Cutaneous Epithelioid Angiomatous Nodule: Report of a New Case and Literature Review.

Cutaneous epithelioid angiomatous nodule is a rare benign vascular tumour of the skin with characteristic microscopic features, of which 65 cases have so far been reported after the initial description of this entity in 2004. We present here a new typical case of this rare lesion and provide a comprehensive review of all the previously published cases, delineating the salient clinicopathological features of this rare tumour.

Evidence-Based Clinical Practice Guidelines for Extramammary Paget Disease.

Importance: Extramammary Paget disease (EMPD) is a frequently recurring malignant neoplasm with metastatic potential that presents in older adults on the genital, perianal, and axillary skin. Extramammary Paget disease can precede or occur along with internal malignant neoplasms.

Objective: To develop recommendations for the care of adults with EMPD.

Tumour Budding Is an Independent Predictive Factor of Cutaneous Squamous-cell Carcinoma Aggressiveness.

Background/aim: Tumour budding (TB), i.e. the presence of groups of ≤5 tumour cells ahead of the invasive tumour front, is a pathological feature associated with an aggressive outcome in several cancer types.

Adult-onset porokeratotic eccrine ostial and dermal duct nevus:dermatoscopic findings and treatment with tazarotene.

Porokeratotic eccrine ostial and dermal duct nevus (PEODDN) is a rare dermatosis initially described as 'comedo nevus' and renamed 'PEODDN'; it has also been referred to as linear eccrine nevus with comedones, porokeratotic eccrine ostial and hair follicle nevus, and porokeratotic adnexal ostial nevus. PEODDN is usually present at birth or develops early in life. Rarely, PEODDN can develop in adults.

Are there distinct clinical and pathological features distinguishing idiopathic from drug-induced subacute cutaneous lupus erythematosus? A European retrospective multicenter study.

Background: Clinical and pathologic criteria to distinguish drug-induced subacute lupus erythematosus (DI-SCLE) from idiopathic (I-SCLE) are controversial.

Objective: The aim of the survey was a retrospective analysis of a consistent number of iatrogenous and idiopathic SCLE cases, by means of clinical and histopathologic investigation.

Methods: Eleven European university dermatology units collected all diagnosed cases from January 2000 to December 2016.

Reactive Perforating Collagenosis.

Reactive perforating collagenosis (RPC) is a rare disease belonging to the spectrum of primary perforating dermatoses. It manifests clinically with brown-erythematous papules with a central plug that develop after minor skin trauma, and it is characterized histologically by epidermal perforation and transepidermal elimination of altered dermal collagen. Familial and acquired forms have been described, the latter usually associated with systemic diseases, among which diabetes mellitus and renal failure are the most common.

Basal-Cell Carcinoma With Matrical Differentiation: Report of a New Case in a Renal-Transplant Recipient and Literature Review.

Basal-cell carcinoma with matrical differentiation (BCC-MD) is one of the rarest pathologic variants of basal-cell carcinoma, of which 41 cases have been so far reported in detail. One of them developed in a heart-transplant recipient. We report a new case of BCC-MD occurring in a renal-transplant recipient and review the relevant literature.

Histopathologic characteristics of scleromyxedema: A study of a series of 34 cases.

Background: Few histologic studies describe the histopathologic aspects of scleromyxedema.

Objective: We sought to describe the histopathologic and immunohistochemical features of scleromyxedema in a large series of patients.

Methods: We studied all the cases with scleromyxedema diagnosed between 2000 and 2014 at participating centers.

Ceruminous Adenoma of the External Auditory Canal: A Case Report with Imaging and Pathologic Findings.

Ceruminous adenomas are benign tumors that are rare in humans and present with a nonspecific symptomatology. The treatment of choice is surgical excision. We present an 87-year-old woman who presented with a reddish, tender, round, soft mass of the outer third of the inferior wall of the left external auditory canal, discharging a yellowish fluid upon pressure.

Histopathologic features predictive of aggressiveness of post-transplant cutaneous squamous-cell carcinomas.

Background: Squamous cell carcinomas (SCC), the commonest malignancies developing in organ-transplant recipients (OTR), may behave aggressively. We searched for pathological features of post-transplant SCC that could predict an aggressive outcome early.

Materials And Methods: We pathologically examined 34 SCC developed in OTR that developed later recurrences/metastases, and compared them with 25 non-aggressive SCC excised from the same OTRs over the same period of time for features believed to predict an aggressive outcome (tumour size and thickness, ulceration, deep tissue invasion, mitotic rate, differentiation, peritumoural infiltrate density, acantholysis, perineural and lymphovascular invasion).

Ultrasound findings in cutaneous sarcoidosis.

The diagnosis of cutaneous sarcoidosis relies mainly on the patient's history, presence of characteristic skin lesions and histological examination that shows a granulomatous, non-necrotizing dermal infiltration. The aim of the study was to assess the ultrasonographic features of cutaneous lesions of sarcoidosis before and after treatment. A 38-year-old woman with systemic sarcoidosis and specific cutaneous lesions was treated with systemic steroids followed by hydroxychloroquine.

Zosteriform lichen planus after herpes zoster: report of a new case of Wolf's isotopic phenomenon and literature review.

The Wolf's isotopic phenomenon corresponds to the occurrence of a skin disease at a body site affected previously by a different, already healed dermatosis. We report a 74-year-old man who presented with a zosteriform eruption consisting of erythematous-scaly, slightly pruritic papules on the right flank some weeks after herpes zoster (HZ) had healed on the same area. Histologic examination showed typical changes of lichen planus, confirming the diagnosis of post-HZ zosteriform lichen planus (ZLP).

Porokeratoses: an update of clinical, aetiopathogenic and therapeutic features.

Porokeratoses represent a group of uncommon, acquired or hereditary dermatoses, due to a keratinization disorder whose origin is still unclear; they could be due to the expansion of a clone of abnormal epidermal keratinocytes. Several clinical forms exist, of which the most common is disseminated superficial actinic porokeratosis; other forms include Mibelli, disseminated superficial, linear, palmoplantaris punctata and palmaris, plantaris et disseminata. These may coexist in the same patient or in different members of the same family.

Proliferating pagetoid dyskeratosis: a new variant of pagetoid dyskeratosis associated with Bowen disease.

Pagetoid dyskeratosis refers to a characteristic pathologic aspect of keratinocytes of the epidermis and other stratified epithelia, that have a size larger than normal, a pale cytoplasm and a pycnotic nucleus surrounded by a clear halo. This aspect has been reported, often as an incidental finding, in benign conditions. We observed a case of Bowen disease featuring pagetoid dyskeratosis remarkable because the cells concerned were in mitosis, a finding so far unreported.

CDX2 expression in cutaneous metastatic carcinomas and extramammary Paget's Disease.

Background: CDX2 is a gene involved in the regulation of intestinal cell proliferation/differentiation. It is considered specific for enterocytes and has been used for the diagnosis of primary and metastatic colon adenocarcinoma. The aim of this study was to assess the usefulness of CDX2 in the diagnosis of cutaneous metastatic tumors and extramammary Paget's disease.