCNVA), refraction, slitlamp biomicroscopy, defocus curve (DFC), high ocular aberrations (HOA), contrast sensitivity (CS), optical quality, subjective quality of vision (QoV) and near activity visual questionnaires (NAVQ).

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Myxedema Coma-associated Pancytopenia: A Case Report.

Rambam Maimonides Med J

October 2024

Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Article Synopsis
  • Pancytopenia is a condition characterized by low levels of red and white blood cells as well as platelets, and diagnosing it can be complex due to various potential causes.
  • The text discusses a rare case of a 53-year-old man experiencing myxedema coma, a severe form of untreated hypothyroidism, which led to his pancytopenia symptoms, including confusion and unstable vital signs.
  • The patient was treated with intravenous levothyroxine and other supportive measures, resulting in improved health and normalized blood counts, highlighting the importance of recognizing myxedema coma in older patients who may not have regular healthcare access.
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Article Synopsis
  • The study aimed to compare the outcomes for pregnant women with gestational diabetes who monitored their blood sugar levels either 1 hour or 2 hours after meals.
  • Researchers included 99 patients who chose their monitoring timing, assessing factors like birth weight and patient satisfaction.
  • Results showed no significant differences in birth weights or other outcomes between the two groups, suggesting patients can choose the timing based on their preference.
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Introduction: Transcatheter aortic valve implantation (TAVI) has emerged as a common and effective treatment for patients with severe aortic stenosis. Changes in systemic blood pressure after TAVI have been described, yet their prognostic value is not established. Thus, we aimed to examine the association of the periprocedural changes in systolic blood pressure (SBP) and in pulse pressure on clinical outcomes after the procedure.

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Article Synopsis
  • Air embolism is a serious risk during central venous catheter (CVC) removal, often overlooked by less experienced healthcare workers, highlighting the need for better training and guidelines.
  • A survey showed that one-third of respondents were unaware of air embolism risks, and many did not follow established protocols during CVC extraction.
  • The study found that less experienced staff, particularly interns, had significantly lower knowledge about preventing air embolism, stressing the importance of hospital protocols and education for safety.
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Humans without a sense of smell breathe differently.

Nat Commun

October 2024

The Azrieli National Institute for Human Brain Imaging and Research, Weizmann Institute of Science, Rehovot, Israel.

Article Synopsis
  • Olfaction may seem limited in influencing human behavior, but losing the sense of smell (anosmia) can lead to serious negative effects, including a shorter lifespan.
  • The study investigates how anosmia affects nasal airflow patterns using a wearable device that tracks breathing over 24 hours in individuals with and without anosmia.
  • Findings show that airflow patterns differ significantly in those with anosmia, which could explain some health and emotional issues linked to the condition, suggesting that altered breathing may be a bigger factor than just the inability to perceive smells.
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Enhancer landscape of lung neuroendocrine tumors reveals regulatory and developmental signatures with potential theranostic implications.

Proc Natl Acad Sci U S A

October 2024

The Lautenberg Center for Immunology and Cancer Research, Institute for Medical Research Israel-Canada, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9112102, Israel.

Article Synopsis
  • The study investigates well-differentiated low-grade lung neuroendocrine tumors (LNETs), focusing on their classification and unique molecular profiles beyond the typical and atypical categories.
  • Researchers used genomic techniques to reveal three distinct regulatory subtypes of LNETs, each characterized by specific transcription factors and differentiation signals: "proneuronal," "luminal-like," and "HNF+."
  • Targeting the FGFR signaling pathway in the HNF+ subtype showed promise for reducing tumor growth, highlighting potential new therapeutic approaches for treating these tumors.
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Background: Recently, breakpoints of Enterobacterales to amikacin were changed from MIC ≤ 16 mg/L to MIC ≤ 4 mg/L based mainly on laboratory data with little supporting clinical evidence. Our aim was to investigate the relation between MIC of Enterobacterales to amikacin and mortality among patients with Enterobacterales bacteraemia from a urinary tract source treated with amikacin.

Patients And Methods: This retrospective, single-centre study included patients with Enterobacterales urinary source bacteraemia treated with amikacin, with Low (MIC ≤ 4 mg/L) and High (MIC 8 or 16 mg/L) MICs.

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Objectives: CALGB140503/JCOG0802 RCTs comparing lobectomy with sublobar resection in stage IA NSCLC have confirmed the non-inferiority of segmentectomy. Additional insight is needed to improve preoperative work-up and intraoperative strategies to increase safety and promote the dissemination of minimally invasive segmentectomy (MIS). A Delphi panel study assessed the level of consensus among surgeons for the planning and management of MIS.

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Factors predicting slow visual recovery following microkeratome-assisted myopic LASIK.

Acta Ophthalmol

September 2024

Department of Ophthalmology, Rambam Health Care Campus, Haifa, Israel.

Purpose: To identify factors predicting slow visual recovery following myopic microkeratome assisted in situ keratomileusis (LASIK).

Design: Retrospective study.

Methods: This study included consecutive patients who underwent microkeratome-assisted myopic LASIK between January 2005 and December 2019 at Care Vision Laser Center, Tel Aviv, Israel.

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Objective: Mastoidectomy surgical training is challenging due to the complex nature of the anatomical structures involved. Traditional training methods based on direct patient care and cadaveric temporal bone training have practical shortcomings. 3D-printed temporal bone models and augmented reality (AR) have emerged as promising solutions, particularly for mastoidectomy surgery, which demands an understanding of intricate anatomical structures.

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Prenatal Sonographic Features of Rubinstein-Taybi Syndrome-A Small Case Series of a Rare Syndrome.

Prenat Diagn

November 2024

Obstetrics and Gynecology Ultrasound Unit of the Maternity Hospital, Sheba Medical Center, Tel-Hashomer, Israel.

Article Synopsis
  • Rubinstein-Taybi syndrome (RSTS) is a rare genetic condition marked by intellectual disabilities, unique facial traits, and specific limb deformities.
  • The diagnosis is primarily based on clinical signs and confirmed through genetic tests.
  • This prenatal case study highlights four instances of RSTS, showcasing both early and later sonographic indicators, including nonspecific signs like corpus callosum dysgenesis and distinctive features like a beaked nose and abnormal scrotum development.
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Article Synopsis
  • The study examines the characteristics and outcomes of patients with tapered raphe-type bicuspid aortic valve (BAV) when undergoing trans-catheter aortic valve replacement (TAVR), focusing on the safety and effectiveness of modern heart valves.
  • Researchers analyzed data from 897 patients, finding that those with tapered configurations showed similar success rates and safety between two sizing strategies: annular and supra-annular.
  • The results indicate that TAVR is a safe and effective procedure for these patients, regardless of the sizing method used, maintaining a high rate of clinical efficacy at mid-term follow-up.
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Biofilm formation and toxin production are some of the virulence factors of Clostridioides difficile (C. difficile), which causes hospital-acquired C. difficile infection (HA-CDI).

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Introduction: Placental abruption (PA) is a major obstetric complication associated with worse maternal and neonatal outcomes. Though ultrasound findings may support the diagnosis of PA, the association of such findings to the severity of PA and maternal and neonatal outcomes is not yet clear. We aimed to assess the maternal and neonatal outcomes of PA cases with vs.

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